0a6c0073d509c8a6fe644854c9554d9a pmc_11393977.pdf 54e1adfdf0ea0acd0b5376ee07cd9aaaf08c9515 pmc_11393977.pdf edf9abc561397240a70e76e9fcab21d3dd595f71ac4a68bc8a9f08f869a2c20c pmc_11393977.pdf Title: The Role of Radiomics in the Prediction of Clinically Significant Prostate Cancer in the PI-RADS v2 and v2.1 Era: A Systematic Review Subject: Early detection of clinically significant prostate cancer (csPCa) has substantially improved with the latest PI-RADS versions. However, there is still an overdiagnosis of indolent lesions (iPCa), and radiomics has emerged as a potential solution. The aim of this systematic review is to evaluate the role of handcrafted and deep radiomics in differentiating lesions with csPCa from those with iPCa and benign lesions on prostate MRI assessed with PI-RADS v2 and/or 2.1. The literature search was conducted in PubMed, Cochrane, and Web of Science databases to select relevant studies. Quality assessment was carried out with Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2), Radiomic Quality Score (RQS), and Checklist for Artificial Intelligence in Medical Imaging (CLAIM) tools. A total of 14 studies were deemed as relevant from 411 publications. The results highlighted a good performance of handcrafted and deep radiomics methods for csPCa detection, but without significant differences compared to radiologists (PI-RADS) in the few studies in which it was assessed. Moreover, heterogeneity and restrictions were found in the studies and quality analysis, which might induce bias. Future studies should tackle these problems to encourage clinical applicability. Prospective studies and comparison with radiologists (PI-RADS) are needed to better understand its potential. Keywords: clinically significant prostate cancer; PI-RADS; magnetic resonance imaging; radiomics; deep learning; machine learning; systematic review; prediction Author: Andreu Antolin, Nuria Roson, Richard Mast, Javier Arce, Ramon Almodovar, Roger Cortada, Almudena Maceda, Manuel Escobar, Enrique Trilla and Juan Morote Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Sat Aug 24 08:14:43 2024 CEST ModDate: Sat Aug 24 08:19:55 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 20 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1804068 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GDDFPQ+VnURWPalladioL Type 1 Custom yes yes yes 10 0 QYQQPF+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 RPWRHM+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 WTZEEZ+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 44 0 EILUJF+CMSY10 Type 1 Builtin yes yes yes 61 0 IFBACH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 78 0 IFBACJ+PalatinoLinotype TrueType WinAnsi yes yes no 81 0 IFBACL+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 84 0 IFBAIL+PalatinoLinotype TrueType MacRoman yes yes no 87 0 IFBACG+PalatinoLinotype,Bold CID TrueType Identity-H yes yes yes 97 0 IFBACH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 103 0 IFBACJ+PalatinoLinotype TrueType WinAnsi yes yes no 106 0 IFBACL+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 109 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-10 02:43:27 CEST RepresentationInformation: pmc_11393977.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-09-26 02:32:00 CEST Size: 1804068 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 799 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Evidence Acquisition Destination: section.2 Children: Item: Title: Literature Search Destination: subsection.2.1 Item: Title: Eligibility Criteria Destination: subsection.2.2 Item: Title: Quality Assessment Destination: subsection.2.3 Item: Title: Artificial Intelligence Quality Assessment Destination: subsection.2.4 Item: Title: Data Collection Destination: subsection.2.5 Item: Title: Evidence Synthesis Destination: section.3 Children: Item: Title: Study Selection Destination: subsection.3.1 Item: Title: QUADAS-2 Risk of Bias Assessment Destination: subsection.3.2 Item: Title: Quality Assessment Based on RQS and CLAIM Destination: subsection.3.3 Item: Title: Study Characteristics Destination: subsection.3.4 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: appendix.A. Info: Title: The Role of Radiomics in the Prediction of Clinically Significant Prostate Cancer in the PI-RADS v2 and v2.1 Era: A Systematic Review Author: Andreu Antolin, Nuria Roson, Richard Mast, Javier Arce, Ramon Almodovar, Roger Cortada, Almudena Maceda, Manuel Escobar, Enrique Trilla and Juan Morote Subject: Early detection of clinically significant prostate cancer (csPCa) has substantially improved with the latest PI-RADS versions. However, there is still an overdiagnosis of indolent lesions (iPCa), and radiomics has emerged as a potential solution. The aim of this systematic review is to evaluate the role of handcrafted and deep radiomics in differentiating lesions with csPCa from those with iPCa and benign lesions on prostate MRI assessed with PI-RADS v2 and/or 2.1. The literature search was conducted in PubMed, Cochrane, and Web of Science databases to select relevant studies. Quality assessment was carried out with Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2), Radiomic Quality Score (RQS), and Checklist for Artificial Intelligence in Medical Imaging (CLAIM) tools. A total of 14 studies were deemed as relevant from 411 publications. The results highlighted a good performance of handcrafted and deep radiomics methods for csPCa detection, but without significant differences compared to radiologists (PI-RADS) in the few studies in which it was assessed. Moreover, heterogeneity and restrictions were found in the studies and quality analysis, which might induce bias. Future studies should tackle these problems to encourage clinical applicability. Prospective studies and comparison with radiologists (PI-RADS) are needed to better understand its potential. 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