ac5f43e4d2787ab75b0d34bbe1963fa3 pmc_11396011.pdf b4713cdc21226eae8710f80f21737a86564de9ca pmc_11396011.pdf 3e1db560f621359b65456e2c894bb1fdd2353c592664caf0da40866393268a42 pmc_11396011.pdf Title: Development of the International Federation for Surgery of Obesity and Metabolic Disorders-European Chapter (IFSO-EC) Grade-Based Guidelines on the Surgical Treatment of Obesity Using Multimodal Strategies: Design and Methodological Aspects Subject: Background: The prevalence of obesity is already a worldwide health concern. The development of straightforward guidelines regarding the whole available armamentarium (i.e., medical, endoscopic, and surgical interventions in conjunction with a guidance program) is paramount to offering the best multimodal approach to patients with obesity. Methods: The International Federation for Surgery of Obesity and Metabolic Disorders-European Chapter (IFSO-EC) identified a panel of experts to develop the present guidelines. The panel formulated a series of clinical questions (based on the patient, intervention, comparison, and outcome conceptual framework), which have been voted on and approved. A GRADE methodology will be applied to assess the quality of evidence and formulate recommendations employed to minimize selection and information biases. This approach aims to enhance the reliability and validity of recommendations, promoting greater adherence to the best available evidence. Results: These guidelines are intended for adult patients with a body mass index (BMI) 30 kg/m2 who are candidates for metabolic bariatric surgery (MBS). The expert panel responsible for developing these guidelines comprised 25 panelists (92% were bariatric surgeons) and 3 evidence reviewers, with an average age of 50.1 10.2 years. The panel focused on 3 key questions regarding the combined use of structured lifestyle interventions, approved obesity management medications, and endoscopic weight loss procedures with MBS. Conclusions: The complexity of obesity as a chronic disease requires a comprehensive knowledge of all the available and feasible therapeutic options. The IFSO-EC society felt the urgent need to develop methodologically valid guidelines to give a full picture and awareness of the possible surgical and non-surgical therapeutic strategies employed with a multimodal approach. Keywords: obesity; metabolic bariatric surgery; obesity-related medical conditions; obesity management medications; lifestyle interventions; endoscopic weight loss procedures; guidelines Author: Maurizio De Luca, Amanda Belluzzi, Paulina Salminen, Marco Bueter, Juan Pujol-Rafols, Nasser Sakran, Christine Stier, Halit Eren Taskin, Sonja Chiappetta, Francesco Maria Carrano, Nicola Di Lorenzo, Simon Nienhuijs, Ramón Vilallonga Puy, Erik Stenberg, Marloes Emous, Gerhard Prager, Jacques Himpens, Daniel Moritz Felsenreich, Antonio Iannelli, Chetan Parmar, Catalin Copaescu, Martin Fried, Elena Ruiz-Úcar, Ricardo V. Cohen, Stefano Olmi, Luigi Angrisani, Rui Ribeiro, Giulia Bandini, Daniele Scoccimarro, Benedetta Ragghianti and Matteo Monami Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Wed Aug 28 12:26:58 2024 CEST ModDate: Wed Aug 28 12:39:13 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 422133 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CMLZCZ+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 HNBQSE+VnURWPalladioL Type 1 Custom yes yes yes 16 0 XWYPSQ+URWPalladioL-Bold Type 1 Custom yes yes yes 21 0 XZCSEL+URWPalladioL-Roma Type 1 Custom yes yes yes 27 0 PIOLNY+URWPalladioL-Ital Type 1 Custom yes yes yes 32 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 48 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 51 0 FESTFF+CMSY10 Type 1 Builtin yes yes yes 68 0 RIJDHR+CMBSY10 Type 1 Builtin yes yes yes 88 0 OFKOKG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 100 0 OFKOKH+PalatinoLinotype,Bold CID TrueType Identity-H yes yes yes 103 0 OFKOKI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 109 0 OFKOKK+PalatinoLinotype TrueType WinAnsi yes yes no 112 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-06 02:48:33 CET RepresentationInformation: pmc_11396011.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-11-14 02:20:58 CET Size: 422133 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 272 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: References Destination: appendix.A. Info: Title: Development of the International Federation for Surgery of Obesity and Metabolic Disorders-European Chapter (IFSO-EC) Grade-Based Guidelines on the Surgical Treatment of Obesity Using Multimodal Strategies: Design and Methodological Aspects Author: Maurizio De Luca, Amanda Belluzzi, Paulina Salminen, Marco Bueter, Juan Pujol-Rafols, Nasser Sakran, Christine Stier, Halit Eren Taskin, Sonja Chiappetta, Francesco Maria Carrano, Nicola Di Lorenzo, Simon Nienhuijs, Ramón Vilallonga Puy, Erik Stenberg, Marloes Emous, Gerhard Prager, Jacques Himpens, Daniel Moritz Felsenreich, Antonio Iannelli, Chetan Parmar, Catalin Copaescu, Martin Fried, Elena Ruiz-Úcar, Ricardo V. Cohen, Stefano Olmi, Luigi Angrisani, Rui Ribeiro, Giulia Bandini, Daniele Scoccimarro, Benedetta Ragghianti and Matteo Monami Subject: Background: The prevalence of obesity is already a worldwide health concern. The development of straightforward guidelines regarding the whole available armamentarium (i.e., medical, endoscopic, and surgical interventions in conjunction with a guidance program) is paramount to offering the best multimodal approach to patients with obesity. Methods: The International Federation for Surgery of Obesity and Metabolic Disorders-European Chapter (IFSO-EC) identified a panel of experts to develop the present guidelines. The panel formulated a series of clinical questions (based on the patient, intervention, comparison, and outcome conceptual framework), which have been voted on and approved. A GRADE methodology will be applied to assess the quality of evidence and formulate recommendations employed to minimize selection and information biases. This approach aims to enhance the reliability and validity of recommendations, promoting greater adherence to the best available evidence. Results: These guidelines are intended for adult patients with a body mass index (BMI) 30 kg/m2 who are candidates for metabolic bariatric surgery (MBS). The expert panel responsible for developing these guidelines comprised 25 panelists (92% were bariatric surgeons) and 3 evidence reviewers, with an average age of 50.1 10.2 years. The panel focused on 3 key questions regarding the combined use of structured lifestyle interventions, approved obesity management medications, and endoscopic weight loss procedures with MBS. Conclusions: The complexity of obesity as a chronic disease requires a comprehensive knowledge of all the available and feasible therapeutic options. The IFSO-EC society felt the urgent need to develop methodologically valid guidelines to give a full picture and awareness of the possible surgical and non-surgical therapeutic strategies employed with a multimodal approach. 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