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Title:           Discontinuation of psychotropic medication: a synthesis of evidence across medication classes
Subject:         Molecular Psychiatry, doi:10.1038/s41380-024-02445-4
Keywords:        
Author:          Christiaan H. Vinkers
Creator:         Springer
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        Title: Introduction
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       Item: 
        Title: Methods
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       Item: 
        Title: Discontinuation evidence across psychotropic medication classes
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         Item: 
          Title: Antidepressants
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            Title: Who can discontinue?
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            Title: Relapse rates after discontinuation
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           Item: 
            Title: Discontinuation symptoms’(DS)
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            Title: When to discontinue?
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            Title: How to discontinue?
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            Title: Discontinuation strategies
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            Title: Dose reduction
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            Title: Discontinuation interventions
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            Title: Who can discontinue?
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            Title: Relapse rates after discontinuation
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            Title: Discontinuation symptoms’(DS)
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            Title: Discontinuation interventions
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          Title: Opioids
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            Title: Who can discontinue?
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            Title: Relapse rates after discontinuation
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           Item: 
            Title: Discontinuation symptoms’(DS)
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            Title: Risk factors for relapse following discontinuation
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            Title: When to discontinue?
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            Title: How to discontinue?
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            Title: Discontinuation strategies
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            Title: Dose reduction
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            Title: Discontinuation interventions
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          Title: Stimulants
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            Title: Who can discontinue?
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            Title: Relapse rates after discontinuation
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            Title: Discontinuation symptoms’(DS)
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            Title: Risk factors for relapse following discontinuation
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            Title: How to discontinue?
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            Title: Dose reduction
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          Title: Integration of evidence across medication classes
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            Title: Discontinuation symptoms are common but remain difficult to predict
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            Title: Do not discontinue medication too quickly
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            Title: Many patients can successfully discontinue
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            Title: Chronic treatment with benzodiazepines and opioids should be discouraged
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            Title: Relapse is too narrow an outcome
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            Title: The need for shared decision making and integrated deprescribing
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        Title: Conclusion
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        Title: Author contributions
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       Item: 
        Title: Competing interests
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       Item: 
        Title: ADDITIONAL INFORMATION
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                  <author:name>Jurjen J. Luykx</author:name>
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                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
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                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
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                           <pdfaProperty:category>internal</pdfaProperty:category>
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                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
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                           <pdfaType:description>A structure containing the characteristics of a font used in a document.</pdfaType:description>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
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                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
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                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
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                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
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                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
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                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
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                           <pdfaProperty:category>internal</pdfaProperty:category>
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                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
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                           <pdfaProperty:description>The Digital Object Identifier for the article.&#xA;The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. &#xA;If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). &#xA;</pdfaProperty:description>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. &#xA;Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. &#xA;Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. &#xA;&#xA;Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. &#xA;The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. &#xA;NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
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                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
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                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
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                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
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               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:&#xA;AO = Author’s Original&#xA;SMUR = Submitted Manuscript Under Review&#xA;AM = Accepted Manuscript&#xA;P = Proof&#xA;VoR = Version of Record&#xA;CVoR = Corrected Version of Record&#xA;EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
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