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Title:           Aggrescan4D: A comprehensive tool for pH‐dependent analysis and engineering of protein aggregation propensity
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      Title: Aggrescan4D: A comprehensive tool for pH-dependent analysis and engineering of protein aggregation propensity
      Destination: atl_PRO_5180_
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       Item: 
        Title: 1  INTRODUCTION
        Destination: HeadingPRO_5180pro5180-sec-0001
       Item: 
        Title: 2  FROM Aggrescan3D TO Aggrescan4D: TRANSFORMATIVE ADVANCES IN PROTEIN AGGREGATION PREDICTION TECHNOLOGY
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       Item: 
        Title: 3  A4D PIPELINE AND OPTIONS
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         Item: 
          Title: 3.1  pH calculations
          Destination: HeadingPRO_5180pro5180-sec-0004
         Item: 
          Title: 3.2  Stability calculations
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         Item: 
          Title: 3.3  Analysis of the globular regions
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         Item: 
          Title: 3.4  Dynamic mode
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         Item: 
          Title: 3.5  Mutations
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         Item: 
          Title: 3.6  Distance of aggregation analysis
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         Item: 
          Title: 3.7  Automated mutations to improve protein solubility
          Destination: HeadingPRO_5180pro5180-sec-0010
         Item: 
          Title: 3.8  Privacy
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         Item: 
          Title: 3.9  A4D RESTful service
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          Title: 3.10  Database for model organisms
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          Title: 3.11  A3D standalone package
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        Title: 4  CASE STUDY: EVALUATION OF AGGREGATION PREDICTION METHODS WITH MEDI1912 MONOCLONAL ANTIBODY VARIANTS
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        Title: 5  CONCLUSIONS
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       Item: 
        Title: AUTHOR CONTRIBUTIONS
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        Title: ACKNOWLEDGMENTS
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       Item: 
        Title: CONFLICT OF INTEREST STATEMENT
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       Item: 
        Title: ORCID
        Destination: HeadingPRO_5180ORCid
       Item: 
        Title: REFERENCES
        Destination: HeadingPRO_5180pro5180-bibl-00011
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