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Title:           Fatty acid synthase (FASN) is a tumor-cell-intrinsic metabolic checkpoint restricting T-cell immunity
Subject:         Cell Death Discovery, doi:10.1038/s41420-024-02184-z
Keywords:        
Author:          Elisabet Cuyàs
Creator:         Springer
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     Item: 
      Title: Fatty acid synthase (FASN) is a tumor-cell-intrinsic metabolic checkpoint restricting T-cell immunity
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       Item: 
        Title: Introduction
        Destination: A1
       Item: 
        Title: Results
        Destination: A2
        Children: 
         Item: 
          Title: FASN gene expression negatively correlates with immune escape landscapes
          Destination: B1
         Item: 
          Title: FASN gene expression positively correlates with hallmarks of immune escape
          Destination: B2
         Item: 
          Title: FASN loss sensitizes cancer cells to cytokine-activated T-„cells (CATs)
          Destination: B3
         Item: 
          Title: FASN loss reduces metabolic fitness and renders cancer cells more susceptible to killing by cytokine-activated T cells
          Destination: B4
         Item: 
          Title: FASN loss suppresses mitochondrial respiration
          Destination: B5
         Item: 
          Title: Elimination of FASN increases susceptibility of cancer cells to CAT killing by lowering the mitochondrial apoptotic threshold
          Destination: B6
         Item: 
          Title: FASN loss targets adaptive and constitutive up-regulation of PD-L1 via post-translational palmitoylation
          Destination: B7
         Item: 
          Title: FASN contributes to intrinsic cancer cell immuno-resistance in PD-L1-overexpressing/HER2-positive breast cancer cells
          Destination: B8
       Item: 
        Title: Discussion
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       Item: 
        Title: Conclusions
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       Item: 
        Title: Materials and Methods
        Destination: A5
        Children: 
         Item: 
          Title: Immune landscape analysis and cancer dependency map
          Destination: B9
         Item: 
          Title: Cell lines and culture conditions
          Destination: B10
         Item: 
          Title: Immunoblotting
          Destination: B11
         Item: 
          Title: Cytokine-activated T cells
          Destination: B12
         Item: 
          Title: Cell-based immunotherapy potency assays
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         Item: 
          Title: Mathematical model
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         Item: 
          Title: Numerical tools
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         Item: 
          Title: Experimental data fitting and parameters estimation
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         Item: 
          Title: Extracellular flux assay
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         Item: 
          Title: Crystal violet cell killing assay
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         Item: 
          Title: PD-L1 immunofluorescence
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         Item: 
          Title: PD-L1 palmitoylation
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         Item: 
          Title: Statistical analysis
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       Item: 
        Title: References
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       Item: 
        Title: Author contributions
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       Item: 
        Title: Funding
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       Item: 
        Title: Competing interests
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       Item: 
        Title: Consent for publication
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       Item: 
        Title: ADDITIONAL INFORMATION
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    Title: Fatty acid synthase (FASN) is a tumor-cell-intrinsic metabolic checkpoint restricting T-cell immunity
    Author: Elisabet Cuyàs
    Subject: Cell Death Discovery, doi:10.1038/s41420-024-02184-z
    Keywords: 
    Creator: Springer
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               <rdf:li xml:lang="x-default">Fatty acid synthase (FASN) is a tumor-cell-intrinsic metabolic checkpoint restricting T-cell immunity</rdf:li>
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               <rdf:li>Miguel Angel Pardo</rdf:li>
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               <rdf:li>Eduard Teixidor</rdf:li>
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               <rdf:li xml:lang="x-default">Cell Death Discovery, doi:10.1038/s41420-024-02184-z</rdf:li>
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                  <author:name>Eila Serrano-Hervás</author:name>
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                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
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                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
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                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
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