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8115d8c520d961479a2a370f4b862e236550b85772655ffd1ede89febc0cc294  pmc_11478586.pdf

Title:           A Phase III Randomized Controlled Trial of Plitidepsin, a Marine-Derived Compound, in Hospitalized Adults With Moderate COVID-19
Subject:         DOI: 10.1093/cid/ciae227; Clinical Infectious Diseases, 79, 4, 2024-08-26.; Abstract:  Background: Plitidepsin has shown potent preclinical activity against severe acute respiratory syndrome coronavirus 2 and was generally well tolerated in a phase I trial of hospitalized patients with coronavirus disease 2019 (COVID-19). NEPTUNO, a phase III, multicenter, randomized, controlled trial, was designed to evaluate the efficacy and safety of plitidepsin in the management of moderate COVID-19 in hospitalized adult patients. Methods: Included patients had documented severe acute respiratory syndrome coronavirus 2 infection, required oxygen therapy, and had adequate organ function. The planned sample size was 609 patients. Patients were randomized 1:1:1 to at least 3 days of dexamethasone plus either plitidepsin (1.5 mg/day or 2.5 mg/day, for 3 days) or standard of care (control). The primary endpoint was the time to sustained withdrawal of supplemental oxygen. Secondary endpoints included t
Keywords:        plitidepsin; SARS-CoV-2; COVID-19; antiviral agents; marine compounds
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      Title: A Phase III Randomized Controlled Trial of Plitidepsin, a Marine-Derived Compound, in Hospitalized Adults With Moderate COVID-19
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        Title: METHODS
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          Title: Study Design
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          Title: Participants
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          Title: Randomization and Trial Regimens
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        Title: RESULTS
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          Title: Premature Termination of the Trial
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          Title: Patient and Disease Characteristics
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          Title: Primary Efficacy Endpoint
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          Title: Secondary Efficacy Endpoints
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          Title: Safety and Tolerability
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        Title: DISCUSSION
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   Type: CRC32
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