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Title:           Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021–2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study
Subject:         DOI: 10.1093/infdis/jiae154; The Journal of Infectious Diseases, 230, 4, 2024-03-28.; Abstract: Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021–2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0–5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 no
Keywords:        enterovirus D68 (EV-D68); respiratory infection; nonpolio enterovirus (NPEV); European Non-Polio Enterovirus Network (ENPEN); acute flaccid myelitis (AFM)
Author:          Margarida Pires Simoes
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      Title: Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021 2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study
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        Title: METHODS
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          Title: Data Collection and Analysis
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          Title: EV-D68 Phylodynamic and Phylogenetic Analysis
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          Title: Detection Frequencies of EV and EV-D68
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          Title: Seasonality of EV and EV-D68
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          Title: Clinical Characteristics of EV-D68 Cases
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          Title: Phylodynamics and Divergence of EV-D68 Strains
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               <rdf:li xml:lang="x-default">DOI: 10.1093/infdis/jiae154; The Journal of Infectious Diseases, 230, 4, 2024-03-28.; Abstract: Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021–2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0–5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 no</rdf:li>
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               <rdf:li xml:lang="x-default">© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.</rdf:li>
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         <dc:subject>
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               <rdf:li>enterovirus D68 (EV-D68)</rdf:li>
               <rdf:li>respiratory infection</rdf:li>
               <rdf:li>nonpolio enterovirus (NPEV)</rdf:li>
               <rdf:li>European Non-Polio Enterovirus Network (ENPEN)</rdf:li>
               <rdf:li>acute flaccid myelitis (AFM)</rdf:li>
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         <prism:publicationName>The Journal of Infectious Diseases</prism:publicationName>
         <prism:copyright>© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.</prism:copyright>
         <prism:issn>0022-1899</prism:issn>
         <prism:elssn>1537-6613</prism:elssn>
         <prism:volume>230</prism:volume>
         <prism:number>4</prism:number>
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         <prism:startingPage>917</prism:startingPage>
         <prism:endingPage>928</prism:endingPage>
         <prism:doi>10.1093/infdis/jiae154</prism:doi>
         <prism:url>https://doi.org/10.1093/infdis/jiae154</prism:url>
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   Type: CRC32
  Checksum: 514c818cc3656c8ed3031c88043cec8f
   Type: MD5
  Checksum: 1e639ebda7d4cc3d53551288561fa63f1272b391
   Type: SHA-1
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   Type: SHA-256