54c0a381931269ad6416417b867a9967 pmc_11496978.pdf 2009b4611cf80add5c5ec46a4e4d1675f8913310 pmc_11496978.pdf 61feefa180986e8e20aedf341845a86c708d608a68f4e42946d6d81e5ecce373 pmc_11496978.pdf Title: Multiple sclerosis: emerging epidemiological trends and redefining the clinical course Subject: The Lancet Regional Health - Europe, 44 (2024) 100977. doi:10.1016/j.lanepe.2024.100977 Author: Emilio Portaccio Creator: Elsevier Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: Sat Aug 24 16:14:35 2024 CEST ModDate: Sat Aug 24 16:17:39 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 792190 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EHNAIE+AdvTTae869a4c+20 Type 1C WinAnsi yes yes no 1258 0 EHNAIF+AdvTTac2dc932 Type 1C WinAnsi yes yes no 1267 0 EHNAFK+AdvOT20212610.B Type 1C WinAnsi yes yes no 1229 0 EHNAGL+AdvOT20212610.B+fb Type 1C Custom yes yes yes 1234 0 EHNAGM+AdvOT2867105d.I Type 1C WinAnsi yes yes no 1236 0 EHNAGN+AdvstixtSym Type 1C Custom yes yes yes 1241 0 EHNAGO+AdvOT3f9da5b7 Type 1C WinAnsi yes yes no 1243 0 EHNAGP+AdvOT3f9da5b7+fb Type 1C Custom yes yes yes 1247 0 EHNAHA+AdvOT3f9da5b7+20 Type 1C WinAnsi yes yes no 1226 0 EHNAHB+AdvTT0d8bc80f.B Type 1C WinAnsi yes yes no 1250 0 EHNAHC+AdvTT0d8bc80f.B+fb Type 1C Custom yes yes yes 1254 0 EHNAIC+AdvTTae869a4c Type 1C WinAnsi yes yes no 1261 0 EHNAID+AdvTTae869a4c+fb Type 1C Custom yes yes yes 1259 0 EHNAPE+AdvOTb0c9bf5d+20 Type 1C WinAnsi yes yes no 820 0 EHNAPF+AdvTTb4077e6a Type 1C WinAnsi yes yes no 818 0 EHNBAF+AdvOT6c21ae48+22 Type 1C Custom yes yes yes 826 0 EHNCHN+AdvOTb0c9bf5d+03 Type 1C Custom yes yes yes 837 0 EHNEGD+Advstixtexrm Type 1C Custom yes yes yes 855 0 EHNEHD+AdvTTac2dc932+fb Type 1C Custom yes yes yes 862 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-08 02:53:26 CET RepresentationInformation: pmc_11496978.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-06 02:52:04 CET Size: 792190 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1333 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Multiple sclerosis: emerging epidemiological trends and redefining the clinical course Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Current epidemiological landscape in Europe: changing trends and challenges Destination: flink2 Item: Title: Traditional view of MS clinical course Destination: flink3 Item: Title: PIRA concept: redefining the disease course Destination: flink4 Item: Title: Towards a new classification of MS clinical course Destination: flink5 Item: Title: Widening the focus on MS clinical features: hidden symptoms Destination: flink6 Children: Item: Title: Cognitive impairment Destination: slink1 Item: Title: Mental health conditions Destination: slink2 Item: Title: Fatigue Destination: slink3 Item: Title: Pain Destination: slink4 Item: Title: Conclusions and future perspectives Destination: flink7 Item: Title: ContributorsConcept and design of the review: E. Portaccio, M.P. Amato, M. Di Filippo. Interpretation of data and drafting ... Destination: blink1 Item: Title: Declaration of interests Destination: blink2 Item: Title: References Destination: blink3 Info: Title: Multiple sclerosis: emerging epidemiological trends and redefining the clinical course Author: Emilio Portaccio Subject: The Lancet Regional Health - Europe, 44 (2024) 100977. doi:10.1016/j.lanepe.2024.100977 Creator: Elsevier Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: Sat Aug 24 16:44:35 CEST 2024 ModDate: Sat Aug 24 16:47:39 CEST 2024 ID: 0x3b87ed0fa2266b00e6880d9a9d000309, 0x72ffad5de0d6d44eb69dfa5e1fa2ac0b Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1352 ImageHeight: 740 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 858 ImageHeight: 810 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1778 ImageHeight: 863 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: EHNAHB+AdvTT0d8bc80f.B FontSubset: true FirstChar: 40 LastChar: 169 FontDescriptor: FontName: EHNAHB+AdvTT0d8bc80f.B Flags: Serif, Nonsymbolic FontBBox: 0, -250, 947, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHNCHN+AdvOTb0c9bf5d+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EHNCHN+AdvOTb0c9bf5d+03 Flags: Symbolic FontBBox: -479, -364, 854, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHNAHC+AdvTT0d8bc80f.B+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EHNAHC+AdvTT0d8bc80f.B+fb Flags: Symbolic FontBBox: 9, -10, 552, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHNAIE+AdvTTae869a4c+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: EHNAIE+AdvTTae869a4c+20 Flags: Nonsymbolic FontBBox: -20, -239, 1197, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHNAHA+AdvOT3f9da5b7+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: EHNAHA+AdvOT3f9da5b7+20 Flags: Nonsymbolic FontBBox: -156, -177, 916, 739 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHNAID+AdvTTae869a4c+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EHNAID+AdvTTae869a4c+fb Flags: Symbolic FontBBox: 19, -10, 552, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHNAIC+AdvTTae869a4c FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: EHNAIC+AdvTTae869a4c Flags: Serif, Nonsymbolic FontBBox: 0, -250, 927, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHNAFK+AdvOT20212610.B FontSubset: true FirstChar: 37 LastChar: 121 FontDescriptor: FontName: EHNAFK+AdvOT20212610.B Flags: Nonsymbolic FontBBox: -52, -239, 833, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHNAGL+AdvOT20212610.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EHNAGL+AdvOT20212610.B+fb Flags: Symbolic FontBBox: 0, 0, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHNAPF+AdvTTb4077e6a FontSubset: true FirstChar: 46 LastChar: 108 FontDescriptor: FontName: EHNAPF+AdvTTb4077e6a Flags: Serif, Nonsymbolic FontBBox: -104, -239, 822, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHNAIF+AdvTTac2dc932 FontSubset: true FirstChar: 45 LastChar: 122 FontDescriptor: FontName: EHNAIF+AdvTTac2dc932 Flags: Serif, Nonsymbolic FontBBox: -166, -250, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHNAGM+AdvOT2867105d.I FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: EHNAGM+AdvOT2867105d.I Flags: Serif, Nonsymbolic FontBBox: -104, -239, 791, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHNAPE+AdvOTb0c9bf5d+20 FontSubset: true FirstChar: 128 LastChar: 128 FontDescriptor: FontName: EHNAPE+AdvOTb0c9bf5d+20 Flags: Nonsymbolic FontBBox: 37, -12, 462, 664 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHNEGD+Advstixtexrm FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EHNEGD+Advstixtexrm Flags: Symbolic FontBBox: -385, -229, 1041, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHNAGN+AdvstixtSym FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EHNAGN+AdvstixtSym Flags: Symbolic FontBBox: -20, -1114, 1135, 822 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHNBAF+AdvOT6c21ae48+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EHNBAF+AdvOT6c21ae48+22 Flags: Symbolic FontBBox: 0, -322, 1312, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHNAGO+AdvOT3f9da5b7 FontSubset: true FirstChar: 40 LastChar: 242 FontDescriptor: FontName: EHNAGO+AdvOT3f9da5b7 Flags: Nonsymbolic FontBBox: -52, -239, 791, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EHNEHD+AdvTTac2dc932+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EHNEHD+AdvTTac2dc932+fb Flags: Symbolic FontBBox: -166, -250, 520, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EHNAGP+AdvOT3f9da5b7+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EHNAGP+AdvOT3f9da5b7+fb Flags: Symbolic FontBBox: 0, 0, 697, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1016/j.lanepe.2024.100977 Multiple sclerosis: emerging epidemiological trends and redefining the clinical course Emilio Portaccio Melinda Magyari Eva Kubala Havrdova Aurelie Ruet Bruno Brochet Antonio Scalfari Massimiliano Di Filippo Carmen Tur Xavier Montalban Maria Pia Amato Multiple sclerosis Epidemiology Progression idependent of relapse activity Clinical classification The Lancet Regional Health - Europe, 44 (2024) 100977. doi:10.1016/j.lanepe.2024.100977 The Author(s) journal The Lancet Regional Health - Europe © 2024 The Author(s). Published by Elsevier Ltd. 2666-7762 44 September 2024 100977 100977 10.1016/j.lanepe.2024.100977 https://doi.org/10.1016/j.lanepe.2024.100977 2010-04-23 true 10.1016/j.lanepe.2024.100977 elsevier.com sciencedirect.com VoR 7.0 10.1016/j.lanepe.2024.100977 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2024-08-24T19:44:35+05:30 2024-08-24T19:47:39+05:30 2024-08-24T19:47:39+05:30 True 1 https://www.elsevier.com/tdm/tdmrep-policy.json Acrobat Distiller 8.0.0 (Windows) uuid:cba81f86-8da7-427f-9a11-5591617fb283 uuid:57fe28e4-39b2-4b0e-ac1d-5a4f4668058a http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 86, 583, 86, 584 Annotation: Subtype: Link Rect: 88, 584, 91, 590 Destination: 1143 Annotation: Subtype: Link Rect: 92, 584, 96, 590 Destination: 1143 Annotation: Subtype: Link Rect: 148, 583, 148, 584 Annotation: Subtype: Link Rect: 150, 584, 153, 591 Destination: 1143 Annotation: Subtype: Link Rect: 218, 583, 218, 584 Annotation: Subtype: Link Rect: 220, 584, 223, 590 Destination: 1143 Annotation: Subtype: Link Rect: 261, 583, 261, 584 Annotation: Subtype: Link Rect: 262, 584, 266, 591 Destination: 1143 Annotation: Subtype: Link Rect: 266, 584, 269, 590 Destination: 1143 Annotation: Subtype: Link Rect: 314, 583, 314, 584 Annotation: Subtype: Link Rect: 315, 584, 319, 591 Destination: 1143 Annotation: Subtype: Link Rect: 368, 583, 368, 584 Annotation: Subtype: Link Rect: 370, 584, 373, 591 Destination: 1143 Annotation: Subtype: Link Rect: 444, 583, 444, 584 Annotation: Subtype: Link Rect: 445, 584, 449, 590 Destination: 1143 Annotation: Subtype: Link Rect: 74, 572, 74, 573 Annotation: Subtype: Link Rect: 76, 573, 79, 580 Destination: 1143 Annotation: Subtype: Link Rect: 135, 572, 135, 573 Annotation: Subtype: Link Rect: 136, 573, 140, 580 Destination: 1143 Annotation: Subtype: Link Rect: 207, 572, 207, 573 Annotation: Subtype: Link Rect: 207, 573, 210, 579 Destination: 1143 Annotation: Subtype: Link Rect: 211, 573, 212, 580 Destination: 1143 Annotation: Subtype: Link Rect: 70, 225, 263, 234 Annotation: Subtype: Link Rect: 246, 154, 249, 161 Destination: 294 Annotation: Subtype: Link Rect: 320, 178, 322, 185 Destination: 294 Annotation: Subtype: Link Rect: 309, 135, 311, 141 Destination: 294 Annotation: Subtype: Link Rect: 115, 88, 247, 95 Annotation: Subtype: Link Rect: 39, 79, 171, 86 Annotation: Subtype: Link Rect: 178, 79, 249, 86 Annotation: Subtype: Link Rect: 39, 70, 100, 77 Annotation: Subtype: Link Rect: 104, 70, 236, 77 Annotation: Subtype: Link Rect: 96, 43, 169, 50 Annotation: Subtype: Link Rect: 487, 612, 515, 640 Annotation: Subtype: Link Rect: 487, 364, 540, 372 Annotation: Subtype: Link Rect: 487, 355, 544, 362 Annotation: Subtype: Link Rect: 487, 345, 509, 352 Annotation: Subtype: Link Rect: 39, 12, 96, 19 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 326, 389, 328, 396 Destination: 294 Annotation: Subtype: Link Rect: 266, 313, 269, 319 Destination: 294 Annotation: Subtype: Link Rect: 269, 313, 269, 322 Destination: 294 Annotation: Subtype: Link Rect: 160, 291, 162, 297 Destination: 294 Annotation: Subtype: Link Rect: 162, 291, 162, 300 Destination: 294 Annotation: Subtype: Link Rect: 326, 258, 328, 264 Destination: 294 Annotation: Subtype: Link Rect: 552, 651, 555, 658 Destination: 294 Annotation: Subtype: Link Rect: 527, 629, 529, 636 Destination: 294 Annotation: Subtype: Link Rect: 511, 608, 513, 614 Destination: 294 Annotation: Subtype: Link Rect: 515, 608, 517, 614 Destination: 294 Annotation: Subtype: Link Rect: 440, 586, 442, 592 Destination: 294 Annotation: Subtype: Link Rect: 443, 586, 446, 592 Destination: 294 Annotation: Subtype: Link Rect: 477, 564, 482, 570 Destination: 294 Annotation: Subtype: Link Rect: 522, 531, 524, 538 Destination: 294 Annotation: Subtype: Link Rect: 524, 531, 525, 540 Destination: 294 Annotation: Subtype: Link Rect: 550, 476, 555, 483 Destination: 294 Annotation: Subtype: Link Rect: 543, 421, 555, 428 Destination: 294 Annotation: Subtype: Link Rect: 403, 399, 408, 406 Destination: 294 Annotation: Subtype: Link Rect: 408, 400, 408, 409 Destination: 294 Annotation: Subtype: Link Rect: 536, 366, 541, 373 Destination: 294 Annotation: Subtype: Link Rect: 542, 366, 547, 373 Destination: 294 Annotation: Subtype: Link Rect: 547, 367, 547, 376 Destination: 294 Annotation: Subtype: Link Rect: 380, 330, 408, 339 Destination: 38 Annotation: Subtype: Link Rect: 458, 290, 463, 296 Destination: 422 Annotation: Subtype: Link Rect: 463, 290, 463, 299 Destination: 422 Annotation: Subtype: Link Rect: 460, 257, 465, 264 Destination: 294 Annotation: Subtype: Link Rect: 465, 257, 465, 266 Destination: 294 Annotation: Subtype: Link Rect: 522, 136, 524, 143 Destination: 294 Annotation: Subtype: Link Rect: 461, 103, 466, 110 Destination: 422 Annotation: Subtype: Link Rect: 427, 60, 432, 66 Destination: 422 Annotation: Subtype: Link Rect: 451, 49, 456, 55 Destination: 294 Annotation: Subtype: Link Rect: 425, 12, 482, 19 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 102, 162, 107, 169 Destination: 422 Annotation: Subtype: Link Rect: 208, 63, 213, 70 Destination: 422 Annotation: Subtype: Link Rect: 438, 107, 443, 114 Destination: 422 Annotation: Subtype: Link Rect: 454, 85, 459, 92 Destination: 422 Annotation: Subtype: Link Rect: 304, 74, 309, 81 Destination: 422 Annotation: Subtype: Link Rect: 328, 52, 333, 59 Destination: 422 Annotation: Subtype: Link Rect: 72, 627, 77, 634 Destination: 294 Annotation: Subtype: Link Rect: 96, 616, 101, 623 Destination: 294 Annotation: Subtype: Link Rect: 119, 606, 124, 613 Destination: 294 Annotation: Subtype: Link Rect: 146, 595, 151, 602 Destination: 294 Annotation: Subtype: Link Rect: 69, 585, 74, 592 Destination: 294 Annotation: Subtype: Link Rect: 69, 574, 74, 581 Destination: 294 Annotation: Subtype: Link Rect: 126, 564, 131, 571 Destination: 294 Annotation: Subtype: Link Rect: 69, 553, 74, 560 Destination: 294 Annotation: Subtype: Link Rect: 75, 553, 80, 560 Destination: 294 Annotation: Subtype: Link Rect: 82, 526, 87, 533 Destination: 294 Annotation: Subtype: Link Rect: 67, 515, 72, 522 Destination: 294 Annotation: Subtype: Link Rect: 71, 505, 76, 512 Destination: 294 Annotation: Subtype: Link Rect: 79, 494, 83, 501 Destination: 294 Annotation: Subtype: Link Rect: 64, 484, 68, 491 Destination: 294 Annotation: Subtype: Link Rect: 93, 473, 98, 480 Destination: 294 Annotation: Subtype: Link Rect: 66, 463, 71, 470 Destination: 294 Annotation: Subtype: Link Rect: 79, 452, 84, 459 Destination: 294 Annotation: Subtype: Link Rect: 85, 442, 90, 449 Destination: 294 Annotation: Subtype: Link Rect: 91, 442, 96, 449 Destination: 294 Annotation: Subtype: Link Rect: 59, 423, 65, 430 Destination: 294 Annotation: Subtype: Link Rect: 77, 412, 82, 419 Destination: 294 Annotation: Subtype: Link Rect: 100, 402, 105, 409 Destination: 422 Annotation: Subtype: Link Rect: 133, 391, 138, 398 Destination: 422 Annotation: Subtype: Link Rect: 105, 381, 110, 388 Destination: 422 Annotation: Subtype: Link Rect: 133, 370, 138, 377 Destination: 422 Annotation: Subtype: Link Rect: 72, 360, 78, 367 Destination: 422 Annotation: Subtype: Link Rect: 65, 349, 70, 356 Destination: 422 Annotation: Subtype: Link Rect: 72, 349, 77, 356 Destination: 422 Annotation: Subtype: Link Rect: 79, 339, 84, 345 Destination: 422 Annotation: Subtype: Link Rect: 80, 328, 86, 335 Destination: 422 Annotation: Subtype: Link Rect: 67, 318, 72, 324 Destination: 422 Annotation: Subtype: Link Rect: 71, 307, 76, 314 Destination: 422 Annotation: Subtype: Link Rect: 72, 297, 77, 303 Destination: 422 Annotation: Subtype: Link Rect: 129, 286, 134, 293 Destination: 422 Annotation: Subtype: Link Rect: 88, 276, 93, 282 Destination: 422 Annotation: Subtype: Link Rect: 39, 12, 96, 19 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 151, 629, 156, 636 Destination: 422 Annotation: Subtype: Link Rect: 291, 542, 296, 549 Destination: 422 Annotation: Subtype: Link Rect: 226, 377, 231, 384 Destination: 422 Annotation: Subtype: Link Rect: 180, 323, 185, 329 Destination: 422 Annotation: Subtype: Link Rect: 294, 290, 299, 296 Destination: 422 Annotation: Subtype: Link Rect: 317, 268, 322, 275 Destination: 422 Annotation: Subtype: Link Rect: 272, 246, 277, 253 Destination: 422 Annotation: Subtype: Link Rect: 252, 158, 264, 165 Destination: 422 Annotation: Subtype: Link Rect: 207, 103, 212, 110 Destination: 422 Annotation: Subtype: Link Rect: 186, 92, 191, 99 Destination: 422 Annotation: Subtype: Link Rect: 192, 71, 197, 77 Destination: 422 Annotation: Subtype: Link Rect: 155, 49, 160, 55 Destination: 422 Annotation: Subtype: Link Rect: 550, 640, 555, 647 Destination: 422 Annotation: Subtype: Link Rect: 398, 618, 403, 625 Destination: 422 Annotation: Subtype: Link Rect: 404, 597, 409, 603 Destination: 422 Annotation: Subtype: Link Rect: 470, 564, 475, 570 Destination: 422 Annotation: Subtype: Link Rect: 550, 553, 555, 559 Destination: 422 Annotation: Subtype: Link Rect: 398, 509, 403, 516 Destination: 422 Annotation: Subtype: Link Rect: 405, 509, 410, 516 Destination: 574 Annotation: Subtype: Link Rect: 419, 498, 424, 505 Destination: 574 Annotation: Subtype: Link Rect: 506, 465, 511, 472 Destination: 422 Annotation: Subtype: Link Rect: 512, 465, 517, 472 Destination: 574 Annotation: Subtype: Link Rect: 490, 432, 495, 439 Destination: 574 Annotation: Subtype: Link Rect: 478, 399, 483, 406 Destination: 574 Annotation: Subtype: Link Rect: 549, 388, 555, 395 Destination: 422 Annotation: Subtype: Link Rect: 524, 323, 529, 329 Destination: 574 Annotation: Subtype: Link Rect: 537, 279, 542, 286 Destination: 422 Annotation: Subtype: Link Rect: 544, 279, 549, 286 Destination: 574 Annotation: Subtype: Link Rect: 550, 279, 555, 286 Destination: 574 Annotation: Subtype: Link Rect: 476, 268, 481, 275 Destination: 574 Annotation: Subtype: Link Rect: 532, 268, 537, 275 Destination: 574 Annotation: Subtype: Link Rect: 381, 257, 386, 264 Destination: 574 Annotation: Subtype: Link Rect: 385, 180, 390, 187 Destination: 574 Annotation: Subtype: Link Rect: 503, 169, 508, 176 Destination: 574 Annotation: Subtype: Link Rect: 485, 158, 490, 165 Destination: 422 Annotation: Subtype: Link Rect: 550, 60, 555, 66 Destination: 574 Annotation: Subtype: Link Rect: 425, 12, 482, 19 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 244, 662, 249, 669 Destination: 574 Annotation: Subtype: Link Rect: 132, 575, 137, 581 Destination: 574 Annotation: Subtype: Link Rect: 197, 531, 210, 538 Destination: 574 Annotation: Subtype: Link Rect: 236, 476, 249, 483 Destination: 574 Annotation: Subtype: Link Rect: 131, 454, 136, 461 Destination: 574 Annotation: Subtype: Link Rect: 136, 455, 136, 464 Destination: 574 Annotation: Subtype: Link Rect: 246, 432, 249, 439 Destination: 294 Annotation: Subtype: Link Rect: 62, 345, 67, 351 Destination: 574 Annotation: Subtype: Link Rect: 67, 345, 67, 354 Destination: 574 Annotation: Subtype: Link Rect: 118, 345, 123, 351 Destination: 574 Annotation: Subtype: Link Rect: 133, 286, 156, 295 Destination: 127 Annotation: Subtype: Link Rect: 161, 290, 166, 296 Destination: 574 Annotation: Subtype: Link Rect: 269, 626, 291, 635 Destination: 127 Annotation: Subtype: Link Rect: 296, 629, 301, 636 Destination: 574 Annotation: Subtype: Link Rect: 304, 564, 309, 570 Destination: 574 Annotation: Subtype: Link Rect: 295, 520, 300, 527 Destination: 574 Annotation: Subtype: Link Rect: 301, 520, 306, 527 Destination: 574 Annotation: Subtype: Link Rect: 378, 498, 383, 505 Destination: 574 Annotation: Subtype: Link Rect: 384, 498, 389, 505 Destination: 574 Annotation: Subtype: Link Rect: 329, 487, 334, 494 Destination: 574 Annotation: Subtype: Link Rect: 468, 487, 476, 494 Destination: 574 Annotation: Subtype: Link Rect: 337, 443, 342, 450 Destination: 574 Annotation: Subtype: Link Rect: 299, 432, 304, 439 Destination: 574 Annotation: Subtype: Link Rect: 305, 432, 313, 439 Destination: 574 Annotation: Subtype: Link Rect: 308, 421, 313, 428 Destination: 574 Annotation: Subtype: Link Rect: 282, 388, 287, 395 Destination: 574 Annotation: Subtype: Link Rect: 289, 388, 294, 395 Destination: 574 Annotation: Subtype: Link Rect: 295, 388, 300, 395 Destination: 574 Annotation: Subtype: Link Rect: 301, 388, 309, 395 Destination: 574 Annotation: Subtype: Link Rect: 287, 355, 292, 362 Destination: 574 Annotation: Subtype: Link Rect: 294, 355, 299, 362 Destination: 574 Annotation: Subtype: Link Rect: 326, 301, 334, 307 Destination: 574 Annotation: Subtype: Link Rect: 335, 301, 343, 307 Destination: 574 Annotation: Subtype: Link Rect: 39, 12, 96, 19 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 296, 651, 304, 658 Destination: 574 Annotation: Subtype: Link Rect: 305, 651, 313, 658 Destination: 574 Annotation: Subtype: Link Rect: 181, 564, 188, 570 Destination: 574 Annotation: Subtype: Link Rect: 190, 564, 197, 570 Destination: 574 Annotation: Subtype: Link Rect: 313, 542, 318, 549 Destination: 574 Annotation: Subtype: Link Rect: 135, 520, 140, 527 Destination: 574 Annotation: Subtype: Link Rect: 204, 520, 211, 527 Destination: 574 Annotation: Subtype: Link Rect: 296, 509, 304, 516 Destination: 574 Annotation: Subtype: Link Rect: 192, 454, 199, 461 Destination: 574 Annotation: Subtype: Link Rect: 271, 377, 274, 384 Destination: 294 Annotation: Subtype: Link Rect: 255, 279, 258, 286 Destination: 294 Annotation: Subtype: Link Rect: 192, 257, 199, 264 Destination: 574 Annotation: Subtype: Link Rect: 302, 155, 323, 164 Destination: 168 Annotation: Subtype: Link Rect: 222, 125, 229, 132 Destination: 574 Annotation: Subtype: Link Rect: 207, 114, 215, 121 Destination: 574 Annotation: Subtype: Link Rect: 484, 213, 491, 220 Destination: 574 Annotation: Subtype: Link Rect: 491, 213, 491, 222 Destination: 574 Annotation: Subtype: Link Rect: 529, 114, 536, 121 Destination: 574 Annotation: Subtype: Link Rect: 410, 397, 415, 404 Destination: 574 Annotation: Subtype: Link Rect: 425, 12, 482, 19 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 191, 564, 199, 570 Destination: 574 Annotation: Subtype: Link Rect: 220, 355, 227, 362 Destination: 574 Annotation: Subtype: Link Rect: 93, 257, 100, 264 Destination: 574 Annotation: Subtype: Link Rect: 191, 81, 198, 88 Destination: 574 Annotation: Subtype: Link Rect: 200, 81, 207, 88 Destination: 574 Annotation: Subtype: Link Rect: 290, 648, 312, 657 Destination: 220 Annotation: Subtype: Link Rect: 297, 443, 300, 450 Destination: 294 Annotation: Subtype: Link Rect: 300, 444, 300, 453 Destination: 294 Annotation: Subtype: Link Rect: 269, 341, 291, 350 Destination: 168 Annotation: Subtype: Link Rect: 384, 235, 391, 242 Destination: 574 Annotation: Subtype: Link Rect: 391, 235, 391, 244 Destination: 574 Annotation: Subtype: Link Rect: 374, 213, 391, 220 Destination: 574 Annotation: Subtype: Link Rect: 391, 213, 391, 222 Destination: 574 Annotation: Subtype: Link Rect: 367, 158, 374, 165 Destination: 706 Annotation: Subtype: Link Rect: 374, 159, 374, 168 Destination: 706 Annotation: Subtype: Link Rect: 458, 114, 465, 121 Destination: 706 Annotation: Subtype: Link Rect: 465, 115, 466, 124 Destination: 706 Annotation: Subtype: Link Rect: 301, 60, 308, 66 Destination: 706 Annotation: Subtype: Link Rect: 308, 60, 308, 69 Destination: 706 Annotation: Subtype: Link Rect: 39, 12, 96, 19 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 145, 291, 152, 297 Destination: 706 Annotation: Subtype: Link Rect: 152, 291, 152, 300 Destination: 706 Annotation: Subtype: Link Rect: 228, 269, 236, 275 Destination: 706 Annotation: Subtype: Link Rect: 236, 269, 236, 278 Destination: 706 Annotation: Subtype: Link Rect: 312, 236, 328, 243 Destination: 706 Annotation: Subtype: Link Rect: 134, 137, 141, 144 Destination: 706 Annotation: Subtype: Link Rect: 487, 280, 495, 286 Destination: 706 Annotation: Subtype: Link Rect: 496, 280, 505, 286 Destination: 706 Annotation: Subtype: Link Rect: 504, 280, 505, 289 Destination: 706 Annotation: Subtype: Link Rect: 529, 269, 537, 275 Destination: 706 Annotation: Subtype: Link Rect: 537, 269, 537, 278 Destination: 706 Annotation: Subtype: Link Rect: 504, 247, 512, 254 Destination: 706 Annotation: Subtype: Link Rect: 513, 247, 521, 254 Destination: 706 Annotation: Subtype: Link Rect: 521, 247, 521, 256 Destination: 706 Annotation: Subtype: Link Rect: 497, 203, 505, 210 Destination: 706 Annotation: Subtype: Link Rect: 505, 203, 505, 212 Destination: 706 Annotation: Subtype: Link Rect: 414, 159, 422, 166 Destination: 706 Annotation: Subtype: Link Rect: 422, 160, 422, 169 Destination: 706 Annotation: Subtype: Link Rect: 362, 82, 370, 89 Destination: 706 Annotation: Subtype: Link Rect: 517, 61, 525, 67 Destination: 706 Annotation: Subtype: Link Rect: 425, 12, 482, 19 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 158, 608, 165, 614 Destination: 706 Annotation: Subtype: Link Rect: 167, 608, 174, 614 Destination: 706 Annotation: Subtype: Link Rect: 174, 608, 174, 617 Destination: 706 Annotation: Subtype: Link Rect: 192, 597, 200, 603 Destination: 706 Annotation: Subtype: Link Rect: 200, 597, 200, 606 Destination: 706 Annotation: Subtype: Link Rect: 211, 553, 218, 559 Destination: 706 Annotation: Subtype: Link Rect: 218, 553, 218, 562 Destination: 706 Annotation: Subtype: Link Rect: 110, 498, 118, 505 Destination: 706 Annotation: Subtype: Link Rect: 118, 498, 118, 507 Destination: 706 Annotation: Subtype: Link Rect: 149, 390, 156, 397 Destination: 706 Annotation: Subtype: Link Rect: 60, 303, 67, 309 Destination: 706 Annotation: Subtype: Link Rect: 69, 303, 76, 309 Destination: 706 Annotation: Subtype: Link Rect: 64, 270, 71, 277 Destination: 706 Annotation: Subtype: Link Rect: 72, 270, 80, 277 Destination: 706 Annotation: Subtype: Link Rect: 201, 270, 208, 277 Destination: 706 Annotation: Subtype: Link Rect: 185, 259, 193, 266 Destination: 706 Annotation: Subtype: Link Rect: 161, 138, 168, 145 Destination: 706 Annotation: Subtype: Link Rect: 168, 139, 168, 148 Destination: 706 Annotation: Subtype: Link Rect: 164, 71, 172, 77 Destination: 706 Annotation: Subtype: Link Rect: 281, 640, 289, 647 Destination: 706 Annotation: Subtype: Link Rect: 290, 640, 297, 647 Destination: 706 Annotation: Subtype: Link Rect: 283, 608, 290, 614 Destination: 706 Annotation: Subtype: Link Rect: 397, 575, 405, 581 Destination: 706 Annotation: Subtype: Link Rect: 406, 575, 414, 581 Destination: 706 Annotation: Subtype: Link Rect: 299, 355, 307, 362 Destination: 706 Annotation: Subtype: Link Rect: 372, 334, 380, 340 Destination: 706 Annotation: Subtype: Link Rect: 381, 334, 389, 340 Destination: 706 Annotation: Subtype: Link Rect: 39, 12, 96, 19 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 245, 389, 253, 395 Destination: 706 Annotation: Subtype: Link Rect: 156, 268, 159, 275 Destination: 294 Annotation: Subtype: Link Rect: 326, 180, 328, 187 Destination: 294 Annotation: Subtype: Link Rect: 296, 634, 320, 643 Annotation: Subtype: Link Rect: 47, 623, 150, 632 Annotation: Subtype: Link Rect: 425, 12, 482, 19 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 93, 532, 232, 539 Annotation: Subtype: Link Rect: 53, 524, 249, 531 Annotation: Subtype: Link Rect: 53, 516, 249, 523 Annotation: Subtype: Link Rect: 53, 508, 110, 515 Annotation: Subtype: Link Rect: 133, 484, 249, 491 Annotation: Subtype: Link Rect: 53, 476, 76, 483 Annotation: Subtype: Link Rect: 227, 453, 249, 460 Annotation: Subtype: Link Rect: 53, 445, 167, 452 Annotation: Subtype: Link Rect: 68, 421, 168, 428 Annotation: Subtype: Link Rect: 112, 397, 233, 404 Annotation: Subtype: Link Rect: 53, 373, 176, 380 Annotation: Subtype: Link Rect: 117, 349, 245, 356 Annotation: Subtype: Link Rect: 120, 317, 227, 324 Annotation: Subtype: Link Rect: 161, 285, 249, 292 Annotation: Subtype: Link Rect: 53, 277, 109, 284 Annotation: Subtype: Link Rect: 88, 245, 211, 252 Annotation: Subtype: Link Rect: 53, 221, 217, 228 Annotation: Subtype: Link Rect: 53, 213, 249, 220 Annotation: Subtype: Link Rect: 53, 205, 247, 212 Annotation: Subtype: Link Rect: 227, 182, 249, 189 Annotation: Subtype: Link Rect: 53, 174, 142, 181 Annotation: Subtype: Link Rect: 161, 150, 249, 157 Annotation: Subtype: Link Rect: 53, 142, 109, 149 Annotation: Subtype: Link Rect: 53, 118, 188, 125 Annotation: Subtype: Link Rect: 150, 94, 249, 101 Annotation: Subtype: Link Rect: 53, 86, 79, 93 Annotation: Subtype: Link Rect: 195, 62, 249, 69 Annotation: Subtype: Link Rect: 53, 54, 115, 61 Annotation: Subtype: Link Rect: 454, 653, 476, 660 Annotation: Subtype: Link Rect: 280, 645, 358, 652 Annotation: Subtype: Link Rect: 294, 613, 395, 620 Annotation: Subtype: Link Rect: 443, 589, 476, 596 Annotation: Subtype: Link Rect: 280, 581, 372, 588 Annotation: Subtype: Link Rect: 340, 549, 464, 556 Annotation: Subtype: Link Rect: 421, 525, 476, 532 Annotation: Subtype: Link Rect: 280, 517, 326, 524 Annotation: Subtype: Link Rect: 308, 493, 435, 500 Annotation: Subtype: Link Rect: 418, 469, 476, 476 Annotation: Subtype: Link Rect: 280, 461, 356, 468 Annotation: Subtype: Link Rect: 454, 445, 476, 452 Annotation: Subtype: Link Rect: 280, 437, 385, 444 Annotation: Subtype: Link Rect: 430, 422, 476, 428 Annotation: Subtype: Link Rect: 280, 414, 369, 421 Annotation: Subtype: Link Rect: 405, 390, 476, 397 Annotation: Subtype: Link Rect: 280, 382, 309, 389 Annotation: Subtype: Link Rect: 339, 358, 462, 365 Annotation: Subtype: Link Rect: 382, 326, 476, 333 Annotation: Subtype: Link Rect: 280, 318, 314, 325 Annotation: Subtype: Link Rect: 421, 294, 476, 301 Annotation: Subtype: Link Rect: 280, 286, 326, 293 Annotation: Subtype: Link Rect: 443, 262, 476, 269 Annotation: Subtype: Link Rect: 280, 254, 381, 261 Annotation: Subtype: Link Rect: 454, 222, 476, 229 Annotation: Subtype: Link Rect: 280, 214, 381, 221 Annotation: Subtype: Link Rect: 280, 182, 410, 189 Annotation: Subtype: Link Rect: 280, 151, 382, 158 Annotation: Subtype: Link Rect: 364, 127, 476, 134 Annotation: Subtype: Link Rect: 280, 119, 300, 126 Annotation: Subtype: Link Rect: 280, 95, 408, 102 Annotation: Subtype: Link Rect: 421, 79, 476, 86 Annotation: Subtype: Link Rect: 280, 71, 351, 78 Annotation: Subtype: Link Rect: 39, 12, 96, 19 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 306, 661, 328, 668 Annotation: Subtype: Link Rect: 132, 653, 235, 660 Annotation: Subtype: Link Rect: 193, 629, 320, 636 Annotation: Subtype: Link Rect: 132, 605, 259, 612 Annotation: Subtype: Link Rect: 254, 581, 328, 588 Annotation: Subtype: Link Rect: 132, 573, 187, 580 Annotation: Subtype: Link Rect: 197, 541, 297, 548 Annotation: Subtype: Link Rect: 143, 509, 246, 516 Annotation: Subtype: Link Rect: 200, 485, 326, 492 Annotation: Subtype: Link Rect: 163, 461, 293, 468 Annotation: Subtype: Link Rect: 132, 430, 244, 436 Annotation: Subtype: Link Rect: 253, 398, 328, 405 Annotation: Subtype: Link Rect: 132, 390, 165, 397 Annotation: Subtype: Link Rect: 143, 366, 246, 373 Annotation: Subtype: Link Rect: 210, 342, 310, 349 Annotation: Subtype: Link Rect: 253, 310, 328, 317 Annotation: Subtype: Link Rect: 132, 302, 190, 309 Annotation: Subtype: Link Rect: 223, 278, 323, 285 Annotation: Subtype: Link Rect: 132, 270, 225, 277 Annotation: Subtype: Link Rect: 228, 270, 285, 277 Annotation: Subtype: Link Rect: 289, 270, 291, 277 Annotation: Subtype: Link Rect: 294, 270, 328, 277 Annotation: Subtype: Link Rect: 132, 262, 232, 269 Annotation: Subtype: Link Rect: 157, 230, 289, 237 Annotation: Subtype: Link Rect: 274, 206, 328, 213 Annotation: Subtype: Link Rect: 132, 198, 210, 205 Annotation: Subtype: Link Rect: 306, 174, 328, 181 Annotation: Subtype: Link Rect: 132, 166, 237, 173 Annotation: Subtype: Link Rect: 274, 143, 328, 150 Annotation: Subtype: Link Rect: 132, 135, 208, 142 Annotation: Subtype: Link Rect: 200, 111, 326, 118 Annotation: Subtype: Link Rect: 257, 87, 328, 94 Annotation: Subtype: Link Rect: 132, 79, 162, 86 Annotation: Subtype: Link Rect: 254, 55, 328, 62 Annotation: Subtype: Link Rect: 132, 47, 199, 54 Annotation: Subtype: Link Rect: 522, 645, 555, 652 Annotation: Subtype: Link Rect: 359, 637, 468, 644 Annotation: Subtype: Link Rect: 522, 613, 555, 620 Annotation: Subtype: Link Rect: 359, 605, 453, 612 Annotation: Subtype: Link Rect: 430, 573, 553, 580 Annotation: Subtype: Link Rect: 436, 549, 555, 556 Annotation: Subtype: Link Rect: 359, 541, 370, 548 Annotation: Subtype: Link Rect: 377, 517, 532, 524 Annotation: Subtype: Link Rect: 359, 509, 555, 516 Annotation: Subtype: Link Rect: 359, 501, 555, 508 Annotation: Subtype: Link Rect: 359, 493, 555, 500 Annotation: Subtype: Link Rect: 359, 485, 473, 492 Annotation: Subtype: Link Rect: 533, 461, 555, 468 Annotation: Subtype: Link Rect: 359, 453, 464, 460 Annotation: Subtype: Link Rect: 522, 430, 555, 436 Annotation: Subtype: Link Rect: 359, 422, 458, 428 Annotation: Subtype: Link Rect: 395, 390, 505, 397 Annotation: Subtype: Link Rect: 359, 366, 472, 373 Annotation: Subtype: Link Rect: 533, 342, 555, 349 Annotation: Subtype: Link Rect: 359, 334, 457, 341 Annotation: Subtype: Link Rect: 501, 310, 555, 317 Annotation: Subtype: Link Rect: 359, 302, 432, 309 Annotation: Subtype: Link Rect: 359, 278, 486, 285 Annotation: Subtype: Link Rect: 510, 262, 555, 269 Annotation: Subtype: Link Rect: 359, 254, 423, 261 Annotation: Subtype: Link Rect: 466, 230, 555, 237 Annotation: Subtype: Link Rect: 359, 222, 380, 229 Annotation: Subtype: Link Rect: 359, 214, 555, 221 Annotation: Subtype: Link Rect: 359, 206, 555, 213 Annotation: Subtype: Link Rect: 359, 198, 479, 205 Annotation: Subtype: Link Rect: 359, 166, 491, 173 Annotation: Subtype: Link Rect: 420, 143, 520, 150 Annotation: Subtype: Link Rect: 510, 119, 555, 126 Annotation: Subtype: Link Rect: 359, 111, 456, 118 Annotation: Subtype: Link Rect: 461, 87, 555, 94 Annotation: Subtype: Link Rect: 359, 79, 400, 86 Annotation: Subtype: Link Rect: 522, 55, 555, 62 Annotation: Subtype: Link Rect: 359, 47, 437, 54 Annotation: Subtype: Link Rect: 425, 12, 482, 19 Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 195, 645, 249, 652 Annotation: Subtype: Link Rect: 53, 637, 110, 644 Annotation: Subtype: Link Rect: 53, 605, 195, 612 Annotation: Subtype: Link Rect: 178, 581, 249, 588 Annotation: Subtype: Link Rect: 53, 573, 107, 580 Annotation: Subtype: Link Rect: 216, 549, 249, 556 Annotation: Subtype: Link Rect: 53, 541, 157, 548 Annotation: Subtype: Link Rect: 216, 517, 249, 524 Annotation: Subtype: Link Rect: 53, 509, 147, 516 Annotation: Subtype: Link Rect: 195, 485, 249, 492 Annotation: Subtype: Link Rect: 53, 477, 122, 484 Annotation: Subtype: Link Rect: 195, 453, 249, 460 Annotation: Subtype: Link Rect: 53, 445, 143, 452 Annotation: Subtype: Link Rect: 160, 422, 249, 428 Annotation: Subtype: Link Rect: 53, 414, 75, 421 Annotation: Subtype: Link Rect: 78, 382, 212, 389 Annotation: Subtype: Link Rect: 130, 358, 249, 365 Annotation: Subtype: Link Rect: 53, 350, 86, 357 Annotation: Subtype: Link Rect: 203, 326, 249, 333 Annotation: Subtype: Link Rect: 53, 318, 131, 325 Annotation: Subtype: Link Rect: 178, 286, 249, 293 Annotation: Subtype: Link Rect: 53, 278, 109, 285 Annotation: Subtype: Link Rect: 114, 254, 214, 261 Annotation: Subtype: Link Rect: 195, 214, 249, 221 Annotation: Subtype: Link Rect: 53, 206, 135, 213 Annotation: Subtype: Link Rect: 203, 190, 249, 197 Annotation: Subtype: Link Rect: 53, 182, 121, 189 Annotation: Subtype: Link Rect: 131, 159, 245, 165 Annotation: Subtype: Link Rect: 162, 127, 249, 134 Annotation: Subtype: Link Rect: 53, 119, 103, 126 Annotation: Subtype: Link Rect: 112, 87, 244, 94 Annotation: Subtype: Link Rect: 84, 55, 225, 62 Annotation: Subtype: Link Rect: 363, 645, 463, 652 Annotation: Subtype: Link Rect: 280, 613, 407, 620 Annotation: Subtype: Link Rect: 405, 589, 476, 596 Annotation: Subtype: Link Rect: 280, 581, 339, 588 Annotation: Subtype: Link Rect: 294, 549, 425, 556 Annotation: Subtype: Link Rect: 332, 525, 453, 532 Annotation: Subtype: Link Rect: 340, 493, 465, 500 Annotation: Subtype: Link Rect: 347, 461, 469, 468 Annotation: Subtype: Link Rect: 335, 437, 468, 444 Annotation: Subtype: Link Rect: 388, 406, 476, 413 Annotation: Subtype: Link Rect: 280, 398, 336, 405 Annotation: Subtype: Link Rect: 280, 390, 476, 397 Annotation: Subtype: Link Rect: 280, 382, 476, 389 Annotation: Subtype: Link Rect: 280, 374, 324, 381 Annotation: Subtype: Link Rect: 403, 350, 476, 357 Annotation: Subtype: Link Rect: 280, 342, 327, 349 Annotation: Subtype: Link Rect: 280, 318, 424, 325 Annotation: Subtype: Link Rect: 280, 294, 406, 301 Annotation: Subtype: Link Rect: 377, 270, 476, 277 Annotation: Subtype: Link Rect: 280, 262, 300, 269 Annotation: Subtype: Link Rect: 370, 238, 476, 245 Annotation: Subtype: Link Rect: 280, 230, 303, 237 Annotation: Subtype: Link Rect: 333, 206, 456, 213 Annotation: Subtype: Link Rect: 280, 174, 421, 181 Annotation: Subtype: Link Rect: 387, 151, 476, 158 Annotation: Subtype: Link Rect: 280, 143, 336, 150 Annotation: Subtype: Link Rect: 319, 119, 441, 126 Annotation: Subtype: Link Rect: 430, 95, 476, 102 Annotation: Subtype: Link Rect: 280, 87, 375, 94 Annotation: Subtype: Link Rect: 443, 63, 476, 70 Annotation: Subtype: Link Rect: 280, 55, 369, 62 Annotation: Subtype: Link Rect: 39, 12, 96, 19 Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 199, 645, 328, 652 Annotation: Subtype: Link Rect: 132, 637, 147, 644 Annotation: Subtype: Link Rect: 295, 613, 328, 620 Annotation: Subtype: Link Rect: 132, 605, 223, 612 Annotation: Subtype: Link Rect: 235, 581, 328, 588 Annotation: Subtype: Link Rect: 132, 573, 164, 580 Annotation: Subtype: Link Rect: 306, 549, 328, 556 Annotation: Subtype: Link Rect: 132, 541, 249, 548 Annotation: Subtype: Link Rect: 253, 517, 328, 524 Annotation: Subtype: Link Rect: 132, 509, 191, 516 Annotation: Subtype: Link Rect: 193, 485, 301, 492 Annotation: Subtype: Link Rect: 280, 453, 328, 460 Annotation: Subtype: Link Rect: 132, 445, 217, 452 Annotation: Subtype: Link Rect: 283, 422, 328, 428 Annotation: Subtype: Link Rect: 132, 414, 214, 421 Annotation: Subtype: Link Rect: 257, 390, 328, 397 Annotation: Subtype: Link Rect: 132, 382, 188, 389 Annotation: Subtype: Link Rect: 191, 358, 323, 365 Annotation: Subtype: Link Rect: 212, 326, 328, 333 Annotation: Subtype: Link Rect: 132, 318, 147, 325 Annotation: Subtype: Link Rect: 274, 294, 328, 301 Annotation: Subtype: Link Rect: 132, 286, 205, 293 Annotation: Subtype: Link Rect: 201, 270, 325, 277 Annotation: Subtype: Link Rect: 132, 238, 256, 245 Annotation: Subtype: Link Rect: 197, 206, 325, 213 Annotation: Subtype: Link Rect: 409, 645, 540, 652 Annotation: Subtype: Link Rect: 359, 621, 484, 628 Annotation: Subtype: Link Rect: 359, 613, 555, 620 Annotation: Subtype: Link Rect: 359, 605, 555, 612 Annotation: Subtype: Link Rect: 359, 597, 456, 604 Annotation: Subtype: Link Rect: 467, 573, 555, 580 Annotation: Subtype: Link Rect: 359, 565, 415, 572 Annotation: Subtype: Link Rect: 415, 541, 535, 548 Annotation: Subtype: Link Rect: 432, 517, 552, 524 Annotation: Subtype: Link Rect: 522, 493, 555, 500 Annotation: Subtype: Link Rect: 359, 485, 462, 492 Annotation: Subtype: Link Rect: 359, 461, 457, 468 Annotation: Subtype: Link Rect: 501, 437, 555, 444 Annotation: Subtype: Link Rect: 359, 430, 429, 436 Annotation: Subtype: Link Rect: 416, 406, 516, 413 Annotation: Subtype: Link Rect: 431, 374, 551, 381 Annotation: Subtype: Link Rect: 359, 350, 495, 357 Annotation: Subtype: Link Rect: 533, 326, 555, 333 Annotation: Subtype: Link Rect: 359, 318, 462, 325 Annotation: Subtype: Link Rect: 533, 286, 555, 293 Annotation: Subtype: Link Rect: 359, 278, 479, 285 Annotation: Subtype: Link Rect: 501, 254, 555, 261 Annotation: Subtype: Link Rect: 359, 246, 445, 253 Annotation: Subtype: Link Rect: 467, 214, 555, 221 Annotation: Subtype: Link Rect: 359, 206, 415, 213 Annotation: Subtype: Link Rect: 425, 12, 482, 19 Checksum: e95b3041 Type: CRC32 Checksum: 54c0a381931269ad6416417b867a9967 Type: MD5 Checksum: 2009b4611cf80add5c5ec46a4e4d1675f8913310 Type: SHA-1 Checksum: 61feefa180986e8e20aedf341845a86c708d608a68f4e42946d6d81e5ecce373 Type: SHA-256