808b3dd8bc9f79e6143f39b823b96190  pmc_11528903.pdf
c83af93a946f7b495bf1b497bcd093600b8a7bb4  pmc_11528903.pdf
d884651b433d353a65e7bbfeb801b09d3aed1c553a9c142919ae56df807939a5  pmc_11528903.pdf

Creator:         Adobe InDesign 19.4 (Windows)
Producer:        Adobe PDF Library 17.0
CreationDate:    Thu Oct 31 16:42:59 2024 CET
ModDate:         Thu Oct 31 16:43:05 2024 CET
Custom Metadata: no
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           13
Encrypted:       no
Page size:       595.276 x 841.89 pts (A4)
Page rot:        0
File size:       1348528 bytes
Optimized:       yes
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
KKLPQJ+MetaPro-Bold                  Type 1C           Custom           yes yes yes    100  0
JBXECL+MinionPro-Medium              Type 1C           WinAnsi          yes yes yes    101  0
FDXBYT+MetaPro-Book                  Type 1C           Custom           yes yes yes    107  0
OGDDJB+MetaPro-Normal                Type 1C           Custom           yes yes yes    112  0
QHEFWX+MetaPro-Medium                Type 1C           Custom           yes yes yes    117  0
JCQPCL+MinionPro-Bold                Type 1C           WinAnsi          yes yes yes    121  0
OGDDJB+MetaPro-Normal                Type 1C           WinAnsi          yes yes yes    132  0
OGDDJB+MetaPro-Normal                Type 1C           WinAnsi          yes yes yes     66  0
BYNOUB+MinionPro-Regular             Type 1C           Custom           yes yes yes     71  0
JFKFCL+MetaPro-Normal                Type 1C           Custom           yes yes no      72  0
JFKFCL+MyriadPro-Bold                Type 1C           WinAnsi          yes yes no      74  0
IBVZON+MyriadPro-Regular             Type 1C           WinAnsi          yes yes no      77  0
IBVZON+Roboto-Regular                CID TrueType      Identity-H       yes yes yes     83  0
IBVZON+MyriadPro-Regular             Type 1C           WinAnsi          yes yes no      80  0
FZMHYT+MetaPro-Bold                  Type 1C           Custom           yes yes no      85  0
FZMHYT+MinionPro-Semibold            Type 1C           WinAnsi          yes yes yes     90  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-02-06 02:46:43 CET
 RepresentationInformation: pmc_11528903.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-12-06 02:29:23 CET
  Size: 1348528
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 142
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseNone
    Language: en-GB
   Info: 
    Creator: Adobe InDesign 19.4 (Windows)
    Producer: Adobe PDF Library 17.0
    CreationDate: Thu Oct 31 16:42:59 CET 2024
    ModDate: Thu Oct 31 16:43:05 CET 2024
   ID: 0x49037c0188a21645bbabf53bf58529f5, 0xfcdc15969ded964398e6389e9896c49c
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1336
      ImageHeight: 1424
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Decode: 0, 255
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 445
      ImageHeight: 996
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Decode: 0, 255
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 148
      ImageHeight: 43
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Decode: 0, 255
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1068
      ImageHeight: 366
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Decode: 0, 255
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1202
      ImageHeight: 650
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Decode: 0, 255
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1199
      ImageHeight: 649
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Decode: 0, 255
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1203
      ImageHeight: 651
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Decode: 0, 255
   Fonts: 
    Type0: 
     Font: 
      BaseFont: IBVZON+Roboto-Regular
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: KKLPQJ+MetaPro-Bold
      FontSubset: true
      FirstChar: 18
      LastChar: 243
      FontDescriptor: 
       FontName: KKLPQJ+MetaPro-Bold
       Flags: Nonsymbolic
       FontBBox: -204, -349, 1450, 980
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JBXECL+MinionPro-Medium
      FontSubset: true
      FirstChar: 32
      LastChar: 119
      FontDescriptor: 
       FontName: JBXECL+MinionPro-Medium
       Flags: Serif, Nonsymbolic
       FontBBox: -295, -360, 1684, 995
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: BYNOUB+MinionPro-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 180
      FontDescriptor: 
       FontName: BYNOUB+MinionPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -290, -360, 1684, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JFKFCL+MetaPro-Normal
      FontSubset: true
      FirstChar: 1
      LastChar: 157
      FontDescriptor: 
       FontName: JFKFCL+MetaPro-Normal
       Flags: Symbolic
       FontBBox: -157, -349, 1356, 980
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: JFKFCL+MyriadPro-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 119
      FontDescriptor: 
       FontName: JFKFCL+MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: FDXBYT+MetaPro-Book
      FontSubset: true
      FirstChar: 31
      LastChar: 252
      FontDescriptor: 
       FontName: FDXBYT+MetaPro-Book
       Flags: Nonsymbolic
       FontBBox: -165, -349, 1390, 980
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IBVZON+MyriadPro-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 119
      FontDescriptor: 
       FontName: IBVZON+MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OGDDJB+MetaPro-Normal
      FontSubset: true
      FirstChar: 29
      LastChar: 150
      FontDescriptor: 
       FontName: OGDDJB+MetaPro-Normal
       Flags: Nonsymbolic
       FontBBox: -157, -349, 1356, 980
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IBVZON+MyriadPro-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 119
      FontDescriptor: 
       FontName: IBVZON+MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: QHEFWX+MetaPro-Medium
      FontSubset: true
      FirstChar: 31
      LastChar: 150
      FontDescriptor: 
       FontName: QHEFWX+MetaPro-Medium
       Flags: Nonsymbolic
       FontBBox: -178, -349, 1408, 980
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FZMHYT+MetaPro-Bold
      FontSubset: true
      FirstChar: 1
      LastChar: 173
      FontDescriptor: 
       FontName: FZMHYT+MetaPro-Bold
       Flags: Symbolic
       FontBBox: -204, -349, 1450, 980
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: JCQPCL+MinionPro-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: JCQPCL+MinionPro-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -319, -360, 1684, 1024
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: FZMHYT+MinionPro-Semibold
      FontSubset: true
      FirstChar: 32
      LastChar: 146
      FontDescriptor: 
       FontName: FZMHYT+MinionPro-Semibold
       Flags: Serif, Nonsymbolic
       FontBBox: -308, -360, 1684, 1011
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: IBVZON+Roboto-Regular
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: IBVZON+Roboto-Regular
       Flags: Symbolic
       FontBBox: -737, -271, 1148, 1056
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 9.1-c002 79.a6a6396, 2024/03/12-07:48:23        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
            xmlns:xmp="http://ns.adobe.com/xap/1.0/"
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <xmpMM:InstanceID>uuid:c72d4545-5873-40ad-8240-ee1786e6f4a3</xmpMM:InstanceID>
         <xmpMM:OriginalDocumentID>adobe:docid:indd:acf6a8e2-a11c-11dd-b3aa-eef015a07001</xmpMM:OriginalDocumentID>
         <xmpMM:DocumentID>xmp.id:91c201f6-e1f9-cc48-9640-1241f470f89b</xmpMM:DocumentID>
         <xmpMM:RenditionClass>proof:pdf</xmpMM:RenditionClass>
         <xmpMM:DerivedFrom rdf:parseType="Resource">
            <stRef:instanceID>xmp.iid:add9b4f8-0dde-e346-b3b0-35f00cfd372c</stRef:instanceID>
            <stRef:documentID>xmp.did:81bb148f-ae34-804e-aa0f-68e45d60091f</stRef:documentID>
            <stRef:originalDocumentID>adobe:docid:indd:acf6a8e2-a11c-11dd-b3aa-eef015a07001</stRef:originalDocumentID>
            <stRef:renditionClass>default</stRef:renditionClass>
         </xmpMM:DerivedFrom>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:parameters>from application/x-indesign to application/pdf</stEvt:parameters>
                  <stEvt:softwareAgent>Adobe InDesign 19.4 (Windows)</stEvt:softwareAgent>
                  <stEvt:changed>/</stEvt:changed>
                  <stEvt:when>2024-10-31T16:42:59+01:00</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <xmp:CreateDate>2024-10-31T16:42:59+01:00</xmp:CreateDate>
         <xmp:ModifyDate>2024-10-31T16:43:05+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2024-10-31T16:43:05+01:00</xmp:MetadataDate>
         <xmp:CreatorTool>Adobe InDesign 19.4 (Windows)</xmp:CreatorTool>
         <dc:format>application/pdf</dc:format>
         <pdf:Producer>Adobe PDF Library 17.0</pdf:Producer>
         <pdf:Trapped>False</pdf:Trapped>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
    Page: 
     Sequence: 2
    Page: 
     Sequence: 3
    Page: 
     Sequence: 4
    Page: 
     Sequence: 5
    Page: 
     Sequence: 6
    Page: 
     Sequence: 7
    Page: 
     Sequence: 8
    Page: 
     Sequence: 9
    Page: 
     Sequence: 10
    Page: 
     Sequence: 11
    Page: 
     Sequence: 12
    Page: 
     Sequence: 13
  Checksum: da20bbef
   Type: CRC32
  Checksum: 808b3dd8bc9f79e6143f39b823b96190
   Type: MD5
  Checksum: c83af93a946f7b495bf1b497bcd093600b8a7bb4
   Type: SHA-1
  Checksum: d884651b433d353a65e7bbfeb801b09d3aed1c553a9c142919ae56df807939a5
   Type: SHA-256