2c46e0929f085bf45aa94b5b0aae3d7e pmc_11546346.pdf 57a66a39cdebf09dec26055d888df9bf7701048d pmc_11546346.pdf 17596634d912ddba67c9d3b6526ffc7b22372dddcb13834a8c4d5b57a7e760cd pmc_11546346.pdf Title: A Study of the Relationship Between Objective Tests to Diagnose Erectile Dysfunction and Markers of Cardiovascular Disease Subject: Background: Erectile dysfunction (ED) can stem from various organic and functional causes but is often linked to vascular health and cardiovascular disease. Limited data exist on how cardiovascular disease markers correlate with objective ED tests like the Nocturnal Penile Tumescence and Rigidity (NPTR) test and Penile Color Doppler Ultrasound (PCDU). Methods: A prospective observational study was performed, and 58 men with ED were assessed using the International Index of Erectile Function-15 (IIEF-15), NPTR test, and PCDU. Peripheral vascular health was evaluated through carotid intima-media thickness (cIMT) and brachial flow-mediated dilation (FMD). Results: Out of the participants, 44 had normal NPTR results, while 14 had abnormal results. The group with abnormal NPTR results was significantly older and had higher rates of hypertension and diabetes. Although the IIEF-15 scores were similar between the two groups, those with abnormal NPTR results had a lower peak systolic velocity (PSV) and a higher prevalence of impaired PSV. Correlations between the IIEF, NPTR, PCDU, and peripheral vascular markers lost significance after the age adjustment. Conclusions: This study suggests that abnormal NPTR results, combined with cardiovascular risk factors, may signal vascular ED and generalized vasculopathy, highlighting the need for cardiovascular assessment. An accurate ED diagnosis should integrate clinical evaluation with multiple tests while considering aging as a key risk factor. Keywords: erectile dysfunction; Penile Color Doppler Ultrasound; Nocturnal Penile Tumescence and Rigidity test Author: Maurizio De Rocco Ponce, Claudia Fabiana Quintian Schwieters, Juliette Meziere, Josvany Rene Sanchez Curbelo, Guillem Abad Carratalá, Eden Troka, Lluis Bassas Arnau, Eduard Ruiz Castañé, Maria José Martinez Barcina and Osvaldo Rajmil Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Wed Oct 23 07:51:42 2024 CEST ModDate: Wed Oct 23 07:53:41 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 259185 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GIFXFT+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 PKDDCC+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 SCBUXB+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 SUZIAA+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 RVDESI+VnURWPalladioL Type 1 Custom yes yes yes 32 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 48 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 51 0 KOSUXD+CMSY10 Type 1 Builtin yes yes yes 71 0 UMQZQJ+EURM10 Type 1 Builtin yes yes yes 76 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 87 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-12-18 02:49:25 CET RepresentationInformation: pmc_11546346.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-12-04 02:21:25 CET Size: 259185 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 237 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: A Study of the Relationship Between Objective Tests to Diagnose Erectile Dysfunction and Markers of Cardiovascular Disease Author: Maurizio De Rocco Ponce, Claudia Fabiana Quintian Schwieters, Juliette Meziere, Josvany Rene Sanchez Curbelo, Guillem Abad Carratalá, Eden Troka, Lluis Bassas Arnau, Eduard Ruiz Castañé, Maria José Martinez Barcina and Osvaldo Rajmil Subject: Background: Erectile dysfunction (ED) can stem from various organic and functional causes but is often linked to vascular health and cardiovascular disease. Limited data exist on how cardiovascular disease markers correlate with objective ED tests like the Nocturnal Penile Tumescence and Rigidity (NPTR) test and Penile Color Doppler Ultrasound (PCDU). Methods: A prospective observational study was performed, and 58 men with ED were assessed using the International Index of Erectile Function-15 (IIEF-15), NPTR test, and PCDU. Peripheral vascular health was evaluated through carotid intima-media thickness (cIMT) and brachial flow-mediated dilation (FMD). Results: Out of the participants, 44 had normal NPTR results, while 14 had abnormal results. The group with abnormal NPTR results was significantly older and had higher rates of hypertension and diabetes. Although the IIEF-15 scores were similar between the two groups, those with abnormal NPTR results had a lower peak systolic velocity (PSV) and a higher prevalence of impaired PSV. Correlations between the IIEF, NPTR, PCDU, and peripheral vascular markers lost significance after the age adjustment. Conclusions: This study suggests that abnormal NPTR results, combined with cardiovascular risk factors, may signal vascular ED and generalized vasculopathy, highlighting the need for cardiovascular assessment. An accurate ED diagnosis should integrate clinical evaluation with multiple tests while considering aging as a key risk factor. 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