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     Item: 
      Title: Phase IV adaptive randomised clinical trials evaluating efficacy and cost-­efficacy of pre-­emptive pharmacogenetic genotyping strategies in the Spanish National Health System: iPHARMGx Master Protocol and PREVESTATGx nested clinical trial
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
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         Item: 
          Title: The iPHARMGx framework
         Item: 
          Title: The PREVESTATGx Trial
       Item: 
        Title: Methods and analysis
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         Item: 
          Title: iPHARMGx: hypothesis and design
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          Title: Overarching iPHARMGx study objectives
         Item: 
          Title: iPHARMGx study population and eligibility criteria
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          Title: PREVESTATGx study objectives
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            Title: Primary objectives
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            Title: Secondary objectives
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            Title: Exploratory objectives
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          Title: Inclusion criteria
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          Title: Exclusion criteria
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          Title: Study procedures
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            Title: Screening visit
           Item: 
            Title: Baseline: up to 6 months after first screening visit
           Item: 
            Title: Visit 3: 30 days after treatment initiation (±7 days window)
           Item: 
            Title: Visit 4: 90 days after treatment initiation (±7 days window)
           Item: 
            Title: Visit 5: 180 days after treatment initiation (±7 days window)
           Item: 
            Title: Visit 6: 270 days after treatment initiation (±7 days window)
         Item: 
          Title: Sample size calculation: efficacy and futility boundaries
         Item: 
          Title: Randomisation and blinding
         Item: 
          Title: Intervention
         Item: 
          Title: Outcomes
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            Title: Primary endpoint
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            Title: Secondary endpoints
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            Title: Exploratory endpoints
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            Title: Biological samples
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            Title: Statistical analysis
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            Title: Economic evaluation
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          Title: Data collection and outcome measures
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          Title: Patient and public involvement
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          Title: Ethics and dissemination
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          Title: Access to data
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       Rect: 494, 534, 539, 525
      Annotation: 
       Subtype: Link
       Rect: 391, 509, 432, 500
      Annotation: 
       Subtype: Link
       Rect: 371, 475, 408, 466
      Annotation: 
       Subtype: Link
       Rect: 407, 449, 476, 440
  Checksum: 6629c12f
   Type: CRC32
  Checksum: 0937e960b89f73caa8cf1179030765c7
   Type: MD5
  Checksum: e7a8b4c958b5475ab04e2a0154673db83e30eabb
   Type: SHA-1
  Checksum: 6cef63fcd966386758b25ea421e26ee78c1c62cf9196ba2f7e1ef10f4566f15b
   Type: SHA-256