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Keywords:        priming, innate immunity, Drosophila melanogaster, infection, sexual dimorphism, pathogen load, ß-glucan, environmental mycobacteria
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      Title: Candida albicans infection model in Drosophila melanogaster suggests a strain-specific virulent factor boosting a stormy innate immune response
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        Title: Highlights
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        Title: 1 Introduction
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        Title: 2 Materials and methods
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          Title: 2.1 Fly maintenance
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         Item: 
          Title: 2.2 Strains
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          Title: 2.3 Experimental design
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          Title: 2.4 Heat-kill preparation
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          Title: 2.5 Assessment of hkMm intake
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          Title: 2.6 Systemic infection
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          Title: 2.7 Pathogen load analysis
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          Title: 2.8 Gene expression analysis
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            Title: 2.8.1 Sample preparation
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            Title: 2.8.2 RNA extraction, purification, and quantification
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            Title: 2.8.3 cDNA synthesis and real-time PCR assay
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          Title: 2.9 Statistical analysis
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        Title: 3 Results
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          Title: 3.1 Mycobacterium manresensis is present in the gut of flies treated with hkMm for 24 and 48 hours
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          Title: 3.2 Oral administration of hkMm and hkCa induces Nox-dependent production of ROS
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          Title: 3.3 Male and female flies present different patterns of gene expression in response to treatment
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          Title: 3.4 hkMm and hkCa administration prompt C. albicans infection clearance
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          Title: 3.5 Infection with C. albicans 4372 leads to sexually-dimorphic and stormy AMP induction
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        Title: Data availability statement
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        Title: Conflict of interest
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        Title: Publisher’s note
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        Title: Supplementary material
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        Title: References
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   Type: CRC32
  Checksum: 8459b0e7af32f9d9976be325b73106a9
   Type: MD5
  Checksum: e17028bd7aee26a3baa5034f5e154832df1e2d74
   Type: SHA-1
  Checksum: 295c09271349996d3f8fbc2d2e66fac619c80810fce6b8f02eab13f2753dac82
   Type: SHA-256