66c2a9fe0fb45c6c7975518bd99d6e42  pmc_11568522.pdf
344336bae0741903310d4ed94dea25b95f7f4cf5  pmc_11568522.pdf
6e3304bfc0c5da8d9482d66ee200622b8deb216ffd8844198f422187ab401e57  pmc_11568522.pdf

Title:           Efficacy of the preformulated irrigation solution Bactisure® in acute periprosthetic joint infection debridement surgery: study protocol for a randomized controlled trial
Subject:         Trials, https://doi.org/10.1186/s13063-024-08637-1
Keywords:        Periprosthetic joint infection;Knee;Hip;Debridement antibiotic and implant retention (DAIR);Irrigation solution
Author:           Rafael Oleo-Taltavull 
Creator:         Adobe InDesign 15.1 (Windows)
Producer:        Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Sat Nov 30 12:41:32 2024 CET
ModDate:         Mon Dec  2 07:08:20 2024 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           9
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       1280702 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     41  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes     42  0
MyriadPro-It                         Type 1C           Custom           yes no  yes     43  0
YCSERT+MyriadPro-LightIt             Type 1C           WinAnsi          yes yes yes     82  0
ILVXYM+MyriadPro-Regular2            Type 1C           WinAnsi          yes yes no     226  0
MyriadPro-Light                      Type 1C           Custom           yes no  yes     46  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     47  0
RPRQML+STIXMath-Regular              Type 1C           WinAnsi          yes yes yes     44  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     45  0
WarnockPro-Light                     Type 1C           Custom           yes no  yes     71  0
MyriadPro-Regular3                   Type 1C           WinAnsi          yes no  yes    184  0
WarnockPro-It                        Type 1C           WinAnsi          yes no  yes    101  0
LORIWX+STIX-Regular                  Type 1C           WinAnsi          yes yes yes    139  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-02-06 02:45:59 CET
 RepresentationInformation: pmc_11568522.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-12-17 02:35:26 CET
  Size: 1280702
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 314
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Efficacy of the preformulated irrigation solution Bactisure® in acute periprosthetic joint infection debridement surgery: study protocol for a randomized controlled trial
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background 
         Item: 
          Title: Methods 
         Item: 
          Title: Discussion 
         Item: 
          Title: Trial registration 
       Item: 
        Title: Background
       Item: 
        Title: Methodsdesign
        Children: 
         Item: 
          Title: Aim
         Item: 
          Title: Design and setting
         Item: 
          Title: Participants
         Item: 
          Title: Interventions
         Item: 
          Title: Outcomes
         Item: 
          Title: Sample size
         Item: 
          Title: Randomization
         Item: 
          Title: Blinding
         Item: 
          Title: Data analysis and statistical tests
         Item: 
          Title: Dissemination plans
       Item: 
        Title: Discussion
        Children: 
         Item: 
          Title: Study limitations
       Item: 
        Title: Trial status
       Item: 
        Title: Conclusions
       Item: 
        Title: Acknowledgements
       Item: 
        Title: References
   Info: 
    Title: Efficacy of the preformulated irrigation solution Bactisure® in acute periprosthetic joint infection debridement surgery: study protocol for a randomized controlled trial
    Author:  Rafael Oleo-Taltavull 
    Subject: Trials, https://doi.org/10.1186/s13063-024-08637-1
    Keywords: Periprosthetic joint infection;Knee;Hip;Debridement antibiotic and implant retention (DAIR);Irrigation solution
    Creator: Adobe InDesign 15.1 (Windows)
    Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Sat Nov 30 12:41:32 CET 2024
    ModDate: Mon Dec 02 07:08:20 CET 2024
   ID: 0x9a6d17e1efdc2e5af1c9c164f348daa9, 0x8cdce8e62e10d07cd83999357cd8f247
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 115
      ImageHeight: 119
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: YCSERT+MyriadPro-LightIt
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: YCSERT+MyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -121, -250, 1007, 863
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: ILVXYM+MyriadPro-Regular2
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: ILVXYM+MyriadPro-Regular2
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WarnockPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -221, -533, 1474, 950
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Light
       Flags: Serif, Nonsymbolic
       FontBBox: -175, -515, 1437, 929
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LORIWX+STIX-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 43
      FontDescriptor: 
       FontName: LORIWX+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: RPRQML+STIXMath-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 174
      FontDescriptor: 
       FontName: RPRQML+STIXMath-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -524, 3238, 2566
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -49, -250, 1046, 883
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2024-11-30T19:41:32+08:00</xmp:CreateDate>
         <xmp:CreatorTool>Adobe InDesign 15.1 (Windows)</xmp:CreatorTool>
         <xmp:ModifyDate>2024-12-02T07:08:20+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2024-12-02T07:08:20+01:00</xmp:MetadataDate>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Keywords>Periprosthetic joint infection;Knee;Hip;Debridement antibiotic and implant retention (DAIR);Irrigation solution</pdf:Keywords>
         <pdf:Trapped>False</pdf:Trapped>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1186/s13063-024-08637-1</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BioMed Central</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Trials, https://doi.org/10.1186/s13063-024-08637-1</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Periprosthetic joint infection</rdf:li>
               <rdf:li>Knee</rdf:li>
               <rdf:li>Hip</rdf:li>
               <rdf:li>Debridement antibiotic and implant retention (DAIR)</rdf:li>
               <rdf:li>Irrigation solution</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Efficacy of the preformulated irrigation solution Bactisure® in acute periprosthetic joint infection debridement surgery: study protocol for a randomized controlled trial</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li> Rafael Oleo-Taltavull </rdf:li>
               <rdf:li> Matías Vicente Gomà-Camps </rdf:li>
               <rdf:li> Nayana Joshi Jubert </rdf:li>
               <rdf:li> Pablo S. Corona </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1186/s13063-024-08637-1</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1186/s13063-024-08637-1</prism:url>
         <prism:doi>10.1186/s13063-024-08637-1</prism:doi>
         <prism:issn>1745-6215</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Trials</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s13063-024-08637-1</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <xmpMM:DocumentID>uuid:2a2d827f-d152-48c1-b365-4829fabe48f7</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:531895f8-4301-4dbf-bb89-5396fe33dffe</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:2a2d827f-d152-48c1-b365-4829fabe48f7</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2024-11-30T11:54:49Z</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name> Rafael Oleo-Taltavull </author:name>
                  <author:orcid>http://orcid.org/0000-0002-0978-9015</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 325, 58, 461, 50
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 683, 540, 650
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 158, 560, 170, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 418, 226, 514, 214
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 63, 213, 131, 202
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 258, 631, 263, 619
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 158, 583, 163, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 168, 583, 173, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 134, 499, 139, 487
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 219, 475, 224, 463
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 230, 475, 235, 463
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 118, 427, 123, 415
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 214, 379, 218, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 224, 379, 234, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 112, 271, 122, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 148, 175, 158, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 162, 175, 172, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 131, 127, 141, 115
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 385, 668, 395, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 399, 668, 410, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 491, 644, 501, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 507, 644, 517, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 465, 560, 475, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 481, 560, 491, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 340, 440, 345, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 82, 452, 92, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 146, 440, 156, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 56, 356, 125, 344
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 125, 356, 290, 344
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 344, 76, 332
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 531, 614, 535, 601
       Flags: Print
       AppearanceDictionary: true
       Destination: 49
      Annotation: 
       Subtype: Link
       Rect: 361, 208, 368, 199
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 371, 208, 379, 199
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 258, 669, 263, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 73
      Annotation: 
       Subtype: Link
       Rect: 396, 693, 401, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 85
     Thumb: true
    Page: 
     Sequence: 5
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 389, 212, 394, 199
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 399, 152, 409, 139
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 410, 128, 420, 115
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 137, 609, 147, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 259, 537, 269, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 59, 453, 69, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 74, 453, 83, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 88, 453, 97, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 238, 441, 242, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 248, 441, 253, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 130, 381, 140, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 137, 261, 147, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 126, 129, 136, 116
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 523, 465, 533, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 143
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 248, 256, 281, 247
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 247, 156, 238
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 83, 89, 174, 80
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 304, 409, 427, 401
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 157, 703, 276, 695
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 694, 174, 686
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 135, 460, 287, 452
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 451, 289, 443
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 442, 225, 434
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 94, 307, 290, 299
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 298, 289, 290
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 289, 187, 281
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 405, 568, 536, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 559, 346, 551
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: b71a1bb6
   Type: CRC32
  Checksum: 66c2a9fe0fb45c6c7975518bd99d6e42
   Type: MD5
  Checksum: 344336bae0741903310d4ed94dea25b95f7f4cf5
   Type: SHA-1
  Checksum: 6e3304bfc0c5da8d9482d66ee200622b8deb216ffd8844198f422187ab401e57
   Type: SHA-256