b6ddd7ff1a833089ef9a22d295fd32bc pmc_11593418.pdf c78d8fa025cd80516e1f34cefb18858390ed15b8 pmc_11593418.pdf d666bc74f685cb277214f11038c9281b164027b021422f41a4a3d4233497224c pmc_11593418.pdf Title: Factors Influencing the Attrition Rate of a 10-Week Multimodal Rehabilitation Program in Patients After Lung Transplant: A Neural Network Analysis Subject: Background/Objectives: Despite the effectiveness of exercise and nutritional interventions to improve aerobic capacity and quality of life in lung transplant (LT) recipients, their compliance is low. Strategies to reduce the high attrition rate (participants lost over time) is a major challenge. Artificial neural networks (ANN) may assist in the early identification of patients with high risk of attrition. The main objective of this study is to evaluate the usefulness of ANNs to identify prognostic factors for high attrition rate of a 10-week rehabilitation program after a LT. Methods: This prospective observational study included first-time LT recipients over 18 years of age. The main outcome for each patient was the attrition rate, which was estimated by the amount of missing data accumulated during the study. Clinical variables including malnutrition, sarcopenia, and their individual components were assessed at baseline. An ANN and regression analysis were used to identify the factors determining a high attrition rate. Results: Of the 41 participants, 17 (41.4%) had a high rate of attrition in the rehabilitation program. Only 23 baseline variables had no missing data and were included in the analysis, from which a low age-dependent body mass index (BMI) was the most important conditioning factor for a high attrition rate (p = 7.08 10-5), followed by end-stage respiratory disease requiring PT (p = 0.000111), low health-related quality-of-life (HRQoL) (p = 0.0009078), and low handgrip strength (p = 0.023). Conclusions: The prevalence of high attrition rate in LT recipients is high. The profile of patients with a high probability of attrition includes those with chronic obstructive pulmonary disease, low BMI and handgrip strength, and reduced HRQoL. Keywords: attrition rate; compliance; lung transplant; artificial neural network; multimodal rehabilitation interventions Author: Vanesa Dávalos-Yerovi, Dolores Sánchez-Rodríguez, Alba Gómez-Garrido, Patricia Launois, Marta Tejero-Sánchez, Vicenta Pujol-Blaya, Yulibeth G. Curbelo, Owen Donohoe and Ester Marco Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Wed Nov 13 03:09:47 2024 CET ModDate: Wed Nov 13 03:15:17 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 5688666 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PRJKGQ+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 QFQGII+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 DRBASU+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 QMSOAW+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 RWBCRL+CMSY10 Type 1 Builtin yes yes yes 32 0 MWHIBA+VnURWPalladioL Type 1 Custom yes yes yes 37 0 AEJLNF+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 116 0 AEJNEN+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 122 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 190 0 DZGEEV+CMBSY10 Type 1 Builtin yes yes yes 195 0 BJOHOL+PalatinoLinotype,Bold CID TrueType Identity-H yes yes yes 210 0 BJOMKK+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 216 0 BJOHOM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 219 0 BJOHON+PalatinoLinotype CID TrueType Identity-H yes yes yes 222 0 BJOHPN+PalatinoLinotype TrueType WinAnsi yes yes no 228 0 BJOHPP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 231 0 BJOIGP+PalatinoLinotype TrueType MacRoman yes yes no 234 0 BJOHOM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 247 0 BJOHON+PalatinoLinotype CID TrueType Identity-H yes yes yes 250 0 BJOHPN+PalatinoLinotype TrueType WinAnsi yes yes no 256 0 BJOHPP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 259 0 BJOIGP+PalatinoLinotype TrueType MacRoman yes yes no 262 0 BJOHOM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 277 0 BJOHON+PalatinoLinotype CID TrueType Identity-H yes yes yes 280 0 BJOHPN+PalatinoLinotype TrueType WinAnsi yes yes no 286 0 BJOHPP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 289 0 BJOIGP+PalatinoLinotype TrueType MacRoman yes yes no 292 0 BJOHOM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 308 0 BJOHON+PalatinoLinotype CID TrueType Identity-H yes yes yes 311 0 BJOHPN+PalatinoLinotype TrueType WinAnsi yes yes no 317 0 BJOHPP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 320 0 BJOIGP+PalatinoLinotype TrueType MacRoman yes yes no 323 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-06 02:45:34 CET RepresentationInformation: pmc_11593418.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-04 02:23:49 CET Size: 5688666 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 516 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Design Destination: subsection.2.1 Item: Title: Setting Destination: subsection.2.2 Item: Title: Multimodal Rehabilitation Program Destination: subsection.2.3 Item: Title: Nutritional Component Destination: subsection.2.4 Item: Title: Exercise Component Destination: subsection.2.5 Item: Title: Variables Destination: subsection.2.6 Item: Title: Malnutrition Destination: subsection.2.7 Item: Title: Sarcopenia Destination: subsection.2.8 Item: Title: Exercise Tolerance Destination: subsection.2.9 Item: Title: Other Pulmonary and Cardiovascular Function Tests Destination: subsection.2.10 Item: Title: Health-Related Quality of Life Destination: subsection.2.11 Item: Title: Ethics Destination: subsection.2.12 Item: Title: Statistical Methods Destination: subsection.2.13 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: appendix.A. Info: Title: Factors Influencing the Attrition Rate of a 10-Week Multimodal Rehabilitation Program in Patients After Lung Transplant: A Neural Network Analysis Author: Vanesa Dávalos-Yerovi, Dolores Sánchez-Rodríguez, Alba Gómez-Garrido, Patricia Launois, Marta Tejero-Sánchez, Vicenta Pujol-Blaya, Yulibeth G. Curbelo, Owen Donohoe and Ester Marco Subject: Background/Objectives: Despite the effectiveness of exercise and nutritional interventions to improve aerobic capacity and quality of life in lung transplant (LT) recipients, their compliance is low. Strategies to reduce the high attrition rate (participants lost over time) is a major challenge. Artificial neural networks (ANN) may assist in the early identification of patients with high risk of attrition. The main objective of this study is to evaluate the usefulness of ANNs to identify prognostic factors for high attrition rate of a 10-week rehabilitation program after a LT. Methods: This prospective observational study included first-time LT recipients over 18 years of age. The main outcome for each patient was the attrition rate, which was estimated by the amount of missing data accumulated during the study. Clinical variables including malnutrition, sarcopenia, and their individual components were assessed at baseline. An ANN and regression analysis were used to identify the factors determining a high attrition rate. Results: Of the 41 participants, 17 (41.4%) had a high rate of attrition in the rehabilitation program. Only 23 baseline variables had no missing data and were included in the analysis, from which a low age-dependent body mass index (BMI) was the most important conditioning factor for a high attrition rate (p = 7.08 10-5), followed by end-stage respiratory disease requiring PT (p = 0.000111), low health-related quality-of-life (HRQoL) (p = 0.0009078), and low handgrip strength (p = 0.023). Conclusions: The prevalence of high attrition rate in LT recipients is high. The profile of patients with a high probability of attrition includes those with chronic obstructive pulmonary disease, low BMI and handgrip strength, and reduced HRQoL. 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