37bd43ece36edd2c046ae6ac822b8aba pmc_11609623.pdf 62843a8e8339766c8f0c4be892a2905bcfc580bb pmc_11609623.pdf 133de5be49abb3f042d8e8d6cff799497c68db3c421f8295ed7a8784cdd89938 pmc_11609623.pdf Title: Association of Tumor Mutational Burden and PD-L1 with the Efficacy of Pembrolizumab with or without Chemotherapy versus Che ... Author: https://orcid.org/0000-0002-0129-6101Aude Fléchon ; https://orcid.org/0000-0001-7398-0685Rafael Morales-Barrera ; https://o ... Creator: PTC Arbortext Layout Developer 12.1.6202/W-x64 Producer: PDFlib+PDI 9.3.1p6 (C++/Win64) CreationDate: Tue Nov 19 00:50:05 2024 CET ModDate: Tue Nov 19 00:50:05 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 584.957 x 782.986 pts Page rot: 0 File size: 1547083 bytes Optimized: yes PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ZDHZMT+Gotham-Bold Type 1C Custom yes yes yes 336 0 RWAZIQ+Gotham-Book Type 1C Custom yes yes yes 341 0 MDZDDD+GothamNarrow-Bold Type 1C Custom yes yes yes 346 0 HWEIYE+GothamNarrow-Book Type 1C Custom yes yes yes 351 0 VZTLGG+Webdings TrueType WinAnsi yes yes yes 356 0 ETZHVL+MinionPro-Bold Type 1C Custom yes yes yes 360 0 FUGVMN+MinionPro-Regular Type 1C Custom yes yes yes 365 0 IOPJCH+MinionPro-It Type 1C Custom yes yes yes 370 0 TeX_CM_Maths_Symbols Type 1 Builtin yes no yes 375 0 MJAQWK+MinionMath-Regular Type 1C Custom yes yes yes 379 0 EMNJAN+GothamNarrow-BookItalic Type 1C Custom yes yes yes 43 0 DBIBVR+GothamNarrow-BoldItalic Type 1C Custom yes yes yes 48 0 OLLHCE+HelveticaLTStd-Roman Type 1C WinAnsi yes yes no 55 0 OLLHDF+HelveticaLTStd-Obl Type 1C WinAnsi yes yes no 58 0 HelveticaLTStd-Obl Type 1C WinAnsi yes no no 86 0 OPBFMB+HelveticaLTStd-Roman Type 1C WinAnsi yes yes no 89 0 OPBFMC+HelveticaLTStd-Bold Type 1C WinAnsi yes yes no 92 0 OPKEKD+HelveticaLTStd-Bold Type 1C Custom yes yes yes 109 0 OPKEKE+HelveticaLTStd-Roman Type 1C WinAnsi yes yes no 114 0 HelveticaLTStd-Obl Type 1C WinAnsi yes no no 117 0 PACIFJ+Arial-BoldMT CID TrueType Identity-H yes yes yes 137 0 PACIFK+ArialMT CID TrueType Identity-H yes yes yes 143 0 PACIFM+Arial-ItalicMT TrueType WinAnsi yes yes no 149 0 PAKGAF+HelveticaLTStd-Roman Type 1C WinAnsi yes yes no 180 0 HelveticaLTStd-Obl Type 1C WinAnsi yes no no 183 0 PAKGAH+HelveticaLTStd-Bold Type 1C Custom yes yes yes 186 0 PBBLDF+HelveticaLTStd-Bold Type 1C Custom yes yes yes 216 0 PBBLDG+HelveticaLTStd-Roman Type 1C WinAnsi yes yes no 221 0 HelveticaLTStd-Obl Type 1C WinAnsi yes no no 224 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-08 02:53:12 CET RepresentationInformation: pmc_11609623.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-06 02:51:31 CET Size: 1547083 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 407 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Language: en Info: Title: Association of Tumor Mutational Burden and PD-L1 with the Efficacy of Pembrolizumab with or without Chemotherapy versus Che ... Author: https://orcid.org/0000-0002-0129-6101Aude Fléchon ; https://orcid.org/0000-0001-7398-0685Rafael Morales-Barrera ; https://o ... Creator: PTC Arbortext Layout Developer 12.1.6202/W-x64 Producer: PDFlib+PDI 9.3.1p6 (C++/Win64) CreationDate: Tue Nov 19 01:20:05 CET 2024 ModDate: Tue Nov 19 01:20:05 CET 2024 ID: 0x278c86060313b39dee23d4ee3dab437a, 0x278c86060313b39dee23d4ee3dab437a Fonts: Type1: Font: BaseFont: ZDHZMT+Gotham-Bold FontSubset: true FirstChar: 1 LastChar: 37 FontDescriptor: FontName: ZDHZMT+Gotham-Bold Flags: Nonsymbolic, ForceBold FontBBox: -54, -297, 1195, 1017 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: DBIBVR+GothamNarrow-BoldItalic FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: DBIBVR+GothamNarrow-BoldItalic Flags: Nonsymbolic, Italic, ForceBold FontBBox: -292, -283, 1090, 995 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IOPJCH+MinionPro-It FontSubset: true FirstChar: 1 LastChar: 7 FontDescriptor: FontName: IOPJCH+MinionPro-It Flags: Nonsymbolic, Italic FontBBox: -201, -360, 1684, 919 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RWAZIQ+Gotham-Book FontSubset: true FirstChar: 1 LastChar: 17 FontDescriptor: FontName: RWAZIQ+Gotham-Book Flags: Nonsymbolic FontBBox: -40, -244, 1158, 994 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: TeX_CM_Maths_Symbols FirstChar: 1 LastChar: 139 FontDescriptor: FontName: TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile: true ToUnicode: true Font: BaseFont: ETZHVL+MinionPro-Bold FontSubset: true FirstChar: 1 LastChar: 61 FontDescriptor: FontName: ETZHVL+MinionPro-Bold Flags: Nonsymbolic, ForceBold FontBBox: -318, -360, 1684, 917 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MDZDDD+GothamNarrow-Bold FontSubset: true FirstChar: 1 LastChar: 61 FontDescriptor: FontName: MDZDDD+GothamNarrow-Bold Flags: Nonsymbolic, ForceBold FontBBox: -203, -274, 1079, 994 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MJAQWK+MinionMath-Regular FontSubset: true FirstChar: 1 LastChar: 6 FontDescriptor: FontName: MJAQWK+MinionMath-Regular Flags: Nonsymbolic FontBBox: -1196, -2876, 2350, 3473 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: EMNJAN+GothamNarrow-BookItalic FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: EMNJAN+GothamNarrow-BookItalic Flags: Nonsymbolic, Italic FontBBox: -277, -231, 1042, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FUGVMN+MinionPro-Regular FontSubset: true FirstChar: 1 LastChar: 88 FontDescriptor: FontName: FUGVMN+MinionPro-Regular Flags: Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HWEIYE+GothamNarrow-Book FontSubset: true FirstChar: 1 LastChar: 83 FontDescriptor: FontName: HWEIYE+GothamNarrow-Book Flags: Nonsymbolic FontBBox: -190, -229, 1034, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: VZTLGG+Webdings FontSubset: true FirstChar: 33 LastChar: 54 FontDescriptor: FontName: VZTLGG+Webdings Flags: Symbolic FontBBox: -1, -200, 4000, 800 FontFile2: true ToUnicode: true XMP: uuid:1D21F232-A5A1-D47C-2EAA-8FD101082094 uuid:76220A2F-83DE-0A35-7C07-54BDAE0279E1 2024-11-19T05:20:05+05:30 2024-11-19T05:20:05+05:30 PTC Arbortext Layout Developer 12.1.6202/W-x64 2024-11-19T05:20:05+05:30 PDFlib+PDI 9.3.1p6 (C++/Win64) https://orcid.org/0000-0002-0129-6101Aude Fléchon ; https://orcid.org/0000-0001-7398-0685Rafael Morales-Barrera ; https://o ... Association of Tumor Mutational Burden and PD-L1 with the Efficacy of Pembrolizumab with or without Chemotherapy versus Che ... PStill version 1.84.42 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 502, 676, 531, 706 Flags: Print Annotation: Subtype: Link Rect: 365, 145, 453, 152 Flags: Print Annotation: Subtype: Link Rect: 311, 114, 400, 121 Flags: Print Annotation: Subtype: Link Rect: 436, 27, 501, 35 Flags: Print Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 95, 410, 99, 419 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 105, 389, 109, 398 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 113, 389, 117, 398 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 167, 379, 170, 387 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 175, 379, 179, 387 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 248, 327, 252, 335 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 257, 327, 261, 335 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 147, 285, 151, 293 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 156, 285, 164, 293 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 106, 211, 114, 220 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 118, 211, 126, 220 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 192, 138, 196, 147 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 56, 86, 64, 94 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 377, 682, 386, 691 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 358, 538, 366, 547 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 400, 528, 408, 536 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 423, 360, 431, 369 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 381, 329, 389, 338 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 443, 128, 451, 136 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 457, 128, 465, 136 Flags: Print Destination: 252 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 92, 578, 100, 586 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 137, 483, 145, 492 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 150, 483, 158, 492 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 85, 410, 93, 419 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 406, 619, 414, 628 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 418, 619, 426, 628 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 365, 546, 372, 555 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 379, 546, 386, 555 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 344, 387, 511, 395 Flags: Print Annotation: Subtype: Link Rect: 53, 27, 118, 35 Flags: Print Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 74, 436, 96, 444 Flags: Print Destination: 41 Annotation: Subtype: Link Rect: 67, 362, 76, 371 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 461, 467, 489, 475 Flags: Print Destination: 41 Annotation: Subtype: Link Rect: 431, 425, 457, 434 Flags: Print Destination: 82 Annotation: Subtype: Link Rect: 354, 373, 380, 381 Flags: Print Destination: 82 Annotation: Subtype: Link Rect: 399, 373, 405, 381 Flags: Print Destination: 82 Annotation: Subtype: Link Rect: 298, 299, 325, 307 Flags: Print Destination: 41 Annotation: Subtype: Link Rect: 193, 213, 196, 221 Flags: Print Destination: 41 Annotation: Subtype: Link Rect: 255, 213, 258, 221 Flags: Print Destination: 41 Annotation: Subtype: Link Rect: 326, 213, 329, 221 Flags: Print Destination: 41 Annotation: Subtype: Link Rect: 392, 213, 395, 221 Flags: Print Destination: 41 Annotation: Subtype: Link Rect: 454, 213, 457, 221 Flags: Print Destination: 41 Annotation: Subtype: Link Rect: 525, 213, 529, 221 Flags: Print Destination: 41 Annotation: Subtype: Link Rect: 298, 147, 300, 155 Flags: Print Destination: 41 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 181, 138, 207, 147 Flags: Print Destination: 82 Annotation: Subtype: Link Rect: 153, 96, 177, 105 Flags: Print Destination: 82 Annotation: Subtype: Link Rect: 195, 96, 200, 105 Flags: Print Destination: 82 Annotation: Subtype: Link Rect: 53, 27, 118, 35 Flags: Print Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 135, 243, 161, 251 Flags: Print Destination: 105 Annotation: Subtype: Link Rect: 91, 201, 117, 209 Flags: Print Destination: 105 Annotation: Subtype: Link Rect: 227, 159, 252, 168 Flags: Print Destination: 133 Annotation: Subtype: Link Rect: 191, 117, 216, 126 Flags: Print Destination: 133 Annotation: Subtype: Link Rect: 333, 295, 356, 304 Flags: Print Destination: 176 Annotation: Subtype: Link Rect: 390, 264, 415, 272 Flags: Print Destination: 176 Annotation: Subtype: Link Rect: 409, 222, 433, 230 Flags: Print Destination: 212 Annotation: Subtype: Link Rect: 492, 191, 516, 199 Flags: Print Destination: 212 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 129, 149, 133, 157 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 137, 149, 141, 157 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 145, 149, 153, 157 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 264, 149, 272, 157 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 130, 86, 134, 94 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 390, 264, 397, 272 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 490, 191, 497, 199 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 321, 159, 325, 168 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 329, 159, 337, 168 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 342, 159, 350, 168 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 380, 107, 384, 115 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 390, 107, 394, 115 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 400, 107, 408, 115 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 413, 107, 421, 115 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 427, 107, 435, 115 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 322, 96, 330, 105 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 335, 96, 343, 105 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 53, 27, 118, 35 Flags: Print Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 69, 253, 73, 262 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 103, 222, 108, 230 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 170, 159, 175, 168 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 56, 128, 65, 136 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 231, 128, 240, 136 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 243, 96, 247, 105 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 252, 96, 256, 105 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 261, 96, 270, 105 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 275, 96, 283, 105 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 171, 75, 180, 84 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 398, 138, 402, 147 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 408, 138, 416, 147 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 421, 138, 429, 147 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 435, 138, 443, 147 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 448, 138, 457, 147 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 415, 96, 424, 105 Flags: Print Destination: 252 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 257, 222, 265, 230 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 272, 170, 281, 178 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 134, 128, 143, 136 Flags: Print Destination: 260 Annotation: Subtype: Link Rect: 328, 243, 332, 251 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 362, 128, 366, 136 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 316, 75, 324, 84 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 53, 27, 118, 35 Flags: Print Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 170, 661, 174, 670 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 204, 640, 208, 649 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 266, 630, 270, 638 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 251, 473, 255, 481 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 260, 473, 265, 481 Flags: Print Destination: 252 Annotation: Subtype: Link Rect: 81, 431, 89, 440 Flags: Print Destination: 260 Annotation: Subtype: Link Rect: 94, 431, 102, 440 Flags: Print Destination: 260 Annotation: Subtype: Link Rect: 128, 368, 136, 377 Flags: Print Destination: 252 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 300, 593, 404, 600 Flags: Print Annotation: Subtype: Link Rect: 53, 27, 118, 35 Flags: Print Page: Label: 12 Checksum: b01a8d3f Type: CRC32 Checksum: 37bd43ece36edd2c046ae6ac822b8aba Type: MD5 Checksum: 62843a8e8339766c8f0c4be892a2905bcfc580bb Type: SHA-1 Checksum: 133de5be49abb3f042d8e8d6cff799497c68db3c421f8295ed7a8784cdd89938 Type: SHA-256