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RepresentationInformation: pmc_11616005.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-05 02:55:04 CET Size: 10631036 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 453 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Outline placeholder Destination: unknown Children: Item: Title: Introduction Destination: head_5_2113392 Item: Title: Results Destination: head_6_884242 Children: Item: Title: Impact of α-syn C-terminal truncation on its aggregation Destination: head_7_968592 Item: Title: Impact of SynuClean-D and ZPD-2 on α-syn-CT119 aggregation kinetics Destination: head_8_1305992 Item: Title: Validation and characterisation of the inhibitory activity of the compounds Destination: head_9_2191668 Item: Title: Modulation of α-syn-CT119 oligomers Destination: head_10_1770012 Item: Title: Impact of SynuClean-D and ZPD-2 on α-syn-CT119 seeded polymerisation Destination: head_11_2276112 Item: Title: Discussion Destination: head_12_1854267 Item: Title: Conclusion Destination: head_13_942417 Item: Title: Methods Destination: head_14_1589043 Children: Item: Title: Protein expression and purification Destination: head_15_1673393 Item: Title: Protein aggregation Destination: head_16_1467197 Item: Title: Secondary structure determination Destination: head_17_1586323 Item: Title: Light-scattering measurements Destination: head_18_2158765 Item: Title: Transmission electron microscopy (TEM) Destination: head_19_274040 Item: Title: Acknowledgements Destination: head_20_1008154 Item: Title: Conflict of interest Destination: head_21_1556430 Item: Title: Author contributions Destination: head_22_1725131 Item: Title: Peer review Destination: head_23_2062532 Item: Title: Data availability statement Destination: head_24_2315583 Info: Title: The small molecule ZPD‐2 inhibits the 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