a7079f0f16f8d83956804efc8825c56f pmc_11616068.pdf ba65b8a44c79715c129ead437608436b0dcddfce pmc_11616068.pdf 732017360e1cab4fc38a3a5408b23f29c9ccfe96c986082e61bbe13d0ce12295 pmc_11616068.pdf Title: Impact of valve-sparing aortic root replacement on aortic fluid dynamics and biomechanics in patients with syndromic heritable thoracic aortic disease Subject: Journal of Cardiovascular Magnetic Resonance, 26 (2024) 101088. doi:10.1016/j.jocmr.2024.101088 Keywords: Syndromic heritable thoracic aortic disease; Marfan syndrome; Loeys-Dietz syndrome; Valve-sparing aortic root replacement; 4D flow CMR; Fluid dynamics; Author: Lydia Dux-Santoy Creator: Elsevier Producer: Unknown CreationDate: Wed Nov 20 14:39:15 2024 CET ModDate: Wed Nov 20 14:40:10 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 6326412 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AJCVCC+CharisSIL Type 1C Custom yes yes yes 1589 0 SSYJMD+UniversLTStd Type 1C Custom yes yes yes 1590 0 NZGHCE+STIXGeneral-Regular Type 1C Custom yes yes yes 1591 0 YUFRFP+CharisSIL-Italic Type 1C Custom yes yes yes 1597 0 MXKCKE+TimesNewRoman CID TrueType Identity-H yes yes yes 1606 0 NMKIBK+CharisSIL-Bold Type 1C Custom yes yes yes 56 0 WOCWKH+STIXTwoMath Type 1 Custom yes yes no 15 0 DHEJTX+STIXTwoText-Italic Type 1 Custom yes yes no 18 0 GHJLRE+STIXTwoText Type 1 Custom yes yes no 21 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-06 02:45:22 CET RepresentationInformation: pmc_11616068.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-01-23 02:36:44 CET Size: 6326412 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1667 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Impact of valve-sparing aortic root replacement on aortic fluid dynamics and biomechanics in patients with syndromic heritable thoracic aortic disease Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Methods Destination: mk:H1_2 Children: Item: Title: 2.1 Study design and population Destination: mk:H2_3 Item: Title: 2.2 Cardiovascular magnetic resonance protocol Destination: mk:H2_4 Item: Title: 2.3 Aortic flow dynamics evaluation with 4D flow CMR Destination: mk:H2_5 Item: Title: 2.4 Aortic mechanical properties Destination: mk:H2_6 Item: Title: 2.5 Aortic geometry Destination: mk:H2_7 Item: Title: 2.6 Statistical analysis Destination: mk:H2_8 Item: Title: 3 Results Destination: mk:H1_9 Children: Item: Title: 3.1 Demographic and clinical data Destination: mk:H2_10 Item: Title: 3.2 Fluid dynamics and biomechanics at different stages of aortic root disease Destination: mk:H2_11 Item: Title: 3.3 Impact of valve-sparing aortic root replacement Destination: mk:H2_12 Item: Title: 4 Discussion Destination: mk:H1_13 Item: Title: 5 Limitations Destination: mk:H1_14 Item: Title: 6 Conclusions Destination: mk:H1_15 Item: Title: Funding Destination: mk:H1_16 Item: Title: Author contributions Destination: mk:H1_17 Item: Title: Ethics approval and consent Destination: mk:H1_18 Item: Title: Consent for publication Destination: mk:H1_19 Item: Title: mk:H1_20 Destination: mk:H1_20 Item: Title: Declaration of Competing Interest Destination: mk:H1_21 Item: Title: Acknowledgements Destination: mk:H1_22 Item: Title: Appendix A Supporting information Destination: mk:H1_23 Item: Title: References Destination: mk:H1_24 Info: Title: Impact of valve-sparing aortic root replacement on aortic fluid dynamics and biomechanics in patients with syndromic heritable thoracic aortic disease Author: Lydia Dux-Santoy Subject: Journal of Cardiovascular Magnetic Resonance, 26 (2024) 101088. doi:10.1016/j.jocmr.2024.101088 Keywords: Syndromic heritable thoracic aortic disease; Marfan syndrome; Loeys-Dietz syndrome; Valve-sparing aortic root replacement; 4D flow CMR; Fluid dynamics; Creator: Elsevier Producer: Unknown CreationDate: Wed Nov 20 15:09:15 CET 2024 ModDate: Wed Nov 20 15:10:10 CET 2024 ID: 0xfe7542750c6908d5120fd4a4802252f0, 0xd7260d1c6eca294dbc5bb13ece1e3678 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 247 ImageHeight: 272 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 85 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: MXKCKE+TimesNewRoman Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: AJCVCC+CharisSIL FontSubset: true FirstChar: 1 LastChar: 105 FontDescriptor: FontName: AJCVCC+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 3000, 1270 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SSYJMD+UniversLTStd FontSubset: true FirstChar: 1 LastChar: 22 FontDescriptor: FontName: SSYJMD+UniversLTStd Flags: Nonsymbolic FontBBox: -168, -250, 992, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NZGHCE+STIXGeneral-Regular FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: NZGHCE+STIXGeneral-Regular Flags: Nonsymbolic FontBBox: -970, -443, 2000, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NMKIBK+CharisSIL-Bold FontSubset: true FirstChar: 1 LastChar: 46 FontDescriptor: FontName: NMKIBK+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 3000, 1270 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YUFRFP+CharisSIL-Italic FontSubset: true FirstChar: 1 LastChar: 70 FontDescriptor: FontName: YUFRFP+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 3058, 1270 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: MXKCKE+TimesNewRoman CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MXKCKE+TimesNewRoman Flags: Nonsymbolic FontBBox: -77, -225, 1009, 878 FontFile2: true XMP: application/pdf doi:10.1016/j.jocmr.2024.101088 Elsevier Journal of Cardiovascular Magnetic Resonance, 26 (2024) 101088. doi:10.1016/j.jocmr.2024.101088 Syndromic heritable thoracic aortic disease Marfan syndrome Loeys-Dietz syndrome Valve-sparing aortic root replacement 4D flow CMR Fluid dynamics Impact of valve-sparing aortic root replacement on aortic fluid dynamics and biomechanics in patients with syndromic heritable thoracic aortic disease Lydia Dux-Santoy Aroa Ruiz-Muñoz Andrea Guala Laura Galian-Gay Rubén Fernandez-Galera Filipa Valente Guillem Casas Ruperto Oliveró Marta Ferrer-Cornet Mireia Bragulat-Arévalo Alejandro Carrasco-Poves Juan Garrido-Oliver Alberto Morales-Galán Kevin M. Johnson Oliver Wieben Ignacio Ferreira-González Arturo Evangelista Jose Rodriguez-Palomares Gisela Teixidó-Turà journal Journal of Cardiovascular Magnetic Resonance © 2024 The Authors. Published by Elsevier Inc. on behalf of Society for Cardiovascular Magnetic Resonance. 1097-6647 26 2 101088 101088 10.1016/j.jocmr.2024.101088 https://doi.org/10.1016/j.jocmr.2024.101088 2010-04-23 true 10.1016/j.jocmr.2024.101088 elsevier.com sciencedirect.com 7.0 10.1016/j.jocmr.2024.101088 noindex 2010-04-23 true elsevier.com sciencedirect.com VoR Elsevier 2024-11-20T19:10:10+05:30 2024-11-20T19:09:15+05:30 2024-11-20T19:10:10+05:30 True Syndromic heritable thoracic aortic disease; Marfan syndrome; Loeys-Dietz syndrome; Valve-sparing aortic root replacement; 4D flow CMR; Fluid dynamics; Unknown uuid:e6cd7481-c6a7-4a52-9f9a-9c818c903f99 uuid:0663ce37-3776-4887-915d-a3830685aff9 https://creativecommons.org/licenses/BY-NC-ND/4.0/ Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 192, 750, 403, 757 Flags: Print Annotation: Subtype: Link Rect: 322, 723, 369, 730 Flags: Print Annotation: Subtype: Link Rect: 261, 667, 417, 675 Flags: Print Annotation: Subtype: Link 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