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Title:           Targeting MarA N‐terminal domain dynamics to prevent DNA binding
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     Item: 
      Title: Targeting MarA N‐terminal domain dynamics to prevent DNA binding
      Destination: atl_PRO_5258_
      Children: 
       Item: 
        Title: Abstract
        Destination: HeadingPRO_5258ABSid_1
       Item: 
        Title: 1  |  INTRODUCTION
        Destination: HeadingPRO_5258pro5258-sec-0001
       Item: 
        Title: 2  |  RESULTS
        Destination: HeadingPRO_5258pro5258-sec-0002
        Children: 
         Item: 
          Title: 2.1  |  The N‐terminal helix of MarA is a crucial structural element for the mechanism of DNA binding
          Destination: HeadingPRO_5258pro5258-sec-0003
         Item: 
          Title: 2.2  |  Constraining movement of the MarA N‐terminal helix reduces activation of acrAB transcription
          Destination: HeadingPRO_5258pro5258-sec-0004
         Item: 
          Title: 2.3  |  Impact of the I13C/M47C and I16C/M47C double cysteine mutations on the dynamics and structure of free MarA
          Destination: HeadingPRO_5258pro5258-sec-0005
         Item: 
          Title: 2.4  |  Intrinsic fluorescence measurements suggest that the disulfide bonds do not affect the overall fold of the N‐termin...
          Destination: HeadingPRO_5258pro5258-sec-0006
         Item: 
          Title: 2.5  |  Impact of the I13C/M47C and I16C/M47C double cysteine variants of MarA on marbox binding
          Destination: HeadingPRO_5258pro5258-sec-0007
         Item: 
          Title: 2.6  |  The N‐terminal helix of MarA seems to be involved in the recognition of the marboxes
          Destination: HeadingPRO_5258pro5258-sec-0008
         Item: 
          Title: 2.7  |  The mechanism of inhibition involving the N‐terminal helix seems to be general for the members of the AraC/XylS tra...
          Destination: HeadingPRO_5258pro5258-sec-0009
       Item: 
        Title: 3  |  DISCUSSION
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       Item: 
        Title: 4  |  MATERIALS AND METHODS
        Destination: HeadingPRO_5258pro5258-sec-0011
        Children: 
         Item: 
          Title: 4.1  |  Bacterial strains and growth conditions
          Destination: HeadingPRO_5258pro5258-sec-0012
         Item: 
          Title: 4.2  |  Cloning and site‐directed mutagenesis
          Destination: HeadingPRO_5258pro5258-sec-0013
         Item: 
          Title: 4.3  |  Protein purification
          Destination: HeadingPRO_5258pro5258-sec-0014
         Item: 
          Title: 4.4  |  Electrophoretic mobility shift assay
          Destination: HeadingPRO_5258pro5258-sec-0015
         Item: 
          Title: 4.5  |  Reporter system
          Destination: HeadingPRO_5258pro5258-sec-0016
         Item: 
          Title: 4.6  |  Western blotting
          Destination: HeadingPRO_5258pro5258-sec-0017
         Item: 
          Title: 4.7  |  Ethidium bromide accumulation assay
          Destination: HeadingPRO_5258pro5258-sec-0018
         Item: 
          Title: 4.8  |  Mass spectrometry
          Destination: HeadingPRO_5258pro5258-sec-0019
         Item: 
          Title: 4.9  |  Intrinsic fluorescence measurements
          Destination: HeadingPRO_5258pro5258-sec-0020
         Item: 
          Title: 4.10  |  Bioinformatic tools
          Destination: HeadingPRO_5258pro5258-sec-0021
         Item: 
          Title: 4.11  |  System preparation for conventional and Gaussian accelerated molecular dynamics simulations
          Destination: HeadingPRO_5258pro5258-sec-0022
         Item: 
          Title: 4.12  |  Conventional molecular dynamics simulations
          Destination: HeadingPRO_5258pro5258-sec-0023
         Item: 
          Title: 4.13  |  Gaussian accelerated molecular dynamics simulations
          Destination: HeadingPRO_5258pro5258-sec-0024
         Item: 
          Title: 4.14  |  Analysis of molecular dynamics simulations
          Destination: HeadingPRO_5258pro5258-sec-0025
       Item: 
        Title: AUTHOR CONTRIBUTIONS
        Destination: HeadingPRO_5258pro5258-sec-0028
       Item: 
        Title: ACKNOWLEDGMENTS
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       Item: 
        Title: CONFLICT OF INTEREST STATEMENT
        Destination: HeadingPRO_5258pro5258-sec-0027
       Item: 
        Title: ORCID
        Destination: HeadingPRO_5258ORCid
       Item: 
        Title: REFERENCES
        Destination: HeadingPRO_5258pro5258-bibl-00011
       Item: 
        Title: SUPPORTING INFORMATION
        Destination: HeadingPRO_5258SUPPid
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