55cc4d19e2608de25bdc561b3a3bfbcd pmc_11638268.pdf aa6636ef8a2e2c794697024715a1dd262f0cb769 pmc_11638268.pdf d7d9963a928a729eec71697fb390d9d934b7c1ae9f9adc0725a5b40f48cb4791 pmc_11638268.pdf Title: Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis Subject: Journal of Neurology, https://doi.org/10.1007/s00415-024-12763-w Keywords: Multiple sclerosis; Primary progressive; Virus; Epstein–Barr virus; Human cytomegalovirus Author: Manuel Comabella Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Thu Dec 5 15:14:15 2024 CET ModDate: Thu Dec 12 13:18:01 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 5 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 529377 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-SemiCn Type 1C WinAnsi yes no yes 28 0 MyriadPro-SemiboldSemiCn Type 1C Custom yes no yes 33 0 MyriadPro-Semibold Type 1C Custom yes no yes 143 0 QAZQII+STIX-Regular Type 1C Custom yes yes yes 30 0 MyriadPro-Bold Type 1C Custom yes no yes 29 0 GPKAFN+MyriadPro-SemiCn2 Type 1C WinAnsi yes yes yes 272 0 DDNKRY+STIX-Bold Type 1C WinAnsi yes yes yes 31 0 VMWGKV+STIX-Italic Type 1C WinAnsi yes yes yes 32 0 MyriadPro-BoldSemiCn Type 1C WinAnsi yes no yes 121 0 GYRNDK+Wingdings-Regular Type 1C WinAnsi yes yes yes 144 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-06 02:45:13 CET RepresentationInformation: pmc_11638268.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-01-25 02:29:54 CET Size: 529377 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 300 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis Children: Item: Title: Abstract Children: Item: Title: Background and objectives Item: Title: Methods Item: Title: Results Item: Title: Discussion Item: Title: Introduction Item: Title: Methods Item: Title: Results Item: Title: Discussion Item: Title: References Info: Title: Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis Author: Manuel Comabella Subject: Journal of Neurology, https://doi.org/10.1007/s00415-024-12763-w Keywords: Multiple sclerosis; Primary progressive; Virus; Epstein Barr virus; Human cytomegalovirus Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Thu Dec 05 15:44:15 CET 2024 ModDate: Thu Dec 12 13:18:01 CET 2024 ID: 0x0bbbc1eb10a33420a95b391425a9d5c1, 0x19100f430967af8535183eb261f6f8cc Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 120 ImageHeight: 119 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 601 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: VMWGKV+STIX-Italic FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: VMWGKV+STIX-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: GYRNDK+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: GYRNDK+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-SemiboldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldSemiCn Flags: Nonsymbolic FontBBox: -131, -250, 1115, 886 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-BoldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-BoldSemiCn Flags: Nonsymbolic FontBBox: -133, -250, 1161, 894 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-SemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiCn Flags: Nonsymbolic FontBBox: -128, -250, 1059, 876 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: QAZQII+STIX-Regular FontSubset: true FirstChar: 26 LastChar: 252 FontDescriptor: FontName: QAZQII+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: DDNKRY+STIX-Bold FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: DDNKRY+STIX-Bold Flags: Serif, Nonsymbolic FontBBox: -998, -552, 2000, 1055 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true XMP: 2024-12-05T19:44:15+05:30 Springer 2024-12-12T13:18:01+01:00 2024-12-12T13:18:01+01:00 Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) Multiple sclerosis; Primary progressive; Virus; Epstein–Barr virus; Human cytomegalovirus False application/pdf https://doi.org/10.1007/s00415-024-12763-w Springer Berlin Heidelberg Journal of Neurology, https://doi.org/10.1007/s00415-024-12763-w Multiple sclerosis Primary progressive Virus Epstein–Barr virus Human cytomegalovirus Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis Manuel Comabella Harald Hegen Luisa M. Villar Konrad Rejdak Augusto Sao-Avilés Malina Behrens Jaume Sastre-Garriga Neus Mongay Klaus Berek Sergio Martínez-Yelamos Francisco Pérez-Miralles Ahmed Abdelhak Franziska Bachhuber Hayrettin Tumani Jan Lycke Pere Carbonell-Mirabent Adrián Valls-Carbó Igal Rosenstein Roberto Alvarez-Lafuente Tamara Castillo-Triviño David Otaegui Sara Llufriu Yolanda Blanco Antonio J. Sánchez-López Antonio García-Merino Nicolás Fissolo Lucía Gutiérrez Javier Villacieros-Álvarez Enric Monreal Heinz Wiendl Xavier Montalban Jan D. Lünemann 10.1007/s00415-024-12763-w 2010-04-23 true springer.com springerlink.com https://doi.org/10.1007/s00415-024-12763-w 10.1007/s00415-024-12763-w 1432-1459 journal Journal of Neurology The Author(s) 2010-04-23 true 10.1007/s00415-024-12763-w noindex springer.com springerlink.com VoR uuid:9f45b74b-02e7-48c9-869b-35bf1affaced uuid:df5cec3b-ad40-4438-8a84-19d9981051a6 default 1 converted uuid:9f45b74b-02e7-48c9-869b-35bf1affaced converted to PDF/A-2b pdfToolbox 2024-12-05T19:46:21+05:30 converted uuid:33987b1f-c9c8-4628-8f7b-fba79032e1ba converted to PDF/A-2b pdfToolbox 2024-12-05T19:46:52+05:30 2 B Jan D. Lünemann http://orcid.org/0000-0002-3007-708X http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 214, 559, 226, 547 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 181, 204, 186, 189 Flags: Print AppearanceDictionary: true Destination: 63 Annotation: Subtype: Link Rect: 220, 154, 225, 139 Flags: Print AppearanceDictionary: true Destination: 63 Annotation: Subtype: Link Rect: 230, 154, 235, 139 Flags: Print AppearanceDictionary: true Destination: 63 Annotation: Subtype: Link Rect: 331, 154, 336, 139 Flags: Print AppearanceDictionary: true Destination: 63 Annotation: Subtype: Link Rect: 513, 726, 546, 694 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 210, 723, 215, 708 Flags: Print AppearanceDictionary: true Destination: 63 Annotation: Subtype: Link Rect: 87, 574, 92, 558 Flags: Print AppearanceDictionary: true Destination: 63 Annotation: Subtype: Link Rect: 533, 635, 538, 620 Flags: Print AppearanceDictionary: true Destination: 3 Annotation: Subtype: Link Rect: 450, 535, 455, 520 Flags: Print AppearanceDictionary: true Destination: 39 Annotation: Subtype: Link Rect: 365, 498, 370, 483 Flags: Print AppearanceDictionary: true Destination: 39 Annotation: Subtype: Link Rect: 498, 460, 503, 445 Flags: Print AppearanceDictionary: true Destination: 39 Annotation: Subtype: Link Rect: 428, 285, 433, 270 Flags: Print AppearanceDictionary: true Destination: 63 Annotation: Subtype: Link Rect: 438, 285, 448, 270 Flags: Print AppearanceDictionary: true Destination: 63 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 275, 349, 285, 334 Flags: Print AppearanceDictionary: true Destination: 63 Annotation: Subtype: Link Rect: 129, 286, 139, 271 Flags: Print AppearanceDictionary: true Destination: 63 Annotation: Subtype: Link Rect: 215, 211, 225, 196 Flags: Print AppearanceDictionary: true Destination: 63 Annotation: Subtype: Link Rect: 136, 149, 146, 134 Flags: Print AppearanceDictionary: true Destination: 63 Annotation: Subtype: Link Rect: 124, 111, 134, 96 Flags: Print AppearanceDictionary: true Destination: 63 Annotation: Subtype: Link Rect: 413, 249, 423, 234 Flags: Print AppearanceDictionary: true Destination: 63 Annotation: Subtype: Link Rect: 496, 86, 501, 71 Flags: Print AppearanceDictionary: true Destination: 63 Annotation: Subtype: Link Rect: 506, 86, 511, 71 Flags: Print AppearanceDictionary: true Destination: 63 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 272, 686, 283, 671 Flags: Print AppearanceDictionary: true Destination: 125 Annotation: Subtype: Link Rect: 135, 617, 287, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 137, 285, 287, 272 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 85, 195, 238, 182 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 138, 145, 274, 132 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 85, 213, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 340, 706, 489, 693 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 413, 576, 522, 563 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 344, 486, 487, 473 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 394, 436, 510, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 404, 396, 544, 383 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 346, 481, 333 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 376, 306, 544, 293 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 506, 216, 544, 203 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 206, 417, 193 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 520, 166, 544, 153 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 156, 467, 143 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 482, 126, 544, 113 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 116, 433, 103 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 214, 573, 226, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 208, 715, 289, 702 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 705, 158, 692 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 395, 735, 544, 722 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 725, 335, 712 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 72bec71d Type: CRC32 Checksum: 55cc4d19e2608de25bdc561b3a3bfbcd Type: MD5 Checksum: aa6636ef8a2e2c794697024715a1dd262f0cb769 Type: SHA-1 Checksum: d7d9963a928a729eec71697fb390d9d934b7c1ae9f9adc0725a5b40f48cb4791 Type: SHA-256