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Immunol. 15:1488042. doi: 10.3389/fimmu.2024.1488042 Keywords: AKR1B10; pan-cancer; progression; tumor microenvironment; immunity Author: Anqi Wu CreationDate: Wed Dec 4 03:51:59 2024 CET ModDate: Wed Dec 4 03:51:59 2024 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 13201330 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BBKAPN+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 600 0 BBKAPO+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 601 0 BBKAPP+AdvPSA18C Type 1C WinAnsi yes yes no 602 0 BBKBBA+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 603 0 BBKBBB+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 604 0 BBKBBC+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 605 0 BBKCFK+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 618 0 BBKCFL+AdvPSA323 Type 1C WinAnsi yes yes no 619 0 BBKCFM+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 620 0 BBKCKN+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 345 0 BBKCKO+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 349 0 BBKCKL+AdvOT1ef757c0 Type 1C Custom yes yes yes 350 0 BBKCKM+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 351 0 BBKCMO+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 360 0 BBKCMP+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 364 0 BBKCOA+AdvPS7DB7 Type 1C WinAnsi yes yes no 367 0 BBKCOB+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 366 0 BBKCOC+AdvP4C4E74 Type 1C Custom yes yes no 365 0 BBKGEN+AdvTT2c8ce45a+20 Type 1C WinAnsi yes yes no 370 0 BBMINL+AdvTT58d178b9+03 Type 1C Custom yes yes yes 371 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-06 02:44:58 CET RepresentationInformation: pmc_11659136.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-01-09 02:27:13 CET Size: 13201330 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 694 FreeObjects: 4 IncrementalUpdates: 3 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: The pan-cancer landscape of aldo-keto reductase1B10 reveals that its expression is diminished in gastric cancer Destination: bmark_110877626 Children: Item: Title: 1 Introduction Destination: s1 Item: Title: 2 Material and methods Destination: s2 Children: Item: Title: 2.1 Data collection Destination: s2_1 Item: Title: 2.2 Analysis of AKR1B10 expression and clinical features Destination: s2_2 Item: Title: 2.3 Mutation analysis Destination: s2_3 Item: Title: 2.4 Visualization of methylation data and single cell RNA sequencing data Destination: s2_4 Item: Title: 2.5 Microenvironment analysis Destination: s2_5 Item: Title: 2.6 Immune cell infiltration analysis Destination: s2_6 Item: Title: 2.7 Correlation of AKR1B10 with immune related gene expression Destination: s2_7 Item: Title: 2.8 Functional analysis Destination: s2_8 Item: Title: 2.9 Multiplex immunofluorescence staining Destination: s2_9 Item: Title: 2.10 Statistical analysis Destination: s2_10 Item: Title: 3 Result Destination: s3 Children: Item: Title: 3.1 Tissue-specific expression of AKR1B10 Destination: s3_1 Item: Title: 3.2 Aberrant AKR1B10 expression in pan-cancers Destination: s3_2 Item: Title: 3.3 Potential role of AKR1B10 in tumor microenvironment Destination: s3_3 Item: Title: 3.4 Potential role of ARK1B10 in immune responses Destination: s3_4 Item: Title: 3.5 Potential role of AKR1B10 in immune therapy responses Destination: s3_5 Item: Title: 3.6 Functional analysis of AKR1B10 in pan-cancer cells Destination: s3_6 Item: Title: 3.7 The prognostic role of AKR1B10 in pan-cancers Destination: s3_7 Item: Title: 3.8 Validation of AKR1B10 expression and its association with immune in gastric cancer Destination: s3_8 Item: Title: 4 Discussion Destination: s4 Item: Title: 5 Conclusion Destination: s5 Item: Title: Data availability statement Destination: bmark_-1258588262 Item: Title: Ethics statement Destination: bmark_1370551237 Item: Title: Author contributions Destination: bmark_-1208584890 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Conflict of interest Destination: bmark_1089982005 Item: Title: Publisher’s note Destination: bmark_-1256977648 Item: Title: Supplementary material Destination: bmark_632582120 Item: Title: References Destination: bmark_2090415954 Info: Title: The pan-cancer landscape of aldo-keto reductase1B10 reveals that its expression is diminished in gastric cancer Author: Anqi Wu Subject: Wu A, Li H, Gao M, Liang J, Huang J, Farrés J, Cao D and Li G (2024) The pan-cancer landscape of aldo-keto reductase1B10 reveals that its expression is diminished in gastric cancer. Front. Immunol. 15:1488042. doi: 10.3389/fimmu.2024.1488042 Keywords: AKR1B10; pan-cancer; progression; tumor microenvironment; immunity CreationDate: Wed Dec 04 03:51:59 CET 2024 ModDate: Wed Dec 04 03:51:59 CET 2024 ID: 0xea05c5a499a41ff30bd14f0888f1b953, 0x4a87191a414c804cb994eda773c69bdf Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1963 ImageHeight: 2565 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2000 ImageHeight: 2308 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2005 ImageHeight: 1586 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png 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Front. Immunol. 15:1488042. doi: 10.3389/fimmu.2024.1488042 Copyright © 2024 Wu, Li, Gao, Liang, Huang, Farrés, Cao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. AKR1B10 pan-cancer progression tumor microenvironment immunity The pan-cancer landscape of aldo-keto reductase1B10 reveals that its expression is diminished in gastric cancer AKR1B10; pan-cancer; progression; tumor microenvironment; immunity True https://www.frontiersin.org/legal/copyright-statement 2024-12-04T10:51:59+08:00 2024-12-04T10:51:59+08:00 2024-12-04T10:51:59+08:00 uuid:3d86e4d5-ac9d-4e3d-a92a-1bad3345a735 uuid:04b8fbb2-346d-4be0-ad7b-6f63aa42f528 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 221, 685, 485, 706 Annotation: Subtype: Link Rect: 221, 660, 490, 681 Annotation: Subtype: Link Rect: 221, 635, 492, 656 Annotation: Subtype: Link Rect: 221, 610, 493, 631 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 690, 125, 705 Annotation: Subtype: Link Rect: 60, 546, 119, 553 Annotation: Subtype: Link Rect: 49, 410, 160, 417 Annotation: Subtype: Link Rect: 155, 369, 180, 376 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