d10ffec7cebb8221cde290c2673a7ddb pmc_11718908.pdf d933d62e87e49c9590e052d990b0f7473379b1cd pmc_11718908.pdf c1ee7fdd334a1232e67307f7ea4b2b7adb3373d7f198e86c49d3f71c2efeb41f pmc_11718908.pdf Title: Analysis of Inflammatory Features in Suspicious Lesions for Significant Prostate Cancer on Magnetic Resonance Imaging—Are They Mimickers of Prostate Cancer? Subject: Background. Inflammatory features can mimic PCa in suspicious MRI-lesions. Objectives: To assess the incidence of inflammatory features in targeted biopsies to suspicious lesions. Methods. A prospective analysis was conducted of 531 MRI-suspicious lesions with Prostate Imaging-Reporting and Data System (PI-RADS) scores of 3 to 5 in 364 men suspected of having PCa. Results. The incidence of inflammatory features in the MRI-suspicious lesions without PCa was 69.6%, compared to 48.1% in those with PCa (p < 0.001). Among the suspicious lesions without PCa, the incidence of inflammatory features ranged from 68.6% to 71.2% across the PI-RADS categories (p = 0.870). Mild chronic prostatitis increased with higher PI-RADS scores, while acute prostatitis decreased, and granulomatous prostatitis was exclusively observed in patients with PI-RADS scores of 4 and 5. The incidence of inflammatory features in the lesions with insignificant PCa (grade group 1) was 66.7%, compared to 42.7% in those with significant PCa (grade group 2 to 5; p = 0.027). The detection of inflammatory features in MRI-suspicious lesions was identified as an independent predictor of a lower likelihood of significant PCa detection, with an odds ratio (OR) of 0.326 (95% CI 0.196–0.541). Mild chronic prostatitis was the only type of prostatitis which was an independent predictor of a lower likelihood of significant PCa, with an OR of 0.398 (95% CI 0.268–0.590). Conclusions. These data suggest that inflammatory features may be considered mimickers of significant PCa on MRI. Keywords: prostate cancer; inflammation; prostatitis; magnetic resonance imaging; prostate biopsy Author: Juan Morote, Ana Celma, María E. Semidey, Andreu Antolín, Berta Miró, Olga Méndez and Enrique Trilla Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Mon Dec 30 09:20:51 2024 CET ModDate: Mon Dec 30 12:04:31 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3799225 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XWOCXD+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 RCEPEA+URWPalladioL-Roma Type 1 Custom yes yes yes 16 0 JTOTAE+URWPalladioL-Bold Type 1 Custom yes yes yes 22 0 XGHRAR+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 HKBJPQ+VnURWPalladioL Type 1 Custom yes yes yes 32 0 PALPCB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 71 0 PALPCD+PalatinoLinotype TrueType WinAnsi yes yes no 74 0 PALPCF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 77 0 PALPCB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 94 0 PALPCD+PalatinoLinotype TrueType WinAnsi yes yes no 97 0 PALPCF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 100 0 PALPLE+PalatinoLinotype TrueType MacRoman yes yes no 103 0 PAMACC+PalatinoLinotype,Italic TrueType MacRoman yes yes no 106 0 PALPCB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 119 0 PALPCD+PalatinoLinotype TrueType WinAnsi yes yes no 122 0 PALPCF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 125 0 PALPLE+PalatinoLinotype TrueType MacRoman yes yes no 128 0 PAMACC+PalatinoLinotype,Italic TrueType MacRoman yes yes no 131 0 PALPCB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 141 0 PALPCD+PalatinoLinotype TrueType WinAnsi yes yes no 144 0 PALPCF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 147 0 PALPLE+PalatinoLinotype TrueType MacRoman yes yes no 150 0 PAMACC+PalatinoLinotype,Italic TrueType MacRoman yes yes no 153 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 159 0 WCBGZO+EURM10 Type 1 Builtin yes yes yes 183 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-13 02:52:18 CET RepresentationInformation: pmc_11718908.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-12 02:33:03 CET Size: 3799225 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 356 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Design, Setting, and Participants Destination: subsection.2.1 Item: Title: Diagnostic Approach for Prostate Cancer Detection Destination: subsection.2.2 Item: Title: Variables in the Study Destination: subsection.2.3 Item: Title: Diagnostic Approach of Inflammatory Features Destination: subsection.2.4 Item: Title: Statistical Analysis Destination: subsection.2.5 Item: Title: Results Destination: section.3 Children: Item: Title: Characteristics of Study Population and Guided-Biopsy Lesions Destination: subsection.3.1 Item: Title: Distribution of Inflammatory Features in Suspicious Lesions Without and with Prostate Cancer Destination: subsection.3.2 Item: Title: Distribution of Inflammatory Features in Targeted Biopsies According to the PI-RADS Category Destination: subsection.3.3 Item: Title: Distribution of Inflammatory Findings in Targeted Biopsies of Suspicious Lesions with Prostate Cancer According to Its Aggressiveness Destination: subsection.3.4 Item: Title: Analysis of Associations with Significant Prostate Cancer and Its Prediction of Characteristics of Suspicious Lesions and Reported Inflammatory Findings Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Analysis of Inflammatory Features in Suspicious Lesions for Significant Prostate Cancer on Magnetic Resonance Imaging Are They Mimickers of Prostate Cancer? Author: Juan Morote, Ana Celma, María E. Semidey, Andreu Antolín, Berta Miró, Olga Méndez and Enrique Trilla Subject: Background. Inflammatory features can mimic PCa in suspicious MRI-lesions. Objectives: To assess the incidence of inflammatory features in targeted biopsies to suspicious lesions. Methods. A prospective analysis was conducted of 531 MRI-suspicious lesions with Prostate Imaging-Reporting and Data System (PI-RADS) scores of 3 to 5 in 364 men suspected of having PCa. Results. The incidence of inflammatory features in the MRI-suspicious lesions without PCa was 69.6%, compared to 48.1% in those with PCa (p < 0.001). Among the suspicious lesions without PCa, the incidence of inflammatory features ranged from 68.6% to 71.2% across the PI-RADS categories (p = 0.870). Mild chronic prostatitis increased with higher PI-RADS scores, while acute prostatitis decreased, and granulomatous prostatitis was exclusively observed in patients with PI-RADS scores of 4 and 5. The incidence of inflammatory features in the lesions with insignificant PCa (grade group 1) was 66.7%, compared to 42.7% in those with significant PCa (grade group 2 to 5; p = 0.027). The detection of inflammatory features in MRI-suspicious lesions was identified as an independent predictor of a lower likelihood of significant PCa detection, with an odds ratio (OR) of 0.326 (95% CI 0.196 0.541). Mild chronic prostatitis was the only type of prostatitis which was an independent predictor of a lower likelihood of significant PCa, with an OR of 0.398 (95% CI 0.268 0.590). Conclusions. These data suggest that inflammatory features may be considered mimickers of significant PCa on MRI. 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