a25bbb4f2d8557b6c186ea0446ca11c6 pmc_11755491.pdf 86146d053a15c1ef93131908990126202244449f pmc_11755491.pdf b4892b2fcd1c0a9f2562cbb12c9874e379b03b72106492b3bc744a601bff6968 pmc_11755491.pdf Title: Impairment of the Functional Status and Decrease in Albumin in Frail Older People After a COVID-19 Outbreak: A Descriptive Study in a Long-Term Care Facility in Chile Subject: Introduction. Frailty is a common condition among older individuals and is associated with increased vulnerability to adverse health outcomes. The COVID-19 pandemic further highlighted the impact of viral infections on frail populations. The present work aimed to determine frailty, functional and cognitive status, and clinical analysis of older persons in a long-term care facility in Chile, before and following the outbreak of COVID-19. Methods. A single-center, pre–post, and Pearson’s correlational study was conducted in a cohort of 20 persons positive for COVID-19 from a total of 45 residents. Data on demographic, clinical, functional (Barthel Index (BI) and Katz) and cognitive (Mini mental Examination) status, and physiological function (hematology, lipidic and biochemical profiles) were collected. Results. The mean age was 84 2.4 years, and 80% were females. The most common comorbidities were Arterial Hypertension, Diabetes Mellitus type II, and Alzheimer’s disease. Physical frailty was confirmed by body weight, body mass index, and calf circumference. Pre-infection, BI was negatively correlated with lipidic profile and erythrocyte sedimentation rate (ESR), and positively with frailty (calf circumference). Pre–post analysis showed that frailty and most analytical results were not modified. However, functional dependence on daily live activities significantly increased as measured by BI, with worse grooming and bowel and bladder controls. Post-infection, correlations were lost except between BI and ESR, and decreased albumin levels were found. Conclusions. The worsening of specific functional limitations emphasizes the need for targeted interventions that can be correlated with ESR. Albumin appears as a potential biomarker for physiological dysfunction associated with their infectious/inflammatory processes. Keywords: COVID-19; disability; frailty; functionality; SARS-CoV-2; physiological function; LTC Author: Lidia Castillo-Mariqueo, Alejandro Aedo Lagos, Lydia Giménez-Llort and Neftalí Guzmán Oyarzo Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Wed Dec 25 09:16:43 2024 CET ModDate: Wed Dec 25 09:18:49 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 230101 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IOJCNK+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 NMCZHP+URWPalladioL-Roma Type 1 Custom yes yes yes 16 0 XCUGYJ+URWPalladioL-Bold Type 1 Custom yes yes yes 22 0 BEBVSC+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 SSJMKU+CMSY10 Type 1 Builtin yes yes yes 32 0 LWJOET+VnURWPalladioL Type 1 Custom yes yes yes 37 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-17 16:54:20 CET RepresentationInformation: pmc_11755491.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-11 02:32:15 CET Size: 230101 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 196 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Design and Participants Destination: subsection.2.1 Item: Title: Data Collection Destination: subsection.2.2 Item: Title: Statistical Analysis Destination: subsection.2.3 Item: Title: Ethics Destination: subsection.2.4 Item: Title: Results Destination: section.3 Children: Item: Title: Baseline Characteristics Destination: subsection.3.1 Item: Title: Frailty and Functional Limitation Destination: subsection.3.2 Item: Title: Physiological Fuction Destination: subsection.3.3 Item: Title: Discussion Destination: section.4 Children: Item: Title: Frailty and Functional Limitation Destination: subsection.4.1 Item: Title: Physiological Function Destination: subsection.4.2 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Impairment of the Functional Status and Decrease in Albumin in Frail Older People After a COVID-19 Outbreak: A Descriptive Study in a Long-Term Care Facility in Chile Author: Lidia Castillo-Mariqueo, Alejandro Aedo Lagos, Lydia Giménez-Llort and Neftalí Guzmán Oyarzo Subject: Introduction. Frailty is a common condition among older individuals and is associated with increased vulnerability to adverse health outcomes. The COVID-19 pandemic further highlighted the impact of viral infections on frail populations. The present work aimed to determine frailty, functional and cognitive status, and clinical analysis of older persons in a long-term care facility in Chile, before and following the outbreak of COVID-19. Methods. A single-center, pre post, and Pearson’s correlational study was conducted in a cohort of 20 persons positive for COVID-19 from a total of 45 residents. Data on demographic, clinical, functional (Barthel Index (BI) and Katz) and cognitive (Mini mental Examination) status, and physiological function (hematology, lipidic and biochemical profiles) were collected. Results. The mean age was 84 2.4 years, and 80% were females. The most common comorbidities were Arterial Hypertension, Diabetes Mellitus type II, and Alzheimer’s disease. Physical frailty was confirmed by body weight, body mass index, and calf circumference. Pre-infection, BI was negatively correlated with lipidic profile and erythrocyte sedimentation rate (ESR), and positively with frailty (calf circumference). Pre post analysis showed that frailty and most analytical results were not modified. However, functional dependence on daily live activities significantly increased as measured by BI, with worse grooming and bowel and bladder controls. Post-infection, correlations were lost except between BI and ESR, and decreased albumin levels were found. Conclusions. The worsening of specific functional limitations emphasizes the need for targeted interventions that can be correlated with ESR. Albumin appears as a potential biomarker for physiological dysfunction associated with their infectious/inflammatory processes. 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