b0d209bd018a8e1f1272be4074f521f6 viruses-17-00993.pdf ad205ea25f6f4fb963691bdc8b7b55677b8ad265 viruses-17-00993.pdf cfb7fe1f42a3ed91b67530f62ae8a8de64cf2012ca2c8409effdc54e634afda9 viruses-17-00993.pdf Title: Barriers and Facilitators of Implementation of the Non-Hospital-Based Administration of Long-Acting Cabotegravir Plus Rilpivirine in People with HIV: Qualitative Data from the HOLA Study Subject: Long-acting (LA) antiretroviral therapies for human immunodeficiency virus (HIV), such as injectable formulations of cabotegravir and rilpivirine (CAB+RPV LA), are now available. Considering the limited data on the out-of-hospital administration of this combination, evaluating the implementation strategies needed is essential to support future clinical efforts. To gather data on barriers and facilitators of implementation for CAB+RPV LA in alternative outpatient facilities, this study used qualitative interviews informed by the Consolidated Framework for Implementation Research (CFIR), with 13 staff participating in the HOLA study (NCT06185452). Data analysis followed qualitative descriptive methods, assisted by Atlas.ti software version 22. The study adhered to the COREQ guidelines. Findings reveal five main factors to consider for implementation: operational and infrastructure adaptations, integrated management of human and organizational resources, need for coordination and follow-up, professional attitudes and work environment, and patient experience and patients’ needs perceived by professionals. This study emphasizes the comprehensive operational and infrastructure adaptations, adequate staff training, and supportive professional environment required for the successful implementation of CAB+RPV LA, while considering patients’ needs throughout the externalization process (trial registration number: NCT06643897). Keywords: HIV; antiretrovirals; cabotegravir + rilpivirine long acting; out-of-hospital administration; implementation; barriers and facilitators; qualitative methods Author: Diana Hernández-Sánchez, Juan M. Leyva-Moral, Julian Olalla, Eugènia Negredo and on behalf of the HOLA Study Group Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25; modified using OpenPDF 1.4.2 CreationDate: Wed Jul 16 11:57:24 2025 CEST ModDate: Wed Jul 16 12:05:04 2025 CEST Custom Metadata: yes Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 325043 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XMFGRC+URWPalladioL-Ital Type 1 Custom yes yes yes 101 0 BGAZTI+VnURWPalladioL Type 1 Custom yes yes yes 102 0 NDQEWF+URWPalladioL-Bold Type 1 Custom yes yes yes 103 0 WYEKQU+VnURWPalladioL-Bold Type 1 Custom yes yes yes 104 0 AMOFKW+URWPalladioL-Roma Type 1 Custom yes yes yes 105 0 LGTZLE+CMSY10 Type 1 Builtin yes yes yes 182 0 JILAEH+Wingdings CID TrueType Identity-H yes yes yes 178 0 JIKPDH+PalatinoLinotype TrueType WinAnsi yes yes no 179 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-09-05 03:09:30 CEST RepresentationInformation: viruses-17-00993.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-09-04 06:05:38 CEST Size: 325043 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 351 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Background Item: Title: Methods Item: Title: Results Children: Item: Title: Operational and Infrastructure Adaptations Item: Title: Integrated Management of Human and Organizational Resources Item: Title: Need for Coordination and Follow-Up Item: Title: Professional Attitudes and Work Environment Item: Title: Patient Experience and Needs Perceived by Professionals Item: Title: Discussion Children: Item: Title: Summary of Considerations for Implementation Item: Title: Patient-Centered Considerations Item: Title: Limitations and Next Steps Item: Title: References Info: Title: Barriers and Facilitators of Implementation of the Non-Hospital-Based Administration of Long-Acting Cabotegravir Plus Rilpivirine in People with HIV: Qualitative Data from the HOLA Study Author: Diana Hernández-Sánchez, Juan M. Leyva-Moral, Julian Olalla, Eugènia Negredo and on behalf of the HOLA Study Group Subject: Long-acting (LA) antiretroviral therapies for human immunodeficiency virus (HIV), such as injectable formulations of cabotegravir and rilpivirine (CAB+RPV LA), are now available. Considering the limited data on the out-of-hospital administration of this combination, evaluating the implementation strategies needed is essential to support future clinical efforts. To gather data on barriers and facilitators of implementation for CAB+RPV LA in alternative outpatient facilities, this study used qualitative interviews informed by the Consolidated Framework for Implementation Research (CFIR), with 13 staff participating in the HOLA study (NCT06185452). Data analysis followed qualitative descriptive methods, assisted by Atlas.ti software version 22. The study adhered to the COREQ guidelines. Findings reveal five main factors to consider for implementation: operational and infrastructure adaptations, integrated management of human and organizational resources, need for coordination and follow-up, professional attitudes and work environment, and patient experience and patients’ needs perceived by professionals. This study emphasizes the comprehensive operational and infrastructure adaptations, adequate staff training, and supportive professional environment required for the successful implementation of CAB+RPV LA, while considering patients’ needs throughout the externalization process (trial registration number: NCT06643897). 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