f7b01819c80d86c5c3242abe5de9c66a 86_Marin-Gual_et_al_BoR_25_.pdf d3143a12f60ec0f274652c5027cade8598a6cd83 86_Marin-Gual_et_al_BoR_25_.pdf b4c1905912af056e413d6b1b4f2dfe95536ec8507f738630fe5656f097f7d466 86_Marin-Gual_et_al_BoR_25_.pdf Title: Male meiosis at the helm: shaping genomes and sex chromosomes in emerging vertebrate models Subject: AcademicSubjects/MED00773, AcademicSubjects/SCI01070, DOI: 10.1093/biolre/ioaf175, Biology of Reproduction, 00, 00, 08 8 2025. Abstract: The generation of haploid gametes is a hallmark of sexual reproduction achieved through a complex, albeit tightly regulated, reductional cell division known as meiosis. While the molecular underpinnings of meiosis have been extensively characterized in eutherian mammalian models, key aspects—particularly those governing chromosome synapsis and recombination—remain poorly understood in non-eutherian mammals and non-model vertebrates. This knowledge gap is especially relevant for understanding genome evolution, with a focus on sex chromosomes. Comparative studies across diverse vertebrate lineages are therefore essential to uncover conserved and lineage-specific features of meiotic regulation. In this review, we explore the evolutionary dynamics of meiosis in vertebrates, emphasizing how the meiotic program influences genome architecture and the evolution of heteromorphic sex chromosomes, especially the Y chromosome. As research in non-model species gains momentum, dissecting the diversity of meiotic mechanisms across taxa emerges as a key to understanding genome plasticity and evolutionary innovation. Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 23.0 (Windows); modified using iTextSharp.LGPLv2.Core 3.7.4.0 CreationDate: Sun Aug 17 14:28:13 2025 CEST ModDate: Wed Aug 20 01:05:09 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.26 x 782.337 pts Page rot: 0 File size: 2087342 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GEPOMP+SabonLTStd-Bold Type 1C Custom yes yes yes 489 0 GEPOOA+SabonLTStd-Roman Type 1C Custom yes yes yes 120 0 GEPPAP+UniversLTStd-CnObl Type 1C Custom yes yes yes 5028 0 GEPPBA+UniversLTStd-Cn Type 1C Custom yes yes yes 5029 0 GEPPCB+UniversLTStd-BoldCn Type 1C Custom yes yes yes 5030 0 GEPPCC+UniversLTStd-Bold Type 1C Custom yes yes yes 121 0 GEPPLP+MTSYN Type 1C Custom yes yes yes 174 0 GEPPNA+UniversLTStd-Light Type 1C Custom yes yes yes 175 0 GJJJMR+ArialMT TrueType WinAnsi yes yes no 1 0 GFACHC+UniversLTStd Type 1C Custom yes yes yes 118 0 GFAEFH+MTMI Type 1C Custom yes yes yes 119 0 GFACGB+UniversLTStd-Obl Type 1C Custom yes yes yes 122 0 GFAPEF+SabonLTStd-Italic Type 1C Custom yes yes yes 208 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-10-28 04:27:28 CET RepresentationInformation: 86_Marin-Gual_et_al_BoR_25_.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-10-23 05:42:00 CEST Size: 2087342 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 5084 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Male meiosis at the helm: shaping genomes and sex chromosomes in emerging vertebrate models Destination: toc.chapter Children: Item: Title: General introduction Destination: section.19.1.1 Item: Title: Patterns of genome evolution in the vertebrate Tree of Life Destination: section.20.1.2 Item: Title: Meiotic patterns within vertebrates Destination: section.23.1.3 Item: Title: Meiotic dynamics of sex chromosomes and their evolutionary implications Destination: section.31.1.4 Item: Title: Concluding remarks Destination: section.35.1.5 Item: Title: Author contributions Destination: section.36.1.6 Item: Title: Data availability Destination: section.37.1.7 Info: Title: Male meiosis at the helm: shaping genomes and sex chromosomes in emerging vertebrate models Author: Subject: AcademicSubjects/MED00773, AcademicSubjects/SCI01070, DOI: 10.1093/biolre/ioaf175, Biology of Reproduction, 00, 00, 08 8 2025. Abstract: The generation of haploid gametes is a hallmark of sexual reproduction achieved through a complex, albeit tightly regulated, reductional cell division known as meiosis. While the molecular underpinnings of meiosis have been extensively characterized in eutherian mammalian models, key aspects particularly those governing chromosome synapsis and recombination remain poorly understood in non-eutherian mammals and non-model vertebrates. This knowledge gap is especially relevant for understanding genome evolution, with a focus on sex chromosomes. Comparative studies across diverse vertebrate lineages are therefore essential to uncover conserved and lineage-specific features of meiotic regulation. In this review, we explore the evolutionary dynamics of meiosis in vertebrates, emphasizing how the meiotic program influences genome architecture and the evolution of heteromorphic sex chromosomes, especially the Y chromosome. As research in non-model species gains momentum, dissecting the diversity of meiotic mechanisms across taxa emerges as a key to understanding genome plasticity and evolutionary innovation. 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Abstract: The generation of haploid gametes is a hallmark of sexual reproduction achieved through a complex, albeit tightly regulated, reductional cell division known as meiosis. While the molecular underpinnings of meiosis have been extensively characterized in eutherian mammalian models, key aspects—particularly those governing chromosome synapsis and recombination—remain poorly understood in non-eutherian mammals and non-model vertebrates. This knowledge gap is especially relevant for understanding genome evolution, with a focus on sex chromosomes. Comparative studies across diverse vertebrate lineages are therefore essential to uncover conserved and lineage-specific features of meiotic regulation. In this review, we explore the evolutionary dynamics of meiosis in vertebrates, emphasizing how the meiotic program influences genome architecture and the evolution of heteromorphic sex chromosomes, especially the Y chromosome. As research in non-model species gains momentum, dissecting the diversity of meiotic mechanisms across taxa emerges as a key to understanding genome plasticity and evolutionary innovation. meiosis, evolution, sex chromosomes, chromosome inactivation, Y chromosome, vertebrates. © The Author(s) 2025. Published by Oxford University Press on behalf of Society for the Study of Reproduction. 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