dd89e92e1e303c8d2f2056c76c65ee75 307644.pdf 55fce6093fcf6dfac5e80c099c80b53d39cc98e4 307644.pdf b83049f0482408b36d5c7cad26a7e981158f0b31aceca84f0a4edf572a382bf1 307644.pdf Title: Evaluation of an Alternative Screening Method for Gestational Diabetes Diagnosis During the COVID-19 Pandemic (DIABECOVID STUDY): An Observational Cohort Study Subject: Background: To evaluate the impact of applying alternative diagnostic criteria for gestational diabetes mellitus (GDM) during the COVID-19 pandemic on GDM prevalence, obstetrical and perinatal outcomes, and costs, as compared to the standard diagnostic method. Methods: A cohort of pregnant individuals undergoing GMD screening with the alternative GDM method, which uses plasma glucose (fasting or non-fasting) and HbA1c, was compared with a cohort of pregnant individuals undergoing the standard GDM screening method. Both cohorts were obtained from six hospitals across Catalonia, Spain, from April 2020 to April 2022. The primary outcome was large for gestational age rate at birth. The secondary outcomes were composite adverse outcomes, including pregnancy complications, delivery complications, and neonatal complications. The cost differences between screening methods were also evaluated. A similar analysis was performed in the subgroup diagnosed with GDM. Results: Data were collected from 1543 pregnant individuals in the standard screening group and 2197 in the alternative screening group. The standard screening group had a higher GDM diagnostic rate than the alternative screening group (10.8% vs. 6.9%, respectively; p < 0.0001). The primary outcome (large for gestational age rate) was similar between groups: 200/1543 (13.0%) vs. 303/2197 (13.8%). The adjusted OR for this outcome was 1.74 (95% CI: 0.74–4.10). An adjusted analysis showed no differences between groups in the composite adverse outcomes for pregnancy complications (OR: 1.11; 95% CI: 0.91–1.36), delivery complications (OR: 0.95; 95% CI: 0.75–1.19), and neonatal complications (OR: 1.28; 95% CI: 0.94–1.75). Among individuals diagnosed with GDM, the large for gestational age rate was similar between groups: 13/166 (7.8%) vs. 15/151 (9.9%). The OR adjusted for this outcome was 1.24 (95% CI: 0.51–3.09). An adjusted analysis showed no differences in the composite adverse outcomes for pregnancy complications (OR: 1.57; 95% CI: 0.84–2.98), delivery complications (OR: 1.21; 95% CI: 0.63–2.35), and neonatal complications (OR: 1.35; 95% CI: 0.61–3.04). The mean cost (which included expenses for consumables, equipment, and personnel) of the alternative screening method was 46.0 euros (22.3 SD), as compared to 85.6 euros (67.5 SD) for the standard screening method. Conclusions: In this Spanish population during the COVID-19 pandemic, GDM prevalence was lower in the alternative screening group than in the standard screening group. After adjusting for GDM risk factors, outcomes related to obstetrics, delivery, and neonatal complications were comparable between both groups. Finally, the alternative screening method was cheaper than the standard screening method. Keywords: gestational diabetes; COVID-19; O’Sullivan; OGTT; glucose level; glycated hemoglobin; screening; macrosomia; large for gestational age (LGA); neonatal hypoglycemia Author: Alba Casellas, Cristina Martínez, Judit Amigó, Roser Ferrer, Laia Martí, Carme Merced, Maria Carmen Medina, Istria Molinero, Marta Calveiro, Anna Maroto, Ester del Barco, Elena Carreras and Maria Goya Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Wed Jan 15 11:48:09 2025 CET ModDate: Wed Jan 15 11:51:40 2025 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 276689 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AIRHKL+VnURWPalladioL Type 1 Custom yes yes yes 10 0 MKAMOA+URWPalladioL-Roma Type 1 Custom yes yes yes 16 0 LWIBHV+URWPalladioL-Bold Type 1 Custom yes yes yes 22 0 LMQPBJ+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 PDTLUH+CMSY10 Type 1 Builtin yes yes yes 56 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes yes 70 0 AWDAAW+VnURWPalladioL-Italic Type 1 Custom yes yes yes 109 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-12 02:42:32 CET RepresentationInformation: 307644.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-11 18:48:33 CET Size: 276689 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 245 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Material and Methods Destination: section.2 Item: Title: Results Destination: section.3 Children: Item: Title: Whole Population Analysis Destination: subsection.3.1 Item: Title: GDM Group Analysis Destination: subsection.3.2 Item: Title: Discussion Destination: section.4 Children: Item: Title: Findings Destination: subsection.4.1 Item: Title: Impact and Correlation with the Literature Destination: subsection.4.2 Item: Title: Strengths Destination: subsection.4.3 Item: Title: Limitations Destination: subsection.4.4 Item: Title: Further Research Destination: subsection.4.5 Item: Title: Conclusions Destination: section.5 Item: Title: Appendix A Destination: appendix.A. Item: Title: References Destination: appendix.B. Info: Title: Evaluation of an Alternative Screening Method for Gestational Diabetes Diagnosis During the COVID-19 Pandemic (DIABECOVID STUDY): An Observational Cohort Study Author: Alba Casellas, Cristina Martínez, Judit Amigó, Roser Ferrer, Laia Martí, Carme Merced, Maria Carmen Medina, Istria Molinero, Marta Calveiro, Anna Maroto, Ester del Barco, Elena Carreras and Maria Goya Subject: Background: To evaluate the impact of applying alternative diagnostic criteria for gestational diabetes mellitus (GDM) during the COVID-19 pandemic on GDM prevalence, obstetrical and perinatal outcomes, and costs, as compared to the standard diagnostic method. Methods: A cohort of pregnant individuals undergoing GMD screening with the alternative GDM method, which uses plasma glucose (fasting or non-fasting) and HbA1c, was compared with a cohort of pregnant individuals undergoing the standard GDM screening method. Both cohorts were obtained from six hospitals across Catalonia, Spain, from April 2020 to April 2022. The primary outcome was large for gestational age rate at birth. The secondary outcomes were composite adverse outcomes, including pregnancy complications, delivery complications, and neonatal complications. The cost differences between screening methods were also evaluated. A similar analysis was performed in the subgroup diagnosed with GDM. Results: Data were collected from 1543 pregnant individuals in the standard screening group and 2197 in the alternative screening group. The standard screening group had a higher GDM diagnostic rate than the alternative screening group (10.8% vs. 6.9%, respectively; p < 0.0001). The primary outcome (large for gestational age rate) was similar between groups: 200/1543 (13.0%) vs. 303/2197 (13.8%). The adjusted OR for this outcome was 1.74 (95% CI: 0.74 4.10). An adjusted analysis showed no differences between groups in the composite adverse outcomes for pregnancy complications (OR: 1.11; 95% CI: 0.91 1.36), delivery complications (OR: 0.95; 95% CI: 0.75 1.19), and neonatal complications (OR: 1.28; 95% CI: 0.94 1.75). Among individuals diagnosed with GDM, the large for gestational age rate was similar between groups: 13/166 (7.8%) vs. 15/151 (9.9%). The OR adjusted for this outcome was 1.24 (95% CI: 0.51 3.09). An adjusted analysis showed no differences in the composite adverse outcomes for pregnancy complications (OR: 1.57; 95% CI: 0.84 2.98), delivery complications (OR: 1.21; 95% CI: 0.63 2.35), and neonatal complications (OR: 1.35; 95% CI: 0.61 3.04). The mean cost (which included expenses for consumables, equipment, and personnel) of the alternative screening method was 46.0 euros (22.3 SD), as compared to 85.6 euros (67.5 SD) for the standard screening method. Conclusions: In this Spanish population during the COVID-19 pandemic, GDM prevalence was lower in the alternative screening group than in the standard screening group. After adjusting for GDM risk factors, outcomes related to obstetrics, delivery, and neonatal complications were comparable between both groups. Finally, the alternative screening method was cheaper than the standard screening method. 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