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Title: Materials and methods Destination: A2 Children: Item: Title: Mice Destination: B1 Item: Title: Behavioral tests Destination: B2 Item: Title: Immunohistochemistry Destination: B3 Item: Title: Bulk RNA transcriptional profiling Destination: B4 Item: Title: Statistical analysis Destination: B5 Item: Title: Results Destination: A3 Children: Item: Title: Aβ and tau accumulation in excitatory neurons results in age-dependent cerebral AD pathology Destination: B6 Item: Title: Hippocampal-dependent learning/memory deficits in young Tau and APP/Tau mice Destination: B7 Item: Title: Age-dependent emotional disturbances in APP and APP/Tau mice Destination: B8 Item: Title: Early Aβ/tau-induced transcriptional responses in the hippocampus are related to synapse disruption and inflammation Destination: B9 Item: Title: Tau and Aβ cooperate to induce differential brain regional effects in synaptic plasticity Destination: B10 Item: Title: Coordinated and divergent transcriptional changes related to inflammation and AD-associated genes occur in the hippocampus and BLA of APP/Tau mice Destination: B11 Item: Title: Discussion Destination: A4 Item: Title: References Destination: A5 Item: Title: Acknowledgements Destination: A6 Item: Title: Author contributions Destination: A7 Item: Title: Competing interests Destination: A8 Item: Title: ADDITIONAL INFORMATION Destination: M1 Info: Title: Synaptic vulnerability to amyloid-β and tau pathologies differentially disrupts emotional and memory neural circuits Author: Maria Dolores Capilla-López Subject: Molecular Psychiatry, doi:10.1038/s41380-025-02901-9 Keywords: Creator: Springer CreationDate: Thu Jan 30 05:53:13 CET 2025 ModDate: Thu Jan 30 05:54:36 CET 2025 ID: 0x7c14270d0d143f956783671ab75e1e47, 0x456b320d608f1e48ac04f11842d6cf9d Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 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Heriberto Coatl-Cuaya Paula Sotillo José Rodríguez-Alvarez Antonio Rodríguez-Moreno Arnaldo Parra-Damas Carlos A. Saura Springer US Molecular Psychiatry, doi:10.1038/s41380-025-02901-9 10.1038/s41380-025-02901-9 http://dx.doi.org/10.1038/s41380-025-02901-9 journal Molecular Psychiatry © 2025, The Author(s) 1476-5578 10.1038/s41380-025-02901-9 springer.com springerlink.com 2010-04-23 True 10.1038/s41380-025-02901-9 springer.com springerlink.com Springer 2025-01-30T09:54:36+05:30 2025-01-30T09:53:13+05:30 2025-01-30T09:54:36+05:30 True VoR uuid:dd65b30f-7fe7-4e80-8476-5d0c5b4b590b uuid:17f68d90-6ea4-4497-ac97-a9916adc05a3 default 1 converted uuid:0eeb8cd1-94bf-498d-a85c-5ce80020e327 converted to PDF/A-2b pdfToolbox 2025-01-30T09:54:33+05:30 2 B Maria Dolores Capilla-López http://orcid.org/0000-0002-9483-4887 Angel Deprada http://orcid.org/0000-0002-7860-6307 Yuniesky Andrade-Talavera http://orcid.org/0000-0002-5295-0169 Irene Martínez-Gallego http://orcid.org/0000-0002-8936-8201 Heriberto Coatl-Cuaya http://orcid.org/0000-0003-4953-6562 Paula Sotillo http://orcid.org/0009-0005-9320-5949 José Rodríguez-Alvarez http://orcid.org/0000-0001-8582-8082 Antonio Rodríguez-Moreno http://orcid.org/0000-0002-8078-6175 Arnaldo Parra-Damas http://orcid.org/0000-0001-5683-060X Carlos A. 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