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Title:           HEBE: A novel chimeric chronokine for ameliorating memory deficits in Alzheimer’s disease
Subject:         Biomedicine & Pharmacotherapy, 183 (2025) 117815. doi:10.1016/j.biopha.2025.117815
Keywords:        Alzheimer’s disease,Chronokine,Chimeric protein,HEBE,Klotho,TREM2,TIMP2,Memory impairment
Author:          Jon Esandi
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      Title: HEBE: A novel chimeric chronokine for ameliorating memory deficits in Alzheimer’s disease
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        Title: 1 Introduction
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        Title: 2 Materials and methods
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          Title: 2.4 All-atom MD simulations
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          Title: 2.6 Construction of models of the united proteins
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          Title: 2.7 Coarse-grained MD simulations
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          Title: 2.8 Plasmid transfection in HEK-293 cells
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          Title: 2.9 Western Blot
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          Title: 2.10 β-glucuronidase assay
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          Title: 2.12 Phagocytosis assay
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          Title: 2.17 Morris water maze
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          Title: 3.1 Bioinformatic analyses yielded a candidate for HEBE
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          Title: 3.2 In vitro assays confirmed HEBE’s stability and activity
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          Title: 3.3 In vivo gene therapy study with HEBE achieved long-term expression of the chimeric chronokine
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          Title: 3.4 HEBE improves behavior and memory in AD mice
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          Title: 3.5 Phosphorylated Tau is reduced after HEBE treatment
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        Title: 4 Discussion
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        Title: CRediT authorship contribution statement
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        Title: Funding
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        Title: Declaration of Competing Interest
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        Title: Appendix A Supporting information
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        Title: Data availability
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    Author: Jon Esandi
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    Keywords: Alzheimer’s disease,Chronokine,Chimeric protein,HEBE,Klotho,TREM2,TIMP2,Memory impairment
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   Type: CRC32
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