1cf0a98efc2ce7da83e1d5f97be2f21d  JouSupFlu_a2025v216p106453.pdf
956f8bd1623d628a0b845aa135c6f24b9dd44273  JouSupFlu_a2025v216p106453.pdf
ed67a24f9c061fd228e0eaa74032cdbca01a94524bdd5fac085e57f7c3c11f2e  JouSupFlu_a2025v216p106453.pdf

Title:           Supercritical CO2 assisted bioMOF drug encapsulation and functionalization for delivery with a synergetic therapeutic value
Subject:         The Journal of Supercritical Fluids, 216 (2025) 106452. doi:10.1016/j.supflu.2024.106452
Keywords:        BioMOF,Supercritical CO2 processing,Hydrophobic functionalization,Stearic acid,Drug delivery
Author:          Albert Rosado
Creator:         Elsevier
Producer:        Acrobat Distiller 8.1.0 (Windows)
CreationDate:    Thu Nov 21 17:46:03 2024 CET
ModDate:         Thu Nov 21 17:47:48 2024 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           9
Encrypted:       no
Page size:       595.276 x 793.701 pts
Page rot:        0
File size:       4200080 bytes
Optimized:       yes
PDF version:     1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
UWLTQO+TeX_CM_Maths_Symbols          Type 1C           Builtin          yes yes yes   1081  0
IBDIBK+CharisSIL                     CID TrueType      Identity-H       yes yes yes   1085  0
BRWWWZ+TeX_CM_Roman                  Type 1C           Builtin          yes yes yes   1090  0
AAARUD+CharisSIL                     CID TrueType      Identity-H       yes yes yes   1094  0
PMCTYY+CharisSIL                     CID TrueType      Identity-H       yes yes yes   1102  0
UQOOJN+Univers                       Type 1C           Builtin          yes yes yes   1108  0
JNANHS+CharisSIL-Italic              CID TrueType      Identity-H       yes yes yes   1112  0
AAAAAD+CharisSIL                     CID TrueType      Identity-H       yes yes yes    280  0
SIFFGJ+STIX-Regular                  Type 1C           Custom           yes yes yes    287  0
MREJNP+CharisSIL-Bold                CID TrueType      Identity-H       yes yes yes    292  0
UMNQBV+CharisSIL-Italic              CID TrueType      Identity-H       yes yes yes    297  0
AAAALV+CharisSIL-Italic              CID TrueType      Identity-H       yes yes yes    303  0
KOENGS+TimesNewRomanPSMT             CID TrueType      Identity-H       yes yes yes    311  0
SSHIIE+TeX_CM_Maths_Italic           Type 1C           Builtin          yes yes yes     48  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-02-27 02:47:43 CET
 RepresentationInformation: JouSupFlu_a2025v216p106453.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-02-26 13:28:50 CET
  Size: 4200080
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF, Tagged PDF
  PDFMetadata: 
   Objects: 1180
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: true
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: English
    Outlines: 
     Item: 
      Title: Supercritical CO2 assisted bioMOF drug encapsulation and functionalization for delivery with a synergetic therapeutic value
      Destination: mk:title
      Children: 
       Item: 
        Title: 1 Introduction
        Destination: mk:H1_1
       Item: 
        Title: 2 Materials and procedure
        Destination: mk:H1_2
        Children: 
         Item: 
          Title: 2.1 Materials
          Destination: mk:H2_1
         Item: 
          Title: 2.2 Synthetic procedure
          Destination: mk:H2_2
         Item: 
          Title: 2.3 Characterization
          Destination: mk:H2_3
          Children: 
           Item: 
            Title: 2.3.1 Physicochemical and morphological properties
            Destination: mk:H3_4
           Item: 
            Title: 2.3.2 In vitro biocompatibility test
            Destination: mk:H3_5
           Item: 
            Title: 2.3.3 Release of bioactive compounds
            Destination: mk:H3_6
       Item: 
        Title: 3 Results and discussions
        Destination: mk:H1_3
        Children: 
         Item: 
          Title: 3.1 Synthesis and characterization
          Destination: mk:H2_7
         Item: 
          Title: 3.2 Cytotoxicity
          Destination: mk:H2_8
         Item: 
          Title: 3.3 Bioactive release
          Destination: mk:H2_9
       Item: 
        Title: 4 Conclusions
        Destination: mk:H1_4
       Item: 
        Title: CRediT authorship contribution statement
        Destination: mk:H1_5
       Item: 
        Title: Declaration of Competing Interest
        Destination: mk:HH1_4
       Item: 
        Title: Acknowledgements
        Destination: mk:HH1_5
       Item: 
        Title: Appendix A. Supplementary data
        Destination: mk:H1_6
       Item: 
        Title: Appendix A Supporting information
        Destination: mk:H1_7
       Item: 
        Title: datalink6
        Destination: datalink6
       Item: 
        Title: References
        Destination: mk:HH2_1
   Info: 
    Title: Supercritical CO2 assisted bioMOF drug encapsulation and functionalization for delivery with a synergetic therapeutic value
    Author: Albert Rosado
    Subject: The Journal of Supercritical Fluids, 216 (2025) 106452. doi:10.1016/j.supflu.2024.106452
    Keywords: BioMOF,Supercritical CO2 processing,Hydrophobic functionalization,Stearic acid,Drug delivery
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Thu Nov 21 17:46:03 CET 2024
    ModDate: Thu Nov 21 17:47:48 CET 2024
   ID: 0xf0c33f9e068977b49ba98fe73e2b527d, 0x618bf320eddb8253332a02df803072fe
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 236
      ImageHeight: 298
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 248
      ImageHeight: 271
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type0: 
     Font: 
      BaseFont: MREJNP+CharisSIL-Bold
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: AAARUD+CharisSIL
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: KOENGS+TimesNewRomanPSMT
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: JNANHS+CharisSIL-Italic
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: AAAAAD+CharisSIL
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: UMNQBV+CharisSIL-Italic
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: IBDIBK+CharisSIL
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: PMCTYY+CharisSIL
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: AAAALV+CharisSIL-Italic
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: SSHIIE+TeX_CM_Maths_Italic
      FontSubset: true
      FirstChar: 1
      LastChar: 127
      FontDescriptor: 
       FontName: SSHIIE+TeX_CM_Maths_Italic
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: BRWWWZ+TeX_CM_Roman
      FontSubset: true
      FirstChar: 1
      LastChar: 128
      FontDescriptor: 
       FontName: BRWWWZ+TeX_CM_Roman
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: UQOOJN+Univers
      FontSubset: true
      FirstChar: 32
      LastChar: 251
      FontDescriptor: 
       FontName: UQOOJN+Univers
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: UWLTQO+TeX_CM_Maths_Symbols
      FontSubset: true
      FirstChar: 1
      LastChar: 138
      FontDescriptor: 
       FontName: UWLTQO+TeX_CM_Maths_Symbols
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: SIFFGJ+STIX-Regular
      FontSubset: true
      FirstChar: 1
      LastChar: 11
      FontDescriptor: 
       FontName: SIFFGJ+STIX-Regular
       Flags: Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: PMCTYY+CharisSIL
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: PMCTYY+CharisSIL
       Flags: Serif, Symbolic
       FontBBox: -692, -533, 1623, 1319
       FontFile2: true
     Font: 
      BaseFont: AAAALV+CharisSIL-Italic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: AAAALV+CharisSIL-Italic
       Flags: Symbolic, Italic
       FontBBox: -716, -533, 1626, 1317
       FontFile2: true
     Font: 
      BaseFont: MREJNP+CharisSIL-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: MREJNP+CharisSIL-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -720, -533, 1759, 1320
       FontFile2: true
     Font: 
      BaseFont: AAARUD+CharisSIL
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: AAARUD+CharisSIL
       Flags: Symbolic
       FontBBox: -692, -533, 1623, 1318
       FontFile2: true
     Font: 
      BaseFont: KOENGS+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: KOENGS+TimesNewRomanPSMT
       Flags: Nonsymbolic
       FontBBox: -568, -307, 2000, 1007
       FontFile2: true
     Font: 
      BaseFont: JNANHS+CharisSIL-Italic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: JNANHS+CharisSIL-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -716, -533, 1627, 1318
       FontFile2: true
     Font: 
      BaseFont: AAAAAD+CharisSIL
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: AAAAAD+CharisSIL
       Flags: Symbolic
       FontBBox: -692, -533, 1623, 1318
       FontFile2: true
     Font: 
      BaseFont: UMNQBV+CharisSIL-Italic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: UMNQBV+CharisSIL-Italic
       Flags: Serif, Symbolic, Italic
       FontBBox: -716, -533, 1627, 1318
       FontFile2: true
     Font: 
      BaseFont: IBDIBK+CharisSIL
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: IBDIBK+CharisSIL
       Flags: Nonsymbolic
       FontBBox: -692, -533, 1623, 1319
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="XMP Core 5.1.2">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.supflu.2024.106452</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1016/j.supflu.2024.106452</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier B.V.</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">The Journal of Supercritical Fluids, 216 (2025) 106452. doi:10.1016/j.supflu.2024.106452</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>BioMOF</rdf:li>
               <rdf:li>Supercritical CO2 processing</rdf:li>
               <rdf:li>Hydrophobic functionalization</rdf:li>
               <rdf:li>Stearic acid</rdf:li>
               <rdf:li>Drug delivery</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Supercritical CO2 assisted bioMOF drug encapsulation and functionalization for delivery with a synergetic therapeutic value</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Albert Rosado</rdf:li>
               <rdf:li>Luis García-Fernández</rdf:li>
               <rdf:li>María Rosa Aguilar</rdf:li>
               <rdf:li>Rosa Ana Ramírez</rdf:li>
               <rdf:li>Ana M. López-Periago</rdf:li>
               <rdf:li>José A. Ayllón</rdf:li>
               <rdf:li>Concepción Domingo</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:CreationDate--Text>21st November 2024</pdf:CreationDate--Text>
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
         <pdf:Keywords>BioMOF,Supercritical CO2 processing,Hydrophobic functionalization,Stearic acid,Drug delivery</pdf:Keywords>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:CreationDate--Text>21st November 2024</pdfx:CreationDate--Text>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <d2UUdnMqKz9mPyweGm9yOm8NNmwz7lwiMnM6Gm.iMm9r.z.uOzdeQo9eQndaOnMiRodyTma/>  
         <pdfx:doi>10.1016/j.supflu.2024.106452</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:copyright>© 2024 The Author(s). Published by Elsevier B.V.</prism:copyright>
         <prism:coverDate>2025-02-01</prism:coverDate>
         <prism:coverDisplayDate>1 February 2025</prism:coverDisplayDate>
         <prism:doi>10.1016/j.supflu.2024.106452</prism:doi>
         <prism:issn>0896-8446</prism:issn>
         <prism:pageRange>106452</prism:pageRange>
         <prism:publicationName>The Journal of Supercritical Fluids</prism:publicationName>
         <prism:startingPage>106452</prism:startingPage>
         <prism:url>https://doi.org/10.1016/j.supflu.2024.106452</prism:url>
         <prism:volume>216</prism:volume>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:tdm="http://www.w3.org/ns/tdmrep/">
         <tdm:policy>https://www.elsevier.com/tdm/tdmrep-policy.json</tdm:policy>
         <tdm:reservation>1</tdm:reservation>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreateDate>2024-11-21T16:46:03</xmp:CreateDate>
         <xmp:CreatorTool>Elsevier</xmp:CreatorTool>
         <xmp:MetadataDate>2024-11-21T16:47:48</xmp:MetadataDate>
         <xmp:ModifyDate>2024-11-21T16:47:48</xmp:ModifyDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:b6ed5266-03cb-4855-90c0-636283357f42</xmpMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 105, 576, 109, 587
       Flags: Print
       Destination: 1072
      Annotation: 
       Subtype: Link
       Rect: 112, 576, 116, 587
       Flags: Print
       Destination: 1072
      Annotation: 
       Subtype: Link
       Rect: 229, 576, 233, 587
       Flags: Print
       Destination: 1072
      Annotation: 
       Subtype: Link
       Rect: 236, 576, 240, 587
       Flags: Print
       Destination: 1072
      Annotation: 
       Subtype: Link
       Rect: 339, 576, 344, 587
       Flags: Print
       Destination: 1072
      Annotation: 
       Subtype: Link
       Rect: 346, 576, 350, 587
       Flags: Print
       Destination: 1072
      Annotation: 
       Subtype: Link
       Rect: 445, 576, 449, 587
       Flags: Print
       Destination: 1072
      Annotation: 
       Subtype: Link
       Rect: 452, 576, 455, 587
       Flags: Print
       Destination: 1072
      Annotation: 
       Subtype: Link
       Rect: 143, 563, 147, 574
       Flags: Print
       Destination: 1072
      Annotation: 
       Subtype: Link
       Rect: 223, 563, 228, 574
       Flags: Print
       Destination: 1072
      Annotation: 
       Subtype: Link
       Rect: 230, 563, 234, 574
       Flags: Print
       Destination: 1072
      Annotation: 
       Subtype: Link
       Rect: 343, 563, 347, 574
       Flags: Print
       Destination: 1072
      Annotation: 
       Subtype: Link
       Rect: 350, 563, 354, 574
       Flags: Print
       Destination: 1072
      Annotation: 
       Subtype: Link
       Rect: 103, 104, 163, 111
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 207, 104, 296, 111
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 344, 104, 399, 111
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 321, 722, 369, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 275, 667, 396, 675
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 37, 87, 186, 94
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 210, 748, 384, 760
      Annotation: 
       Subtype: Link
       Rect: 501, 616, 529, 644
      Annotation: 
       Subtype: Link
       Rect: 406, 59, 552, 70
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 170, 689, 182, 696
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 178, 626, 189, 634
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 66, 594, 77, 602
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 87, 563, 98, 571
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 68, 532, 79, 540
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 136, 469, 147, 477
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 250, 448, 261, 456
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 96, 417, 114, 425
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 456, 720, 472, 728
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 344, 647, 363, 655
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 433, 594, 449, 602
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 475, 573, 491, 581
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 336, 511, 352, 519
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 420, 469, 436, 477
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 377, 427, 404, 435
       Flags: Print
       Destination: 114
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 184, 699, 200, 707
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 37, 678, 53, 686
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 270, 668, 286, 676
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 112, 605, 127, 613
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 69, 584, 96, 592
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 230, 511, 245, 519
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 123, 490, 138, 498
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 219, 458, 248, 466
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 37, 427, 53, 435
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 37, 333, 53, 341
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 69, 322, 85, 330
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 306, 730, 322, 738
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 350, 175, 436, 183
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 454, 175, 495, 183
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 409, 165, 433, 173
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 531, 165, 554, 173
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 351, 154, 375, 162
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 309, 123, 333, 131
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 309, 113, 334, 121
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 309, 92, 333, 100
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 485, 92, 510, 100
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 520, 81, 544, 89
       Flags: Print
       Destination: 114
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 533, 646, 555, 654
       Flags: Print
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 358, 615, 381, 623
       Flags: Print
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 523, 604, 544, 612
       Flags: Print
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 493, 594, 518, 602
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 532, 594, 557, 602
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 306, 583, 368, 591
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 452, 458, 467, 466
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 373, 353, 400, 361
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 425, 311, 441, 319
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 523, 290, 538, 298
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 421, 207, 436, 215
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 306, 123, 322, 131
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 407, 60, 423, 68
       Flags: Print
       Destination: 114
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 217, 337, 233, 345
       Flags: Print
       Destination: 246
      Annotation: 
       Subtype: Link
       Rect: 40, 243, 61, 251
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 243, 243, 268, 251
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 181, 201, 200, 209
       Flags: Print
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 146, 107, 170, 115
       Flags: Print
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 101, 65, 122, 73
       Flags: Print
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 524, 149, 540, 157
       Flags: Print
       Destination: 246
      Annotation: 
       Subtype: Link
       Rect: 460, 86, 484, 94
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 504, 76, 524, 84
       Flags: Print
       Destination: 65
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 62, 348, 78, 356
       Flags: Print
       Destination: 246
      Annotation: 
       Subtype: Link
       Rect: 157, 337, 177, 345
       Flags: Print
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 227, 337, 251, 345
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 263, 337, 288, 345
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 37, 327, 98, 335
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 187, 316, 211, 324
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 123, 285, 147, 293
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 61, 160, 86, 167
       Flags: Print
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 40, 55, 60, 63
       Flags: Print
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 418, 358, 442, 366
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 470, 348, 494, 356
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 505, 348, 557, 356
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 306, 337, 336, 345
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 369, 327, 389, 335
       Flags: Print
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 407, 306, 438, 314
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 453, 306, 539, 314
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 377, 275, 398, 283
       Flags: Print
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 423, 102, 444, 110
       Flags: Print
       Destination: 104
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 231, 217, 251, 225
       Flags: Print
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 238, 165, 257, 173
       Flags: Print
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 256, 123, 272, 131
       Flags: Print
       Destination: 246
      Annotation: 
       Subtype: Link
       Rect: 128, 92, 144, 100
       Flags: Print
       Destination: 246
      Annotation: 
       Subtype: Link
       Rect: 129, 71, 145, 79
       Flags: Print
       Destination: 246
      Annotation: 
       Subtype: Link
       Rect: 330, 339, 357, 347
       Flags: Print
       Destination: 246
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 49, 293, 134, 301
       Flags: Print
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 99, 228, 221, 236
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 53, 146, 285, 152
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 53, 138, 198, 144
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 53, 130, 279, 136
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 53, 122, 223, 128
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 53, 114, 266, 120
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 53, 106, 135, 112
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 53, 98, 274, 104
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 53, 90, 169, 96
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 53, 82, 286, 88
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 53, 74, 78, 80
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 53, 66, 262, 73
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 53, 58, 286, 65
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 53, 50, 230, 57
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 732, 537, 738
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 724, 555, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 716, 481, 722
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 708, 550, 714
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 700, 542, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 692, 426, 698
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 684, 543, 690
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 676, 550, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 668, 545, 674
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 660, 554, 666
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 652, 555, 658
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 644, 495, 651
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 636, 555, 643
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 628, 555, 635
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 620, 396, 627
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 612, 555, 619
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 604, 555, 611
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 596, 515, 603
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 588, 551, 595
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 580, 554, 587
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 572, 547, 579
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 565, 369, 571
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 557, 555, 563
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 549, 555, 555
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 541, 415, 547
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 533, 531, 539
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 525, 534, 531
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 517, 555, 523
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 509, 548, 515
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 501, 536, 507
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 493, 543, 499
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 485, 555, 491
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 477, 514, 483
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 469, 539, 475
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 461, 545, 467
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 453, 401, 459
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 445, 554, 451
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 437, 555, 443
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 429, 550, 435
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 421, 398, 427
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 413, 544, 419
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 405, 508, 411
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 397, 535, 403
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 389, 551, 396
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 381, 355, 388
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 373, 555, 380
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 365, 495, 372
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 357, 555, 364
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 349, 533, 356
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 341, 527, 348
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 333, 515, 340
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 325, 548, 332
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 317, 520, 324
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 309, 545, 316
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 301, 555, 308
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 294, 481, 300
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 286, 555, 292
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 278, 552, 284
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 270, 434, 276
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 262, 538, 268
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 254, 478, 260
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 246, 535, 252
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 238, 531, 244
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 198, 540, 204
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 190, 555, 196
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 182, 513, 188
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 174, 467, 180
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 166, 555, 172
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 158, 555, 164
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 150, 532, 156
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 142, 522, 148
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 134, 407, 140
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 126, 542, 133
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 118, 488, 125
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 110, 531, 117
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 102, 555, 109
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 94, 480, 101
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 86, 555, 93
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 78, 532, 85
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 70, 537, 77
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 62, 548, 69
       Flags: Print
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 732, 286, 738
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 724, 153, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 716, 283, 722
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 708, 279, 714
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 700, 276, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 692, 221, 698
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 684, 286, 690
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 676, 281, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 668, 238, 674
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 660, 286, 666
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 652, 278, 658
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 644, 78, 651
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 732, 550, 738
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 724, 552, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 716, 361, 722
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 708, 555, 714
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 700, 504, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 692, 555, 698
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 684, 447, 690
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 676, 555, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 668, 555, 674
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 660, 333, 666
       Flags: Print
  Checksum: 2da18dc9
   Type: CRC32
  Checksum: 1cf0a98efc2ce7da83e1d5f97be2f21d
   Type: MD5
  Checksum: 956f8bd1623d628a0b845aa135c6f24b9dd44273
   Type: SHA-1
  Checksum: ed67a24f9c061fd228e0eaa74032cdbca01a94524bdd5fac085e57f7c3c11f2e
   Type: SHA-256