c3b313b4f25765be789d47f36514dd41 s12985-025-02677-y.pdf f139c65c8a105d159bc62d0e8a970ea61fa27cc5 s12985-025-02677-y.pdf b23dd8467c3aaa5d78f3cec259dc828581875ee791e27da25e3f5d10d17a01ec s12985-025-02677-y.pdf Creator: Adobe InDesign 18.0 (Windows) Producer: Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Mon Mar 3 10:23:47 2025 CET ModDate: Tue Mar 4 11:28:06 2025 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 7 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1168986 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Light Type 1C Custom yes no yes 54 0 MyriadPro-Regular Type 1C Custom yes no yes 26 0 MyriadPro-Bold Type 1C WinAnsi yes no yes 28 0 MyriadPro-Semibold Type 1C Custom yes no yes 30 0 MyriadPro-It Type 1C WinAnsi yes no yes 900 0 MyriadPro-LightIt Type 1C WinAnsi yes no yes 901 0 MyriadPro-Bold Type 1C WinAnsi yes no yes 956 0 WarnockPro-Regular Type 1C Custom yes no yes 27 0 WarnockPro-Bold Type 1C WinAnsi yes no yes 29 0 MyriadPro-Regular Type 1C WinAnsi yes no yes 36 0 MyriadPro-It Type 1C WinAnsi yes no yes 39 0 WarnockPro-It Type 1C WinAnsi yes no yes 52 0 MyriadPro-SemiboldIt Type 1C WinAnsi yes no yes 53 0 MyriadPro-Regular Type 1C WinAnsi yes no yes 137 0 MyriadPro-It Type 1C WinAnsi yes no yes 138 0 MORHDZ+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 65 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-03-18 02:43:46 CET RepresentationInformation: s12985-025-02677-y.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-03-17 11:47:18 CET Size: 1168986 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 980 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Frequency of IgE antibody response to SARS-CoV-2 RBD protein across different disease severity COVID19 groups Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Methods Children: Item: Title: Ethical issues Item: Title: Statistical analysis Item: Title: Results Children: Item: Title: Anti-RBD IgE in SARS-CoV-2 patients across different severity groups Item: Title: Anti-RBD IgE SARS-CoV-2 and clinical characteristics Item: Title: Discussion Item: Title: References Info: Creator: Adobe InDesign 18.0 (Windows) Producer: Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Mon Mar 03 10:23:47 CET 2025 ModDate: Tue Mar 04 11:28:06 CET 2025 ID: 0xb77f1dc28ad7d126aaf03e0fb9159865, 0x379fcbe40981f8318918a132ca941450 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1145 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric ImageMask: true Decode: 0, 1 Name: X Fonts: Type1: Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: WarnockPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -222, -533, 1474, 950 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-LightIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-LightIt Flags: Nonsymbolic, Italic FontBBox: -175, -250, 1007, 933 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-SemiboldIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldIt Flags: Nonsymbolic, Italic FontBBox: -193, -250, 1164, 972 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Light Flags: Nonsymbolic FontBBox: -153, -250, 1046, 935 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WarnockPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-Regular Flags: Serif, Nonsymbolic FontBBox: -177, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: WarnockPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-Bold Flags: Serif, Nonsymbolic FontBBox: -183, -599, 1614, 1030 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: MORHDZ+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 32 FontDescriptor: FontName: MORHDZ+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true XMP: uuid:eefded61-f253-4580-97d9-4c606e78587a adobe:docid:indd:aca9e6a3-b7bc-11dd-9b31-8d92eded7c31 xmp.id:89ad3b76-fcbc-6b4a-969e-356be6e7a7ce proof:pdf 1 xmp.iid:06f3ce9a-555d-ae4c-a08f-86b2d1094be2 xmp.did:4540a7c7-7451-d046-a8b0-fef5ba067bfe default converted from application/x-indesign to application/pdf Adobe InDesign 18.0 (Windows) 2025-03-03T10:23:48+01:00 converted uuid:a2463842-6100-4c63-9dd7-466e19797385 converted to PDF/A-2b pdfToolbox 2025-03-03T16:17:18+01:00 2025-03-03T10:23:47+01:00 2025-03-04T11:28:06+01:00 2025-03-04T11:28:06+01:00 Adobe InDesign 18.0 (Windows) journal 10.1186/s12985-025-02677-y 2010-04-23 true springer.com springerlink.com 2010-04-23 true 10.1186/s12985-025-02677-y springer.com springerlink.com VoR application/pdf Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) False 2 B http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef internal An unordered array of references to resources that were incorporated, by inclusion or reference, into this document. Ingredients Bag ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text internal Mirrors crossmark:DOI doi Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 508, 73, 538, 65 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 180, 65, 279, 57 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 508, 682, 540, 649 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 268, 659, 273, 646 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 280, 659, 285, 646 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 82, 611, 87, 598 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 224, 539, 229, 526 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 234, 539, 238, 526 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 82, 503, 87, 490 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 93, 503, 98, 490 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 59, 479, 64, 466 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 69, 479, 74, 466 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 278, 455, 288, 442 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 56, 443, 66, 430 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 189, 359, 199, 346 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 204, 359, 214, 346 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 236, 311, 246, 298 Flags: Print AppearanceDictionary: true Destination: 100 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 478, 431, 483, 418 Flags: Print AppearanceDictionary: true Destination: 42 Annotation: Subtype: Link Rect: 392, 383, 401, 370 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 407, 383, 417, 370 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 449, 251, 453, 238 Flags: Print AppearanceDictionary: true Destination: 56 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 105, 179, 110, 166 Flags: Print AppearanceDictionary: true Destination: 56 Annotation: Subtype: Link Rect: 520, 167, 525, 154 Flags: Print AppearanceDictionary: true Destination: 70 Annotation: Subtype: Link Rect: 336, 107, 341, 94 Flags: Print AppearanceDictionary: true Destination: 70 Annotation: Subtype: Link Rect: 476, 71, 481, 58 Flags: Print AppearanceDictionary: true Destination: 70 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 146, 155, 156, 142 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 275, 119, 285, 106 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 275, 71, 285, 58 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 417, 119, 427, 106 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 434, 119, 444, 106 Flags: Print AppearanceDictionary: true Destination: 100 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 82, 563, 92, 550 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 98, 563, 108, 550 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 212, 311, 217, 298 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 223, 311, 232, 298 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 238, 311, 248, 298 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 125, 287, 130, 274 Flags: Print AppearanceDictionary: true Destination: 70 Annotation: Subtype: Link Rect: 197, 251, 207, 238 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 212, 251, 222, 238 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 59, 215, 64, 202 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 71, 215, 76, 202 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 82, 215, 92, 202 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 393, 671, 403, 658 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 411, 671, 421, 658 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 496, 383, 535, 374 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 374, 397, 365 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 88, 572, 159, 563 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 159, 572, 288, 563 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 563, 75, 554 Flags: Print AppearanceDictionary: true Thumb: true Checksum: a36dbe62 Type: CRC32 Checksum: c3b313b4f25765be789d47f36514dd41 Type: MD5 Checksum: f139c65c8a105d159bc62d0e8a970ea61fa27cc5 Type: SHA-1 Checksum: b23dd8467c3aaa5d78f3cec259dc828581875ee791e27da25e3f5d10d17a01ec Type: SHA-256