df7449e6059208c8a0b2c6daf41c9793 1-s2.0-S0044848624015710-main.pdf 21469d9bbeac8b9cd4020b4bc97ab0da94d7e243 1-s2.0-S0044848624015710-main.pdf f406bb57627b0a06bb5789f828c97ea183046ae5b5e67e21297a2c95bd5ed3f2 1-s2.0-S0044848624015710-main.pdf Title: Thymol-carvacrol essential oil extract mitigates the mucosal stress-immune response induced by intraperitoneal immunization in sea bass ( Dicentrarchus labrax ) Subject: Aquaculture, 599 (2025) 742109. doi:10.1016/j.aquaculture.2024.742109 Keywords: Vaccine,Mucosal stress-immune response,Gene expression,Cortisol,Plant-based sedative,Sea bass ( Dicentrarchus labrax ) Author: Sheida Azizi Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Tue Feb 11 03:17:08 2025 CET ModDate: Tue Feb 11 15:30:28 2025 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1122673 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NNLAUQ+TeX_CM_Roman Type 1C Builtin yes yes yes 2090 0 UPXIUE+CharisSIL CID TrueType Identity-H yes yes yes 2094 0 LYHXCT+STIX-Italic Type 1C Custom yes yes yes 2099 0 AAAKJD+CharisSIL CID TrueType Identity-H yes yes yes 2104 0 HENFTM+CharisSIL-Bold CID TrueType Identity-H yes yes yes 2112 0 JPYHKK+CharisSIL-Italic CID TrueType Identity-H yes yes yes 2117 0 SSVQBK+STIX-Regular Type 1C Custom yes yes yes 2122 0 WYHLTL+CharisSIL CID TrueType Identity-H yes yes yes 2127 0 EFWNBW+Univers Type 1C Builtin yes yes yes 2133 0 PAESTO+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 422 0 GDRKJF+CharisSIL-Italic CID TrueType Identity-H yes yes yes 427 0 AAAAME+CharisSIL-Italic CID TrueType Identity-H yes yes yes 433 0 JBURRB+CharisSIL-BoldItalic CID TrueType Identity-H yes yes yes 440 0 FPTJLV+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 445 0 AAAAAD+CharisSIL CID TrueType Identity-H yes yes yes 449 0 YKLPNV+STIXGeneral Type 1C Custom yes yes yes 40 0 VVCCGG+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 456 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-03-26 02:08:52 CET RepresentationInformation: 1-s2.0-S0044848624015710-main.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-03-25 12:46:27 CET Size: 1122673 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 2212 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: English Outlines: Item: Title: Thymol-carvacrol essential oil extract mitigates the mucosal stress-immune response induced by intraperitoneal immunization ... Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Material and methods Destination: mk:H1_2 Children: Item: Title: 2.1 Fish husbandry Destination: mk:H2_1 Item: Title: 2.2 Plant-based products Destination: mk:H2_2 Item: Title: 2.3 Vaccine Destination: mk:H2_3 Item: Title: 2.4 Experimental design Destination: mk:H2_4 Item: Title: 2.5 Skin mucus, blood and tissue sampling Destination: mk:H2_5 Item: Title: 2.6 Cortisol assay in plasma and skin mucus Destination: mk:H2_6 Item: Title: 2.7 IgM detection in skin mucus Destination: mk:H2_7 Item: Title: 2.8 RNA isolation and cDNA synthesis Destination: mk:H2_8 Item: Title: 2.9 Real time quantitative PCR (qPCR) Destination: mk:H2_9 Item: Title: 2.10 Statistical analysis Destination: mk:H2_10 Item: Title: 3 Results Destination: mk:H1_3 Children: Item: Title: 3.1 Cortisol in plasma and mucus Destination: mk:H2_11 Item: Title: 3.2 SALT response Destination: mk:H2_12 Item: Title: 3.3 GIALT response Destination: mk:H2_13 Item: Title: 3.4 GALT response Destination: mk:H2_14 Item: Title: 4 Discussion Destination: mk:H1_4 Children: Item: Title: 4.1 SALT response Destination: mk:H2_15 Item: Title: 4.2 GIALT response Destination: mk:H2_16 Item: Title: 4.3 GALT response Destination: mk:H2_17 Item: Title: 5 Conclusion Destination: mk:H1_5 Item: Title: CRediT authorship contribution statement Destination: mk:H1_6 Item: Title: Declaration of competing interest Destination: mk:HH1_3 Item: Title: datalink4 Destination: datalink4 Item: Title: Acknowledgements Destination: mk:HH1_5 Item: Title: Appendix A Supplementary data Destination: mk:H1_7 Item: Title: References Destination: mk:HH2_1 Info: Title: Thymol-carvacrol essential oil extract mitigates the mucosal stress-immune response induced by intraperitoneal immunization in sea bass ( Dicentrarchus labrax ) Author: Sheida Azizi Subject: Aquaculture, 599 (2025) 742109. doi:10.1016/j.aquaculture.2024.742109 Keywords: Vaccine,Mucosal stress-immune response,Gene expression,Cortisol,Plant-based sedative,Sea bass ( Dicentrarchus labrax ) Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Tue Feb 11 03:17:08 CET 2025 ModDate: Tue Feb 11 15:30:28 CET 2025 ID: 0x962296a3bf2a4278b6232669cb0c40dc, 0xec9d1fc74b3eb0f648ccd0c0218b8291 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: HENFTM+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: AAAAME+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: AAAAAD+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: JPYHKK+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: PAESTO+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: AAAKJD+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: JBURRB+CharisSIL-BoldItalic Encoding: Identity-H ToUnicode: true Font: BaseFont: GDRKJF+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: UPXIUE+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: WYHLTL+CharisSIL Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: LYHXCT+STIX-Italic FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LYHXCT+STIX-Italic Flags: Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: EFWNBW+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: EFWNBW+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: YKLPNV+STIXGeneral FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: YKLPNV+STIXGeneral Flags: Nonsymbolic FontBBox: -178, -443, 2000, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VVCCGG+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 127 FontDescriptor: FontName: VVCCGG+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: NNLAUQ+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: NNLAUQ+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: SSVQBK+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 9 FontDescriptor: FontName: SSVQBK+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FPTJLV+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: FPTJLV+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: UPXIUE+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: UPXIUE+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: WYHLTL+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: WYHLTL+CharisSIL Flags: Serif, Symbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: HENFTM+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: HENFTM+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true Font: BaseFont: AAAAME+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AAAAME+CharisSIL-Italic Flags: Symbolic, Italic FontBBox: -716, -533, 1626, 1317 FontFile2: true Font: BaseFont: AAAAAD+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AAAAAD+CharisSIL Flags: Symbolic FontBBox: -692, -533, 1623, 1318 FontFile2: true Font: BaseFont: JPYHKK+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JPYHKK+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: PAESTO+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: PAESTO+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Font: BaseFont: AAAKJD+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AAAKJD+CharisSIL Flags: Symbolic FontBBox: -692, -533, 1623, 1318 FontFile2: true Font: BaseFont: JBURRB+CharisSIL-BoldItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JBURRB+CharisSIL-BoldItalic Flags: Nonsymbolic, Italic, ForceBold FontBBox: -741, -533, 1795, 1320 FontFile2: true Font: BaseFont: GDRKJF+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: GDRKJF+CharisSIL-Italic Flags: Serif, Symbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true XMP: http://creativecommons.org/licenses/by/4.0/ elsevier.com sciencedirect.com true 10.1016/j.aquaculture.2024.742109 2010-04-23 application/pdf 10.1016/j.aquaculture.2024.742109 Elsevier B.V. Aquaculture, 599 (2025) 742109. doi:10.1016/j.aquaculture.2024.742109 Vaccine Mucosal stress-immune response Gene expression Cortisol Plant-based sedative Sea bass ( Dicentrarchus labrax ) Thymol-carvacrol essential oil extract mitigates the mucosal stress-immune response induced by intraperitoneal immunization in sea bass ( Dicentrarchus labrax ) Sheida Azizi Mahsa Shahbazi Sara Cartan Ismael Jerez-Cepa Juan M. Mancera Darragh Doyle Lluis Tort Ali Reza Khansari VoR 11th February 2025 Acrobat Distiller 8.1.0 (Windows) Vaccine,Mucosal stress-immune response,Gene expression,Cortisol,Plant-based sedative,Sea bass ( Dicentrarchus labrax ) 11th February 2025 sciencedirect.com elsevier.com true 2010-04-23 10.1016/j.aquaculture.2024.742109 noindex journal © 2024 The Authors. Published by Elsevier B.V. 2025-04-15 15 April 2025 10.1016/j.aquaculture.2024.742109 0044-8486 742109 Aquaculture 742109 https://doi.org/10.1016/j.aquaculture.2024.742109 599 https://www.elsevier.com/tdm/tdmrep-policy.json 1 2025-02-11T02:17:08 Elsevier 2025-02-11T14:30:28 2025-02-11T14:30:28 uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 True Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 97, 559, 101, 569 Flags: Print Destination: 2081 Annotation: Subtype: Link Rect: 186, 559, 190, 569 Flags: Print Destination: 2081 Annotation: Subtype: Link Rect: 254, 559, 257, 569 Flags: Print Destination: 2081 Annotation: Subtype: Link Rect: 351, 559, 354, 569 Flags: Print Destination: 2081 Annotation: Subtype: Link Rect: 445, 559, 449, 569 Flags: Print Destination: 2081 Annotation: Subtype: Link Rect: 107, 546, 112, 556 Flags: Print Destination: 2081 Annotation: Subtype: Link Rect: 166, 546, 170, 556 Flags: Print Destination: 2081 Annotation: Subtype: Link Rect: 172, 546, 176, 556 Flags: Print Destination: 2081 Annotation: Subtype: Link Rect: 269, 546, 273, 556 Flags: Print Destination: 2081 Annotation: Subtype: Link Rect: 275, 546, 280, 556 Flags: Print Destination: 2081 Annotation: Subtype: Link Rect: 282, 546, 286, 556 Flags: Print Destination: 2081 Annotation: Subtype: Link Rect: 98, 192, 195, 200 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 343, 255, 401, 262 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 406, 255, 461, 262 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 513, 223, 557, 231 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 306, 213, 324, 221 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 429, 192, 496, 200 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 502, 192, 557, 200 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 306, 181, 324, 189 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 329, 181, 394, 189 Flags: Print Destination: 396 Annotation: Subtype: Link Rect: 309, 150, 437, 158 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 103, 104, 160, 111 Flags: Print Annotation: Subtype: Link Rect: 194, 104, 278, 111 Flags: Print Annotation: Subtype: Link Rect: 321, 722, 369, 730 Flags: Print Annotation: Subtype: Link Rect: 265, 667, 406, 675 Flags: Print Annotation: Subtype: Link Rect: 37, 87, 204, 94 Flags: Print Annotation: Subtype: Link Rect: 245, 748, 348, 760 Annotation: Subtype: Link Rect: 501, 616, 529, 644 Annotation: Subtype: Link Rect: 406, 59, 552, 70 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 71, 709, 121, 717 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 126, 709, 165, 717 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 40, 678, 107, 686 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 112, 678, 193, 686 Flags: Print Destination: 396 Annotation: Subtype: Link Rect: 69, 668, 137, 676 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 232, 668, 286, 676 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 37, 657, 93, 665 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 51, 647, 125, 655 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 118, 605, 155, 613 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 180, 584, 233, 592 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 68, 553, 128, 561 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 83, 490, 156, 498 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 161, 490, 227, 498 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 232, 490, 283, 498 Flags: Print Destination: 396 Annotation: Subtype: Link Rect: 132, 417, 194, 425 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 198, 417, 250, 425 Flags: Print Destination: 396 Annotation: Subtype: Link Rect: 72, 322, 147, 330 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 153, 322, 218, 330 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 82, 270, 189, 278 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 138, 249, 206, 257 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 211, 249, 286, 257 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 37, 239, 129, 247 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 134, 239, 207, 247 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 177, 186, 234, 194 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 238, 186, 288, 194 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 37, 176, 55, 184 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 59, 176, 127, 184 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 131, 176, 204, 184 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 255, 92, 288, 100 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 37, 82, 77, 90 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 495, 333, 557, 341 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 306, 322, 324, 330 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 371, 312, 437, 320 Flags: Print Destination: 190 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 258, 615, 288, 623 Flags: Print Destination: 396 Annotation: Subtype: Link Rect: 37, 605, 61, 613 Flags: Print Destination: 396 Annotation: Subtype: Link Rect: 40, 270, 112, 278 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 474, 550, 501, 558 Flags: Print Destination: 37 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 237, 499, 255, 507 Flags: Print Destination: 49 Annotation: Subtype: Link Rect: 330, 699, 351, 707 Flags: Print Destination: 49 Annotation: Subtype: Link Rect: 485, 636, 505, 644 Flags: Print Destination: 49 Annotation: Subtype: Link Rect: 390, 594, 410, 602 Flags: Print Destination: 49 Annotation: Subtype: Link Rect: 473, 573, 493, 581 Flags: Print Destination: 49 Annotation: Subtype: Link Rect: 496, 521, 516, 529 Flags: Print Destination: 49 Annotation: Subtype: Link Rect: 525, 405, 552, 413 Flags: Print Destination: 67 Annotation: Subtype: Link Rect: 347, 364, 374, 372 Flags: Print Destination: 67 Annotation: Subtype: Link Rect: 525, 322, 552, 330 Flags: Print Destination: 67 Annotation: Subtype: Link Rect: 338, 249, 364, 256 Flags: Print Destination: 67 Annotation: Subtype: Link Rect: 417, 217, 444, 225 Flags: Print Destination: 67 Annotation: Subtype: Link Rect: 506, 165, 534, 173 Flags: Print Destination: 67 Annotation: Subtype: Link Rect: 333, 60, 360, 68 Flags: Print Destination: 67 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 257, 338, 283, 346 Flags: Print Destination: 67 Annotation: Subtype: Link Rect: 438, 485, 464, 493 Flags: Print Destination: 67 Annotation: Subtype: Link Rect: 406, 432, 434, 440 Flags: Print Destination: 67 Annotation: Subtype: Link Rect: 422, 401, 448, 409 Flags: Print Destination: 67 Annotation: Subtype: Link Rect: 517, 317, 544, 325 Flags: Print Destination: 67 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 138, 720, 164, 728 Flags: Print Destination: 75 Annotation: Subtype: Link Rect: 255, 689, 283, 696 Flags: Print Destination: 75 Annotation: Subtype: Link Rect: 162, 615, 188, 623 Flags: Print Destination: 75 Annotation: Subtype: Link Rect: 219, 500, 246, 508 Flags: Print Destination: 75 Annotation: Subtype: Link Rect: 239, 469, 266, 477 Flags: Print Destination: 75 Annotation: Subtype: Link Rect: 40, 396, 66, 404 Flags: Print Destination: 75 Annotation: Subtype: Link Rect: 211, 333, 237, 341 Flags: Print Destination: 75 Annotation: Subtype: Link Rect: 221, 281, 248, 289 Flags: Print Destination: 75 Annotation: Subtype: Link Rect: 400, 615, 426, 623 Flags: Print Destination: 75 Annotation: Subtype: Link Rect: 410, 594, 437, 602 Flags: Print Destination: 75 Annotation: Subtype: Link Rect: 411, 421, 449, 429 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 368, 390, 444, 398 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 450, 390, 521, 398 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 526, 390, 557, 398 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 306, 379, 347, 387 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 352, 379, 390, 387 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 363, 358, 441, 366 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 446, 358, 528, 366 Flags: Print Destination: 396 Annotation: Subtype: Link Rect: 370, 327, 441, 335 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 446, 327, 513, 335 Flags: Print Destination: 396 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 262, 730, 288, 738 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 37, 720, 79, 728 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 85, 720, 155, 728 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 57, 678, 140, 686 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 193, 636, 251, 644 Flags: Print Destination: 396 Annotation: Subtype: Link Rect: 184, 584, 253, 592 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 257, 584, 288, 592 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 37, 573, 78, 581 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 131, 479, 206, 487 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 211, 479, 288, 487 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 37, 469, 55, 477 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 231, 469, 288, 477 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 37, 458, 61, 466 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 40, 427, 133, 435 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 92, 396, 165, 404 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 170, 396, 242, 404 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 260, 364, 288, 372 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 37, 354, 80, 362 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 86, 302, 187, 309 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 214, 270, 288, 278 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 37, 260, 55, 268 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 239, 228, 288, 236 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 37, 218, 55, 226 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 40, 197, 115, 205 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 120, 197, 198, 205 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 203, 197, 288, 205 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 37, 186, 55, 194 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 233, 155, 288, 163 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 37, 145, 55, 153 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 221, 103, 286, 111 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 37, 92, 109, 100 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 425, 709, 490, 717 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 517, 678, 557, 686 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 306, 668, 363, 676 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 445, 626, 514, 634 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 518, 626, 557, 634 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 306, 615, 324, 623 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 507, 584, 557, 592 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 306, 573, 324, 581 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 330, 573, 431, 581 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 435, 553, 514, 561 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 383, 511, 442, 519 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 309, 427, 414, 435 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 420, 427, 498, 435 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 473, 396, 557, 404 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 306, 385, 324, 393 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 432, 280, 492, 288 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 497, 280, 552, 288 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 337, 133, 414, 141 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 361, 113, 456, 121 Flags: Print Destination: 279 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 235, 730, 288, 738 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 37, 720, 55, 728 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 65, 689, 125, 696 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 67, 657, 150, 665 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 40, 605, 125, 613 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 214, 573, 288, 581 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 37, 563, 55, 571 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 40, 542, 139, 550 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 143, 542, 205, 550 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 195, 511, 257, 519 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 109, 490, 177, 498 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 186, 448, 250, 456 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 91, 364, 165, 372 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 194, 312, 251, 320 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 255, 312, 288, 320 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 37, 302, 76, 309 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 270, 165, 288, 173 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 37, 154, 78, 162 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 40, 92, 124, 100 Flags: Print Destination: 190 Annotation: Subtype: Link Rect: 129, 92, 166, 100 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 514, 730, 557, 738 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 306, 720, 324, 728 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 459, 699, 523, 707 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 410, 594, 489, 602 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 334, 532, 399, 540 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 417, 532, 472, 540 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 538, 500, 557, 508 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 306, 490, 351, 498 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 505, 385, 557, 393 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 306, 375, 324, 383 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 502, 333, 557, 341 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 306, 322, 324, 330 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 329, 322, 391, 330 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 420, 291, 502, 299 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 501, 249, 557, 257 Flags: Print Destination: 279 Annotation: Subtype: Link Rect: 306, 239, 324, 247 Flags: Print Destination: 279 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 247, 364, 288, 372 Flags: Print Annotation: Subtype: Link Rect: 37, 354, 181, 362 Flags: Print Annotation: Subtype: Link Rect: 264, 297, 286, 304 Flags: Print Annotation: Subtype: Link Rect: 49, 289, 136, 296 Flags: Print Annotation: Subtype: Link Rect: 148, 257, 271, 264 Flags: Print Annotation: Subtype: Link Rect: 159, 233, 234, 240 Flags: Print Annotation: Subtype: Link Rect: 49, 226, 122, 232 Flags: Print Annotation: Subtype: Link Rect: 89, 202, 191, 208 Flags: Print Annotation: Subtype: Link Rect: 264, 178, 286, 184 Flags: Print Annotation: Subtype: Link Rect: 49, 170, 147, 176 Flags: Print Annotation: Subtype: Link Rect: 37, 162, 279, 168 Flags: Print Annotation: Subtype: Link Rect: 49, 154, 205, 160 Flags: Print Annotation: Subtype: Link Rect: 194, 138, 270, 144 Flags: Print Annotation: Subtype: Link Rect: 49, 130, 94, 136 Flags: Print Annotation: Subtype: Link Rect: 123, 114, 265, 120 Flags: Print Annotation: Subtype: Link Rect: 225, 90, 270, 96 Flags: Print Annotation: Subtype: Link Rect: 49, 82, 151, 88 Flags: Print Annotation: Subtype: Link Rect: 78, 50, 225, 57 Flags: Print Annotation: Subtype: Link Rect: 480, 716, 555, 722 Flags: Print Annotation: Subtype: Link Rect: 318, 708, 389, 714 Flags: Print Annotation: Subtype: Link Rect: 377, 668, 504, 674 Flags: Print Annotation: Subtype: Link Rect: 391, 644, 510, 651 Flags: Print Annotation: Subtype: Link Rect: 318, 612, 441, 619 Flags: Print Annotation: Subtype: Link Rect: 459, 572, 547, 579 Flags: Print Annotation: Subtype: Link Rect: 318, 565, 381, 571 Flags: Print Annotation: Subtype: Link Rect: 306, 557, 555, 563 Flags: Print Annotation: Subtype: Link Rect: 318, 549, 555, 555 Flags: Print Annotation: Subtype: Link Rect: 318, 541, 544, 547 Flags: Print Annotation: Subtype: Link Rect: 318, 533, 553, 539 Flags: Print Annotation: Subtype: Link Rect: 475, 501, 550, 507 Flags: Print Annotation: Subtype: Link Rect: 318, 493, 364, 499 Flags: Print Annotation: Subtype: Link Rect: 347, 461, 493, 467 Flags: Print Annotation: Subtype: Link Rect: 416, 445, 546, 451 Flags: Print Annotation: Subtype: Link Rect: 406, 413, 537, 419 Flags: Print Annotation: Subtype: Link Rect: 456, 389, 528, 396 Flags: Print Annotation: Subtype: Link Rect: 318, 381, 369, 388 Flags: Print Annotation: Subtype: Link Rect: 422, 357, 549, 364 Flags: Print Annotation: Subtype: Link Rect: 347, 333, 493, 340 Flags: Print Annotation: Subtype: Link Rect: 404, 309, 520, 316 Flags: Print Annotation: Subtype: Link Rect: 472, 294, 544, 300 Flags: Print Annotation: Subtype: Link Rect: 318, 286, 376, 292 Flags: Print Annotation: Subtype: Link Rect: 455, 246, 527, 252 Flags: Print Annotation: Subtype: Link Rect: 318, 238, 376, 244 Flags: Print Annotation: Subtype: Link Rect: 532, 206, 554, 212 Flags: Print Annotation: Subtype: Link Rect: 318, 198, 416, 204 Flags: Print Annotation: Subtype: Link Rect: 371, 150, 485, 156 Flags: Print Annotation: Subtype: Link Rect: 306, 142, 555, 148 Flags: Print Annotation: Subtype: Link Rect: 318, 134, 548, 140 Flags: Print Annotation: Subtype: Link Rect: 318, 126, 350, 133 Flags: Print Annotation: Subtype: Link Rect: 533, 110, 555, 117 Flags: Print Annotation: Subtype: Link Rect: 318, 102, 416, 109 Flags: Print Annotation: Subtype: Link Rect: 347, 78, 471, 85 Flags: Print Annotation: Subtype: Link Rect: 470, 62, 541, 69 Flags: Print Annotation: Subtype: Link Rect: 318, 54, 400, 61 Flags: Print Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 67, 700, 190, 706 Flags: Print Annotation: Subtype: Link Rect: 264, 668, 286, 674 Flags: Print Annotation: Subtype: Link Rect: 49, 660, 164, 666 Flags: Print Annotation: Subtype: Link Rect: 192, 628, 268, 635 Flags: Print Annotation: Subtype: Link Rect: 49, 620, 103, 627 Flags: Print Annotation: Subtype: Link Rect: 49, 580, 175, 587 Flags: Print Annotation: Subtype: Link Rect: 157, 541, 278, 547 Flags: Print Annotation: Subtype: Link Rect: 153, 525, 280, 531 Flags: Print Annotation: Subtype: Link Rect: 49, 517, 78, 523 Flags: Print Annotation: Subtype: Link Rect: 253, 493, 286, 499 Flags: Print Annotation: Subtype: Link Rect: 49, 485, 165, 491 Flags: Print Annotation: Subtype: Link Rect: 148, 461, 268, 467 Flags: Print Annotation: Subtype: Link Rect: 174, 429, 272, 435 Flags: Print Annotation: Subtype: Link Rect: 49, 421, 78, 427 Flags: Print Annotation: Subtype: Link Rect: 241, 397, 286, 403 Flags: Print Annotation: Subtype: Link Rect: 49, 389, 133, 396 Flags: Print Annotation: Subtype: Link Rect: 229, 365, 275, 372 Flags: Print Annotation: Subtype: Link Rect: 49, 357, 127, 364 Flags: Print Annotation: Subtype: Link Rect: 67, 317, 215, 324 Flags: Print Annotation: Subtype: Link Rect: 157, 294, 260, 300 Flags: Print Annotation: Subtype: Link Rect: 49, 270, 179, 276 Flags: Print Annotation: Subtype: Link Rect: 192, 246, 286, 252 Flags: Print Annotation: Subtype: Link Rect: 49, 238, 82, 244 Flags: Print Annotation: Subtype: Link Rect: 139, 214, 260, 220 Flags: Print Annotation: Subtype: Link Rect: 49, 182, 167, 188 Flags: Print Annotation: Subtype: Link Rect: 214, 166, 286, 172 Flags: Print Annotation: Subtype: Link Rect: 49, 158, 103, 164 Flags: Print Annotation: Subtype: Link Rect: 169, 126, 245, 133 Flags: Print Annotation: Subtype: Link Rect: 49, 118, 120, 125 Flags: Print Annotation: Subtype: Link Rect: 251, 102, 284, 109 Flags: Print Annotation: Subtype: Link Rect: 49, 94, 136, 101 Flags: Print Annotation: Subtype: Link Rect: 253, 70, 286, 77 Flags: Print Annotation: Subtype: Link Rect: 49, 62, 153, 69 Flags: Print Annotation: Subtype: Link Rect: 411, 716, 550, 722 Flags: Print Annotation: Subtype: Link Rect: 533, 708, 555, 714 Flags: Print Annotation: Subtype: Link Rect: 318, 700, 433, 706 Flags: Print Annotation: Subtype: Link Rect: 533, 676, 555, 682 Flags: Print Annotation: Subtype: Link Rect: 318, 668, 408, 674 Flags: Print Annotation: Subtype: Link Rect: 343, 636, 468, 643 Flags: Print Annotation: Subtype: Link Rect: 464, 620, 540, 627 Flags: Print Annotation: Subtype: Link Rect: 318, 612, 364, 619 Flags: Print Annotation: Subtype: Link Rect: 456, 580, 531, 587 Flags: Print Annotation: Subtype: Link Rect: 318, 572, 362, 579 Flags: Print Annotation: Subtype: Link Rect: 306, 565, 555, 571 Flags: Print Annotation: Subtype: Link Rect: 318, 557, 527, 563 Flags: Print Annotation: Subtype: Link Rect: 391, 517, 510, 523 Flags: Print Annotation: Subtype: Link Rect: 372, 477, 481, 483 Flags: Print Annotation: Subtype: Link Rect: 531, 453, 553, 459 Flags: Print Annotation: Subtype: Link Rect: 318, 445, 443, 451 Flags: Print Annotation: Subtype: Link Rect: 347, 413, 466, 419 Flags: Print Annotation: Subtype: Link Rect: 498, 389, 543, 396 Flags: Print Annotation: Subtype: Link Rect: 318, 381, 392, 388 Flags: Print Annotation: Subtype: Link Rect: 447, 349, 522, 356 Flags: Print Annotation: Subtype: Link Rect: 318, 341, 362, 348 Flags: Print Annotation: Subtype: Link Rect: 318, 309, 412, 316 Flags: Print Annotation: Subtype: Link Rect: 385, 278, 487, 284 Flags: Print Annotation: Subtype: Link Rect: 498, 254, 543, 260 Flags: Print Annotation: Subtype: Link Rect: 318, 246, 400, 252 Flags: Print Annotation: Subtype: Link Rect: 387, 206, 507, 212 Flags: Print Annotation: Subtype: Link Rect: 354, 190, 475, 196 Flags: Print Annotation: Subtype: Link Rect: 494, 166, 539, 172 Flags: Print Annotation: Subtype: Link Rect: 318, 158, 402, 164 Flags: Print Annotation: Subtype: Link Rect: 416, 134, 554, 140 Flags: Print Annotation: Subtype: Link Rect: 318, 126, 322, 133 Flags: Print Annotation: Subtype: Link Rect: 473, 110, 548, 117 Flags: Print Annotation: Subtype: Link Rect: 318, 102, 368, 109 Flags: Print Annotation: Subtype: Link Rect: 409, 86, 529, 93 Flags: Print Annotation: Subtype: Link Rect: 306, 78, 542, 85 Flags: Print Annotation: Subtype: Link Rect: 318, 70, 549, 77 Flags: Print Annotation: Subtype: Link Rect: 318, 62, 513, 69 Flags: Print Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 49, 708, 166, 714 Flags: Print Annotation: Subtype: Link Rect: 37, 700, 286, 706 Flags: Print Annotation: Subtype: Link Rect: 49, 692, 286, 698 Flags: Print Annotation: Subtype: Link Rect: 49, 684, 248, 690 Flags: Print Annotation: Subtype: Link Rect: 49, 652, 162, 658 Flags: Print Annotation: Subtype: Link Rect: 78, 620, 226, 627 Flags: Print Annotation: Subtype: Link Rect: 483, 724, 555, 730 Flags: Print Annotation: Subtype: Link Rect: 318, 716, 376, 722 Flags: Print Annotation: Subtype: Link Rect: 448, 700, 555, 706 Flags: Print Annotation: Subtype: Link Rect: 318, 692, 338, 698 Flags: Print Annotation: Subtype: Link Rect: 463, 652, 538, 658 Flags: Print Annotation: Subtype: Link Rect: 318, 644, 389, 651 Flags: Print Annotation: Subtype: Link Rect: 452, 620, 544, 627 Flags: Print Annotation: Subtype: Link Rect: 318, 612, 373, 619 Flags: Print Checksum: 1ffda321 Type: CRC32 Checksum: df7449e6059208c8a0b2c6daf41c9793 Type: MD5 Checksum: 21469d9bbeac8b9cd4020b4bc97ab0da94d7e243 Type: SHA-1 Checksum: f406bb57627b0a06bb5789f828c97ea183046ae5b5e67e21297a2c95bd5ed3f2 Type: SHA-256