c89dbb2d1d4b4526f79658d6c0248cfc  s12029-024-01155-y.pdf
aab76f786ff4e4f13e52e203015f2a15d52f7c72  s12029-024-01155-y.pdf
e87e109d910eac6593bf52854e6fffa2f0236233c105dc304b836d9d06737ef9  s12029-024-01155-y.pdf

Title:           Immunotherapy or Targeted Therapy Versus Best Supportive Care for Advanced Gastric Cancer: A Systematic Review and Meta-analysis of Randomized Trials
Subject:         Journal of Gastrointestinal Cancer, https://doi.org/10.1007/s12029-024-01155-y
Keywords:        Advanced gastric cancer;Immunotherapy;Targeted therapy;Systematic review;Meta-analysis;Non-chemotherapy anticancer drugs
Author:           Adriana Meade 
Creator:         Adobe InDesign 15.1 (Windows)
Producer:        Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Mon Mar  3 21:42:56 2025 CET
ModDate:         Tue Mar  4 02:57:53 2025 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           13
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       1102896 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-SemiCn                     Type 1C           WinAnsi          yes no  yes     60  0
MyriadPro-SemiboldSemiCn             Type 1C           Custom           yes no  yes     94  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes    341  0
USTQUF+STIX-Regular                  Type 1C           Custom           yes yes yes     61  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes     62  0
VUTHQY+MyriadPro-SemiCn2             Type 1C           WinAnsi          yes yes yes    421  0
MyriadPro-BoldSemiCn                 Type 1C           Custom           yes no  yes     63  0
TGILFW+STIX-Italic                   Type 1C           WinAnsi          yes yes yes     93  0
DYOURS+Wingdings-Regular             Type 1C           WinAnsi          yes yes yes    342  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-04-02 02:07:56 CEST
 RepresentationInformation: s12029-024-01155-y.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-04-01 12:38:51 CEST
  Size: 1102896
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 487
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Immunotherapy or Targeted Therapy Versus Best Supportive Care for Advanced Gastric Cancer: A Systematic Review and Meta-analysis of Randomized Trials
      Children: 
       Item: 
        Title: Abstract
        Children: 
         Item: 
          Title: Purpose 
         Item: 
          Title: Methods 
         Item: 
          Title: Results 
         Item: 
          Title: Conclusions 
         Item: 
          Title: Trial Registration 
       Item: 
        Title: Introduction
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Study Design
         Item: 
          Title: Eligibility Criteria
         Item: 
          Title: Search Strategy
         Item: 
          Title: Selection and Data Extraction
         Item: 
          Title: Quality Assessment
         Item: 
          Title: Statistical Analysis
         Item: 
          Title: Certainty of the Evidence
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Study Selection
          Children: 
           Item: 
            Title: Study Characteristics
         Item: 
          Title: Risk of Bias
         Item: 
          Title: Outcomes
          Children: 
           Item: 
            Title: Overall Survival
           Item: 
            Title: Progression-free Survival
           Item: 
            Title: Toxicity
           Item: 
            Title: Quality of Life
       Item: 
        Title: Discussion
        Children: 
         Item: 
          Title: Main Findings
         Item: 
          Title: Our Research in Context
         Item: 
          Title: Strengths and Limitations
       Item: 
        Title: Conclusions
       Item: 
        Title: Acknowledgements 
       Item: 
        Title: References
   Info: 
    Title: Immunotherapy or Targeted Therapy Versus Best Supportive Care for Advanced Gastric Cancer: A Systematic Review and Meta-analysis of Randomized Trials
    Author:  Adriana Meade 
    Subject: Journal of Gastrointestinal Cancer, https://doi.org/10.1007/s12029-024-01155-y
    Keywords: Advanced gastric cancer;Immunotherapy;Targeted therapy;Systematic review;Meta-analysis;Non-chemotherapy anticancer drugs
    Creator: Adobe InDesign 15.1 (Windows)
    Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Mon Mar 03 21:42:56 CET 2025
    ModDate: Tue Mar 04 02:57:53 CET 2025
   ID: 0x56c91f80ed6c725791823305c94326bc, 0xab95a9f99011f0449acc1351d6e81c0c
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2032
      ImageHeight: 1187
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2033
      ImageHeight: 804
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2034
      ImageHeight: 801
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2034
      ImageHeight: 945
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: DYOURS+Wingdings-Regular
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: DYOURS+Wingdings-Regular
       Flags: Nonsymbolic
       FontBBox: 0, -103, 1359, 439
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiCn
       Flags: Nonsymbolic
       FontBBox: -128, -250, 1059, 876
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: USTQUF+STIX-Regular
      FontSubset: true
      FirstChar: 26
      LastChar: 252
      FontDescriptor: 
       FontName: USTQUF+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: TGILFW+STIX-Italic
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: TGILFW+STIX-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -970, -305, 1429, 1023
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldSemiCn
       Flags: Nonsymbolic
       FontBBox: -131, -250, 1115, 886
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-BoldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-BoldSemiCn
       Flags: Nonsymbolic
       FontBBox: -133, -250, 1161, 894
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2025-03-04T04:42:56+08:00</xmp:CreateDate>
         <xmp:CreatorTool>Adobe InDesign 15.1 (Windows)</xmp:CreatorTool>
         <xmp:ModifyDate>2025-03-04T02:57:53+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2025-03-04T02:57:53+01:00</xmp:MetadataDate>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Keywords>Advanced gastric cancer;Immunotherapy;Targeted therapy;Systematic review;Meta-analysis;Non-chemotherapy anticancer drugs</pdf:Keywords>
         <pdf:Trapped>False</pdf:Trapped>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1007/s12029-024-01155-y</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Journal of Gastrointestinal Cancer, https://doi.org/10.1007/s12029-024-01155-y</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Advanced gastric cancer</rdf:li>
               <rdf:li>Immunotherapy</rdf:li>
               <rdf:li>Targeted therapy</rdf:li>
               <rdf:li>Systematic review</rdf:li>
               <rdf:li>Meta-analysis</rdf:li>
               <rdf:li>Non-chemotherapy anticancer drugs</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Immunotherapy or Targeted Therapy Versus Best Supportive Care for Advanced Gastric Cancer: A Systematic Review and Meta-analysis of Randomized Trials</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li> Adriana Meade </rdf:li>
               <rdf:li> Marilina Santero </rdf:li>
               <rdf:li> Olga Savall-Esteve </rdf:li>
               <rdf:li> Javier Bracchiglione </rdf:li>
               <rdf:li> Leire Leache </rdf:li>
               <rdf:li> Anna Selva </rdf:li>
               <rdf:li> Ismael Macias </rdf:li>
               <rdf:li> Paula Cerdà </rdf:li>
               <rdf:li> Xavier Bonfill </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1007/s12029-024-01155-y</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1007/s12029-024-01155-y</prism:url>
         <prism:doi>10.1007/s12029-024-01155-y</prism:doi>
         <prism:issn>1941-6636</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Journal of Gastrointestinal Cancer</prism:publicationName>
         <prism:copyright>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1007/s12029-024-01155-y</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <xmpMM:DocumentID>uuid:3323df4f-49c8-42a0-899f-1bdf1f829545</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:c175f760-4338-4570-9bbc-b74e2ea7d2d7</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:3323df4f-49c8-42a0-899f-1bdf1f829545</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2025-03-04T01:11:12Z</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 513, 726, 546, 694
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 297, 348, 463, 333
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 127, 696, 132, 681
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 244, 684, 249, 669
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 255, 684, 260, 669
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 156, 659, 161, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 78, 646, 83, 631
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 88, 646, 93, 631
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 253, 584, 258, 569
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 263, 584, 268, 569
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 273, 584, 283, 569
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 172, 571, 182, 556
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 187, 571, 198, 556
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 85, 534, 95, 519
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 100, 534, 110, 519
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 151, 521, 161, 506
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 54, 484, 64, 469
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 69, 484, 79, 469
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 54, 359, 64, 344
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 250, 346, 260, 331
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 265, 346, 276, 331
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 89, 296, 99, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 200, 96, 211, 81
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 216, 96, 226, 81
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 434, 685, 444, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 449, 685, 458, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 463, 685, 473, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 429, 660, 439, 645
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 309, 560, 319, 545
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 513, 435, 523, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 528, 435, 538, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 335, 335, 345, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 413, 198, 424, 183
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 239, 724, 249, 709
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 161, 499, 171, 484
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 250, 86, 260, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 481, 511, 491, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 334, 261, 344, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 437, 224, 442, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 447, 224, 457, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 462, 224, 472, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 477, 224, 487, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 492, 224, 502, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 539, 224, 544, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 96
      Annotation: 
       Subtype: Link
       Rect: 332, 149, 337, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 377, 99, 387, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 192, 390, 198, 375
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 203, 390, 213, 375
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 54, 278, 64, 263
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 146, 253, 156, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 161, 253, 171, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 91, 153, 101, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 164, 153, 175, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 224, 153, 234, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 309, 390, 319, 375
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 400, 390, 411, 375
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 460, 378, 470, 363
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 475, 378, 485, 363
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 489, 378, 499, 363
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 326, 365, 331, 350
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 336, 365, 346, 350
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 351, 365, 361, 350
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 365, 365, 375, 350
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 427, 340, 432, 325
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 454, 315, 459, 300
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 464, 315, 473, 300
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 392, 290, 402, 275
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 407, 290, 417, 275
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 422, 290, 433, 275
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 454, 278, 459, 263
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 464, 278, 474, 263
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 479, 278, 489, 263
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 494, 278, 504, 263
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 509, 278, 519, 263
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 309, 253, 319, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 377, 190, 387, 175
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 393, 190, 403, 175
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 426, 178, 431, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 436, 178, 446, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 451, 178, 461, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 365, 153, 375, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
     Thumb: true
    Page: 
     Sequence: 5
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 470, 685, 475, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 481, 685, 492, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 498, 685, 508, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 515, 685, 525, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 530, 685, 540, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 539, 623, 544, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 342, 548, 347, 533
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 352, 548, 362, 533
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 367, 548, 377, 533
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 382, 548, 392, 533
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 397, 548, 407, 533
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 444, 535, 449, 520
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 470, 473, 476, 458
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 482, 473, 492, 458
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 498, 473, 508, 458
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 514, 473, 525, 458
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 530, 473, 540, 458
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 522, 385, 527, 370
       Flags: Print
       AppearanceDictionary: true
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 331, 223, 336, 208
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 341, 223, 351, 208
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 356, 223, 366, 208
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 371, 223, 381, 208
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 370, 185, 375, 170
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 345, 135, 355, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 361, 135, 371, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 376, 135, 386, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 539, 110, 544, 95
       Flags: Print
       AppearanceDictionary: true
       Destination: 229
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 276, 173, 286, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 51, 161, 61, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 66, 161, 76, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 81, 161, 91, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 139, 136, 149, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 277
      Annotation: 
       Subtype: Link
       Rect: 223, 136, 233, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 430, 236, 440, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 530, 236, 540, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 234, 174, 244, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 250, 174, 261, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 380, 411, 391, 396
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 396, 411, 406, 396
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 412, 411, 422, 396
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 366, 349, 376, 334
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 413, 86, 424, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 429, 86, 440, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 115, 736, 126, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 297
      Annotation: 
       Subtype: Link
       Rect: 257, 549, 267, 534
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 272, 549, 283, 534
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 85, 499, 96, 484
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 139, 486, 149, 471
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 276, 361, 286, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 51, 349, 61, 334
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 77, 111, 87, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 416, 661, 426, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 431, 661, 441, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 475, 461, 485, 446
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 463, 336, 473, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 479, 336, 489, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 369, 249, 379, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 385, 249, 395, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 111, 524, 121, 509
       Flags: Print
       AppearanceDictionary: true
       Destination: 327
      Annotation: 
       Subtype: Link
       Rect: 136, 492, 287, 479
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 392, 626, 542, 613
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 482, 523, 544, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 513, 381, 500
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 362, 363, 539, 350
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 76, 386, 195, 373
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 132, 336, 286, 323
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 145, 236, 289, 223
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 226, 80, 213
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 371, 726, 529, 713
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 446, 464, 433
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 441, 376, 544, 363
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 366, 366, 353
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 438, 256, 507, 243
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 493, 336, 544, 323
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 326, 415, 313
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 13
     Thumb: true
  Checksum: bf4afcc4
   Type: CRC32
  Checksum: c89dbb2d1d4b4526f79658d6c0248cfc
   Type: MD5
  Checksum: aab76f786ff4e4f13e52e203015f2a15d52f7c72
   Type: SHA-1
  Checksum: e87e109d910eac6593bf52854e6fffa2f0236233c105dc304b836d9d06737ef9
   Type: SHA-256