bc2c36c52daf63e0cf45e86c17a2bcdd pharmaceutics-17-00319-v2.pdf 1c79c631d9d0a8049138e277dcde8f4912c06742 pharmaceutics-17-00319-v2.pdf 13008742910226dd967b6c1512597eb7b80bee4c42f61e69109ecb61e27c7831 pharmaceutics-17-00319-v2.pdf Title: An Overview of the Potential for Pharmacokinetic Interactions Between Drugs and Cannabis Products in Humans Subject: Cannabis is the most commonly used illicit substance worldwide. Recent years have seen an increase in cannabis consumption, and with new approvals and therapeutic indications, there are challenges in minimizing the risks and interactions between cannabis-based products, cannabis prescription drugs, other approved prescription drugs, and other substances of abuse. Thus, identifying the enzymes metabolizing cannabinoid drugs and their relationship with other prescription drugs is crucial for understanding the potential interactions and effects of their simultaneous use. This article offers a comprehensive review of cannabis and the pharmacokinetic interactions between cannabis products, cannabis prescription drugs, and other approved prescription drugs, as well as other substances of abuse. It also compiles existing evidence of these interactions and describes the clinical outcomes associated with the inhibition or induction of various enzymes. Keywords: cannabis; tetrahydrocannabinol; THC; cannabidiol; CBD; drug interactions; medicines; pharmacokinetics Author: Dolly Andrea Caicedo, Clara Pérez-Mañá, Magí Farré and Esther Papaseit Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Wed Mar 5 01:38:58 2025 CET ModDate: Wed Mar 5 01:42:04 2025 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 32 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1842385 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- QKZKVH+VnURWPalladioL Type 1 Custom yes yes yes 10 0 UFZJXK+URWPalladioL-Roma Type 1 Custom yes yes yes 16 0 CWCKKL+URWPalladioL-Bold Type 1 Custom yes yes yes 22 0 TVBRJM+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 QGSPAQ+PazoMath Type 1 Builtin yes yes yes 53 0 DJFGHD+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 77 0 DJFGHF+PalatinoLinotype TrueType WinAnsi yes yes no 80 0 DJFGHH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 83 0 DJFGNG+PalatinoLinotype TrueType MacRoman yes yes no 86 0 DJFGHD+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 99 0 DJFGHF+PalatinoLinotype TrueType WinAnsi yes yes no 102 0 DJFGHH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 105 0 DJFGNG+PalatinoLinotype TrueType MacRoman yes yes no 108 0 QQOGDI+EURM10 Type 1 Builtin yes yes yes 117 0 WYEYUQ+CMSY10 Type 1 Builtin yes yes yes 122 0 RIJDHR+CMBSY10 Type 1 Builtin yes yes yes 136 0 DJFGHD+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 151 0 DJFGHE+PalatinoLinotype CID TrueType Identity-H yes yes yes 154 0 DJFGHF+PalatinoLinotype TrueType WinAnsi yes yes no 160 0 DJFGHH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 163 0 DJFGNG+PalatinoLinotype TrueType MacRoman yes yes no 166 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-04-10 02:44:31 CEST RepresentationInformation: pharmaceutics-17-00319-v2.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-04-09 13:42:50 CEST Size: 1842385 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 753 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Children: Item: Title: Cannabis Destination: subsection.1.1 Item: Title: Cannabis Products Destination: subsection.1.2 Item: Title: Epidemiology Destination: subsection.1.3 Item: Title: Pharmacokinetics Destination: subsection.1.4 Children: Item: Title: Absorption Destination: subsubsection.1.4.1 Item: Title: Distribution Destination: subsubsection.1.4.2 Item: Title: Metabolism Destination: subsubsection.1.4.3 Item: Title: Elimination Destination: subsubsection.1.4.4 Item: Title: Pharmacogenetics/Pharmacogenomics Destination: subsection.1.5 Item: Title: Acute, Chronic Effects and Intoxication Destination: subsection.1.6 Item: Title: Data Search and Selection Methods Destination: section.2 Item: Title: Cannabis Products’ Drug Interactions Destination: section.3 Children: Item: Title: Interactions with Medicines Destination: subsection.3.1 Children: Item: Title: Anticoagulants Destination: subsubsection.3.1.1 Item: Title: Antiepileptics Destination: subsubsection.3.1.2 Item: Title: Analgesics Destination: subsubsection.3.1.3 Item: Title: Opioids Destination: subsubsection.3.1.4 Item: Title: Benzodiazepines Destination: subsubsection.3.1.5 Item: Title: Immunosuppressants and Proliferation Inhibitors Destination: subsubsection.3.1.6 Item: Title: Selective Serotonin Reuptake Inhibitors (SSRIs) Destination: subsubsection.3.1.7 Item: Title: Tricyclic Antidepressants Destination: subsubsection.3.1.8 Item: Title: Anti-Infectives Destination: subsubsection.3.1.9 Item: Title: Antiretrovirals Destination: subsubsection.3.1.10 Item: Title: Proton Pump Inhibitors (PPIs) Destination: subsubsection.3.1.11 Item: Title: Psychostimulants Destination: subsubsection.3.1.12 Item: Title: Antipsychotics Destination: subsubsection.3.1.13 Item: Title: Methylxanthine Derivatives Destination: subsubsection.3.1.14 Item: Title: Interactions with Drugs of Abuse Destination: subsection.3.2 Item: Title: Pharmacodynamic Interactions (Medicines and Drugs of Abuse) Destination: subsection.3.3 Item: Title: Conclusions Destination: section.4 Item: Title: References Destination: section.5 Info: Title: An Overview of the Potential for Pharmacokinetic Interactions Between Drugs and Cannabis Products in Humans Author: Dolly Andrea Caicedo, Clara Pérez-Mañá, Magí Farré and Esther Papaseit Subject: Cannabis is the most commonly used illicit substance worldwide. Recent years have seen an increase in cannabis consumption, and with new approvals and therapeutic indications, there are challenges in minimizing the risks and interactions between cannabis-based products, cannabis prescription drugs, other approved prescription drugs, and other substances of abuse. Thus, identifying the enzymes metabolizing cannabinoid drugs and their relationship with other prescription drugs is crucial for understanding the potential interactions and effects of their simultaneous use. This article offers a comprehensive review of cannabis and the pharmacokinetic interactions between cannabis products, cannabis prescription drugs, and other approved prescription drugs, as well as other substances of abuse. It also compiles existing evidence of these interactions and describes the clinical outcomes associated with the inhibition or induction of various enzymes. 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