276a4ee654554a22cb1456586d3a8d15 311120.pdf 926923af2018ca5b5f29bac675863d37c4cb27a3 311120.pdf b8c9411a4060968ded0b04437770af3eb6b7b9842048b5e405620f820610e1db 311120.pdf Creator: Adobe InDesign 18.3 (Windows) Producer: Adobe PDF Library 17.0 CreationDate: Fri Jan 24 07:30:00 2025 CET ModDate: Fri Jan 24 07:58:12 2025 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 5199535 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JGURDW+Wingdings-Regular CID TrueType Identity-H yes yes yes 1494 0 WVILIW+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 1507 0 MyriadPro-SemiCn Type 1C WinAnsi yes no yes 1496 0 MyriadPro-SemiboldSemiCn Type 1C Custom yes no yes 1497 0 MyriadPro-Bold Type 1C WinAnsi yes no yes 1508 0 OERCTM+STIX-Regular Type 1C Custom yes yes yes 1514 0 MyriadPro-Semibold Type 1C Custom yes no yes 1522 0 AYUMHO+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 1501 0 OERCTM+TimesNewRomanPS-ItalicMT TrueType WinAnsi yes yes yes 1515 0 Springnew TrueType WinAnsi yes no yes 1525 0 Springnew TrueType WinAnsi yes no yes 101 0 MyriadPro-BoldSemiCn Type 1C WinAnsi yes no yes 114 0 BNEHFV+TimesNewRomanPS-BoldMT TrueType WinAnsi yes yes yes 177 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-05-16 02:57:18 CEST RepresentationInformation: 311120.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-05-15 14:34:36 CEST Size: 5199535 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 1630 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Real-world evidence of effectiveness and safety of pasireotide in the treatment of acromegaly: a systematic review and meta-analysis Children: Item: Title: Abstract Item: Title: 1 Introduction Item: Title: 2 Methods Children: Item: Title: 2.1 Protocol registration Item: Title: 2.2 Eligibility criteria Item: Title: 2.3 Information sources and search strategy Item: Title: 2.4 Data extraction and quality assessment Item: Title: 2.5 Outcomes Item: Title: 2.6 Data synthesis and statistical analysis Item: Title: 3 Results Children: Item: Title: 3.1 Study selection Item: Title: 3.2 Study characteristics Item: Title: 3.3 Demographics Item: Title: 3.4 Disease characteristics Item: Title: 3.5 Baseline biochemical disease activity and glucose metabolism Item: Title: 3.6 Metanalysis Children: Item: Title: 3.6.1 Growth hormone levels Item: Title: 3.6.2 IGF-1- ULN levels Item: Title: 3.6.3 Fasting glucose metabolism Item: Title: 3.6.4 IGF-1 control Item: Title: 3.6.5 Clinically relevant tumor shrinkage Item: Title: 3.7 Sensitivity analysis on studies with radiotherapy Item: Title: 4 Discussion Children: Item: Title: 4.1 Biochemical control Item: Title: 4.2 Percentage of patients with clinically relevant tumor shrinkage Item: Title: 4.3 Glucose metabolism Item: Title: 4.4 Implications for clinical practice Item: Title: 4.5 Limitations Item: Title: 4.6 Future directions Item: Title: References Info: Creator: Adobe InDesign 18.3 (Windows) Producer: Adobe PDF Library 17.0 CreationDate: Fri Jan 24 07:30:00 CET 2025 ModDate: Fri Jan 24 07:58:12 CET 2025 ID: 0xc884592ea9e6784aa7c5bf015680d5a7, 0xcd2b1d94191f6a4489c4808904939c6e Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2055 ImageHeight: 1506 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2055 ImageHeight: 686 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2055 ImageHeight: 1532 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2055 ImageHeight: 2413 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2055 ImageHeight: 2374 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2055 ImageHeight: 2244 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: WVILIW+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: JGURDW+Wingdings-Regular Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-BoldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-BoldSemiCn Flags: Nonsymbolic FontBBox: -159, -250, 1161, 980 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-SemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiCn Flags: Nonsymbolic FontBBox: -152, -250, 1059, 947 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-SemiboldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldSemiCn Flags: Nonsymbolic FontBBox: -156, -250, 1115, 963 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: OERCTM+STIX-Regular FontSubset: true FirstChar: 30 LastChar: 177 FontDescriptor: FontName: OERCTM+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: BNEHFV+TimesNewRomanPS-BoldMT FontSubset: true FirstChar: 40 LastChar: 99 FontDescriptor: FontName: BNEHFV+TimesNewRomanPS-BoldMT Flags: Serif, Nonsymbolic FontBBox: -558, -328, 2000, 1056 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Springnew FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Springnew Flags: Serif, Nonsymbolic FontBBox: -1430, -456, 2446, 800 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: OERCTM+TimesNewRomanPS-ItalicMT FontSubset: true FirstChar: 78 LastChar: 112 FontDescriptor: FontName: OERCTM+TimesNewRomanPS-ItalicMT Flags: Serif, Nonsymbolic, Italic FontBBox: -498, -307, 1333, 1023 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: AYUMHO+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 253 FontDescriptor: FontName: AYUMHO+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: JGURDW+Wingdings-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JGURDW+Wingdings-Regular Flags: Symbolic FontBBox: 0, -211, 1359, 899 FontFile2: true Font: BaseFont: WVILIW+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: WVILIW+TimesNewRomanPSMT Flags: Serif, Symbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true XMP: uuid:15c17814-c74d-4321-88dd-a1ab65aedbeb adobe:docid:indd:24bb93d9-bd1e-11dd-84db-a83b50d2aaad xmp.id:52fd9c25-04fd-074d-9967-42f1a06618e3 proof:pdf 1 xmp.iid:5890d45f-0c47-0b44-b7a3-7eeb6e2c8e49 xmp.did:21d562bf-389a-4247-8416-238589a9ea9b default converted from application/x-indesign to application/pdf Adobe InDesign 18.3 (Windows) 2025-01-24T07:30:00+01:00 converted uuid:b367a6a7-cf70-4adc-bfe1-3104733cf164 converted to PDF/A-2b pdfToolbox 2025-01-24T07:58:11+01:00 2025-01-24T07:58:12+01:00 2025-01-24T07:58:12+01:00 Adobe InDesign 18.3 (Windows) 2025-01-24T07:30:00+01:00 journal 10.1007/s11154-024-09928-3 2010-04-23 true springer.com springerlink.com 2010-04-23 true 10.1007/s11154-024-09928-3 springer.com springerlink.com VoR application/pdf Adobe PDF Library 17.0 False 2 B Betina Biagetti http://orcid.org/0000-0002-8837-4343 Marta Araujo-Castro http://orcid.org/0000-0002-0519-0072 Cristian Tebe http://orcid.org/0000-0003-2320-1385 M nica Marazuela http://orcid.org/0000-0003-1158-9618 Manel Puig-Domingo http://orcid.org/0000-0002-6744-7195 http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text internal Mirrors crossmark:DOI doi Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the name of an author. name Text Gives the ORCID of an author. orcid URI http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Label: 97 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 116, 634, 129, 622 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 223, 634, 236, 622 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 297, 634, 310, 622 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 395, 634, 408, 622 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 506, 634, 519, 622 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 513, 721, 546, 688 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 98 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 211, 518, 216, 504 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 223, 518, 228, 504 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 231, 480, 236, 467 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 220, 430, 225, 417 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 230, 430, 235, 417 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 74, 355, 79, 342 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 207, 218, 212, 204 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 138, 155, 148, 142 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 253, 118, 263, 104 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 360, 605, 370, 592 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 337, 593, 347, 579 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 509, 568, 519, 554 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 524, 568, 534, 554 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 513, 555, 523, 542 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 528, 555, 538, 542 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 473, 493, 483, 479 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 488, 493, 498, 479 Flags: Print AppearanceDictionary: true Destination: 60 Thumb: true Page: Label: 99 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 205, 668, 215, 654 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 140, 268, 289, 254 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 51, 255, 157, 242 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 82, 193, 289, 179 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 51, 180, 289, 167 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 51, 168, 82, 154 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 495, 580, 500, 567 Flags: Print AppearanceDictionary: true Destination: 9 Annotation: Subtype: Link Rect: 379, 343, 389, 329 Flags: Print AppearanceDictionary: true Destination: 60 Thumb: true Page: Label: 100 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 407, 230, 412, 217 Flags: Print AppearanceDictionary: true Destination: 9 Annotation: Subtype: Link Rect: 529, 193, 539, 179 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 306, 180, 316, 167 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 320, 180, 330, 167 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 335, 180, 345, 167 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 516, 168, 526, 154 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 531, 168, 541, 154 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 306, 155, 316, 142 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 323, 155, 333, 142 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 514, 155, 524, 142 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 531, 155, 541, 142 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 306, 143, 316, 129 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 321, 143, 331, 129 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 337, 143, 347, 129 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 353, 143, 363, 129 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 426, 130, 436, 117 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 463, 130, 473, 117 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 334, 105, 344, 92 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 54, 268, 64, 254 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 223, 105, 233, 92 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 123, 93, 133, 79 Flags: Print AppearanceDictionary: true Destination: 60 Thumb: true Page: Label: 101 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 79, 730, 89, 717 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 54, 705, 64, 692 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 70, 605, 80, 592 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 115, 605, 120, 592 Flags: Print AppearanceDictionary: true Destination: 17 Annotation: Subtype: Link Rect: 71, 555, 81, 542 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 86, 555, 96, 542 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 254, 518, 264, 504 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 251, 368, 256, 354 Flags: Print AppearanceDictionary: true Destination: 17 Annotation: Subtype: Link Rect: 262, 180, 267, 167 Flags: Print AppearanceDictionary: true Destination: 17 Annotation: Subtype: Link Rect: 80, 118, 85, 104 Flags: Print AppearanceDictionary: true Destination: 21 Annotation: Subtype: Link Rect: 365, 138, 377, 130 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 377, 139, 388, 130 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 389, 143, 400, 134 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 400, 166, 412, 157 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 412, 130, 424, 122 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 424, 194, 436, 186 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 436, 134, 447, 125 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 448, 139, 459, 130 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 459, 145, 471, 137 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 471, 141, 482, 132 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 482, 130, 494, 122 Flags: Print AppearanceDictionary: true Destination: 64 Thumb: true Page: Label: 102 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 329, 168, 334, 154 Flags: Print AppearanceDictionary: true Destination: 27 Annotation: Subtype: Link Rect: 328, 105, 333, 92 Flags: Print AppearanceDictionary: true Destination: 27 Annotation: Subtype: Link Rect: 107, 168, 112, 154 Flags: Print AppearanceDictionary: true Destination: 21 Annotation: Subtype: Link Rect: 107, 698, 116, 687 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 108, 687, 116, 675 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 111, 675, 120, 664 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 135, 664, 143, 652 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 99, 652, 108, 641 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 163, 641, 171, 629 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 103, 629, 111, 618 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 108, 617, 116, 606 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 114, 606, 123, 594 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 110, 594, 118, 583 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 99, 583, 107, 571 Flags: Print AppearanceDictionary: true Destination: 64 Thumb: true Page: Label: 103 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 417, 243, 422, 229 Flags: Print AppearanceDictionary: true Destination: 33 Annotation: Subtype: Link Rect: 445, 143, 450, 129 Flags: Print AppearanceDictionary: true Destination: 33 Annotation: Subtype: Link Rect: 74, 230, 79, 217 Flags: Print AppearanceDictionary: true Destination: 27 Annotation: Subtype: Link Rect: 279, 130, 284, 117 Flags: Print AppearanceDictionary: true Destination: 33 Thumb: true Page: Label: 104 Sequence: 8 Thumb: true Page: Label: 105 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 454, 643, 464, 629 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 470, 643, 480, 629 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 309, 543, 319, 529 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 326, 543, 335, 529 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 348, 518, 358, 504 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 363, 518, 373, 504 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 384, 455, 394, 442 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 400, 455, 410, 442 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 496, 405, 501, 392 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 326, 118, 336, 104 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 341, 118, 351, 104 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 473, 118, 483, 104 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 396, 105, 406, 92 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 412, 105, 422, 92 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 429, 105, 439, 92 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 446, 105, 456, 92 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 125, 630, 130, 617 Flags: Print AppearanceDictionary: true Destination: 41 Annotation: Subtype: Link Rect: 240, 493, 245, 479 Flags: Print AppearanceDictionary: true Destination: 46 Annotation: Subtype: Link Rect: 124, 455, 134, 442 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 101, 443, 111, 429 Flags: Print AppearanceDictionary: true Destination: 60 Annotation: Subtype: Link Rect: 213, 380, 218, 367 Flags: Print AppearanceDictionary: true Destination: 46 Annotation: Subtype: Link Rect: 273, 268, 278, 254 Flags: Print AppearanceDictionary: true Destination: 46 Thumb: true Page: Label: 106 Sequence: 10 Thumb: true Page: Label: 107 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 141, 165, 146, 153 Flags: Print AppearanceDictionary: true Destination: 46 Thumb: true Page: Label: 108 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 485, 618, 495, 604 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 500, 618, 510, 604 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 363, 443, 413, 429 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Rect: 345, 368, 355, 354 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 361, 368, 371, 354 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 513, 330, 523, 317 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 411, 280, 421, 267 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 368, 230, 378, 217 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 361, 218, 371, 204 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 423, 180, 433, 167 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 475, 155, 485, 142 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 200, 318, 210, 304 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 216, 318, 226, 304 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 191, 293, 201, 279 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 54, 280, 64, 267 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 148, 280, 158, 267 Flags: Print AppearanceDictionary: true Destination: 64 Thumb: true Page: Label: 109 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 455, 280, 544, 269 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 306, 270, 342, 259 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 273, 718, 283, 704 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 273, 380, 283, 367 Flags: Print AppearanceDictionary: true Destination: 60 Thumb: true Page: Label: 110 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 350, 615, 439, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 342, 95, 544, 84 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 85, 336, 74 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 51, 645, 222, 634 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 111 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 323, 495, 530, 484 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 267, 265, 289, 254 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 255, 191, 244 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 0da5ac38 Type: CRC32 Checksum: 276a4ee654554a22cb1456586d3a8d15 Type: MD5 Checksum: 926923af2018ca5b5f29bac675863d37c4cb27a3 Type: SHA-1 Checksum: b8c9411a4060968ded0b04437770af3eb6b7b9842048b5e405620f820610e1db Type: SHA-256