197504f48e9c8a1b76e7d6d32776af86 jcm-14-03352.pdf 2f334537a61fb1e64fb3618f4e1e80fe8be6f7f6 jcm-14-03352.pdf 876bb565c00d4c8d5ac723ad7dc36862afd1f2796aed6dadde5e97602f528265 jcm-14-03352.pdf Title: Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies: Results from the ENEIDA Registry Subject: Background: Pediatric-onset familial inflammatory bowel disease (IBD) may differ from sporadic pediatric-onset IBD in its genetic and environmental background and may have distinct clinical and therapeutic implications. Objective: To evaluate the influence of a positive family history of IBD on the use of medical therapies and surgical interventions in adult patients with pediatric-onset IBD. Methods: Retrospective case–control study using the Spanish ENEIDA registry, including adults diagnosed with pediatric-onset IBD since 2006. Familial forms (FFs) (defined by a first-degree relative with IBD) and sporadic forms (SF) (with no relatives of any grade with IBD) were matched 1:4 by type of IBD, sex, age at IBD diagnosis, disease location, disease pattern, development of perianal disease and smoking status at diagnosis. The study outcomes were the use of immunomodulators, biological therapies, intestinal surgery, and perianal surgery during follow-up. Results: Six-hundred and fifty-five Crohn’s disease (CD) (131 FF) and 440 ulcerative colitis (UC) (88 FF) patients were included. Immunomodulators, biological therapy, and intestinal surgery were used evenly among FF and SF patients for both UC and CD. However, a higher requirement for perianal surgery among FF-CD patients (18.3% vs. 10.5%, p = 0.014), together with a shorter time to perianal surgery (11 vs. 20 months, log-rank p = 0.004), was observed. Conclusions: Patients with FF of pediatric-onset IBD do not exhibit an increased use of immunomodulators, biological agents, or intestinal surgery, but do exhibit a higher need for perianal surgery, as compared to patients with SF pediatric-onset IBD. Keywords: pediatric; familial history; inflammatory bowel disease; surgery; biologicals Author: Carlos González-Muñoza, Antonio Giordano, Elena Ricart, Pilar Nos, Eva Iglesias, Javier P. Gisbert, Santiago García-López, Francisco Mesonero, Isabel Pascual, Carlos Tardillo, Montserrat Rivero, Sabino Riestra, Míriam Mañosa, Yamile Zabana, Fernando Gomollón, Xavier Calvet, Mariana Fe García-Sepulcre, Ana Gutiérrez, Jose Lázaro Pérez-Calle, Mónica Sierra-Ausín, Fernando Bermejo, Lara Arias, Manuel Barreiro-de Acosta, Jesús Barrio, Rufo Lorente, Jordi Guardiola, Pilar Varela, Ángel Ponferrada-Díaz, Ignacio Marín-Jiménez, Cristina Martínez Pascual, Esther Garcia-Planella and Eugeni Domènech Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Mon May 12 11:27:36 2025 CEST ModDate: Mon May 12 11:34:04 2025 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1246468 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WYEKQU+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 GSINYH+VnURWPalladioL Type 1 Custom yes yes yes 16 0 CGBOBJ+URWPalladioL-Roma Type 1 Custom yes yes yes 21 0 OJEGPW+URWPalladioL-Bold Type 1 Custom yes yes yes 27 0 OGBIGQ+URWPalladioL-Ital Type 1 Custom yes yes yes 32 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes yes 64 0 APIONP+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 87 0 APIOOA+PalatinoLinotype CID TrueType Identity-H yes yes yes 90 0 APIOOB+PalatinoLinotype TrueType WinAnsi yes yes no 96 0 APIOOD+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 99 0 APIPPO+PalatinoLinotype TrueType MacRoman yes yes no 102 0 APIONP+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 127 0 APIOOA+PalatinoLinotype CID TrueType Identity-H yes yes yes 130 0 APIOOB+PalatinoLinotype TrueType WinAnsi yes yes no 136 0 APIOOD+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 139 0 APIPPO+PalatinoLinotype TrueType MacRoman yes yes no 142 0 APIONP+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 163 0 APIOOA+PalatinoLinotype CID TrueType Identity-H yes yes yes 166 0 APIOOB+PalatinoLinotype TrueType WinAnsi yes yes no 172 0 APIOOD+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 175 0 APIPPO+PalatinoLinotype TrueType MacRoman yes yes no 178 0 APIONP+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 194 0 APIOOA+PalatinoLinotype CID TrueType Identity-H yes yes yes 197 0 APIOOB+PalatinoLinotype TrueType WinAnsi yes yes no 203 0 APIOOD+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 206 0 APIPPO+PalatinoLinotype TrueType MacRoman yes yes no 209 0 AOPHAZ+CMSY10 Type 1 Builtin yes yes yes 233 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-06-12 02:41:16 CEST RepresentationInformation: jcm-14-03352.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-06-11 11:37:58 CEST Size: 1246468 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 467 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Design Destination: subsection.2.1 Item: Title: Study Population, Data Collection, and Definitions Destination: subsection.2.2 Item: Title: Statistical Analysis Destination: subsection.2.3 Item: Title: Results Destination: section.3 Children: Item: Title: Immunomodulators Destination: subsection.3.1 Item: Title: Biological Therapy Destination: subsection.3.2 Item: Title: Intestinal Surgeries Destination: subsection.3.3 Item: Title: Perianal Surgeries Destination: subsection.3.4 Item: Title: Discussion Destination: section.4 Item: Title: References Destination: section.5 Info: Title: Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies: Results from the ENEIDA Registry Author: Carlos González-Muñoza, Antonio Giordano, Elena Ricart, Pilar Nos, Eva Iglesias, Javier P. Gisbert, Santiago García-López, Francisco Mesonero, Isabel Pascual, Carlos Tardillo, Montserrat Rivero, Sabino Riestra, Míriam Mañosa, Yamile Zabana, Fernando Gomollón, Xavier Calvet, Mariana Fe García-Sepulcre, Ana Gutiérrez, Jose Lázaro Pérez-Calle, Mónica Sierra-Ausín, Fernando Bermejo, Lara Arias, Manuel Barreiro-de Acosta, Jesús Barrio, Rufo Lorente, Jordi Guardiola, Pilar Varela, Ángel Ponferrada-Díaz, Ignacio Marín-Jiménez, Cristina Martínez Pascual, Esther Garcia-Planella and Eugeni Domènech Subject: Background: Pediatric-onset familial inflammatory bowel disease (IBD) may differ from sporadic pediatric-onset IBD in its genetic and environmental background and may have distinct clinical and therapeutic implications. Objective: To evaluate the influence of a positive family history of IBD on the use of medical therapies and surgical interventions in adult patients with pediatric-onset IBD. Methods: Retrospective case control study using the Spanish ENEIDA registry, including adults diagnosed with pediatric-onset IBD since 2006. Familial forms (FFs) (defined by a first-degree relative with IBD) and sporadic forms (SF) (with no relatives of any grade with IBD) were matched 1:4 by type of IBD, sex, age at IBD diagnosis, disease location, disease pattern, development of perianal disease and smoking status at diagnosis. The study outcomes were the use of immunomodulators, biological therapies, intestinal surgery, and perianal surgery during follow-up. Results: Six-hundred and fifty-five Crohn’s disease (CD) (131 FF) and 440 ulcerative colitis (UC) (88 FF) patients were included. Immunomodulators, biological therapy, and intestinal surgery were used evenly among FF and SF patients for both UC and CD. However, a higher requirement for perianal surgery among FF-CD patients (18.3% vs. 10.5%, p = 0.014), together with a shorter time to perianal surgery (11 vs. 20 months, log-rank p = 0.004), was observed. Conclusions: Patients with FF of pediatric-onset IBD do not exhibit an increased use of immunomodulators, biological agents, or intestinal surgery, but do exhibit a higher need for perianal surgery, as compared to patients with SF pediatric-onset IBD. 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