cf5b6d3893f8f86b52a48a11da77df96 311656.pdf 25c48c1546b3c41d4699dcb8ce4458cb3655b618 311656.pdf 63ad64b73139f760a704a6d659c5b4f469ed4bf65c554c59943bffc018ded421 311656.pdf Title: Implementation of guideline‐recommended medical therapy for patients with heart failure in Europe Subject: Keywords: 10.1002/ehf2.15105 and guideline‐directed medical therapy; heart failure; phenotypes; worsening heart failure Author: Maurizio Volterrani, Petar Seferovic, Gianluigi Savarese, Ilaria Spoletini, Egidio Imbalzano, Antoni Bayes‐Genis, Ewa Jankowska, Michele Senni, Marco Metra, Ovidiu Chioncel, Andrew J. S. Coats, Giuseppe M. C. Rosano Creator: Arbortext Advanced Print Publisher 9.1.520/W Unicode Producer: Acrobat Distiller 24.0 (Windows) CreationDate: Wed Mar 5 06:41:09 2025 CET ModDate: Wed Mar 12 10:52:20 2025 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 439731 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DBOKHG+Calibri Type 1C WinAnsi yes yes no 342 0 DBOKKG+CalibriItalic Type 1C WinAnsi yes yes no 341 0 DBOKKH+CalibriItalic+20 Type 1C WinAnsi yes yes no 331 0 DBOKKI+Calibri+20 Type 1C Custom yes yes yes 360 0 DBOKKJ+CalibriBold Type 1C WinAnsi yes yes no 353 0 DBOKKK+Calibri+fb Type 1C Custom yes yes yes 358 0 DBOKLK+TimesNewRomanUnic+03 Type 1C Custom yes yes yes 157 0 DBOKLL+TimesNewRomanUnic+22 Type 1C Custom yes yes yes 170 0 DBOKLM+Humanist777BTUnicBoldB Type 1C WinAnsi yes yes no 161 0 DBOKMN+Calibri+21 Type 1C Custom yes yes yes 17 0 DBOKMO+TeXCMMathsItalic Type 1C WinAnsi yes yes no 166 0 DBOLIK+CalibriBold+fb Type 1C Custom yes yes yes 167 0 DBOLJL+AdvTTf696b0bf.B Type 1C WinAnsi yes yes no 75 0 DBOLJM+CharterITCUnic Type 1C WinAnsi yes yes no 173 0 DBOLJN+CharterITCUnicItalic Type 1C WinAnsi yes yes no 155 0 DBOLJO+CharterITCUnicBold Type 1C WinAnsi yes yes no 165 0 DBOLJP+CharterITCUnic+20 Type 1C WinAnsi yes yes no 171 0 DBOLLA+CharterITCUnic+01 Type 1C Custom yes yes yes 125 0 DBOLLB+TimesNewRoman+01 Type 1C Custom yes yes yes 105 0 DBOLMB+CharterITCUnic+fb Type 1C Custom yes yes yes 187 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-07-12 02:45:25 CEST RepresentationInformation: 311656.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-07-11 12:37:25 CEST Size: 439731 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 361 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Implementation of „guideline„‐„recommended medical therapy for patients with heart failure in Europe Destination: maintitle Item: Title: Abstract Destination: section_abs Item: Title: Introduction Destination: sectionehf215105-sec-0001 Item: Title: Current status of HF treatment implementation Destination: sectionehf215105-sec-0002 Item: Title: Barriers to implementation Destination: sectionehf215105-sec-0004 Item: Title: Strategies for uptitration Destination: sectionehf215105-sec-0006 Item: Title: In‐hospital and outpatients HF patients: SGLT2 inhibitors as foundational therapies for HF patients regardless ejection fraction Destination: sectionehf215105-sec-0007 Item: Title: Defining worsening HF: An update Destination: sectionehf215105-sec-0008 Item: Title: Conclusions Destination: sectionehf215105-sec-0009 Item: Title: Conflict of interest statement Destination: sectionehf215105-sec-0010 Item: Title: Funding Destination: sectionehf215105-sec-1001 Item: Title: References Destination: ref_title Info: Title: Implementation of guideline‐recommended medical therapy for patients with heart failure in Europe Author: Maurizio Volterrani, Petar Seferovic, Gianluigi Savarese, Ilaria Spoletini, Egidio Imbalzano, Antoni Bayes‐Genis, Ewa Jankowska, Michele Senni, Marco Metra, Ovidiu Chioncel, Andrew J. S. Coats, Giuseppe M. C. Rosano Subject: Keywords: 10.1002/ehf2.15105 and guideline‐directed medical therapy; heart failure; phenotypes; worsening heart failure Creator: Arbortext Advanced Print Publisher 9.1.520/W Unicode Producer: Acrobat Distiller 24.0 (Windows) CreationDate: Wed Mar 05 06:41:09 CET 2025 ModDate: Wed Mar 12 10:52:20 CET 2025 Trapped: False ID: 0x648eecc41fd3925e6241d0ba87eba130, 0x32ec4e9eec9323658b86abf60ae32e6d Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 46 ImageHeight: 45 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Fonts: Type1: Font: BaseFont: DBOKKJ+CalibriBold FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: DBOKKJ+CalibriBold Flags: Serif, Nonsymbolic FontBBox: -83, -187, 875, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBOKLM+Humanist777BTUnicBoldB FontSubset: true FirstChar: 46 LastChar: 117 FontDescriptor: FontName: DBOKLM+Humanist777BTUnicBoldB Flags: Nonsymbolic FontBBox: -41, -229, 947, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBOLJO+CharterITCUnicBold FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: DBOLJO+CharterITCUnicBold Flags: Nonsymbolic FontBBox: -218, -229, 937, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBOKKK+Calibri+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DBOKKK+Calibri+fb Flags: Symbolic FontBBox: -114, -302, 906, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DBOKMO+TeXCMMathsItalic FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: DBOKMO+TeXCMMathsItalic Flags: Nonsymbolic, Italic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBOLIK+CalibriBold+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DBOLIK+CalibriBold+fb Flags: Symbolic FontBBox: -125, -302, 979, 937 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DBOKKI+Calibri+20 FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: DBOKKI+Calibri+20 Flags: Symbolic FontBBox: -208, -229, 1041, 854 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DBOLLB+TimesNewRoman+01 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DBOLLB+TimesNewRoman+01 Flags: Symbolic FontBBox: -72, -208, 1302, 1000 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DBOKLL+TimesNewRomanUnic+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DBOKLL+TimesNewRomanUnic+22 Flags: Symbolic FontBBox: -41, -270, 1177, 1020 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DBOKKH+CalibriItalic+20 FontSubset: true FirstChar: 145 LastChar: 146 FontDescriptor: FontName: DBOKKH+CalibriItalic+20 Flags: Nonsymbolic, Italic FontBBox: -208, -229, 1041, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBOLJL+AdvTTf696b0bf.B FontSubset: true FirstChar: 82 LastChar: 115 FontDescriptor: FontName: DBOLJL+AdvTTf696b0bf.B Flags: Nonsymbolic FontBBox: -218, -218, 947, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBOLJP+CharterITCUnic+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: DBOLJP+CharterITCUnic+20 Flags: Nonsymbolic FontBBox: -218, -156, 1552, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBOLJM+CharterITCUnic FontSubset: true FirstChar: 40 LastChar: 248 FontDescriptor: FontName: DBOLJM+CharterITCUnic Flags: Serif, Nonsymbolic FontBBox: -218, -229, 937, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBOKMN+Calibri+21 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DBOKMN+Calibri+21 Flags: Symbolic FontBBox: 0, -187, 1208, 843 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DBOKKG+CalibriItalic FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: DBOKKG+CalibriItalic Flags: Serif, Nonsymbolic, Italic FontBBox: -104, -187, 937, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBOKHG+Calibri FontSubset: true FirstChar: 37 LastChar: 215 FontDescriptor: FontName: DBOKHG+Calibri Flags: Serif, Nonsymbolic FontBBox: -93, -187, 854, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBOLJN+CharterITCUnicItalic FontSubset: true FirstChar: 65 LastChar: 118 FontDescriptor: FontName: DBOLJN+CharterITCUnicItalic Flags: Serif, Nonsymbolic, Italic FontBBox: -218, -229, 947, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DBOLMB+CharterITCUnic+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DBOLMB+CharterITCUnic+fb Flags: Symbolic FontBBox: 0, 0, 864, 739 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DBOKLK+TimesNewRomanUnic+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DBOKLK+TimesNewRomanUnic+03 Flags: Symbolic FontBBox: -812, -281, 1010, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DBOLLA+CharterITCUnic+01 FontSubset: true FirstChar: 2 LastChar: 20 FontDescriptor: FontName: DBOLLA+CharterITCUnic+01 Flags: Symbolic FontBBox: -72, -229, 958, 1000 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: VoR10.1002/ehf2.15105 Pages: Page: Label: 790 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 142, 587, 152, 598 Destination: 298 Annotation: Subtype: Link Rect: 225, 587, 230, 598 Destination: 298 Annotation: Subtype: Link Rect: 317, 587, 321, 598 Destination: 298 Annotation: Subtype: Link Rect: 391, 587, 395, 598 Destination: 298 Annotation: Subtype: Link Rect: 477, 587, 481, 598 Destination: 298 Annotation: Subtype: Link Rect: 142, 573, 146, 584 Destination: 298 Annotation: Subtype: Link Rect: 221, 573, 225, 584 Destination: 298 Annotation: Subtype: Link Rect: 294, 573, 298, 584 Destination: 298 Annotation: Subtype: Link Rect: 363, 573, 367, 584 Destination: 298 Annotation: Subtype: Link Rect: 443, 573, 452, 584 Destination: 298 Annotation: Subtype: Link Rect: 138, 559, 147, 570 Destination: 298 Annotation: Subtype: Link Rect: 275, 559, 289, 570 Destination: 298 Annotation: Subtype: Link Rect: 297, 557, 307, 567 Annotation: Subtype: Link Rect: 354, 325, 436, 332 Annotation: Subtype: Link Rect: 158, 234, 162, 243 Destination: 64 Annotation: Subtype: Link Rect: 206, 222, 209, 231 Destination: 64 Annotation: Subtype: Link Rect: 94, 198, 97, 207 Destination: 64 Annotation: Subtype: Link Rect: 190, 186, 194, 195 Destination: 64 Annotation: Subtype: Link Rect: 171, 126, 175, 135 Destination: 64 Annotation: Subtype: Link Rect: 144, 102, 154, 111 Destination: 64 Annotation: Subtype: Link Rect: 536, 125, 539, 134 Destination: 64 Annotation: Subtype: Link Rect: 536, 101, 539, 110 Destination: 82 Annotation: Subtype: Link Rect: 206, 33, 341, 40 Thumb: true Page: Label: 791 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 139, 634, 157, 643 Destination: 64 Annotation: Subtype: Link Rect: 250, 634, 253, 643 Destination: 64 Annotation: Subtype: Link Rect: 130, 622, 137, 631 Destination: 82 Annotation: Subtype: Link Rect: 133, 598, 136, 607 Destination: 82 Annotation: Subtype: Link Rect: 155, 562, 162, 571 Destination: 82 Annotation: Subtype: Link Rect: 169, 430, 176, 439 Destination: 82 Annotation: Subtype: Link Rect: 500, 682, 507, 691 Destination: 82 Annotation: Subtype: Link Rect: 404, 478, 411, 487 Destination: 82 Thumb: true Page: Label: 792 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 284, 124, 291, 134 Destination: 82 Thumb: true Page: Label: 793 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 138, 250, 145, 259 Destination: 82 Annotation: Subtype: Link Rect: 164, 82, 171, 91 Destination: 82 Annotation: Subtype: Link Rect: 445, 178, 452, 187 Destination: 82 Annotation: Subtype: Link Rect: 401, 166, 408, 175 Destination: 82 Annotation: Subtype: Link Rect: 456, 118, 463, 127 Destination: 82 Annotation: Subtype: Link Rect: 506, 94, 513, 103 Destination: 82 Thumb: true Page: Label: 794 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 284, 706, 291, 715 Destination: 82 Annotation: Subtype: Link Rect: 100, 574, 107, 583 Destination: 82 Annotation: Subtype: Link Rect: 196, 526, 204, 535 Destination: 82 Annotation: Subtype: Link Rect: 156, 406, 164, 415 Destination: 82 Annotation: Subtype: Link Rect: 532, 670, 539, 679 Destination: 82 Annotation: Subtype: Link Rect: 358, 537, 374, 547 Destination: 82 Annotation: Subtype: Link Rect: 498, 461, 503, 471 Destination: 30 Thumb: true Page: Label: 795 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 159, 706, 166, 715 Destination: 82 Annotation: Subtype: Link Rect: 284, 598, 291, 607 Destination: 82 Annotation: Subtype: Link Rect: 284, 562, 291, 571 Destination: 82 Annotation: Subtype: Link Rect: 253, 550, 256, 559 Destination: 82 Annotation: Subtype: Link Rect: 209, 430, 216, 439 Destination: 82 Annotation: Subtype: Link Rect: 212, 406, 220, 415 Destination: 82 Annotation: Subtype: Link Rect: 281, 238, 291, 247 Destination: 82 Annotation: Subtype: Link Rect: 55, 226, 62, 235 Destination: 82 Annotation: Subtype: Link Rect: 275, 202, 291, 211 Destination: 82 Annotation: Subtype: Link Rect: 486, 622, 502, 631 Destination: 131 Annotation: Subtype: Link Rect: 375, 598, 391, 607 Destination: 131 Annotation: Subtype: Link Rect: 439, 490, 457, 499 Destination: 64 Annotation: Subtype: Link Rect: 432, 418, 439, 427 Destination: 131 Annotation: Subtype: Link Rect: 469, 358, 476, 367 Destination: 131 Annotation: Subtype: Link Rect: 490, 298, 497, 307 Destination: 131 Annotation: Subtype: Link Rect: 433, 165, 440, 175 Destination: 82 Thumb: true Page: Label: 796 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 114, 706, 117, 715 Destination: 64 Annotation: Subtype: Link Rect: 174, 694, 181, 703 Destination: 131 Annotation: Subtype: Link Rect: 155, 538, 171, 547 Destination: 131 Annotation: Subtype: Link Rect: 89, 430, 96, 439 Destination: 131 Annotation: Subtype: Link Rect: 214, 370, 221, 379 Destination: 131 Annotation: Subtype: Link Rect: 84, 171, 147, 179 Annotation: Subtype: Link Rect: 125, 117, 194, 125 Annotation: Subtype: Link Rect: 249, 144, 313, 152 Annotation: Subtype: Link Rect: 338, 117, 374, 125 Annotation: Subtype: Link Rect: 236, 108, 281, 116 Annotation: Subtype: Link Rect: 439, 180, 529, 188 Annotation: Subtype: Link Rect: 414, 99, 477, 107 Thumb: true Page: Label: 797 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 155, 687, 209, 695 Annotation: Subtype: Link Rect: 70, 678, 132, 686 Annotation: Subtype: Link Rect: 84, 597, 199, 605 Annotation: Subtype: Link Rect: 84, 534, 179, 542 Annotation: Subtype: Link Rect: 154, 480, 209, 488 Annotation: Subtype: Link Rect: 71, 471, 95, 479 Annotation: Subtype: Link Rect: 125, 336, 188, 344 Annotation: Subtype: Link Rect: 129, 264, 193, 272 Annotation: Subtype: Link Rect: 84, 192, 171, 200 Annotation: Subtype: Link Rect: 137, 120, 200, 128 Annotation: Subtype: Link Rect: 125, 66, 189, 74 Annotation: Subtype: Link Rect: 290, 642, 354, 650 Annotation: Subtype: Link Rect: 343, 579, 374, 587 Annotation: Subtype: Link Rect: 236, 570, 300, 578 Annotation: Subtype: Link Rect: 249, 516, 319, 524 Annotation: Subtype: Link Rect: 249, 453, 320, 461 Annotation: Subtype: Link Rect: 282, 399, 346, 407 Annotation: Subtype: Link Rect: 249, 264, 313, 272 Annotation: Subtype: Link Rect: 249, 183, 312, 191 Annotation: Subtype: Link Rect: 340, 138, 374, 146 Annotation: Subtype: Link Rect: 236, 129, 307, 137 Annotation: Subtype: Link Rect: 343, 75, 374, 83 Annotation: Subtype: Link Rect: 236, 66, 268, 74 Annotation: Subtype: Link Rect: 490, 669, 539, 677 Annotation: Subtype: Link Rect: 400, 660, 443, 668 Annotation: Subtype: Link Rect: 493, 606, 539, 614 Annotation: Subtype: Link Rect: 401, 597, 419, 605 Annotation: Subtype: Link Rect: 493, 534, 539, 542 Annotation: Subtype: Link Rect: 401, 525, 414, 533 Annotation: Subtype: Link Rect: 508, 390, 539, 398 Annotation: Subtype: Link Rect: 401, 381, 433, 389 Annotation: Subtype: Link Rect: 414, 300, 478, 308 Annotation: Subtype: Link Rect: 467, 228, 531, 236 Annotation: Subtype: Link Rect: 414, 174, 478, 182 Annotation: Subtype: Link Rect: 493, 102, 539, 110 Annotation: Subtype: Link Rect: 401, 93, 419, 101 Thumb: true Page: Label: 798 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 84, 660, 148, 668 Annotation: Subtype: Link Rect: 163, 579, 209, 587 Annotation: Subtype: Link Rect: 71, 570, 88, 578 Annotation: Subtype: Link Rect: 178, 525, 209, 533 Annotation: Subtype: Link Rect: 70, 516, 129, 524 Annotation: Subtype: Link Rect: 178, 471, 209, 479 Annotation: Subtype: Link Rect: 71, 462, 130, 470 Annotation: Subtype: Link Rect: 301, 660, 374, 668 Annotation: Subtype: Link Rect: 236, 651, 264, 659 Annotation: Subtype: Link Rect: 249, 588, 346, 596 Annotation: Subtype: Link Rect: 316, 525, 374, 533 Annotation: Subtype: Link Rect: 235, 516, 279, 524 Annotation: Subtype: Link Rect: 343, 471, 374, 479 Annotation: Subtype: Link Rect: 236, 462, 295, 470 Annotation: Subtype: Link Rect: 508, 660, 539, 668 Annotation: Subtype: Link Rect: 401, 651, 461, 659 Annotation: Subtype: Link Rect: 415, 597, 505, 605 Annotation: Subtype: Link Rect: 456, 534, 520, 542 Annotation: Subtype: Link Rect: 414, 480, 520, 488 Thumb: true Checksum: d7f9b9e3 Type: CRC32 Checksum: cf5b6d3893f8f86b52a48a11da77df96 Type: MD5 Checksum: 25c48c1546b3c41d4699dcb8ce4458cb3655b618 Type: SHA-1 Checksum: 63ad64b73139f760a704a6d659c5b4f469ed4bf65c554c59943bffc018ded421 Type: SHA-256