5d0ddfaf17cd5a8ed604b5bf44f262c7 annclitra_a2025m7v12n7p1465.pdf f51285acceccc94827d8b80d9311455a341b6735 annclitra_a2025m7v12n7p1465.pdf daf2f1583f45d04d2bcdd97be433b618b775ad34b5f26145ee3a0ab00759f8b5 annclitra_a2025m7v12n7p1465.pdf Title: Translating Muscle RNAseq Into the Clinic for the Diagnosis of Muscle Diseases Subject: Ann Clin Transl Neurol 2025.12:1465-1479 Creator: Adobe InDesign 19.5 (Windows) Producer: Adobe PDF Library 17.0; modified using iText 4.2.0 by 1T3XT CreationDate: Mon Jul 7 09:43:01 2025 CEST ModDate: Wed Apr 22 09:24:49 2026 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 8142147 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WFQTSB+STIXTwoText-Italic Type 1C WinAnsi yes yes yes 57 0 LHCVUX+STIXTwoText-BoldItalic Type 1C WinAnsi yes yes yes 149 0 TLAWCH+STIXTwoText Type 1C Custom yes yes yes 55 0 TJZMCH+ArialRoundedMTBold Type 1C WinAnsi yes yes no 600 0 TBBRCH+STIXTwoText-Bold Type 1C Custom yes yes yes 56 0 Times-Roman Type 1 WinAnsi no no no 5 0 SKKGOJ+STIXMath-Regular Type 1C Custom yes yes yes 147 0 SKKGOJ+STIXMath-Regular Type 1C Custom yes yes yes 148 0 RGAAAL+STIX-Bold Type 1C Custom yes yes yes 217 0 DLXUMN+STIX-Regular Type 1C Custom yes yes yes 218 0 SKKGOJ+STIXMath-Regular Type 1C Custom yes yes yes 275 0 SKKGOJ+STIXMath-Regular Type 1C Custom yes yes yes 276 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-04-23 04:06:14 CEST RepresentationInformation: annclitra_a2025m7v12n7p1465.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-04-22 09:25:58 CEST Size: 8142147 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Translating Muscle RNAseq Into the Clinic for the Diagnosis of Muscle Diseases Children: Item: Title: ABSTRACT Item: Title: 1   |   Introduction Item: Title: 2   |   Materials and Methods Children: Item: Title: 2.1   |   Patients Item: Title: 2.2   |   RNA Extraction, Library Preparation, and Sequencing Item: Title: 2.3   |   RNAseq Data Analysis Item: Title: 2.4   |   Aberrant Splicing Item: Title: 2.5   |   Gene Expression Item: Title: 2.6   |   Variant Calling (VC) Item: Title: 2.7   |   Monoallelic Expression (MAE) Item: Title: 2.8   |   Prioritization, Interpretation, and Validation Item: Title: 3   |   Results Children: Item: Title: 3.1   |   Muscle Transcriptome Analysis in a Cohort of 70 Genetically Unsolved Cases Item: Title: 3.2   |   Aberrant Splicing Detection Item: Title: 3.3   |   VUS Reclassification Children: Item: Title: 3.3.1   |   Aberrant Splicing Caused by an Apparent Synonymous RYR1 Variant Item: Title: 3.3.2   |   Intron Retention due to a Missense TTN Variant Item: Title: 3.4   |   RNAseq Accelerates Prioritization of GS Results Children: Item: Title: 3.4.1   |   Exon Skipping due to an Exon Deletion Missed by CNV Callers Item: Title: 3.4.2   |   Identification ofEight Down-Expressed Genes Underlying a De Novo Deletion Item: Title: 3.4.3   |   Detection of Monoallelic Expression in an Autosomal Recessive Gene Probably due to a 5'UTR Deletion Item: Title: 4   |   Discussion Item: Title: Author Contributions Item: Title: Acknowledgments Item: Title: Conflicts of Interest Item: Title: Data Availability Statement Item: Title: References Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1895 ImageHeight: 2002 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2048 ImageHeight: 2098 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2085 ImageHeight: 2083 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2054 ImageHeight: 2548 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: SKKGOJ+STIXMath-Regular FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: SKKGOJ+STIXMath-Regular Flags: Symbolic FontBBox: 0, -189, 637, 690 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SKKGOJ+STIXMath-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: SKKGOJ+STIXMath-Regular Flags: Symbolic FontBBox: 0, -189, 637, 690 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SKKGOJ+STIXMath-Regular FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: SKKGOJ+STIXMath-Regular Flags: Symbolic FontBBox: 0, -189, 637, 690 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SKKGOJ+STIXMath-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: SKKGOJ+STIXMath-Regular Flags: Symbolic FontBBox: 0, -189, 637, 690 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: LHCVUX+STIXTwoText-BoldItalic FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: LHCVUX+STIXTwoText-BoldItalic Flags: Serif, Nonsymbolic, Italic FontBBox: -893, -427, 1451, 1047 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: TLAWCH+STIXTwoText FontSubset: true FirstChar: 27 LastChar: 252 FontDescriptor: FontName: TLAWCH+STIXTwoText Flags: Serif, Nonsymbolic FontBBox: -948, -373, 1297, 1047 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: TJZMCH+ArialRoundedMTBold FontSubset: true FirstChar: 32 LastChar: 83 FontDescriptor: FontName: TJZMCH+ArialRoundedMTBold Flags: Nonsymbolic FontBBox: -174, -211, 1185, 946 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: TBBRCH+STIXTwoText-Bold FontSubset: true FirstChar: 27 LastChar: 124 FontDescriptor: FontName: TBBRCH+STIXTwoText-Bold Flags: Serif, Nonsymbolic FontBBox: -948, -434, 1429, 1047 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WFQTSB+STIXTwoText-Italic FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: WFQTSB+STIXTwoText-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -893, -362, 1298, 1047 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: RGAAAL+STIX-Bold FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: RGAAAL+STIX-Bold Flags: Serif, Nonsymbolic FontBBox: -998, -552, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: DLXUMN+STIX-Regular FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: DLXUMN+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: application/pdfdoi:10.1002/acn3.70078 10.1002/acn3.70078https://doi.org/10.1002/acn3.70078 2025-05-25trueonlinelibrary.wiley.com10.1002/acn3.70078 onlinelibrary.wiley.comtrue10.1002/acn3.700782025-05-25 VoR Pages: Page: Label: 1465 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 45, 26, 149, 16 Annotation: Subtype: Link Rect: 162, 672, 217, 656 Annotation: Subtype: Link Rect: 120, 582, 138, 569 ActionDest: 526 Annotation: Subtype: Link Rect: 138, 583, 151, 571 Annotation: Subtype: Link Rect: 280, 582, 288, 569 ActionDest: 526 Annotation: Subtype: Link Rect: 393, 582, 405, 569 ActionDest: 526 Annotation: Subtype: Link Rect: 405, 583, 418, 571 Annotation: Subtype: Link Rect: 510, 582, 518, 569 ActionDest: 526 Annotation: Subtype: Link Rect: 140, 571, 146, 558 ActionDest: 526 Annotation: Subtype: Link Rect: 233, 571, 244, 558 ActionDest: 526 Annotation: Subtype: Link Rect: 244, 572, 257, 560 Annotation: Subtype: Link Rect: 319, 571, 331, 558 ActionDest: 526 Annotation: Subtype: Link Rect: 331, 572, 343, 560 Annotation: Subtype: Link Rect: 403, 571, 416, 558 ActionDest: 526 Annotation: Subtype: Link Rect: 474, 571, 489, 558 ActionDest: 526 Annotation: Subtype: Link Rect: 125, 560, 147, 547 ActionDest: 526 Annotation: Subtype: Link Rect: 256, 560, 276, 547 ActionDest: 526 Annotation: Subtype: Link Rect: 371, 560, 374, 547 ActionDest: 526 Annotation: Subtype: Link Rect: 470, 560, 476, 547 ActionDest: 526 Annotation: Subtype: Link Rect: 106, 549, 112, 536 ActionDest: 526 Annotation: Subtype: Link Rect: 226, 549, 249, 536 ActionDest: 526 Annotation: Subtype: Link Rect: 376, 549, 394, 536 ActionDest: 526 Annotation: Subtype: Link Rect: 511, 549, 523, 536 ActionDest: 526 Annotation: Subtype: Link Rect: 523, 550, 536, 538 Annotation: Subtype: Link Rect: 124, 538, 131, 525 ActionDest: 526 Annotation: Subtype: Link Rect: 239, 538, 270, 525 ActionDest: 526 Annotation: Subtype: Link Rect: 336, 538, 355, 525 ActionDest: 526 Annotation: Subtype: Link Rect: 442, 538, 455, 525 ActionDest: 526 Annotation: Subtype: Link Rect: 110, 527, 121, 514 ActionDest: 526 Annotation: Subtype: Link Rect: 183, 527, 195, 514 ActionDest: 526 Annotation: Subtype: Link Rect: 250, 527, 264, 514 ActionDest: 526 Annotation: Subtype: Link Rect: 369, 527, 369, 514 Annotation: Subtype: Link Rect: 369, 527, 369, 514 Annotation: Subtype: Link Rect: 369, 527, 387, 514 ActionDest: 526 Annotation: Subtype: Link Rect: 191, 277, 266, 266 Annotation: Subtype: Link Rect: 270, 277, 348, 266 Annotation: Subtype: Link Rect: 202, 78, 380, 68 Annotation: Subtype: Link Rect: 519, 782, 595, 767 Page: Label: 1466 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 156, 304, 159, 291 ActionDest: 325 Annotation: Subtype: Link Rect: 193, 281, 206, 268 ActionDest: 325 Annotation: Subtype: Link Rect: 99, 189, 113, 176 ActionDest: 325 Annotation: Subtype: Link Rect: 126, 132, 144, 119 ActionDest: 325 Annotation: Subtype: Link Rect: 308, 511, 330, 498 ActionDest: 325 Annotation: Subtype: Link Rect: 443, 511, 452, 498 ActionDest: 325 Annotation: Subtype: Link Rect: 308, 442, 331, 429 ActionDest: 325 Annotation: Subtype: Link Rect: 445, 408, 467, 395 ActionDest: 325 Page: Label: 1467 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 196, 401, 205, 388 ActionDest: 506 Annotation: Subtype: Link Rect: 105, 325, 114, 313 ActionDest: 411 Annotation: Subtype: Link Rect: 153, 325, 165, 313 ActionDest: 126 Annotation: Subtype: Link Rect: 138, 252, 146, 239 ActionDest: 325 Annotation: Subtype: Link Rect: 239, 252, 248, 239 ActionDest: 411 Annotation: Subtype: Link Rect: 107, 240, 131, 228 ActionDest: 411 Annotation: Subtype: Link Rect: 259, 240, 283, 228 ActionDest: 411 Annotation: Subtype: Link Rect: 205, 229, 214, 216 ActionDest: 506 Annotation: Subtype: Link Rect: 165, 130, 173, 118 ActionDest: 411 Annotation: Subtype: Link Rect: 94, 61, 102, 49 ActionDest: 411 Annotation: Subtype: Link Rect: 411, 740, 420, 727 ActionDest: 411 Annotation: Subtype: Link Rect: 411, 728, 420, 716 ActionDest: 506 Annotation: Subtype: Link Rect: 308, 659, 318, 647 ActionDest: 411 Annotation: Subtype: Link Rect: 309, 648, 333, 635 ActionDest: 325 Annotation: Subtype: Link Rect: 481, 544, 490, 532 ActionDest: 506 Annotation: Subtype: Link Rect: 343, 510, 355, 497 ActionDest: 126 Annotation: Subtype: Link Rect: 439, 383, 450, 371 ActionDest: 126 Annotation: Subtype: Link Rect: 308, 314, 317, 302 ActionDest: 411 Annotation: Subtype: Link Rect: 348, 314, 356, 302 ActionDest: 506 Annotation: Subtype: Link Rect: 455, 245, 464, 233 ActionDest: 506 Annotation: Subtype: Link Rect: 389, 234, 398, 221 ActionDest: 506 Annotation: Subtype: Link Rect: 361, 211, 370, 198 ActionDest: 506 Annotation: Subtype: Link Rect: 379, 188, 388, 175 ActionDest: 411 Annotation: Subtype: Link Rect: 524, 85, 533, 72 ActionDest: 506 Page: Label: 1468 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 82, 109, 91, 96 ActionDest: 506 Annotation: Subtype: Link Rect: 150, 109, 159, 96 ActionDest: 506 Annotation: Subtype: Link Rect: 191, 109, 200, 96 ActionDest: 506 Annotation: Subtype: Link Rect: 239, 74, 248, 61 ActionDest: 126 Annotation: Subtype: Link Rect: 279, 74, 283, 61 ActionDest: 142 Annotation: Subtype: Link Rect: 537, 63, 547, 50 ActionDest: 126 Page: Label: 1469 Sequence: 5 Page: Label: 1470 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 68, 751, 72, 739 ActionDest: 142 Annotation: Subtype: Link Rect: 48, 694, 70, 681 ActionDest: 411 Annotation: Subtype: Link Rect: 209, 694, 219, 681 ActionDest: 126 Annotation: Subtype: Link Rect: 98, 625, 108, 612 ActionDest: 126 Annotation: Subtype: Link Rect: 79, 510, 88, 497 ActionDest: 506 Annotation: Subtype: Link Rect: 216, 498, 227, 486 ActionDest: 207 Annotation: Subtype: Link Rect: 125, 372, 135, 359 ActionDest: 207 Annotation: Subtype: Link Rect: 76, 337, 86, 325 ActionDest: 207 Annotation: Subtype: Link Rect: 79, 268, 99, 255 ActionDest: 207 Annotation: Subtype: Link Rect: 132, 268, 136, 255 ActionDest: 215 Annotation: Subtype: Link Rect: 78, 245, 89, 232 ActionDest: 207 Annotation: Subtype: Link Rect: 78, 233, 90, 221 ActionDest: 207 Annotation: Subtype: Link Rect: 272, 233, 283, 221 ActionDest: 207 Annotation: Subtype: Link Rect: 533, 705, 544, 693 ActionDest: 223 Annotation: Subtype: Link Rect: 497, 659, 507, 647 ActionDest: 223 Annotation: Subtype: Link Rect: 536, 648, 546, 635 ActionDest: 223 Annotation: Subtype: Link Rect: 337, 636, 357, 624 ActionDest: 223 Annotation: Subtype: Link Rect: 337, 625, 348, 612 ActionDest: 223 Annotation: Subtype: Link Rect: 435, 613, 446, 601 ActionDest: 223 Annotation: Subtype: Link Rect: 514, 452, 526, 440 ActionDest: 223 Annotation: Subtype: Link Rect: 512, 383, 516, 371 ActionDest: 215 Annotation: Subtype: Link Rect: 494, 337, 506, 325 ActionDest: 223 Page: Label: 1471 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 275, 120, 286, 108 ActionDest: 207 Annotation: Subtype: Link Rect: 158, 204, 162, 192 ActionDest: 215 Page: Label: 1472 Sequence: 8 Page: Label: 1473 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 276, 60, 286, 48 ActionDest: 241 Annotation: Subtype: Link Rect: 424, 118, 434, 105 ActionDest: 241 Annotation: Subtype: Link Rect: 537, 72, 547, 59 ActionDest: 241 Annotation: Subtype: Link Rect: 330, 60, 334, 48 ActionDest: 215 Page: Label: 1474 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 391, 95, 401, 82 ActionDest: 241 Page: Label: 1475 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 207, 624, 218, 611 ActionDest: 241 Annotation: Subtype: Link Rect: 156, 578, 168, 565 ActionDest: 241 Annotation: Subtype: Link Rect: 126, 390, 135, 377 ActionDest: 506 Annotation: Subtype: Link Rect: 148, 379, 152, 366 ActionDest: 325 Annotation: Subtype: Link Rect: 175, 199, 183, 186 ActionDest: 506 Annotation: Subtype: Link Rect: 113, 130, 122, 117 ActionDest: 411 Annotation: Subtype: Link Rect: 338, 567, 349, 554 ActionDest: 126 Annotation: Subtype: Link Rect: 380, 567, 384, 554 ActionDest: 142 Annotation: Subtype: Link Rect: 416, 486, 425, 473 ActionDest: 506 Annotation: Subtype: Link Rect: 536, 475, 544, 462 ActionDest: 411 Annotation: Subtype: Link Rect: 540, 394, 544, 381 ActionDest: 142 Annotation: Subtype: Link Rect: 391, 360, 442, 347 ActionDest: 325 Annotation: Subtype: Link Rect: 493, 187, 524, 174 ActionDest: 325 Annotation: Subtype: Link Rect: 535, 164, 544, 151 ActionDest: 506 Annotation: Subtype: Link Rect: 468, 61, 476, 48 ActionDest: 411 Page: Label: 1476 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 107, 751, 111, 739 ActionDest: 241 Annotation: Subtype: Link Rect: 91, 694, 100, 681 ActionDest: 411 Annotation: Subtype: Link Rect: 149, 671, 172, 658 ActionDest: 411 Annotation: Subtype: Link Rect: 275, 636, 283, 624 ActionDest: 325 Annotation: Subtype: Link Rect: 251, 602, 255, 589 ActionDest: 215 Annotation: Subtype: Link Rect: 118, 556, 129, 543 ActionDest: 207 Annotation: Subtype: Link Rect: 144, 521, 148, 509 ActionDest: 215 Annotation: Subtype: Link Rect: 222, 510, 245, 497 ActionDest: 411 Annotation: Subtype: Link Rect: 275, 498, 286, 486 ActionDest: 207 Annotation: Subtype: Link Rect: 261, 280, 283, 267 ActionDest: 411 Annotation: Subtype: Link Rect: 78, 119, 102, 106 ActionDest: 325 Annotation: Subtype: Link Rect: 48, 84, 87, 72 ActionDest: 325 Annotation: Subtype: Link Rect: 164, 61, 173, 49 ActionDest: 506 Annotation: Subtype: Link Rect: 205, 61, 209, 49 ActionDest: 215 Annotation: Subtype: Link Rect: 338, 567, 348, 555 ActionDest: 126 Annotation: Subtype: Link Rect: 377, 567, 381, 555 ActionDest: 142 Annotation: Subtype: Link Rect: 308, 556, 332, 543 ActionDest: 411 Annotation: Subtype: Link Rect: 424, 418, 446, 405 ActionDest: 506 Annotation: Subtype: Link Rect: 497, 268, 517, 256 ActionDest: 207 Annotation: Subtype: Link Rect: 415, 245, 426, 233 ActionDest: 126 Page: Label: 1477 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 48, 481, 186, 470 Annotation: Subtype: Link Rect: 263, 481, 289, 470 Annotation: Subtype: Link Rect: 45, 471, 174, 460 Annotation: Subtype: Link Rect: 222, 471, 289, 460 Annotation: Subtype: Link Rect: 45, 461, 118, 450 Annotation: Subtype: Link Rect: 181, 461, 289, 450 Annotation: Subtype: Link Rect: 45, 451, 143, 440 Annotation: Subtype: Link Rect: 202, 451, 289, 440 Annotation: Subtype: Link Rect: 45, 441, 108, 430 Annotation: Subtype: Link Rect: 144, 441, 267, 430 Annotation: Subtype: Link Rect: 83, 431, 286, 420 Annotation: Subtype: Link Rect: 204, 360, 289, 349 Annotation: Subtype: Link Rect: 45, 350, 104, 339 Annotation: Subtype: Link Rect: 237, 315, 289, 304 Annotation: Subtype: Link Rect: 45, 305, 139, 294 Annotation: Subtype: Link Rect: 86, 260, 217, 249 Annotation: Subtype: Link Rect: 109, 215, 220, 204 Annotation: Subtype: Link Rect: 141, 170, 261, 159 Annotation: Subtype: Link Rect: 120, 135, 258, 124 Annotation: Subtype: Link Rect: 100, 90, 248, 79 Annotation: Subtype: Link Rect: 337, 741, 486, 730 Annotation: Subtype: Link Rect: 364, 686, 486, 675 Annotation: Subtype: Link Rect: 391, 631, 536, 620 Annotation: Subtype: Link Rect: 306, 586, 429, 575 Annotation: Subtype: Link Rect: 524, 541, 549, 530 Annotation: Subtype: Link Rect: 306, 531, 431, 520 Annotation: Subtype: Link Rect: 512, 496, 549, 485 Annotation: Subtype: Link Rect: 306, 486, 392, 475 Annotation: Subtype: Link Rect: 524, 451, 549, 440 Annotation: Subtype: Link Rect: 306, 441, 435, 430 Annotation: Subtype: Link Rect: 524, 406, 549, 395 Annotation: Subtype: Link Rect: 306, 396, 405, 385 Annotation: Subtype: Link Rect: 306, 351, 456, 340 Annotation: Subtype: Link Rect: 393, 316, 545, 305 Annotation: Subtype: Link Rect: 497, 281, 549, 270 Annotation: Subtype: Link Rect: 306, 271, 398, 260 Annotation: Subtype: Link Rect: 339, 226, 480, 215 Annotation: Subtype: Link Rect: 355, 191, 485, 180 Annotation: Subtype: Link Rect: 380, 146, 496, 135 Annotation: Subtype: Link Rect: 395, 111, 539, 100 Annotation: Subtype: Link Rect: 426, 75, 549, 64 Annotation: Subtype: Link Rect: 306, 65, 332, 54 Page: Label: 1478 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 85, 721, 226, 710 Annotation: Subtype: Link Rect: 251, 686, 289, 675 Annotation: Subtype: Link Rect: 45, 676, 169, 665 Annotation: Subtype: Link Rect: 101, 631, 242, 620 Annotation: Subtype: Link Rect: 227, 586, 289, 575 Annotation: Subtype: Link Rect: 45, 576, 121, 565 Annotation: Subtype: Link Rect: 208, 531, 289, 520 Annotation: Subtype: Link Rect: 45, 521, 115, 510 Annotation: Subtype: Link Rect: 183, 486, 289, 475 Annotation: Subtype: Link Rect: 45, 476, 86, 465 Annotation: Subtype: Link Rect: 102, 441, 222, 430 Annotation: Subtype: Link Rect: 101, 406, 246, 395 Annotation: Subtype: Link Rect: 263, 381, 289, 370 Annotation: Subtype: Link Rect: 45, 371, 177, 360 Annotation: Subtype: Link Rect: 151, 346, 289, 335 Annotation: Subtype: Link Rect: 45, 336, 274, 325 Annotation: Subtype: Link Rect: 165, 301, 289, 290 Annotation: Subtype: Link Rect: 45, 291, 73, 280 Annotation: Subtype: Link Rect: 187, 256, 289, 245 Annotation: Subtype: Link Rect: 45, 246, 91, 235 Annotation: Subtype: Link Rect: 244, 211, 289, 200 Annotation: Subtype: Link Rect: 45, 201, 289, 190 Annotation: Subtype: Link Rect: 45, 191, 289, 180 Annotation: Subtype: Link Rect: 45, 181, 289, 170 Annotation: Subtype: Link Rect: 45, 171, 63, 160 Annotation: Subtype: Link Rect: 133, 116, 276, 105 Annotation: Subtype: Link Rect: 45, 61, 182, 50 Annotation: Subtype: Link Rect: 497, 731, 549, 720 Annotation: Subtype: Link Rect: 306, 721, 366, 710 Annotation: Subtype: Link Rect: 306, 676, 422, 665 Annotation: Subtype: Link Rect: 363, 631, 505, 620 Annotation: Subtype: Link Rect: 431, 586, 549, 575 Annotation: Subtype: Link Rect: 306, 576, 328, 565 Annotation: Subtype: Link Rect: 306, 531, 454, 520 Annotation: Subtype: Link Rect: 306, 496, 423, 485 Annotation: Subtype: Link Rect: 371, 461, 511, 450 Annotation: Subtype: Link Rect: 469, 426, 549, 415 Annotation: Subtype: Link Rect: 306, 416, 372, 405 Annotation: Subtype: Link Rect: 306, 371, 440, 360 Annotation: Subtype: Link Rect: 427, 336, 549, 325 Annotation: Subtype: Link Rect: 306, 326, 332, 315 Annotation: Subtype: Link Rect: 381, 291, 530, 280 Annotation: Subtype: Link Rect: 306, 236, 446, 225 Annotation: Subtype: Link Rect: 403, 191, 521, 180 Annotation: Subtype: Link Rect: 306, 136, 454, 125 Annotation: Subtype: Link Rect: 338, 89, 490, 78 Page: Label: 1479 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 167, 751, 289, 740 Annotation: Subtype: Link Rect: 45, 741, 74, 730 Annotation: Subtype: Link Rect: 116, 696, 264, 685 Annotation: Subtype: Link Rect: 65, 651, 197, 640 Annotation: Subtype: Link Rect: 251, 616, 289, 605 Annotation: Subtype: Link Rect: 45, 606, 148, 595 Checksum: ceb7cce1 Type: CRC32 Checksum: 5d0ddfaf17cd5a8ed604b5bf44f262c7 Type: MD5 Checksum: f51285acceccc94827d8b80d9311455a341b6735 Type: SHA-1 Checksum: daf2f1583f45d04d2bcdd97be433b618b775ad34b5f26145ee3a0ab00759f8b5 Type: SHA-256