ee0e72e63eca12b20c787d5ecc96bfb8 biomedicines-13-01030.pdf 6e193431b336d3f640e2406c9b4efb5eeae9d016 biomedicines-13-01030.pdf dcda59bf387fe0ffe6e6b2dcd76f234a185420beac397ffdc8c644b886fb4bd4 biomedicines-13-01030.pdf Title: The Role of miRNAs as Early Biomarkers in Obesity-Related Glomerulopathy: Implications for Early Detection and Treatment Subject: Obesity increases the risk of cardiovascular disease, diabetes and chronic kidney disease. Obesity-related glomerulopathy (ORG) is a potentially reversible cause of kidney disease that often progresses silently until it reaches irreversible stages. However, we are still lacking a sensitive and specific biomarker to identify patients with obesity who are at risk of developing CKD. The role of microRNAs (miRNAs) has emerged as a promising area for diagnostic and therapeutic applications in kidney disease. Recent research has highlighted the specific roles of various miRNAs in renal function, showing that their dysregulation can contribute to the development of kidney diseases. This review will discuss the emerging role of miRNAs in the context of ORG, focusing on their potential as biomarkers and therapeutic targets for this increasingly prevalent disease. Keywords: microRNA; biomarker; obesity-related glomerulopathy Author: Maruja Navarro-Díaz and Marina López-Martínez Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Thu Apr 24 11:38:06 2025 CEST ModDate: Thu Apr 24 11:42:46 2025 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1064878 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EFHXCQ+VnURWPalladioL Type 1 Custom yes yes yes 10 0 KAVLHE+URWPalladioL-Roma Type 1 Custom yes yes yes 16 0 ORLFOC+URWPalladioL-Bold Type 1 Custom yes yes yes 22 0 YQDTPU+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 DLHIJN+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 59 0 DLHIKN+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 65 0 DLHILO+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 71 0 DLHILP+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 77 0 DLHIMA+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 80 0 DLHIMB+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 83 0 DLHJFO+PalatinoLinotype-Roman TrueType MacRoman yes yes no 86 0 LHCXDL+EURM10 Type 1 Builtin yes yes yes 97 0 MMNAIC+CMSY10 Type 1 Builtin yes yes yes 108 0 DLHIJN+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 122 0 DLHOBF+Arial-BoldMT TrueType WinAnsi yes yes no 128 0 DLHIKN+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 131 0 DLHILO+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 137 0 DLHILP+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 143 0 DLHIMA+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 146 0 DLHIMB+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 149 0 DLHJFO+PalatinoLinotype-Roman TrueType MacRoman yes yes no 152 0 DLHOAE+Calibri-Bold CID TrueType Identity-H yes yes yes 155 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-06-03 02:07:37 CEST RepresentationInformation: biomedicines-13-01030.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-06-02 15:03:21 CEST Size: 1064878 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 378 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: MicroRNAs: Biological Functions and Roles in Obesity-Associated Pathophysiology Destination: section.2 Item: Title: An Overview of miRNA Changes in Different Diseases, with an Emphasis on Renal Pathologies Destination: section.3 Item: Title: The Emerging Role of miRNAs in Obesity-Related Glomerulopathy Destination: section.4 Item: Title: Future Perspectives and Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: The Role of miRNAs as Early Biomarkers in Obesity-Related Glomerulopathy: Implications for Early Detection and Treatment Author: Maruja Navarro-Díaz and Marina López-Martínez Subject: Obesity increases the risk of cardiovascular disease, diabetes and chronic kidney disease. Obesity-related glomerulopathy (ORG) is a potentially reversible cause of kidney disease that often progresses silently until it reaches irreversible stages. However, we are still lacking a sensitive and specific biomarker to identify patients with obesity who are at risk of developing CKD. The role of microRNAs (miRNAs) has emerged as a promising area for diagnostic and therapeutic applications in kidney disease. Recent research has highlighted the specific roles of various miRNAs in renal function, showing that their dysregulation can contribute to the development of kidney diseases. This review will discuss the emerging role of miRNAs in the context of ORG, focusing on their potential as biomarkers and therapeutic targets for this increasingly prevalent disease. 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