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Title:           NK cell depletion in bispecific antibody therapy is associated with lack of HIV control after ART interruption
Subject:         Communications Biology, doi:10.1038/s42003-025-07651-6
Keywords:        
Author:          N. Sánchez-Gaona
Creator:         Springer
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      Title: NK cell depletion in bispecific antibody therapy is associated with lack of HIV control after ART interruption
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       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: Bi-Ab32/16 promotes specific cell-to-cell contact between HIV-expressing CD4+ T and NK cells, and shifts the NK cell phenotype
          Destination: B1
         Item: 
          Title: Bi-Ab32/16 elicits robust NK cell activation and ADCC responses in the presence of HIV-expressing cells
          Destination: B2
         Item: 
          Title: Bi-Ab32/16 effectively binds and elicits a robust ADCC response against ex vivo HIV-infected cells
          Destination: B3
         Item: 
          Title: Bi-Ab32/16 enhances the NK-mediated killing of latently HIV-infected cells from PWH following viral reactivation
          Destination: B4
         Item: 
          Title: Evaluation of the Bi-Ab32/16 in a humanized mice model expressing IL-15
          Destination: B5
         Item: 
          Title: Bi-Ab32/16 modulates NK cell dynamics in vivo
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        Title: Discussion
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       Item: 
        Title: Materials and methods
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         Item: 
          Title: Ethics statement
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         Item: 
          Title: Cells, antibodies, and reagents
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         Item: 
          Title: Cell binding assays
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         Item: 
          Title: NK cell phenotyping
          Destination: B10
         Item: 
          Title: Cell-to-cell contact assays
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         Item: 
          Title: NK cell activation and functional activity assays
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         Item: 
          Title: Antibody-dependent cell-mediated cytotoxicity (ADCC) assays
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         Item: 
          Title: Ex vivo infection of CD4+ T cells and functional ADCC assay
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         Item: 
          Title: Viral reactivation in ART-suppressed PWH samples
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         Item: 
          Title: NK killing of cells harboring intact provirus
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         Item: 
          Title: Intact proviral DNA assay (IPDA)
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         Item: 
          Title: Animal model
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         Item: 
          Title: In vivo sample processing
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         Item: 
          Title: Viral load determination
          Destination: B20
         Item: 
          Title: Longitudinal analysis of immune populations and NK cell phenotype by flow cytometry in HIV-infected Hu-NSG-Tg (IL-15) mice
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         Item: 
          Title: Dimensionality reduction analysis
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         Item: 
          Title: Study approval
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          Title: Statistics and reproducibility
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         Item: 
          Title: Reporting summary
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        Title: Data availability
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       Item: 
        Title: References
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       Item: 
        Title: Acknowledgements
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       Item: 
        Title: Author contributions
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       Item: 
        Title: Competing interests
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       Item: 
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    Author: N. Sánchez-Gaona
    Subject: Communications Biology, doi:10.1038/s42003-025-07651-6
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Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

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                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
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                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
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                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
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                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
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                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
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SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
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