db0c82c124f2ddaf318cffe7eb3041a0 2025-07-02_Front_Public_Health_1_article_SupplMat_002.pdf 30b6fa5f6af6d17ed8722390afc71f14458db397 2025-07-02_Front_Public_Health_1_article_SupplMat_002.pdf e8c317b71463e3c4b9b861a462446b7b704ec496149d8f54eabf30914183402f 2025-07-02_Front_Public_Health_1_article_SupplMat_002.pdf Title: Stability of cytokine and immunoglobulin concentrations in the general population: prepandemic basal concentrations and intraindividual changes until the COVID-19 pandemic Subject: Gasull M, Pumarega J, Aguilar R, Campi L, ​Prieto-Merino D, ​Villar-García J, Rius C, Bolúmar F, Trasande L, Dobaño C, Moncunill G and Porta M (2025) Stability of cytokine and immunoglobulin concentrations in the general population: prepandemic basal concentrations and intraindividual changes until the COVID-19 pandemic. Front. Public Health 13:1548379. doi: 10.3389/fpubh.2025.1548379 Author: Magda Gasull Creator: Adobe InDesign 19.5 (Windows) Producer: Adobe PDF Library 17.0 CreationDate: Sat Jun 28 12:22:34 2025 CEST ModDate: Mon Jul 7 15:43:51 2025 CEST Custom Metadata: no Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 115 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 16778176 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MMCIOF+MuseoSans-500 Type 1C Custom yes yes yes 46854 0 JFTQYL+MuseoSans-300 Type 1C Custom yes yes yes 46857 0 HCPEWP+MuseoSans-700 Type 1C Custom yes yes yes 46860 0 EAGMGV+MuseoSans-300Italic Type 1C WinAnsi yes yes yes 46862 0 DWRGSX+STIXGeneral-Regular Type 1C Custom yes yes yes 1184 0 BTSUQB+MinionPro-Regular Type 1C Custom yes yes yes 1186 0 PUJLEZ+STIXGeneral-Italic Type 1C 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PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Stability of cytokine and immunoglobulin concentrations in the general population: prepandemic basal concentrations and intraindividual changes until the COVID-19 pandemic Children: Item: Title: 1 Introduction Item: Title: 2 Methods Children: Item: Title: 2.1 Study population Item: Title: 2.2 Socioeconomic and living conditions Item: Title: 2.3 Quantification of cytokines, chemokines and growth factors Item: Title: 2.4 Serology of viral exposures Item: Title: 2.5 Quantification of total immunoglobulins Item: Title: 2.6 Determination of SARS-CoV-2 infection and COVID-19 disease Item: Title: 2.6.1 SARS-CoV-2 infection Item: Title: 2.6.2 COVID-19 disease Item: Title: 2.7 Comorbidities Item: Title: 2.8 Statistical analyses Item: Title: 3 Results Children: Item: Title: 3.1 Intraindividual change in concentrations of cytokines Item: Title: 3.2 Intraindividual change in concentrations of immunoglobulins against viral exposures and of total immunoglobulins Item: Title: 4 Discussion Item: Title: 5 Conclusion Item: Title: References Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 64 ImageHeight: 64 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3170 ImageHeight: 2064 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3804 ImageHeight: 2852 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3804 ImageHeight: 2889 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: 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2025-06-28T15:52:34+05:30 2025-06-28T15:52:34+05:30 2025-07-07T15:43:51+02:00 2025-07-07T15:43:51+02:00 Adobe InDesign 19.5 (Windows) application/pdf Stability of cytokine and immunoglobulin concentrations in the general population: prepandemic basal concentrations and intraindividual changes until the COVID-19 pandemic Magda Gasull José Pumarega Ruth Aguilar Laura Campi David Prieto-Merino Judit Villar-García Cristina Rius Francisco Bolúmar Leonardo Trasande Carlota Dobaño Gemma Moncunill Miquel Porta Gasull M, Pumarega J, Aguilar R, Campi L, ​Prieto-Merino D, ​Villar-García J, Rius C, Bolúmar F, Trasande L, Dobaño C, Moncunill G and Porta M (2025) Stability of cytokine and immunoglobulin concentrations in the general population: prepandemic basal concentrations and intraindividual changes until the COVID-19 pandemic. Front. Public Health 13:1548379. doi: 10.3389/fpubh.2025.1548379 cytokines immunoglobulins SARS-CoV-2 COVID-19 population-based Copyright © 2025 Gasull, Pumarega, Aguilar, Campi, Prieto-Merino, Villar-García, Rius, Bolúmar, Trasande, Dobaño, Moncunill and Porta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. 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