67fb7cd9bebaabb383ace01de979a365 315686.pdf dc052c730cab2f1e35812c388e7b3fb02533b5d3 315686.pdf 5075abf8446cbbcf8286a42b34890c3de85ecdbd3477c4923f01fe0b623219eb 315686.pdf Title: Diabetes Mellitus in Kidney Transplant Recipients: New Horizons in Treatment Subject: Diabetes mellitus (DM) in kidney transplant recipients (KTR) is a risk factor for mortality, increases the risk of infections and, in the long term, can lead to graft loss due to diabetic kidney disease. A preventive approach applied to those on the waiting list could decrease the incidence of post-transplant DM (PTDM) by detecting those patients at risk, thus allowing strategies to minimize the probability of developing a New Onset Diabetes After Transplant (NODAT). On the other hand, modifications of immunosuppressive therapy may improve glucose control in patients with KTR. In recent years, two new classes of antidiabetic drugs and non-steroidal mineralocorticoid receptor antagonists have demonstrated cardiovascular and renal benefits in randomized clinical trials where the transplant population has not been represented. Because of the potential benefit expected in this population, the clinical use of glucagon-like peptide-1 receptor agonists (GLP-1RA), sodium-glucose cotransporter 2 inhibitors (SGLT2i) and finerenone is increasing in the kidney transplant setting. This review focuses on comprehensive pharmacological interventions in KTR with glucose metabolism disorders. In-depth knowledge in this area will allow prevention and identification of potential adverse effects or drug interactions in the clinical course of KTR with DM. Keywords: post-transplant diabetes mellitus; diabetes mellitus; cardiovascular disease Author: Maya Sanchez-Baya, Mónica Bolufer, Federico Vázquez, Nuria Alonso, Elisabet Massó, Javier Paul, Veronica Coll-Brito, Omar Taco, Paula Anton-Pampols, Rosana Gelpi, Iara DaSilva, Ángela Casas, Rosely Rodríguez, Maria Molina, Laura Cañas, Anna Vila, Jordi Ara and Jordi Bover Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Fri Feb 7 10:12:58 2025 CET ModDate: Fri Feb 7 10:14:20 2025 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 283353 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WOEAAN+URWPalladioL-Roma Type 1 Custom yes yes yes 10 0 GDNPBJ+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 IKUMCN+URWPalladioL-Ital Type 1 Custom yes yes yes 21 0 LWLIVD+EURM10 Type 1 Builtin yes yes yes 47 0 PDTLUH+CMSY10 Type 1 Builtin yes yes yes 67 0 KCISZQ+VnURWPalladioL Type 1 Custom yes yes yes 78 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-07-25 02:49:33 CEST RepresentationInformation: 315686.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-07-24 14:42:23 CEST Size: 283353 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 373 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Risk Factors for Diabetes Mellitus Post Transplant Destination: section.2 Item: Title: Impact on Cardiovascular Health Destination: section.3 Item: Title: Complications and Long-Term Consequences of DM in KTR Destination: section.4 Item: Title: New Pharmacological Interventions in KTR Destination: section.5 Children: Item: Title: Sodium Glucose Cotransporter-2 Inhibitors Destination: subsection.5.1 Item: Title: Glucagon-like Peptide Receptor Agonists Destination: subsection.5.2 Item: Title: Finerenone Destination: subsection.5.3 Item: Title: Discussion Destination: section.6 Item: Title: Conclusions Destination: section.7 Item: Title: References Destination: section.8 Info: Title: Diabetes Mellitus in Kidney Transplant Recipients: New Horizons in Treatment Author: Maya Sanchez-Baya, Mónica Bolufer, Federico Vázquez, Nuria Alonso, Elisabet Massó, Javier Paul, Veronica Coll-Brito, Omar Taco, Paula Anton-Pampols, Rosana Gelpi, Iara DaSilva, Ángela Casas, Rosely Rodríguez, Maria Molina, Laura Cañas, Anna Vila, Jordi Ara and Jordi Bover Subject: Diabetes mellitus (DM) in kidney transplant recipients (KTR) is a risk factor for mortality, increases the risk of infections and, in the long term, can lead to graft loss due to diabetic kidney disease. A preventive approach applied to those on the waiting list could decrease the incidence of post-transplant DM (PTDM) by detecting those patients at risk, thus allowing strategies to minimize the probability of developing a New Onset Diabetes After Transplant (NODAT). On the other hand, modifications of immunosuppressive therapy may improve glucose control in patients with KTR. In recent years, two new classes of antidiabetic drugs and non-steroidal mineralocorticoid receptor antagonists have demonstrated cardiovascular and renal benefits in randomized clinical trials where the transplant population has not been represented. Because of the potential benefit expected in this population, the clinical use of glucagon-like peptide-1 receptor agonists (GLP-1RA), sodium-glucose cotransporter 2 inhibitors (SGLT2i) and finerenone is increasing in the kidney transplant setting. This review focuses on comprehensive pharmacological interventions in KTR with glucose metabolism disorders. In-depth knowledge in this area will allow prevention and identification of potential adverse effects or drug interactions in the clinical course of KTR with DM. 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