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Title:           An encapsulation-free oral subunit vaccine for VHSV: Inducing robust antiviral and antibody responses
Subject:         Aquaculture, 609 (2025) 742794. doi:10.1016/j.aquaculture.2025.742794
Keywords:        Recombinant protein,Nanoparticles,VHSV,Subunit vaccine,IFNγ,Oral delivery,Rainbow trout
Author:          Patricia Aceituno
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      Title: An encapsulation-free oral subunit vaccine for VHSV: Inducing robust antiviral and antibody responses
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        Title: 1 Introduction
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        Title: 2 Materials and methods
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          Title: 2.1 Design, production and quantification of VHSV-IFNNP
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            Title: 2.1.1 Viral strains and plasmids
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            Title: 2.1.2 Production and purification
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            Title: 2.1.3 Quantification, and fluorescent labelling
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          Title: 2.2 Morphometric characterization of VHSV-IFNNP
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          Title: 2.3 Functional characterization of VHSV-IFNNP subunit vaccine in vitro
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            Title: 2.3.1 Cell culture
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            Title: 2.3.2 Uptake of VHSV-IFNNP by RTgutGC and HKM cells
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            Title: 2.3.3 Gene expression analysis in HKM stimulated with VHSV-IFNNP
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          Title: 2.4 Functional characterization of VHSV-IFNNP subunit vaccine in vivo
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            Title: 2.4.1 Fish husbandry
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            Title: 2.4.2 Oral intubation of rainbow trout
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            Title: 2.4.3 Fish feed manufacturing and in-feed oral vaccination
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            Title: 2.4.4 Local response of gut leukocyte populations after oral administration of VHSV-IFNNP
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            Title: 2.4.5 Bio-distribution of VHSV-IFNNP vaccine administered by oral intubation
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            Title: 2.4.6 Antigen specific antibody titers and neutralization assays
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          Title: 2.5 RNA extraction, cDNA synthesis and qPCR
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          Title: 3.1 Characterization of the modular VHSV-IFNNP subunit vaccine
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          Title: 3.2 Uptake of subunit vaccine by RTgutGC and HKM cells
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          Title: 3.3 Gene expression analysis in HKM after VHSV-IFNNP treatment
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          Title: 3.4 Uptake of VHSV-IFNNP vaccine administered by oral intubation
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          Title: 3.5 Characterization of the local immune response of gut leukocyte populations after VHSV-IFNNP oral intubation
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          Title: 3.6 VHSV-IFNNP bio-distribution: Gene expression in HK and spleen after intubation
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          Title: 3.7 Specific and neutralizing antibody titer elicited by VHSV-IFNNP subunit vaccine
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        Title: 4 Conclusions
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        Title: Authors contributions
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        Title: Ethics statement
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        Title: Funding
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        Title: Declaration of competing interest
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        Title: Acknowledgements
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        Title: Appendix A Supplementary data
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        Title: Data availability
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        Title: References
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    Keywords: Recombinant protein,Nanoparticles,VHSV,Subunit vaccine,IFNγ,Oral delivery,Rainbow trout
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  Checksum: 7d60a93f
   Type: CRC32
  Checksum: 919b204a6f9afb9ff87e4f4402d9e6ed
   Type: MD5
  Checksum: b48fea133051b87bdce931dadf934877bfc98497
   Type: SHA-1
  Checksum: accb5f3705737e0d94d22efcac2b970d87db30d7a6e91fd8f579cc4197718808
   Type: SHA-256