0880a2818fc2c4d1bd89630f9c1d9b07 s41408-024-01205-5.pdf e4c28585955d597aee52fa759835a559c9293649 s41408-024-01205-5.pdf ee0b9597c41e64fc33c8458a60efd1950839448a1a7ecdcdc0f0fceb89a95745 s41408-024-01205-5.pdf Title: Diverse real-life outcomes after intensive risk-adapted therapy for 1034 AML patients from the CETLAM Group Subject: Blood Cancer Journal, doi:10.1038/s41408-024-01205-5 Keywords: Author: Guadalupe Oñate Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sat Jan 11 09:41:38 2025 CET ModDate: Sat Jan 11 11:26:59 2025 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 2695597 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EEACCN+AdvMyriad_I Type 1C WinAnsi yes yes no 518 0 EEACBK+AdvOT46dcae81+22 Type 1C Custom yes yes yes 98 0 EEACCO+AdvMyriad_R Type 1C WinAnsi yes yes no 34 0 EEACBL+AdvOT65f8a23b.I Type 1C WinAnsi yes yes no 35 0 EEACBM+AdvTTab7e17fd Type 1C WinAnsi yes yes no 36 0 EEACEA+AdvOTa20b42a7 Type 1C WinAnsi yes yes no 519 0 EEACCP+AdvOT3b30f6db.B Type 1C WinAnsi yes yes no 39 0 EEACDA+AdvOT46dcae81+20 Type 1C WinAnsi yes yes no 40 0 EEABCK+AdvTT5afe5d37.B Type 1C WinAnsi yes yes no 520 0 EEABEK+Arial-BoldMT Type 1C WinAnsi yes yes no 69 0 EEABGK+AdvOT46dcae81 Type 1C WinAnsi yes yes no 37 0 EEABGL+AdvTT6780a46b Type 1C WinAnsi yes yes no 56 0 EEACBI+AdvTT2876772e+27 Type 1C Custom yes yes yes 521 0 EEACBJ+AdvOT46dcae81+fb Type 1C Custom yes yes yes 41 0 EEACIA+AdvOT7d2ebc01 Type 1C WinAnsi yes yes no 38 0 EEACLC+AdvTT6780a46b+20 Type 1C WinAnsi yes yes no 52 0 EEACLD+AdvTT6780a46b+22 Type 1C Custom yes yes yes 53 0 EEACKA+AdvOT919a0533.B Type 1C WinAnsi yes yes no 54 0 EEACKB+AdvOTd0125be5.BI Type 1C WinAnsi yes yes no 55 0 EEAGCA+ArialMT Type 1C Custom yes yes yes 66 0 EEAGFP+AdvTT6780a46b+fb Type 1C Custom yes yes yes 67 0 EEAGBP+Arial-BoldItalicMT Type 1C WinAnsi yes yes no 68 0 EEALGB+AdvOT3b30f6db.B+20 Type 1C WinAnsi yes yes no 112 0 EEAOIA+Calibri-Bold Type 1C Custom yes yes yes 125 0 EEAOJB+AdvOT3b30f6db.B+fb Type 1C Custom yes yes yes 126 0 EEAOHA+Calibri-BoldItalic Type 1C Custom yes yes yes 127 0 EEBCLI+Calibri Type 1C WinAnsi yes yes no 223 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-07-24 02:41:17 CEST RepresentationInformation: s41408-024-01205-5.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-07-23 15:36:27 CEST Size: 2695597 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 631 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Diverse real-life outcomes after intensive risk-adapted therapy for 1034 AML patients from the CETLAM Group Destination: title_link Children: Item: Title: Introduction Destination: A1 Item: Title: Methods Destination: A2 Children: Item: Title: Ethics approval and consent to participate Destination: B1 Item: Title: Treatment description Destination: B2 Item: Title: Laboratory testing Destination: B3 Item: Title: Statistical analyses Destination: B4 Item: Title: Results Destination: A3 Children: Item: Title: Patient characteristics Destination: B5 Item: Title: Induction therapy Destination: B6 Item: Title: Post-remission therapy Destination: B7 Children: Item: Title: Patients with favorable genetics Destination: C1 Item: Title: Patients with intermediate and adverse genetics with indication of alloHCT in CR1 Destination: C2 Item: Title: Time-dependent outcomes Destination: B8 Item: Title: MRD Destination: B9 Item: Title: Outcomes of alloHCT in CR1 for intermediate and adverse-risk patients Destination: B10 Item: Title: Prognostic factors and ICSA risk score Destination: B11 Item: Title: Discussion Destination: A4 Item: Title: References Destination: A5 Item: Title: Acknowledgements Destination: A6 Item: Title: Author contributions Destination: A7 Item: Title: Competing interests Destination: A8 Item: Title: ADDITIONAL INFORMATION Destination: M1 Info: Title: Diverse real-life outcomes after intensive risk-adapted therapy for 1034 AML patients from the CETLAM Group Author: Guadalupe Oñate Subject: Blood Cancer Journal, doi:10.1038/s41408-024-01205-5 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sat Jan 11 10:11:38 CET 2025 ModDate: Sat Jan 11 11:26:59 CET 2025 ID: 0x9067b58b4d400b75f0e27f920aaf9be1, 0xa0cc0d68a5524eb0ebc11f1b61f87c55 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1567 ImageHeight: 2278 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2000 ImageHeight: 587 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1953 ImageHeight: 1144 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1176 ImageHeight: 685 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1968 ImageHeight: 713 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Fonts: Type1: Font: BaseFont: EEAGCA+ArialMT FontSubset: true FirstChar: 2 LastChar: 124 FontDescriptor: FontName: EEAGCA+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EEAGFP+AdvTT6780a46b+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EEAGFP+AdvTT6780a46b+fb Flags: Symbolic FontBBox: 9, 0, 875, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EEAGBP+Arial-BoldItalicMT FontSubset: true FirstChar: 49 LastChar: 114 FontDescriptor: FontName: EEAGBP+Arial-BoldItalicMT Flags: Nonsymbolic, Italic FontBBox: -560, -376, 1390, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEABEK+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: EEABEK+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEACCN+AdvMyriad_I FontSubset: true FirstChar: 66 LastChar: 117 FontDescriptor: FontName: EEACCN+AdvMyriad_I Flags: Nonsymbolic FontBBox: -104, -239, 1083, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEACEA+AdvOTa20b42a7 FontSubset: true FirstChar: 48 LastChar: 118 FontDescriptor: FontName: EEACEA+AdvOTa20b42a7 Flags: Nonsymbolic FontBBox: -72, -239, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEABCK+AdvTT5afe5d37.B FontSubset: true FirstChar: 65 LastChar: 84 FontDescriptor: FontName: EEABCK+AdvTT5afe5d37.B Flags: Nonsymbolic FontBBox: -31, -250, 895, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEACBI+AdvTT2876772e+27 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EEACBI+AdvTT2876772e+27 Flags: Symbolic FontBBox: 0, -197, 968, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EEBCLI+Calibri FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: EEBCLI+Calibri Flags: Nonsymbolic FontBBox: -503, -312, 1240, 1026 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEACCO+AdvMyriad_R FontSubset: true FirstChar: 35 LastChar: 117 FontDescriptor: FontName: EEACCO+AdvMyriad_R Flags: Nonsymbolic FontBBox: -41, -239, 1125, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEACBK+AdvOT46dcae81+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EEACBK+AdvOT46dcae81+22 Flags: Symbolic FontBBox: 0, -145, 687, 822 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EEACBL+AdvOT65f8a23b.I FontSubset: true FirstChar: 40 LastChar: 119 FontDescriptor: FontName: EEACBL+AdvOT65f8a23b.I Flags: Nonsymbolic FontBBox: -104, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEACBM+AdvTTab7e17fd FontSubset: true FirstChar: 43 LastChar: 61 FontDescriptor: FontName: EEACBM+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEABGK+AdvOT46dcae81 FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: EEABGK+AdvOT46dcae81 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEACIA+AdvOT7d2ebc01 FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: EEACIA+AdvOT7d2ebc01 Flags: Nonsymbolic FontBBox: -31, -208, 958, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEACCP+AdvOT3b30f6db.B FontSubset: true FirstChar: 37 LastChar: 121 FontDescriptor: FontName: EEACCP+AdvOT3b30f6db.B Flags: Nonsymbolic FontBBox: -31, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEACDA+AdvOT46dcae81+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: EEACDA+AdvOT46dcae81+20 Flags: Nonsymbolic FontBBox: 0, -197, 1125, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEACBJ+AdvOT46dcae81+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: EEACBJ+AdvOT46dcae81+fb Flags: Symbolic FontBBox: 0, 0, 739, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EEALGB+AdvOT3b30f6db.B+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: EEALGB+AdvOT3b30f6db.B+20 Flags: Nonsymbolic FontBBox: -10, -197, 1250, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEACLC+AdvTT6780a46b+20 FontSubset: true FirstChar: 150 LastChar: 151 FontDescriptor: FontName: EEACLC+AdvTT6780a46b+20 Flags: Nonsymbolic FontBBox: 0, -114, 1156, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEACLD+AdvTT6780a46b+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EEACLD+AdvTT6780a46b+22 Flags: Symbolic FontBBox: 0, -250, 875, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EEACKA+AdvOT919a0533.B FontSubset: true FirstChar: 46 LastChar: 108 FontDescriptor: FontName: EEACKA+AdvOT919a0533.B Flags: Nonsymbolic FontBBox: -31, -250, 656, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEACKB+AdvOTd0125be5.BI FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: EEACKB+AdvOTd0125be5.BI Flags: Nonsymbolic FontBBox: -93, -250, 927, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEABGL+AdvTT6780a46b FontSubset: true FirstChar: 37 LastChar: 241 FontDescriptor: FontName: EEABGL+AdvTT6780a46b Flags: Nonsymbolic FontBBox: -41, -250, 875, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEAOIA+Calibri-Bold FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: EEAOIA+Calibri-Bold Flags: Symbolic FontBBox: -519, -349, 1263, 1039 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EEAOJB+AdvOT3b30f6db.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EEAOJB+AdvOT3b30f6db.B+fb Flags: Symbolic FontBBox: 0, 0, 833, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EEAOHA+Calibri-BoldItalic FontSubset: true FirstChar: 2 LastChar: 116 FontDescriptor: FontName: EEAOHA+Calibri-BoldItalic Flags: Symbolic, Italic FontBBox: -691, -306, 1330, 1039 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1038/s41408-024-01205-5 Diverse real-life outcomes after intensive risk-adapted therapy for 1034 AML patients from the CETLAM Group Guadalupe Oñate Ana Garrido Montserrat Arnan Helena Pomares Ester Alonso Mar Tormo Marina Diaz-Beya Susana Vives Lurdes Zamora Antonia Sampol Rosa Coll Olga Salamero Marta Cervera Antoni Garcia Ferran Vall-Llovera Sara Garcia-Avila Joan Bargay Xavier Ortin Eva Iranzo Francisca Guijarro Marta Pratcorona Josep F. Nomdedeu Jordi Esteve Jorge Sierra Springer US Blood Cancer Journal, doi:10.1038/s41408-024-01205-5 10.1038/s41408-024-01205-5 http://dx.doi.org/10.1038/s41408-024-01205-5 journal Blood Cancer Journal © 2024, The Author(s) 2044-5385 10.1038/s41408-024-01205-5 springer.com springerlink.com 2010-04-23 True 10.1038/s41408-024-01205-5 springer.com springerlink.com Springer 2025-01-11T11:26:59+01:00 2025-01-11T14:11:38+05:30 2025-01-11T11:26:59+01:00 True VoR uuid:e43a19b9-9b9c-433f-b51e-31361dc4e26a uuid:c48b0856-33aa-4b00-9ddd-db5c9f236fcd default 1 converted uuid:62cffdc6-6e51-4ce5-95ff-b06ecd15117a converted to PDF/A-2b pdfToolbox 2025-01-11T14:13:18+05:30 2 B Guadalupe Oñate http://orcid.org/0000-0003-2180-2371 Mar Tormo http://orcid.org/0000-0001-9622-1649 Antonia Sampol http://orcid.org/0000-0001-7465-6203 Olga Salamero http://orcid.org/0000-0003-3237-0025 Francisca Guijarro http://orcid.org/0000-0001-6376-0929 Josep F. Nomdedeu http://orcid.org/0000-0003-3399-346X Jorge Sierra http://orcid.org/0000-0002-7966-0356 http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the name of an author. name Text Gives the ORCID of an author. orcid URI http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 478, 689, 480, 721 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 478, 695, 534, 727 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 534, 695, 549, 705 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 534, 695, 549, 705 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 104, 628, 105, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 104, 628, 105, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 628, 116, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 107, 628, 114, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 628, 114, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 425, 628, 426, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 425, 628, 426, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 435, 628, 437, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 428, 628, 435, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 435, 628, 435, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 223, 617, 224, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 223, 617, 224, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 233, 617, 236, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 226, 617, 233, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 233, 617, 233, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 343, 617, 344, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 343, 617, 344, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 352, 617, 355, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 345, 617, 352, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 352, 617, 353, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 430, 606, 431, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 430, 606, 431, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 440, 606, 442, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 432, 606, 440, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 440, 606, 440, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 112, 595, 113, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 112, 595, 113, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 122, 595, 124, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 115, 595, 122, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 122, 595, 122, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 247, 595, 248, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 247, 595, 248, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 257, 595, 259, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 250, 595, 257, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 257, 595, 257, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 239, 408, 404, 417 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 179, 320, 183, 329 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 191, 320, 195, 329 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 256, 300, 260, 309 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 265, 300, 269, 309 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 212, 270, 216, 279 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 221, 270, 226, 279 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 143, 261, 147, 269 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 152, 261, 161, 269 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 153, 241, 162, 250 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 167, 241, 176, 250 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 119, 201, 128, 210 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 133, 201, 142, 210 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 420, 235, 489, 243 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 160, 80, 216, 87 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 476, 749, 549, 757 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 196, 664, 204, 672 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 87, 602, 95, 610 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 47, 584, 55, 592 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 59, 584, 67, 592 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 216, 575, 224, 583 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 230, 575, 238, 583 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 151, 390, 159, 398 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 261, 305, 269, 313 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 207, 170, 215, 178 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 406, 703, 410, 712 Flags: Print AppearanceDictionary: true Destination: 46 Annotation: Subtype: Link Rect: 550, 474, 555, 483 Flags: Print AppearanceDictionary: true Destination: 61 Annotation: Subtype: Link Rect: 365, 324, 369, 333 Flags: Print AppearanceDictionary: true Destination: 84 Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 67, 60, 76, 69 Flags: Print AppearanceDictionary: true Destination: 235 Thumb: true Page: Label: 4 Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 318, 275, 323, 284 Flags: Print AppearanceDictionary: true Destination: 84 Annotation: Subtype: Link Rect: 435, 215, 439, 224 Flags: Print AppearanceDictionary: true Destination: 84 Annotation: Subtype: Link Rect: 393, 195, 397, 204 Flags: Print AppearanceDictionary: true Destination: 108 Annotation: Subtype: Link Rect: 320, 145, 325, 154 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 488, 65, 493, 74 Flags: Print AppearanceDictionary: true Destination: 117 Thumb: true Page: Label: 6 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 145, 222, 150, 231 Flags: Print AppearanceDictionary: true Destination: 108 Annotation: Subtype: Link Rect: 389, 132, 393, 141 Flags: Print AppearanceDictionary: true Destination: 142 Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 225, 355, 230, 364 Flags: Print AppearanceDictionary: true Destination: 197 Annotation: Subtype: Link Rect: 266, 275, 275, 284 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 280, 275, 289, 284 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 181, 265, 190, 274 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 146, 255, 156, 264 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 96, 235, 105, 244 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 109, 235, 119, 244 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 123, 235, 132, 244 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 137, 235, 146, 244 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 207, 166, 217, 175 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 224, 86, 233, 95 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 238, 86, 247, 95 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 451, 455, 456, 464 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 460, 455, 469, 464 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 345, 325, 350, 334 Flags: Print AppearanceDictionary: true Destination: 108 Annotation: Subtype: Link Rect: 392, 325, 397, 334 Flags: Print AppearanceDictionary: true Destination: 61 Annotation: Subtype: Link Rect: 418, 325, 423, 334 Flags: Print AppearanceDictionary: true Destination: 84 Annotation: Subtype: Link Rect: 446, 196, 455, 205 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 416, 116, 425, 125 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 474, 76, 483, 85 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 487, 76, 497, 85 Flags: Print AppearanceDictionary: true Destination: 243 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 258, 189, 267, 198 Flags: Print AppearanceDictionary: true Destination: 243 Annotation: Subtype: Link Rect: 272, 189, 281, 198 Flags: Print AppearanceDictionary: true Destination: 243 Annotation: Subtype: Link Rect: 78, 159, 87, 168 Flags: Print AppearanceDictionary: true Destination: 243 Annotation: Subtype: Link Rect: 213, 100, 218, 109 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 223, 100, 232, 109 Flags: Print AppearanceDictionary: true Destination: 235 Annotation: Subtype: Link Rect: 237, 100, 247, 109 Flags: Print AppearanceDictionary: true Destination: 243 Annotation: Subtype: Link Rect: 137, 90, 146, 99 Flags: Print AppearanceDictionary: true Destination: 243 Annotation: Subtype: Link Rect: 150, 90, 160, 99 Flags: Print AppearanceDictionary: true Destination: 243 Annotation: Subtype: Link Rect: 119, 80, 128, 89 Flags: Print AppearanceDictionary: true Destination: 243 Annotation: Subtype: Link Rect: 38, 70, 47, 79 Flags: Print AppearanceDictionary: true Destination: 243 Annotation: Subtype: Link Rect: 509, 339, 518, 348 Flags: Print AppearanceDictionary: true Destination: 243 Thumb: true Page: Label: 10 Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 337, 538, 465, 545 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 479, 502, 549, 509 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 301, 493, 324, 500 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 531, 323, 549, 330 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 301, 314, 431, 321 Flags: Print AppearanceDictionary: true Thumb: true Checksum: a2e609ad Type: CRC32 Checksum: 0880a2818fc2c4d1bd89630f9c1d9b07 Type: MD5 Checksum: e4c28585955d597aee52fa759835a559c9293649 Type: SHA-1 Checksum: ee0b9597c41e64fc33c8458a60efd1950839448a1a7ecdcdc0f0fceb89a95745 Type: SHA-256