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Title:           Structural basis for the human SENP5’s SUMO isoform discrimination
Subject:         Nature Communications, doi:10.1038/s41467-025-60029-4
Keywords:        
Author:          Lucía Sánchez-Alba
Creator:         Springer
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      Title: Structural basis for the human SENP5’s SUMO isoform discrimination
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        Title: Results
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         Item: 
          Title: SENP5 prefers SUMO2 deconjugation
          Destination: B1
         Item: 
          Title: Crystal structure of the human SENP5CD in complex with SUMO1 and SUMO2
          Destination: B2
         Item: 
          Title: SENP5CD interface with SUMO1 and SUMO2
          Destination: B3
         Item: 
          Title: Major role of Arg624 in the SENP5CD selectivity for SUMO2 substrates
          Destination: B4
         Item: 
          Title: Swapping the SUMO isoforms activities in SENP5CD
          Destination: B5
         Item: 
          Title: The crystal structure of SUMO1E67D resembles the SUMO2 interface to SENP5CD
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       Item: 
        Title: Discussion
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       Item: 
        Title: Methods
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         Item: 
          Title: Plasmids, cloning and point mutation
          Destination: B7
         Item: 
          Title: Protein expression and purification
          Destination: B8
         Item: 
          Title: Synthesis of Δ18 N SUMO1 wild-type and E67D PA
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         Item: 
          Title: Synthesis of SUMO-Rhodamine-Morpholine (RM) reagents
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         Item: 
          Title: Synthesis of SUMO propargylamide activity-based probes
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         Item: 
          Title: Generation of SENP5-SUMO complexes
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         Item: 
          Title: Crystallization, data collection and refinement
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         Item: 
          Title: Transient cell transfection
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         Item: 
          Title: Western blot analysis
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         Item: 
          Title: SUMO-AMC hydrolysis assays
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         Item: 
          Title: SUMO-Rhodamine Morpholine hydrolysis assays
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         Item: 
          Title: In vitro de-SUMOyation assays
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         Item: 
          Title: Labeling of endogenous SENP3 in cell lysates
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       Item: 
        Title: Data availability
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       Item: 
        Title: References
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       Item: 
        Title: Acknowledgements
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       Item: 
        Title: Author contributions
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       Item: 
        Title: Competing interests
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       Item: 
        Title: Additional information
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