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Title:           Fluorescent substrates enable specific detection and structure-function insights into human aldehyde dehydrogenase isoforms
Subject:         Chemico-Biological Interactions, 418 (2025) 111609. doi:10.1016/j.cbi.2025.111609
Keywords:        Breast cancer,Enzyme inhibition,Fluorescence,Kinetic properties,Oxidoreductases,Structure-function relationships
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      Title: Fluorescent substrates enable specific detection and structure-function insights into human aldehyde dehydrogenase isoforms
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        Title: 1 Introduction
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        Title: 2 Materials and methods
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          Title: 2.1 ALDH substrates and inhibitors
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          Title: 2.2 Protein expression and purification
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          Title: 2.3 Determination of kinetic constants
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          Title: 2.6 ALDH activity assays in cell extracts
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          Title: 3.1 Determination of kinetic parameters for ALDH1A isoforms using BODIPY-aminoacetaldehyde as a substrate
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          Title: 3.2 Kinetic characterization of ALDH1A1, ALDH1A2, ALDH1A3, ALDH2 and ALDH3A1 isoforms using naphthaldehyde derivatives as s ...
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          Title: 3.3 Molecular docking analysis of naphthaldehyde derivatives reveals isoform-specific interactions with ALDH1A1 and ALDH1A3
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          Title: 3.5 The use of MONAL-62 as a substrate along with inhibitors enable complete ALDH1A1 inhibition in triple-negative breast c ...
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        Title: Declaration of competing interest
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  Checksum: 00b587c3
   Type: CRC32
  Checksum: 916367c8b3ebd771b8f1d1ccf4995f6c
   Type: MD5
  Checksum: 751222850a6b7e03dfd5e83e3be6827f4d4e0d2b
   Type: SHA-1
  Checksum: ee282c398f2b6024e41f322814872a38009d73b5f3ff01b971a7af8a30e60cc3
   Type: SHA-256