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Title:           LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson’s disease model
Subject:         Communications Biology, doi:10.1038/s42003-025-08544-4
Keywords:        
Author:          Lucas Blasco-Agell
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      Title: LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson’s disease model
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       Item: 
        Title: Results
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        Children: 
         Item: 
          Title: iPSC-derived hMG express typical microglial markers
          Destination: B1
         Item: 
          Title: Functional validation of hMG
          Destination: B2
         Item: 
          Title: L2-PD hMG increases NM uptake and releases ROS
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         Item: 
          Title: L2-PD hMG induces dopaminergic neuronal degeneration upon NM exposure
          Destination: B4
         Item: 
          Title: Treatment with Ivermectin prevents L2-PD hMG induced dopaminergic neuronal degeneration upon NM exposure
          Destination: B5
         Item: 
          Title: Microglial activation is increased in post-mortem brains from L2-PD patients
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        Title: Discussion
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          Title: Experimental procedures
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           Item: 
            Title: iPSC derived microglia (hMG)
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           Item: 
            Title: iPSC-derived vmDAn
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            Title: iPSC-derived organoid generation
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         Item: 
          Title: 2D and 3D Neuron/Microglia co-culture systems
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         Item: 
          Title: Immunocytochemistry
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         Item: 
          Title: Flow cytometry
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          Title: Gene expression analysis
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         Item: 
          Title: Cytokine array
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          Title: Synaptosome extraction
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         Item: 
          Title: Western blot
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         Item: 
          Title: pHrodo labeled synaptosome phagocytic assay
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          Title: Isolation of pure NM extracts from cultured TR5TY6 neuroblastoma cells
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         Item: 
          Title: Neuromelanin phagocytosis assay
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         Item: 
          Title: Motility analysis
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          Title: Intracellular ROS measurement
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         Item: 
          Title: Preparation of α-synuclein pre-formed fibrils (PFF)
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          Title: Human post-mortem brain tissue
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          Title: Statistics and reproducibility
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          Title: Reporting summary
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        Title: Data availability
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        Title: References
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       Item: 
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    Author: Lucas Blasco-Agell
    Subject: Communications Biology, doi:10.1038/s42003-025-08544-4
    Keywords: 
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