a003dadcbfe8c3a8e453c9741ed2e091 319505.pdf 3ddcbc695eb9b0b32212bbf4e570d2f437da5537 319505.pdf 0274c7aa6eb7e8d3a9a3d6d40bc6f64f5b7d0e488e272e19bc7f5208ebfabc55 319505.pdf Title: Update on the Prevalence, Incidence, Mortality, and Trends in Treatment of Inflammatory Bowel Disease in a Population-Based Registry in Catalonia Between 2017 and 2023 Subject: Background: The prevalence of inflammatory bowel disease (IBD) is increasing worldwide, while the incidence is tending to stabilize. Moreover, the use of biological treatments is increasing; some studies suggest that surgeries and hospitalizations are decreasing instead. Methods: A population-based, retrospective cohort study was conducted using data from the Catalan Health Surveillance System (CHSS). All patients diagnosed with IBD were included between 2017 and 2023. Crude incidence and prevalence rates were calculated for the Catalan population. Data on pharmacological therapy, surgical procedures, hospitalizations, and mortality were analyzed. Trends in age-sex-adjusted rates were also estimated, and logistic regression was used to calculate the adjusted mortality odds ratio (OR). Data for Crohn’s disease (CD) and ulcerative colitis (UC) were analyzed separately. Results: The number of prevalent IBD cases rose from 28,752 in 2017 to 41,423 in 2023. Despite incidence rates remaining stable (30.8 in 2017 and 29.9 per 100,000 inhabitants in 2023), prevalence rates increased (386.9 and 510.9 per 100,000 inhabitants, respectively). The use of biologics significantly increased (from 13.5% in 2017 to 21.0% in 2023), particularly ustekinumab and vedolizumab. In parallel, a decline in the use of immunosuppressants was observed. IBD-related surgeries and hospitalizations decreased during the study period, particularly among CD patients. Mortality remained low but was higher among IBD patients compared to the general population. Conclusions: The incidence of IBD in Catalonia has stabilized, while its prevalence continues rising, suggesting a transition to Stage 3 (compounding prevalence). The use of biological treatments is increasing steadily, whereas rates of surgeries and hospitalizations are consistently decreasing.12pt Keywords: epidemiology; quality of life; socio-economical; psychological endpoints Author: Eduard Brunet-Mas, Belen Garcia-Sagué, Emili Vela, Caridad Pontes, Luigi Melcarne, Luís E. Frisancho, Laura P. Llovet, Patricia Pedregal-Pascual, Sergio Lario, Maria J. Ramírez-Lázaro, Albert Villoria and Xavier Calvet Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25; modified using OpenPDF 1.4.2 CreationDate: Sat Aug 16 13:05:10 2025 CEST ModDate: Sat Aug 16 13:07:19 2025 CEST Custom Metadata: yes Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 770700 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JZCPVH+URWPalladioL-Ital Type 1 Custom yes yes yes 98 0 AIRHKL+VnURWPalladioL Type 1 Custom yes yes yes 99 0 UASSHQ+URWPalladioL-Bold Type 1 Custom yes yes yes 100 0 RODOWN+URWPalladioL-Roma Type 1 Custom yes yes yes 101 0 AMIPCF+PalatinoLinotype TrueType WinAnsi yes yes no 162 0 AMIPCH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 191 0 AMIPCF+PalatinoLinotype TrueType WinAnsi yes yes no 192 0 AMIPCF+PalatinoLinotype TrueType WinAnsi yes yes no 182 0 AMIPCD+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 183 0 FXXUVH+CMSY10 Type 1 Builtin yes yes yes 208 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-09-18 03:44:53 CEST RepresentationInformation: 319505.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-09-17 09:39:54 CEST Size: 770700 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 332 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Study Design, Participants, and Database Item: Title: Statistical Analysis Item: Title: Results Children: Item: Title: Patients’ Characteristics Item: Title: Prevalence and Incidence Item: Title: Mortality Item: Title: Time Trends in the Use of Drugs Item: Title: Surgical Procedures Item: Title: Hospital Admissions Item: Title: Discussion Item: Title: References Info: Title: Update on the Prevalence, Incidence, Mortality, and Trends in Treatment of Inflammatory Bowel Disease in a Population-Based Registry in Catalonia Between 2017 and 2023 Author: Eduard Brunet-Mas, Belen Garcia-Sagué, Emili Vela, Caridad Pontes, Luigi Melcarne, Luís E. Frisancho, Laura P. Llovet, Patricia Pedregal-Pascual, Sergio Lario, Maria J. Ramírez-Lázaro, Albert Villoria and Xavier Calvet Subject: Background: The prevalence of inflammatory bowel disease (IBD) is increasing worldwide, while the incidence is tending to stabilize. Moreover, the use of biological treatments is increasing; some studies suggest that surgeries and hospitalizations are decreasing instead. Methods: A population-based, retrospective cohort study was conducted using data from the Catalan Health Surveillance System (CHSS). All patients diagnosed with IBD were included between 2017 and 2023. Crude incidence and prevalence rates were calculated for the Catalan population. Data on pharmacological therapy, surgical procedures, hospitalizations, and mortality were analyzed. Trends in age-sex-adjusted rates were also estimated, and logistic regression was used to calculate the adjusted mortality odds ratio (OR). Data for Crohn’s disease (CD) and ulcerative colitis (UC) were analyzed separately. Results: The number of prevalent IBD cases rose from 28,752 in 2017 to 41,423 in 2023. Despite incidence rates remaining stable (30.8 in 2017 and 29.9 per 100,000 inhabitants in 2023), prevalence rates increased (386.9 and 510.9 per 100,000 inhabitants, respectively). The use of biologics significantly increased (from 13.5% in 2017 to 21.0% in 2023), particularly ustekinumab and vedolizumab. In parallel, a decline in the use of immunosuppressants was observed. IBD-related surgeries and hospitalizations decreased during the study period, particularly among CD patients. Mortality remained low but was higher among IBD patients compared to the general population. Conclusions: The incidence of IBD in Catalonia has stabilized, while its prevalence continues rising, suggesting a transition to Stage 3 (compounding prevalence). 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