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Infective endocarditis; Mortality; Oral antibiotic therapy; Oral step-down antibiotic treatment; Partial oral treatment; OPAT; Outpatient parenteral antibiotic treatment; Reinfections; Relapses application/pdf https://doi.org/10.1007/s40121-025-01110-9 Springer Healthcare Infectious Diseases and Therapy, https://doi.org/10.1007/s40121-025-01110-9 Randomized controlled trial Infective endocarditis Mortality Oral antibiotic therapy Oral step-down antibiotic treatment Partial oral treatment OPAT Outpatient parenteral antibiotic treatment Reinfections Relapses Oral vs. Outpatient Parenteral Antimicrobial Treatment for Infective Endocarditis: Study Protocol for the Spanish OraPAT-IE GAMES Trial Guillermo Cuervo Marta Hernández-Meneses Arístides de Alarcón Rafael Luque-Marquez María M. Alonso-Socas Ana López-Lirola Víctor González-Ramallo Ane J. Goikoetxea-Agirre David Nicolás Miguel A. Goenaga Esperanza Merino Francesc Escrihuela-Vidal Pilar Martín-Dávila Belén Loeches Lucía Boix-Palop Oriol Gasch Marta Camprecios Alicia Hernández-Torres Lara García-Álvarez Marcos Pajarón María Angels Ribas Rosa Blanes-Hernández Inmaculada López-Montesinos Luis E. López-Cortés Bárbara Vidal Mariana Fernández-Pittol Dolores Navarro Asunción Moreno Coral Sala Juan Ambrosioni José M. Miró Rut Andrea Manuel Almela Jorge Alcocer María Ascaso Manuel Azqueta Mercè Brunet Ramón Cartañá Manuel Castellá María Alexandra Cañas Guillermo Cuervo Oriol de Diego Carlos Falces Mateu Espasa Mariana Fernández-Pittol Guillermina Fita David Fuster Cristina García de la María Delia García-Pares Marta Hernández-Meneses Jaume Llopis-Pérez Teresa López Francesc Marco José M. Miró Asunción Moreno David Nicolás Salvador Ninot José Ortiz Carlos Paré Daniel Pereda Juan M. Pericás Andrés Perissinotti José L. Pomar Eduard Quintana José Ramírez Ander Regueiro Carlos Roca Mercè Roque Irene Rovira Elena Sandoval Laura Sanchis Marta Sitges Dolors Soy Adrián Téllez José M. Tolosana Xabier Urra Bárbara Vidal Montse Tuset Jordi Vila Arístides de Alarcón Dolores Navarro-Amuedo Encarnación Gutiérrez-Carretero José Antonio Lepe José López-Haldón Rafael Luque-Márquez Guillermo Marín Antonio Ortiz-Carrellán Eladio Sánchez-Domínguez Manuel Poyato-Borrego María del Mar Alonso Beatriz Castro Teresa Delgado-Melian Javier Fernández-Sarabia Dácil García-Rosado Julia González González Juan Lacalzada Lissete Lorenzo de la Peña Alina Pérez-Ramírez Pablo Prada-Arrondo Fermín Rodríguez-Moreno Iván Adán Juan Carlos Alonso Ana Álvarez-Uría Javier Bermejo Emilio Bouza Javier Calatayud Gregorio Cuerpo-Caballero Antonia Delgado-Montero Agustín Estévez Ramón Fortuny-Ribas Esther Gargallo María Eugenia García-Leoni Ana González Mansilla Francisco Javier González-Moraga Víctor González-Ramallo Martha Kestler-Hernández Amaia Mari Hualde Marina Machado Mercedes Marín Manuel Martínez-Sellés Rosa Melero Patricia Muñoz Diego Monzón María Olmedo Álvaro Pedraz Blanca Pinilla Ángel Pinto Cristina Rincón Hugo Rodríguez-Abella Eduardo Sánchez-Pérez Antonio Segado Maricela Valerio Pilar Vázquez Eduardo Verde-Moreno Sofía de la Villa Elena Bereciartua María José Blanco-Vidal Roberto Blanco María Victoria Boado Marta Campaña-Lázaro Alejandro Crespo Laura Guio-Carrión Mikel Del Álamo Martínez de Lagos Gorane Euba-Ugarte Ane Josune Goikoetxea Marta Ibarrola-Hierro José Ramón Iruretagoyena Josu Irurzun-Zuazabal Leire López-Soria Miguel Montejo Javier Nieto David Rodrigo Regino Rodríguez Yolanda Vitoria Roberto Voces Ignacio Álvarez-Rodríguez Xabier Camino Harkaitz Azkune-Galparsoro Elisa Berritu-Boronat María Jesús Bustinduy-Odriozola Cristina del Bosque-Martín Tomás Echeverría Alberto Eizaguirre-Yarza Ana Fuentes Miguel Ángel Goenaga Muskilda Goyeneche del Río Ángela Granda-Bauza José Antonio Iribarren Xabier Kortajarena-Urkola José Ignacio Pérez-Moreiras-López Ainhoa Rengel-Jiménez Karlos Reviejo Alberto Sáez-Berbejillo Elou Sánchez-Haza Rosa Sebastián-Alda Itziar Solla-Ruiz Irati Unamuno-Ugartemendia Diego Vicente-Anza Iñaki Villanueva-Benito Mar Zabalo-Arrieta Sara Sánchez Mikel Bidegain Muskilda Goyeneche Rafael Carrasco Vicente Climent Patricio Llamas Esperanza Merino Joaquín Plazas Sergio Reus Héctor Pinargote-Celorio Pilar González-de-la-Aleja Francesc Escrihuela-Vidal Jordi Carratalà Inmaculada Grau Carmen Ardanuy Dámaris Berbel José Carlos Sánchez-Salado Oriol Alegre Alejandro Ruiz-Majoral Fabrizio Sbraga Arnau Blasco Laura Gracia-Sánchez Iván Sánchez-Rodríguez Tomasa Centella Jos Manuel Hermida José Luis Moya Pilar Martín-Dávila Enrique Navas Enrique Oliva Alejandro del Río Jorge Rodríguez-Roda-Stuart Soledad Ruiz Isabel Antorrena Belén Loeches Mar Moreno Ulises Ramírez Verónica Rial-Bastón María Romero Sandra Rosillo Cristina Badía Lucía Boix-Palop Mariona Xercavins Sónia Ibars Beatriz Dietl Gastón Araujo Francesca Castaldo Eva Guillaumet Laura Guillamon Silvia Capilla Lucía Lozano Emili Díaz Sonia Calzado Aina Gomila Víctor Monsálvez Oriol Gasch Marta Camprecios Antonio Barros-Membrilla Antonino Ginel-Iglesias Sara Grillo Rubén Leta-Petracca Joaquín López-Contreras María Alba Rivera-Martínez Laura Albert Sergio Cánovas Elisa García Vázquez Alicia Hernández-Torres Ana Blázquez Gonzalo de la Morena Valenzuela José H. de Gea María Carmen Martínez-Toldos Encarnación Moral-Escudero María José Oliva Alejandro Ortín Joaquín Pérez-Andreu Avchel Roura-Piloto Daniel Saura Luis Javier Alonso Pedro Azcárate José Manuel Azcona-Gutiérrez José Ramón Blanco Estíbaliz Corral-Armas Lara García-Álvarez José Antonio Oteo Natalia Martín-Blanco Jesús Agüero-Balbín Cristina Amado-Fernández Carlos Armiñanzas-Castillo Francisco Arnaiz de las Revillas Manuel Cobo-Belaustegui María Carmen Fariñas Concepción Fariñas-Álvarez Marta Fernández-Sampedro Iván García Raquel Garrido Claudia González-Rico Laura Gutiérrez-Fernández Manuel Gutiérrez-Cuadra José Gutiérrez-Díez Marcos Pajarón José Antonio Parra Noelia Ruiz-Alonso Ramón Teira Jesús Zarauza María Ángels Ribas-Blanco Enrique Ruiz de Gopegui-Bordes Laura Vidal-Bonet Miquel Vives-Borràs Rosa Blanes-Hernández Miguel Ángel Arnau-Vives Diana Domingo-Valero Mariona Tasias-Pitarch Marta Montero-Alonso Eva Calabuig-Muñoz Juan Antonio Fernández-Navarro Víctor García-Bustos Miguel Salavert-Lleti Inmaculada López-Montesinos Mireia Ble Juan Pablo Horcajada-Gallego Antonio José Ginel Alexandra Mas Antoni Mestres Lluís Molina Ramón Serrat Núria Ribas Francisca Sánchez Ana Silverio Marina Suárez Luisa Sorlí Lluís Recasens Manuel Taurón Alicia Calvo-Fernández Ariadna Brasé Manuel Almendro-Delia Omar Araji José Miguel Barquero Román Calvo-Jambrina Marina de Cueto Irene Méndez Isabel Morales Luis Eduardo López-Cortés Paula Olivares 10.1007/s40121-025-01110-9 2010-04-23 true springer.com springerlink.com https://doi.org/10.1007/s40121-025-01110-9 10.1007/s40121-025-01110-9 2193-6382 14 3 643 655 journal Infectious Diseases and Therapy The Author(s) 2010-04-23 true 10.1007/s40121-025-01110-9 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