19b6e29de878bc540bb985267eccaa45 animals-15-01716-v2.pdf 0cf6719a7961b65fc3cfe603347349f268a95986 animals-15-01716-v2.pdf ed7d0aaa53ae4c780f28a50ada22d6b73f66c253ad2c15f8ae884f7adf31e6f4 animals-15-01716-v2.pdf Title: Clinical and Clinico-Pathological Observations of the Erythrocyte Sedimentation Rate in Dogs Affected by Leishmaniosis and Monitored During Antileishmanial Treatment Subject: The erythrocyte sedimentation rate (ESR) is used in canine medicine in several disorders, especially to evaluate the levels of inflammation. ESR is a valid inflammatory marker in canine leishmaniosis (CanL), being markedly increased in sick dogs. This study evaluated the ESR together with several other inflammatory and immune response markers in 43 dogs affected by severe leishmaniosis, treated with antileishmanial treatment. Dogs were monitored at the beginning (T1) of treatment, in the middle (T2) of treatment, and 7–10 days after the end of the treatment (T3). The antileishmanial treatment was based on meglumine antimoniate and allopurinol for four weeks plus adding prednisolone at the anti-inflammatory dosage progressively tapered within the T2 set point. The ESR was measured and compared to immune and/or inflammatory markers (C-reactive protein, fibrinogen, ferritin, gamma-globulins, IgG). ESR levels were statistically reduced during treatment and significantly decreased at the end of the treatment. This came along with an improvement in other blood markers. This study shows the utility of ESR as a point-of-care test that can be used to monitor the response of dogs to antileishmanial treatment. Keywords: canine; erythrocyte sedimentation rate; leishmaniosis; inflammatory markers; immune response markers Author: George Lubas, Saverio Paltrinieri, Roberto Amerigo Papini, Ilaria Lensi, Silvia Benali, Oscar Cortadellas, Alessandra Fondati, Xavier Roura and Eric Zini Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Fri Jun 13 02:25:07 2025 CEST ModDate: Fri Jun 13 05:09:07 2025 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 531541 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JANXKW+VnURWPalladioL Type 1 Custom yes yes yes 10 0 AHUENB+URWPalladioL-Roma Type 1 Custom yes yes yes 16 0 OUEKYK+URWPalladioL-Bold Type 1 Custom yes yes yes 22 0 YMCINQ+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 OVNEXW+EURM10 Type 1 Builtin yes yes yes 65 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 70 0 HCPSKZ+CMSY10 Type 1 Builtin yes yes yes 75 0 GBMKGO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 96 0 GBMKIA+PalatinoLinotype TrueType WinAnsi yes yes no 99 0 GBMKGO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 110 0 GBMKIA+PalatinoLinotype TrueType WinAnsi yes yes no 113 0 UGLOHL+PazoMath Type 1 Builtin yes yes yes 140 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-09-17 03:09:34 CEST RepresentationInformation: animals-15-01716-v2.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-09-16 14:36:22 CEST Size: 531541 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 353 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Design Destination: subsection.2.1 Item: Title: Enrollment of Dogs Destination: subsection.2.2 Item: Title: Laboratory Assays Destination: subsection.2.3 Item: Title: Statistical Analysis Destination: subsection.2.4 Item: Title: Results Destination: section.3 Children: Item: Title: Number of Dogs, Samples Collected and Type of Treatment Destination: subsection.3.1 Item: Title: Number, Signalment, and Clinical Classification of Enrolled Dogs Destination: subsection.3.2 Item: Title: Comparison of Measurements at Times T1 and T3 Destination: subsection.3.3 Item: Title: Comparison of Measurements at T1, T2, and T3 Destination: subsection.3.4 Item: Title: Comparison of Percentages of Values Outside the Reference Interval Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Clinical and Clinico-Pathological Observations of the Erythrocyte Sedimentation Rate in Dogs Affected by Leishmaniosis and Monitored During Antileishmanial Treatment Author: George Lubas, Saverio Paltrinieri, Roberto Amerigo Papini, Ilaria Lensi, Silvia Benali, Oscar Cortadellas, Alessandra Fondati, Xavier Roura and Eric Zini Subject: The erythrocyte sedimentation rate (ESR) is used in canine medicine in several disorders, especially to evaluate the levels of inflammation. ESR is a valid inflammatory marker in canine leishmaniosis (CanL), being markedly increased in sick dogs. This study evaluated the ESR together with several other inflammatory and immune response markers in 43 dogs affected by severe leishmaniosis, treated with antileishmanial treatment. Dogs were monitored at the beginning (T1) of treatment, in the middle (T2) of treatment, and 7 10 days after the end of the treatment (T3). The antileishmanial treatment was based on meglumine antimoniate and allopurinol for four weeks plus adding prednisolone at the anti-inflammatory dosage progressively tapered within the T2 set point. The ESR was measured and compared to immune and/or inflammatory markers (C-reactive protein, fibrinogen, ferritin, gamma-globulins, IgG). ESR levels were statistically reduced during treatment and significantly decreased at the end of the treatment. This came along with an improvement in other blood markers. This study shows the utility of ESR as a point-of-care test that can be used to monitor the response of dogs to antileishmanial treatment. 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