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      Title: The role of innate immune responses against two strains of PEDV (S INDEL and non-S INDEL) in newborn and weaned piglets inoculated by combined orogastric and intranasal routes
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       Item: 
        Title: 1 Introduction
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       Item: 
        Title: 2 Materials and methods
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         Item: 
          Title: 2.1 Viral inocula
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         Item: 
          Title: 2.2 Experimental design
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          Title: 2.3 Nucleic acid extraction and RT-qPCR/PCR for detection of viral pathogens
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          Title: 2.4 Detection of antibodies against PEDV and TGEV
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         Item: 
          Title: 2.5 Pathological analyses and immunohistochemistry
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         Item: 
          Title: 2.6 Methacarn-fixed paraffin-embedded tissue specimens
          Destination: s2_6
         Item: 
          Title: 2.7 Lasser capture microdissection
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         Item: 
          Title: 2.8 Total RNA isolation and cDNA synthesis
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         Item: 
          Title: 2.9 Transcriptomic analyses by microfluidic RT-qPCR
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         Item: 
          Title: 2.10 Selection of antiviral-related genes
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          Title: 2.11 Statistical analyses
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       Item: 
        Title: 3 Results
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         Item: 
          Title: 3.1 Newborn piglets experienced more severe disease than weaned piglets, but neither PEDV strain caused fever or mortality after acute infection
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          Title: 3.2 Age and strain independence in PEDV-induced small intestinal damage
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          Title: 3.3 Non-S INDEL and S INDEL PEDV isolates had similar loads in small intestine and feces in newborn and weaned piglets
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          Title: 3.4 Both PEDV strains actively replicated in the jejunum of newborn and weaned piglets
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          Title: 3.5 Weaned piglets mount a stronger antiviral (IFN I/III and ISGs) jejunal response against PEDV USA and PEDV CALAF isolates compared to newborn piglets
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          Title: 3.6 Both non-S INDEL and S INDEL PEDV strains modulated the MAPK signaling pathway in weaned piglets but not in newborn piglets
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          Title: 3.7 Junctional membrane and pyroptosis-related genes were upregulated in weaned piglets but not in newborn piglets inoculated with both PEDV strains
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          Title: 3.8 Weaned piglets mounted a proinflammatory intestinal response mediated by Th1 and Th17 cytokines, and prostaglandins against both PEDV strains, whereas this response was suppressed in newborn piglets
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        Title: 4 Discussion
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       Item: 
        Title: Data availability statement
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       Item: 
        Title: Ethics statement
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       Item: 
        Title: Author contributions
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       Item: 
        Title: Funding
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       Item: 
        Title: Acknowledgments
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       Item: 
        Title: Conflict of interest
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       Item: 
        Title: Generative AI statement
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       Item: 
        Title: Publisher’s note
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        Title: Supplementary material
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        Title: References
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    <rdf:li>C. López-Figueroa</rdf:li>
    <rdf:li>E. Cano</rdf:li>
    <rdf:li>N. Navarro</rdf:li>
    <rdf:li>M. Pérez</rdf:li>
    <rdf:li>R. López</rdf:li>
    <rdf:li>K. Skovgaard</rdf:li>
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    <rdf:li xml:lang='x-default'>López-Figueroa C, Cano E, Navarro N, Pérez M, López R, Skovgaard K, Vorsholt H, Heegaard PMH, Vergara-Alert J and Segalés J (2025) The role of innate immune responses against two strains of PEDV (S INDEL and non-S INDEL) in newborn and weaned piglets inoculated by combined orogastric and intranasal routes. Front. Immunol. 16:1584785. doi: 10.3389/fimmu.2025.1584785</rdf:li>
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    <rdf:li xml:lang='x-default'>Copyright © 2025 López-Figueroa, Cano, Navarro, Pérez, López, Skovgaard, Vorsholt, Heegaard, Vergara-Alert and Segalés. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</rdf:li>
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    <rdf:li>porcine epidemic diarrhea virus (PEDV)</rdf:li>
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    <rdf:li>S INDEL strain</rdf:li>
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   Type: CRC32
  Checksum: d20fb02badecbf58508725c56c0cf972
   Type: MD5
  Checksum: 4d70f7edbe5685ca2030e680e836a2ead48f7c08
   Type: SHA-1
  Checksum: 50152192a0e0f9a60c271f7a53b48caaeb7bcfee3166fc122082ee57b473ed56
   Type: SHA-256