37339a316a5344e656c0fcee903ade84  12020_2025_Article_4216.pdf
19feffa2331bbc0aa9d2d66f261ce88bc2b08f19  12020_2025_Article_4216.pdf
a73e06d32af15ef7d84a594457c6e53ec71807bafe88f45c88dea420acd1a9a8  12020_2025_Article_4216.pdf

Title:           Modern treatment of craniopharyngioma to improve outcomes: evidence of a change of paradigm
Subject:         Endocrine, doi:10.1007/s12020-025-04216-9
Keywords:        BRAF-MEK inhibitors; Papillary craniopharyngioma; Adamantinomatous craniopharyngioma; BRAF V600E mutation; Wnt/beta-catenin; Targeted treatment
Author:          Carlos González-Gallego
Creator:         Springer
CreationDate:    Wed Jun 25 13:20:37 2025 CEST
ModDate:         Wed Jun 25 13:22:33 2025 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           10
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       799133 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
ECPDKF+AdvOT5fcf1b24                 Type 1C           WinAnsi          yes yes no     411  0
ECPDON+AdvTT4ff65459                 Type 1C           WinAnsi          yes yes no     441  0
ECPDKG+AdvOT5fcf1b24+20              Type 1C           WinAnsi          yes yes no     412  0
ECPDKH+AdvOTce3d9a73                 Type 1C           WinAnsi          yes yes no     413  0
ECPDNH+AdvOTc20ddc96                 Type 1C           WinAnsi          yes yes no     421  0
ECPDNI+AdvOT8608a8d1+25              Type 1C           Custom           yes yes yes    422  0
ECPDNJ+AdvOT3b30f6db.B               Type 1C           WinAnsi          yes yes no     423  0
ECPDOK+AdvOTf9433e2d                 Type 1C           WinAnsi          yes yes no     424  0
ECPDOL+AdvOTf9433e2d+fb              Type 1C           Custom           yes yes yes    425  0
ECPDOM+AdvOTf9433e2d+20              Type 1C           WinAnsi          yes yes no     438  0
ECPEBN+AdvOT8608a8d1+03              Type 1C           Custom           yes yes yes    271  0
ECPEIL+AdvOT3b30f6db.B+fb            Type 1C           Custom           yes yes yes    276  0
ECPEML+AdvOT35387326.B               Type 1C           WinAnsi          yes yes no     277  0
ECPMPJ+AdvOTc20ddc96+fb              Type 1C           Custom           yes yes yes    285  0
ECPMPK+AdvOTc20ddc96+20              Type 1C           WinAnsi          yes yes no     284  0
ECPMPL+AdvOT9d60b855.B               Type 1C           WinAnsi          yes yes no     281  0
ECPNAM+AdvOT8608a8d1+01              Type 1C           Custom           yes yes yes    280  0
ECPNHK+AdvOTb4af3d5d.I               Type 1C           WinAnsi          yes yes no     287  0
ECPNHL+AdvTT7b515deb                 Type 1C           WinAnsi          yes yes no     286  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-10-10 03:52:55 CEST
 RepresentationInformation: 12020_2025_Article_4216.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-10-09 17:24:59 CEST
  Size: 799133
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 763
   FreeObjects: 88
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Modern treatment of craniopharyngioma to improve outcomes: evidence of a change of paradigm
      Destination: title_link
      Children: 
       Item: 
        Title: Abstract
        Destination: A1
       Item: 
        Title: Introduction
        Destination: A2
       Item: 
        Title: Methods
        Destination: A3
       Item: 
        Title: Results
        Destination: A4
       Item: 
        Title: Clinical evaluation
        Destination: A5
       Item: 
        Title: Radiologic assessment
        Destination: A6
       Item: 
        Title: Histologic confirmation
        Destination: A7
       Item: 
        Title: Surgical treatment
        Destination: A8
        Children: 
         Item: 
          Title: Radiation therapy
          Destination: B1
         Item: 
          Title: Medical therapy: preoperative and postoperative approaches
          Destination: B2
         Item: 
          Title: Papillary craniopharyngioma
          Destination: B3
         Item: 
          Title: Adamantinomatous craniopharyngioma
          Destination: B4
       Item: 
        Title: Conclusions
        Destination: A9
        Children: 
         Item: 
          Title: Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Author contributions
          Destination: B5
         Item: 
          Title: Compliance with ethical standards
          Destination: B6
       Item: 
        Title: ACKNOWLEDGMENTS
        Destination: M1
       Item: 
        Title: References
        Destination: A10
   Info: 
    Title: Modern treatment of craniopharyngioma to improve outcomes: evidence of a change of paradigm
    Author: Carlos González-Gallego
    Subject: Endocrine, doi:10.1007/s12020-025-04216-9
    Keywords: BRAF-MEK inhibitors; Papillary craniopharyngioma; Adamantinomatous craniopharyngioma; BRAF V600E mutation; Wnt/beta-catenin; Targeted treatment
    Creator: Springer
    CreationDate: Wed Jun 25 13:50:37 CEST 2025
    ModDate: Wed Jun 25 13:52:33 CEST 2025
   ID: 0xb6010a9414326c90d1f801ec6142e2db, 0x02a9ecaa30da1a46bdaa692067676f1c
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 96
      ImageHeight: 82
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1500
      ImageHeight: 854
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1500
      ImageHeight: 1311
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
   Fonts: 
    Type1: 
     Font: 
      BaseFont: ECPDNH+AdvOTc20ddc96
      FontSubset: true
      FirstChar: 46
      LastChar: 121
      FontDescriptor: 
       FontName: ECPDNH+AdvOTc20ddc96
       Flags: Nonsymbolic
       FontBBox: -31, -250, 791, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ECPDNI+AdvOT8608a8d1+25
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: ECPDNI+AdvOT8608a8d1+25
       Flags: Symbolic
       FontBBox: -10, -302, 1208, 906
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ECPDNJ+AdvOT3b30f6db.B
      FontSubset: true
      FirstChar: 65
      LastChar: 118
      FontDescriptor: 
       FontName: ECPDNJ+AdvOT3b30f6db.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 875, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ECPDOK+AdvOTf9433e2d
      FontSubset: true
      FirstChar: 37
      LastChar: 252
      FontDescriptor: 
       FontName: ECPDOK+AdvOTf9433e2d
       Flags: Serif, Nonsymbolic
       FontBBox: -62, -208, 927, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ECPDOL+AdvOTf9433e2d+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: ECPDOL+AdvOTf9433e2d+fb
       Flags: Symbolic
       FontBBox: 0, 0, 520, 697
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ECPEBN+AdvOT8608a8d1+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: ECPEBN+AdvOT8608a8d1+03
       Flags: Symbolic
       FontBBox: -479, -364, 854, 927
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ECPEIL+AdvOT3b30f6db.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: ECPEIL+AdvOT3b30f6db.B+fb
       Flags: Symbolic
       FontBBox: 0, 0, 833, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ECPEML+AdvOT35387326.B
      FontSubset: true
      FirstChar: 58
      LastChar: 121
      FontDescriptor: 
       FontName: ECPEML+AdvOT35387326.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 802, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ECPDOM+AdvOTf9433e2d+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: ECPDOM+AdvOTf9433e2d+20
       Flags: Nonsymbolic
       FontBBox: -166, -145, 1000, 708
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ECPNAM+AdvOT8608a8d1+01
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: ECPNAM+AdvOT8608a8d1+01
       Flags: Symbolic
       FontBBox: -62, -270, 927, 937
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ECPDON+AdvTT4ff65459
      FontSubset: true
      FirstChar: 42
      LastChar: 42
      FontDescriptor: 
       FontName: ECPDON+AdvTT4ff65459
       Flags: Nonsymbolic
       FontBBox: 0, -208, 1354, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ECPMPL+AdvOT9d60b855.B
      FontSubset: true
      FirstChar: 48
      LastChar: 57
      FontDescriptor: 
       FontName: ECPMPL+AdvOT9d60b855.B
       Flags: Nonsymbolic
       FontBBox: -62, -208, 979, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ECPDKF+AdvOT5fcf1b24
      FontSubset: true
      FirstChar: 40
      LastChar: 169
      FontDescriptor: 
       FontName: ECPDKF+AdvOT5fcf1b24
       Flags: Nonsymbolic
       FontBBox: -31, -250, 770, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ECPDKG+AdvOT5fcf1b24+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: ECPDKG+AdvOT5fcf1b24+20
       Flags: Nonsymbolic
       FontBBox: -125, -197, 1052, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ECPMPK+AdvOTc20ddc96+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: ECPMPK+AdvOTc20ddc96+20
       Flags: Nonsymbolic
       FontBBox: -125, -197, 1114, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ECPDKH+AdvOTce3d9a73
      FontSubset: true
      FirstChar: 44
      LastChar: 225
      FontDescriptor: 
       FontName: ECPDKH+AdvOTce3d9a73
       Flags: Nonsymbolic
       FontBBox: -41, -250, 854, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ECPMPJ+AdvOTc20ddc96+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: ECPMPJ+AdvOTc20ddc96+fb
       Flags: Symbolic
       FontBBox: 0, 0, 750, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ECPNHL+AdvTT7b515deb
      FontSubset: true
      FirstChar: 174
      LastChar: 174
      FontDescriptor: 
       FontName: ECPNHL+AdvTT7b515deb
       Flags: Nonsymbolic
       FontBBox: -93, -187, 854, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ECPNHK+AdvOTb4af3d5d.I
      FontSubset: true
      FirstChar: 65
      LastChar: 82
      FontDescriptor: 
       FontName: ECPNHK+AdvOTb4af3d5d.I
       Flags: Nonsymbolic
       FontBBox: -166, -208, 906, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2020/06/23-02:37:56        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
            xmlns:crossmark="http://crossref.org/crossmark/1.0/"
            xmlns:xmp="http://ns.adobe.com/xap/1.0/"
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
            xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
            xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
            xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
            xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
            xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1007/s12020-025-04216-9</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Modern treatment of craniopharyngioma to improve outcomes: evidence of a change of paradigm</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Carlos González-Gallego</rdf:li>
               <rdf:li>Pedro Molina</rdf:li>
               <rdf:li>Cristina Hostalot</rdf:li>
               <rdf:li>Anna Oliva</rdf:li>
               <rdf:li>Alberto Blanco</rdf:li>
               <rdf:li>Paloma Puyalto de Pablo</rdf:li>
               <rdf:li>Silvia Comas</rdf:li>
               <rdf:li>Cristina Carrato</rdf:li>
               <rdf:li>Elena Valassi</rdf:li>
               <rdf:li>Manel Puig-Domingo</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>BRAF-MEK inhibitors</rdf:li>
               <rdf:li>Papillary craniopharyngioma</rdf:li>
               <rdf:li>Adamantinomatous craniopharyngioma</rdf:li>
               <rdf:li>BRAF V600E mutation</rdf:li>
               <rdf:li>Wnt/beta-catenin</rdf:li>
               <rdf:li>Targeted treatment</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Endocrine, doi:10.1007/s12020-025-04216-9</rdf:li>
            </rdf:Alt>
         </dc:description>
         <prism:doi>10.1007/s12020-025-04216-9</prism:doi>
         <prism:url>http://dx.doi.org/10.1007/s12020-025-04216-9</prism:url>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Endocrine</prism:publicationName>
         <prism:copyright>© 2025, The Author(s)</prism:copyright>
         <prism:issn>1559-0100</prism:issn>
         <pdfx:doi>10.1007/s12020-025-04216-9</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>True</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1007/s12020-025-04216-9</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2025-06-25T16:52:33+05:30</xmp:ModifyDate>
         <xmp:CreateDate>2025-06-25T16:50:37+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2025-06-25T16:52:33+05:30</xmp:MetadataDate>
         <xmpRights:Marked>True</xmpRights:Marked>
         <pdf:Keywords>BRAF-MEK inhibitors; Papillary craniopharyngioma; Adamantinomatous craniopharyngioma; BRAF V600E mutation; Wnt/beta-catenin; Targeted treatment</pdf:Keywords>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:405ae8fb-02cd-477e-bc0b-1f285f2f2ed0</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:d8bc4514-58b2-4e09-83ad-4ba0deef3495</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:f4780e5e-17a6-4a5f-aab0-3c03e28354b2</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2025-06-25T16:52:32+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. &#xA;Comment &#xA;PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. &#xA;Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. &#xA;&#xA;</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.&#xA;The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. &#xA;If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. &#xA;Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. &#xA;Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. &#xA;&#xA;Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. &#xA;The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. &#xA;NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:&#xA;AO = Author’s Original&#xA;SMUR = Submitted Manuscript Under Review&#xA;AM = Accepted Manuscript&#xA;P = Proof&#xA;VoR = Version of Record&#xA;CVoR = Corrected Version of Record&#xA;EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 20
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 488, 698, 490, 723
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 488, 699, 546, 724
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 544, 715, 546, 725
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 544, 715, 546, 725
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 339, 286, 344, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 487, 236, 492, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 65, 150, 157, 158
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 21
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 182, 635, 187, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 149, 510, 154, 520
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 174, 373, 179, 383
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 234, 348, 239, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 244, 348, 249, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 255, 348, 259, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 266, 87, 270, 97
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 383, 659, 388, 669
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 397, 610, 402, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 408, 610, 413, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 419, 610, 424, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 474, 560, 479, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 412, 498, 417, 508
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 423, 498, 428, 508
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 433, 498, 438, 508
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 443, 498, 453, 508
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 462, 435, 467, 445
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 473, 435, 478, 445
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
     Thumb: true
    Page: 
     Label: 22
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 460, 59, 470
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 65, 460, 70, 470
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 75, 460, 85, 470
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 90, 460, 100, 470
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 111, 398, 116, 408
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 124, 398, 129, 408
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 136, 398, 146, 408
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 188, 261, 193, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 199, 261, 209, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 98, 224, 103, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 54, 186, 59, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 65, 186, 75, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 192, 74, 202, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 208, 74, 218, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 223, 74, 233, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 239, 74, 249, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 446, 635, 451, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 330, 149, 335, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 341, 149, 346, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 352, 149, 362, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 485, 74, 495, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 505, 74, 515, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
     Thumb: true
    Page: 
     Label: 23
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 169, 697, 179, 707
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 251, 510, 261, 520
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 186, 448, 196, 458
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 201, 448, 211, 458
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 216, 448, 226, 458
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 139, 410, 148, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 254, 323, 264, 333
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 269, 323, 279, 333
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 246, 186, 251, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 257, 186, 267, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 273, 186, 283, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 148, 149, 153, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 85, 74, 95, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 100, 74, 110, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 431, 659, 441, 669
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 446, 659, 455, 669
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 379, 597, 384, 607
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 390, 597, 400, 607
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 309, 572, 319, 582
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 395, 473, 405, 483
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 426, 398, 436, 408
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 424, 298, 434, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 440, 298, 450, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 208
      Annotation: 
       Subtype: Link
       Rect: 332, 273, 342, 283
       Flags: Print
       AppearanceDictionary: true
       Destination: 208
      Annotation: 
       Subtype: Link
       Rect: 528, 124, 538, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 208
     Thumb: true
    Page: 
     Label: 24
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 206, 672, 211, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 216, 672, 226, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 221, 597, 231, 607
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 90, 423, 100, 433
       Flags: Print
       AppearanceDictionary: true
       Destination: 208
      Annotation: 
       Subtype: Link
       Rect: 179, 398, 184, 408
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 93, 211, 103, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 220, 149, 225, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 231, 149, 241, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 246, 149, 256, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 261, 149, 271, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 208
      Annotation: 
       Subtype: Link
       Rect: 138, 74, 148, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 208
      Annotation: 
       Subtype: Link
       Rect: 154, 74, 164, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 208
      Annotation: 
       Subtype: Link
       Rect: 402, 373, 412, 383
       Flags: Print
       AppearanceDictionary: true
       Destination: 208
      Annotation: 
       Subtype: Link
       Rect: 417, 373, 427, 383
       Flags: Print
       AppearanceDictionary: true
       Destination: 208
      Annotation: 
       Subtype: Link
       Rect: 441, 323, 451, 333
       Flags: Print
       AppearanceDictionary: true
       Destination: 208
      Annotation: 
       Subtype: Link
       Rect: 528, 286, 538, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 208
      Annotation: 
       Subtype: Link
       Rect: 512, 261, 522, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 208
      Annotation: 
       Subtype: Link
       Rect: 456, 186, 461, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 118
      Annotation: 
       Subtype: Link
       Rect: 467, 186, 472, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 118
      Annotation: 
       Subtype: Link
       Rect: 460, 74, 465, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
     Thumb: true
    Page: 
     Label: 25
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 53, 124, 63, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 208
      Annotation: 
       Subtype: Link
       Rect: 149, 124, 153, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 276, 99, 285, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 208
      Annotation: 
       Subtype: Link
       Rect: 401, 136, 406, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 446, 99, 451, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 456, 99, 466, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 208
      Annotation: 
       Subtype: Link
       Rect: 472, 99, 482, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 208
     Thumb: true
    Page: 
     Label: 26
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 258, 659, 268, 669
       Flags: Print
       AppearanceDictionary: true
       Destination: 208
      Annotation: 
       Subtype: Link
       Rect: 273, 659, 283, 669
       Flags: Print
       AppearanceDictionary: true
       Destination: 257
      Annotation: 
       Subtype: Link
       Rect: 96, 75, 265, 84
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 508, 690, 544, 698
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 680, 435, 688
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 521, 480, 544, 489
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 471, 442, 479
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 464, 411, 544, 419
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 401, 372, 409
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 508, 321, 544, 330
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 311, 435, 320
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 484, 271, 544, 280
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 261, 406, 270
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 221, 460, 230
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 27
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 93, 662, 233, 671
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 121, 613, 266, 621
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 563, 219, 571
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 265, 513, 289, 521
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 503, 177, 511
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 134, 443, 267, 452
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 253, 403, 289, 412
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 393, 180, 402
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 141, 304, 275, 312
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 188, 264, 289, 272
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 254, 114, 262
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 228, 204, 289, 212
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 194, 156, 203
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 154, 198, 163
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 194, 114, 289, 123
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 104, 88, 113
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 457, 692, 544, 701
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 682, 372, 691
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 484, 642, 544, 651
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 632, 386, 641
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 593, 447, 601
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 448, 543, 544, 551
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 533, 342, 541
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 464, 493, 544, 501
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 483, 405, 491
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 443, 471, 452
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 348, 383, 480, 392
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 494, 314, 544, 322
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 304, 384, 312
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 380, 274, 525, 282
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 508, 234, 544, 242
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 224, 430, 232
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 385, 184, 544, 193
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 174, 335, 183
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 437, 104, 544, 113
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 94, 337, 103
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 28
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 266, 712, 289, 721
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 702, 190, 711
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 190, 652, 289, 661
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 642, 111, 651
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 265, 593, 289, 601
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 583, 187, 591
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 106, 533, 248, 541
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 443, 216, 452
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 93, 393, 241, 402
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 93, 344, 227, 352
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 284, 216, 292
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 93, 244, 237, 252
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 194, 211, 203
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 182, 154, 289, 163
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 144, 105, 153
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 209, 104, 289, 113
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 94, 136, 103
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 440, 692, 544, 701
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 682, 380, 691
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 494, 632, 544, 641
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 622, 390, 631
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 348, 563, 499, 571
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 460, 543, 544, 551
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 533, 387, 541
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 521, 503, 544, 511
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 493, 449, 501
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 379, 443, 511, 452
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 494, 393, 544, 402
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 383, 388, 392
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 464, 304, 544, 312
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 294, 380, 302
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 484, 254, 544, 262
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 244, 410, 252
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 380, 194, 541, 203
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 462, 154, 544, 163
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 144, 392, 153
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 437, 104, 544, 113
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 94, 360, 103
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 29
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 209, 702, 289, 711
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 692, 135, 701
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 412, 712, 544, 721
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 702, 342, 711
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 652, 448, 661
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: fecefb84
   Type: CRC32
  Checksum: 37339a316a5344e656c0fcee903ade84
   Type: MD5
  Checksum: 19feffa2331bbc0aa9d2d66f261ce88bc2b08f19
   Type: SHA-1
  Checksum: a73e06d32af15ef7d84a594457c6e53ec71807bafe88f45c88dea420acd1a9a8
   Type: SHA-256